Amino acid dipepetide frequency for Alteriqipengyuania lutimaris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.62AlaAla: 16.62 ± 0.197	1.106AlaCys: 1.106 ± 0.04	7.658AlaAsp: 7.658 ± 0.104	8.063AlaGlu: 8.063 ± 0.113	4.421AlaPhe: 4.421 ± 0.072	10.81AlaGly: 10.81 ± 0.138	2.168AlaHis: 2.168 ± 0.049	7.051AlaIle: 7.051 ± 0.095	3.999AlaLys: 3.999 ± 0.091	13.589AlaLeu: 13.589 ± 0.133	3.878AlaMet: 3.878 ± 0.077	3.276AlaAsn: 3.276 ± 0.075	6.012AlaPro: 6.012 ± 0.092	5.015AlaGln: 5.015 ± 0.093	9.599AlaArg: 9.599 ± 0.126	6.781AlaSer: 6.781 ± 0.096	6.06AlaThr: 6.06 ± 0.102	7.832AlaVal: 7.832 ± 0.099	1.58AlaTrp: 1.58 ± 0.042	2.417AlaTyr: 2.417 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.08CysAla: 1.08 ± 0.034	0.081CysCys: 0.081 ± 0.01	0.577CysAsp: 0.577 ± 0.028	0.523CysGlu: 0.523 ± 0.021	0.246CysPhe: 0.246 ± 0.016	0.916CysGly: 0.916 ± 0.031	0.175CysHis: 0.175 ± 0.014	0.333CysIle: 0.333 ± 0.022	0.156CysLys: 0.156 ± 0.013	0.689CysLeu: 0.689 ± 0.027	0.131CysMet: 0.131 ± 0.01	0.206CysAsn: 0.206 ± 0.016	0.382CysPro: 0.382 ± 0.019	0.193CysGln: 0.193 ± 0.014	0.502CysArg: 0.502 ± 0.019	0.438CysSer: 0.438 ± 0.021	0.367CysThr: 0.367 ± 0.019	0.568CysVal: 0.568 ± 0.025	0.093CysTrp: 0.093 ± 0.009	0.151CysTyr: 0.151 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.126AspAla: 8.126 ± 0.104	0.507AspCys: 0.507 ± 0.022	3.841AspAsp: 3.841 ± 0.085	4.269AspGlu: 4.269 ± 0.067	2.371AspPhe: 2.371 ± 0.056	6.298AspGly: 6.298 ± 0.106	1.282AspHis: 1.282 ± 0.038	2.997AspIle: 2.997 ± 0.054	1.737AspLys: 1.737 ± 0.05	6.141AspLeu: 6.141 ± 0.087	1.551AspMet: 1.551 ± 0.042	1.496AspAsn: 1.496 ± 0.041	3.967AspPro: 3.967 ± 0.072	1.78AspGln: 1.78 ± 0.043	5.037AspArg: 5.037 ± 0.081	2.626AspSer: 2.626 ± 0.057	2.981AspThr: 2.981 ± 0.058	3.983AspVal: 3.983 ± 0.063	1.15AspTrp: 1.15 ± 0.036	1.664AspTyr: 1.664 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	8.582GluAla: 8.582 ± 0.116	0.374GluCys: 0.374 ± 0.018	3.979GluAsp: 3.979 ± 0.072	4.354GluGlu: 4.354 ± 0.082	1.868GluPhe: 1.868 ± 0.048	5.634GluGly: 5.634 ± 0.071	1.227GluHis: 1.227 ± 0.037	3.289GluIle: 3.289 ± 0.062	2.204GluLys: 2.204 ± 0.06	5.604GluLeu: 5.604 ± 0.081	1.713GluMet: 1.713 ± 0.042	1.822GluAsn: 1.822 ± 0.044	3.175GluPro: 3.175 ± 0.064	2.439GluGln: 2.439 ± 0.047	5.569GluArg: 5.569 ± 0.096	2.842GluSer: 2.842 ± 0.056	3.659GluThr: 3.659 ± 0.061	4.064GluVal: 4.064 ± 0.064	0.975GluTrp: 0.975 ± 0.032	