Amino acid dipepetide frequency for Flavobacterium phage vB_FspS_laban6-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.946AlaAla: 2.946 ± 0.756
0.431AlaCys: 0.431 ± 0.156
2.659AlaAsp: 2.659 ± 0.603
4.527AlaGlu: 4.527 ± 0.591
3.593AlaPhe: 3.593 ± 0.544
2.946AlaGly: 2.946 ± 0.418
0.79AlaHis: 0.79 ± 0.212
5.102AlaIle: 5.102 ± 0.561
4.671AlaLys: 4.671 ± 0.77
5.102AlaLeu: 5.102 ± 0.721
1.796AlaMet: 1.796 ± 0.327
3.593AlaAsn: 3.593 ± 0.435
1.796AlaPro: 1.796 ± 0.401
2.587AlaGln: 2.587 ± 0.727
2.084AlaArg: 2.084 ± 0.449
3.377AlaSer: 3.377 ± 0.665
3.521AlaThr: 3.521 ± 0.754
2.515AlaVal: 2.515 ± 0.452
0.647AlaTrp: 0.647 ± 0.183
1.725AlaTyr: 1.725 ± 0.347
0.0AlaXaa: 0.0 ± 0.0
Cys
0.647CysAla: 0.647 ± 0.198
0.287CysCys: 0.287 ± 0.156
0.503CysAsp: 0.503 ± 0.218
0.719CysGlu: 0.719 ± 0.278
0.719CysPhe: 0.719 ± 0.266
0.431CysGly: 0.431 ± 0.226
0.144CysHis: 0.144 ± 0.102
0.287CysIle: 0.287 ± 0.127
0.647CysLys: 0.647 ± 0.204
0.79CysLeu: 0.79 ± 0.282
0.359CysMet: 0.359 ± 0.153
0.287CysAsn: 0.287 ± 0.155
0.216CysPro: 0.216 ± 0.116
0.359CysGln: 0.359 ± 0.156
0.359CysArg: 0.359 ± 0.184
0.503CysSer: 0.503 ± 0.18
0.287CysThr: 0.287 ± 0.153
0.287CysVal: 0.287 ± 0.169
0.144CysTrp: 0.144 ± 0.101
0.144CysTyr: 0.144 ± 0.108
0.0CysXaa: 0.0 ± 0.0
Asp
3.233AspAla: 3.233 ± 0.514
0.359AspCys: 0.359 ± 0.22
3.233AspAsp: 3.233 ± 0.496
3.233AspGlu: 3.233 ± 0.439
3.665AspPhe: 3.665 ± 0.517
4.024AspGly: 4.024 ± 0.526
0.216AspHis: 0.216 ± 0.122
4.455AspIle: 4.455 ± 0.551
5.03AspLys: 5.03 ± 0.57
4.814AspLeu: 4.814 ± 0.599
1.796AspMet: 1.796 ± 0.367
3.88AspAsn: 3.88 ± 0.476
1.15AspPro: 1.15 ± 0.278
1.509AspGln: 1.509 ± 0.485
1.653AspArg: 1.653 ± 0.346
2.946AspSer: 2.946 ± 0.476
2.371AspThr: 2.371 ± 0.468
3.449AspVal: 3.449 ± 0.5
1.006AspTrp: 1.006 ± 0.275
2.587AspTyr: 2.587 ± 0.564
0.0AspXaa: 0.0 ± 0.0
Glu
4.311GluAla: 4.311 ± 0.535
0.503GluCys: 0.503 ± 0.196
3.449GluAsp: 3.449 ± 0.436
5.748GluGlu: 5.748 ± 0.742
3.88GluPhe: 3.88 ± 0.572
3.593GluGly: 3.593 ± 0.563
1.581GluHis: 1.581 ± 0.388
7.185GluIle: 7.185 ± 1.011
7.617GluLys: 7.617 ± 1.048
7.976GluLeu: 7.976 ± 0.908
2.156GluMet: 2.156 ± 0.346
5.317GluAsn: 5.317 ± 0.671
1.222GluPro: 1.222 ± 0.404
3.162GluGln: 3.162 ± 0.495
1.94GluArg: 1.94 ± 0.394
4.311GluSer: 4.311 ± 0.496
3.09GluThr: 3.09 ± 0.382
4.886GluVal: 4.886 ± 0.553