1.197GluTyr: 1.197 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	5.031PheAla: 5.031 ± 0.079	0.336PheCys: 0.336 ± 0.018	2.803PheAsp: 2.803 ± 0.06	2.409PheGlu: 2.409 ± 0.057	1.345PhePhe: 1.345 ± 0.043	3.704PheGly: 3.704 ± 0.071	0.7PheHis: 0.7 ± 0.023	1.451PheIle: 1.451 ± 0.039	0.8PheLys: 0.8 ± 0.028	3.105PheLeu: 3.105 ± 0.072	0.75PheMet: 0.75 ± 0.025	0.941PheAsn: 0.941 ± 0.034	1.506PhePro: 1.506 ± 0.035	0.87PheGln: 0.87 ± 0.031	2.113PheArg: 2.113 ± 0.047	2.005PheSer: 2.005 ± 0.048	1.987PheThr: 1.987 ± 0.047	2.808PheVal: 2.808 ± 0.06	0.502PheTrp: 0.502 ± 0.026	0.952PheTyr: 0.952 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	9.854GlyAla: 9.854 ± 0.115	0.824GlyCys: 0.824 ± 0.034	5.387GlyAsp: 5.387 ± 0.085	6.175GlyGlu: 6.175 ± 0.099	3.547GlyPhe: 3.547 ± 0.065	8.341GlyGly: 8.341 ± 0.182	1.766GlyHis: 1.766 ± 0.043	4.391GlyIle: 4.391 ± 0.069	3.016GlyLys: 3.016 ± 0.06	8.46GlyLeu: 8.46 ± 0.107	2.378GlyMet: 2.378 ± 0.057	2.381GlyAsn: 2.381 ± 0.077	3.75GlyPro: 3.75 ± 0.062	2.979GlyGln: 2.979 ± 0.061	6.012GlyArg: 6.012 ± 0.082	5.188GlySer: 5.188 ± 0.098	5.144GlyThr: 5.144 ± 0.186	5.878GlyVal: 5.878 ± 0.075	1.525GlyTrp: 1.525 ± 0.047	2.377GlyTyr: 2.377 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.373HisAla: 2.373 ± 0.054	0.243HisCys: 0.243 ± 0.017	1.18HisAsp: 1.18 ± 0.038	1.153HisGlu: 1.153 ± 0.036	0.808HisPhe: 0.808 ± 0.031	1.897HisGly: 1.897 ± 0.044	0.535HisHis: 0.535 ± 0.026	0.814HisIle: 0.814 ± 0.029	0.481HisLys: 0.481 ± 0.023	1.735HisLeu: 1.735 ± 0.046	0.411HisMet: 0.411 ± 0.023	0.414HisAsn: 0.414 ± 0.022	1.185HisPro: 1.185 ± 0.039	0.485HisGln: 0.485 ± 0.02	1.428HisArg: 1.428 ± 0.04	0.908HisSer: 0.908 ± 0.03	0.772HisThr: 0.772 ± 0.032	1.267HisVal: 1.267 ± 0.041	0.319HisTrp: 0.319 ± 0.019	0.533HisTyr: 0.533 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.852IleAla: 7.852 ± 0.093	0.424IleCys: 0.424 ± 0.023	3.922IleAsp: 3.922 ± 0.067	3.995IleGlu: 3.995 ± 0.07	1.608IlePhe: 1.608 ± 0.041	5.015IleGly: 5.015 ± 0.082	0.848IleHis: 0.848 ± 0.029	1.973IleIle: 1.973 ± 0.057	1.065IleLys: 1.065 ± 0.034	4.027IleLeu: 4.027 ± 0.075	0.946IleMet: 0.946 ± 0.031	1.262IleAsn: 1.262 ± 0.041	2.204IlePro: 2.204 ± 0.05	1.042IleGln: 1.042 ± 0.033	3.035IleArg: 3.035 ± 0.062	2.606IleSer: 2.606 ± 0.059	2.359IleThr: 2.359 ± 0.053	4.101IleVal: 4.101 ± 0.075	0.558IleTrp: 0.558 ± 0.026	1.016IleTyr: 1.016 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.603LysAla: 3.603 ± 0.072	0.152LysCys: 0.152 ± 0.013	1.633LysAsp: 1.633 ± 0.044	1.442LysGlu: 1.442 ± 0.047	0.799LysPhe: 0.799 ± 0.029	2.336LysGly: 2.336 ± 0.056	0.591LysHis: 0.591 ± 0.027	1.405LysIle: 1.405 ± 0.044	1.132LysLys: 1.132 ± 0.049	3.044LysLeu: 3.044 ± 0.067	0.687LysMet: 0.687 ± 0.028	0.714LysAsn: 0.714 ± 0.029	1.788LysPro: 1.788 ± 0.047	0.902LysGln: 0.902 ± 0.034	2.273LysArg: 2.273 ± 0.055	1.543LysSer: 1.543 ± 0.045	1.585LysThr: 1.585 ± 0.043	2.04LysVal: 2.04 ± 0.05	0.367LysTrp: 0.367 ± 0.018	0.585LysTyr: 0.585 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	14.147LeuAla: 14.147 ± 0.14	0.749LeuCys: 0.749 ± 0.026	6.394LeuAsp: 6.394 ± 0.087	5.512LeuGlu: 5.512 ± 0.088	3.593LeuPhe: 3.593 ± 0.077	8.219LeuGly: 8.219 ± 0.117	1.742LeuHis: 1.742 ± 0.047	4.478LeuIle: 4.478 ± 0.078	2.686LeuLys: 2.686 ± 0.051	8.972LeuLeu: 8.972 ± 0.14	2.087LeuMet: 2.087 ± 0.048	2.16LeuAsn: 2.16 ± 0.046	5.438LeuPro: 5.438 ± 0.088	2.488LeuGln: 2.488 ± 0.054	6.755LeuArg: 6.755 ± 0.092	5.741LeuSer: 5.741 ± 0.08	5.436LeuThr: 5.436 ± 0.104	7.288LeuVal: 7.288 ± 0.097	1.166LeuTrp: 1.166 ± 0.037	1.913LeuTyr: 1.913 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	3.227MetAla: 3.227 ± 0.06	0.146MetCys: 0.146 ± 0.013	1.213MetAsp: 1.213 ± 0.038	1.268MetGlu: 1.268 ± 0.037	0.632MetPhe: 0.632 ± 0.025	1.912MetGly: 1.912 ± 0.054	0.446MetHis: 0.446 ± 0.025	1.331MetIle: 1.331 ± 0.041	0.901MetLys: 0.901 ± 0.03	2.683MetLeu: 2.683 ± 0.054	0.65MetMet: 0.65 ± 0.028	0.672MetAsn: 0.672 ± 0.026	1.491MetPro: 1.491 ± 0.043	0.814MetGln: 0.814 ± 0.03	1.882MetArg: 1.882 ± 0.043	1.435MetSer: 1.435 ± 0.038	1.6MetThr: 1.6 ± 0.04	1.594MetVal: 1.594 ± 0.042	0.231MetTrp: 0.231 ± 0.015	0.278MetTyr: 0.278 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.325AsnAla: 3.325 ± 0.075	0.224AsnCys: 0.224 ± 0.017	1.415AsnAsp: 1.415 ± 0.047	1.39AsnGlu: 1.39 ± 0.037	0.942AsnPhe: 0.942 ± 0.03	2.321AsnGly: 2.321 ± 0.066	0.452AsnHis: 0.452 ± 0.021	1.246AsnIle: 1.246 ± 0.034	0.559AsnLys: 0.559 ± 0.023	2.49AsnLeu: 2.49 ± 0.059	0.549AsnMet: 0.549 ± 0.025	0.658AsnAsn: 0.658 ± 0.033	1.739AsnPro: 1.739 ± 0.044	0.697AsnGln: 0.697 ± 0.03	1.896AsnArg: 1.896 ± 0.041	1.294AsnSer: 1.294 ± 0.055	1.292AsnThr: 1.292 ± 0.045	1.843AsnVal: 1.843 ± 0.048	0.431AsnTrp: 0.431 ± 0.023	0.693AsnTyr: 0.693 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	6.399ProAla: 6.399 ± 0.109	0.325ProCys: 0.325 ± 0.017	3.982ProAsp: 3.982 ± 0.069	4.203ProGlu: 4.203 ± 0.068	1.974ProPhe: 1.974 ± 0.049	4.664ProGly: 4.664 ± 0.067	0.995ProHis: 0.995 ± 0.034	2.45ProIle: 2.45 ± 0.058	1.348ProLys: 1.348 ± 0.045	4.668ProLeu: 4.668 ± 0.073	1.144ProMet: 1.144 ± 0.032	1.201ProAsn: 1.201 ± 0.035	2.729ProPro: 2.729 ± 0.081	1.962ProGln: 1.962 ± 0.051	3.01ProArg: 3.01 ± 0.057	2.733ProSer: 2.733 ± 0.056	2.588ProThr: 2.588 ± 0.061	4.083ProVal: 4.083 ± 0.067	0.629ProTrp: 0.629 ± 0.027	1.104ProTyr: 1.104 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.124GlnAla: 4.124 ± 0.07	0.215GlnCys: 0.215 ± 0.015	1.679GlnAsp: 1.679 ± 0.042	1.675GlnGlu: 1.675 ± 0.041	1.127GlnPhe: 1.127 ± 0.034	2.619GlnGly: 2.619 ± 0.056	0.566GlnHis: 0.566 ± 0.025	1.738GlnIle: 1.738 ± 0.045	0.849GlnLys: 0.849 ± 0.03	3.109GlnLeu: 3.109 ± 0.059	0.851GlnMet: 0.851 ± 0.032	0.787GlnAsn: 0.787 ± 0.031	1.863GlnPro: 1.863 ± 0.047	1.218GlnGln: 1.218 ± 0.042	2.456GlnArg: 2.456 ± 0.054	1.761GlnSer: 1.761 ± 0.046	1.689GlnThr: 1.689 ± 0.045	2.343GlnVal: 2.343 ± 0.057	0.434GlnTrp: 0.434 ± 0.021	0.665GlnTyr: 0.665 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	8.468ArgAla: 8.468 ± 0.117	0.478ArgCys: 0.478 ± 0.027	4.577ArgAsp: 4.577 ± 0.071	5.176ArgGlu: 5.176 ± 0.077	2.953ArgPhe: 2.953 ± 0.055	5.22ArgGly: 5.22 ± 0.074	1.533ArgHis: 1.533 ± 0.043	4.129ArgIle: 4.129 ± 0.066	2.228ArgLys: 2.228 ± 0.057	7.353ArgLeu: 7.353 ± 0.101	2.01ArgMet: 2.01 ± 0.042	1.812ArgAsn: 1.812 ± 0.045	3.389ArgPro: 3.389 ± 0.058	2.34ArgGln: 2.34 ± 0.057	5.278ArgArg: 5.278 ± 0.092	3.707ArgSer: 3.707 ± 0.067	3.466ArgThr: 3.466 ± 0.061	4.669ArgVal: 4.669 ± 0.068	1.158ArgTrp: 1.158 ± 0.038	1.715ArgTyr: 1.715 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.437SerAla: 6.437 ± 0.095	0.372SerCys: 0.372 ± 0.019	3.518SerAsp: 3.518 ± 0.065	3.281SerGlu: 3.281 ± 0.066	2.112SerPhe: 2.112 ± 0.046	5.559SerGly: 5.559 ± 0.12	0.952SerHis: 0.952 ± 0.032	2.639SerIle: 2.639 ± 0.056	1.422SerLys: 1.422 ± 0.042	5.197SerLeu: 5.197 ± 0.083	1.217SerMet: 1.217 ± 0.033	1.409SerAsn: 1.409 ± 0.039	2.853SerPro: 2.853 ± 0.057	1.633SerGln: 1.633 ± 0.046	3.47SerArg: 3.47 ± 0.069	2.77SerSer: 2.77 ± 0.07	2.662SerThr: 2.662 ± 0.059	3.573SerVal: 3.573 ± 0.059	0.755SerTrp: 0.755 ± 0.028	1.298SerTyr: 1.298 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.902ThrAla: 5.902 ± 0.108	0.354ThrCys: 0.354 ± 0.021	3.054ThrAsp: 3.054 ± 0.059	2.706ThrGlu: 2.706 ± 0.063	1.949ThrPhe: 1.949 ± 0.055	5.374ThrGly: 5.374 ± 0.112	0.903ThrHis: 0.903 ± 0.032	3.093ThrIle: 3.093 ± 0.068	1.345ThrLys: 1.345 ± 0.039	5.677ThrLeu: 5.677 ± 0.133	1.237ThrMet: 1.237 ± 0.034	1.358ThrAsn: 1.358 ± 0.043	3.245ThrPro: 3.245 ± 0.062	1.648ThrGln: 1.648 ± 0.047	3.56ThrArg: 3.56 ± 0.067	2.67ThrSer: 2.67 ± 0.063	2.56ThrThr: 2.56 ± 0.072	3.788ThrVal: 3.788 ± 0.067	0.595ThrTrp: 0.595 ± 0.029	1.239ThrTyr: 1.239 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	8.932ValAla: 8.932 ± 0.101	0.538ValCys: 0.538 ± 0.022	4.516ValAsp: 4.516 ± 0.069	4.901ValGlu: 4.901 ± 0.076	2.379ValPhe: 2.379 ± 0.054	5.452ValGly: 5.452 ± 0.074	1.245ValHis: 1.245 ± 0.044	3.569ValIle: 3.569 ± 0.075	1.798ValLys: 1.798 ± 0.049	6.573ValLeu: 6.573 ± 0.088	1.507ValMet: 1.507 ± 0.04	1.828ValAsn: 1.828 ± 0.045	3.753ValPro: 3.753 ± 0.061	1.931ValGln: 1.931 ± 0.046	4.684ValArg: 4.684 ± 0.067	3.98ValSer: 3.98 ± 0.064	4.288ValThr: 4.288 ± 0.067	5.116ValVal: 5.116 ± 0.086	0.867ValTrp: 0.867 ± 0.032	1.28ValTyr: 1.28 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.315TrpAla: 1.315 ± 0.039	0.123TrpCys: 0.123 ± 0.012	0.801TrpAsp: 0.801 ± 0.032	0.657TrpGlu: 0.657 ± 0.027	0.552TrpPhe: 0.552 ± 0.024	0.951TrpGly: 0.951 ± 0.032	0.373TrpHis: 0.373 ± 0.019	0.65TrpIle: 0.65 ± 0.028	0.399TrpLys: 0.399 ± 0.02	1.796TrpLeu: 1.796 ± 0.058	0.349TrpMet: 0.349 ± 0.022	0.458TrpAsn: 0.458 ± 0.022	0.669TrpPro: 0.669 ± 0.026	0.628TrpGln: 0.628 ± 0.023	1.227TrpArg: 1.227 ± 0.04	0.867TrpSer: 0.867 ± 0.029	0.738TrpThr: 0.738 ± 0.023	0.804TrpVal: 0.804 ± 0.035	0.243TrpTrp: 0.243 ± 0.017	0.317TrpTyr: 0.317 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.536TyrAla: 2.536 ± 0.053	0.239TyrCys: 0.239 ± 0.015	1.675TyrAsp: 1.675 ± 0.041	1.418TyrGlu: 1.418 ± 0.042	0.892TyrPhe: 0.892 ± 0.035	2.131TyrGly: 2.131 ± 0.046	0.442TyrHis: 0.442 ± 0.022	0.83TyrIle: 0.83 ± 0.03	0.495TyrLys: 0.495 ± 0.027	2.05TyrLeu: 2.05 ± 0.045	0.36TyrMet: 0.36 ± 0.02	0.599TyrAsn: 0.599 ± 0.025	1.054TyrPro: 1.054 ± 0.035	0.701TyrGln: 0.701 ± 0.027	1.873TyrArg: 1.873 ± 0.046	1.236TyrSer: 1.236 ± 0.037	1.026TyrThr: 1.026 ± 0.034	1.494TyrVal: 1.494 ± 0.041	0.341TyrTrp: 0.341 ± 0.017	0.691TyrTyr: 0.691 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3062 proteins (978603 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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