1.078GluTrp: 1.078 ± 0.343
2.946GluTyr: 2.946 ± 0.501
0.0GluXaa: 0.0 ± 0.0
Phe
2.371PheAla: 2.371 ± 0.388
0.575PheCys: 0.575 ± 0.22
3.377PheAsp: 3.377 ± 0.45
4.814PheGlu: 4.814 ± 0.951
3.162PhePhe: 3.162 ± 0.526
3.018PheGly: 3.018 ± 0.421
0.719PheHis: 0.719 ± 0.243
3.88PheIle: 3.88 ± 0.757
4.024PheLys: 4.024 ± 0.721
5.82PheLeu: 5.82 ± 0.761
1.293PheMet: 1.293 ± 0.294
2.946PheAsn: 2.946 ± 0.449
1.293PhePro: 1.293 ± 0.417
2.084PheGln: 2.084 ± 0.522
2.227PheArg: 2.227 ± 0.372
3.593PheSer: 3.593 ± 0.391
3.952PheThr: 3.952 ± 0.541
4.168PheVal: 4.168 ± 0.543
0.862PheTrp: 0.862 ± 0.223
2.227PheTyr: 2.227 ± 0.45
0.0PheXaa: 0.0 ± 0.0
Gly
3.09GlyAla: 3.09 ± 0.625
0.575GlyCys: 0.575 ± 0.209
2.443GlyAsp: 2.443 ± 0.416
2.012GlyGlu: 2.012 ± 0.349
2.73GlyPhe: 2.73 ± 0.346
2.012GlyGly: 2.012 ± 0.352
0.647GlyHis: 0.647 ± 0.219
3.808GlyIle: 3.808 ± 0.51
5.174GlyLys: 5.174 ± 0.724
4.599GlyLeu: 4.599 ± 0.588
1.078GlyMet: 1.078 ± 0.303
3.808GlyAsn: 3.808 ± 0.446
0.719GlyPro: 0.719 ± 0.169
1.509GlyGln: 1.509 ± 0.458
1.868GlyArg: 1.868 ± 0.347
4.024GlySer: 4.024 ± 0.585
4.024GlyThr: 4.024 ± 0.709
3.162GlyVal: 3.162 ± 0.528
0.719GlyTrp: 0.719 ± 0.275
2.084GlyTyr: 2.084 ± 0.346
0.0GlyXaa: 0.0 ± 0.0
His
0.719HisAla: 0.719 ± 0.243
0.287HisCys: 0.287 ± 0.132
1.437HisAsp: 1.437 ± 0.312
1.796HisGlu: 1.796 ± 0.397
1.006HisPhe: 1.006 ± 0.282
0.503HisGly: 0.503 ± 0.168
0.503HisHis: 0.503 ± 0.222
1.653HisIle: 1.653 ± 0.363
1.293HisLys: 1.293 ± 0.379
1.15HisLeu: 1.15 ± 0.294
0.359HisMet: 0.359 ± 0.141
0.503HisAsn: 0.503 ± 0.189
1.006HisPro: 1.006 ± 0.262
0.647HisGln: 0.647 ± 0.22
0.647HisArg: 0.647 ± 0.25
1.293HisSer: 1.293 ± 0.384
0.934HisThr: 0.934 ± 0.387
0.359HisVal: 0.359 ± 0.157
0.0HisTrp: 0.0 ± 0.0
1.15HisTyr: 1.15 ± 0.244
0.0HisXaa: 0.0 ± 0.0
Ile
4.311IleAla: 4.311 ± 0.579
0.862IleCys: 0.862 ± 0.283
4.599IleAsp: 4.599 ± 0.504
6.826IleGlu: 6.826 ± 0.682
2.802IlePhe: 2.802 ± 0.507
3.305IleGly: 3.305 ± 0.518
1.437IleHis: 1.437 ± 0.433
5.82IleIle: 5.82 ± 0.877
8.335IleLys: 8.335 ± 0.784
6.539IleLeu: 6.539 ± 0.883
1.725IleMet: 1.725 ± 0.411
5.748IleAsn: 5.748 ± 0.706
2.515IlePro: 2.515 ± 0.497
3.377IleGln: 3.377 ± 0.471
2.443IleArg: 2.443 ± 0.433
6.898IleSer: 6.898 ± 0.728
4.024IleThr: 4.024 ± 0.665
4.455IleVal: 4.455 ± 0.655
0.79IleTrp: 0.79 ± 0.186
2.946IleTyr: 2.946 ± 0.492
0.0IleXaa: 0.0 ± 0.0
Lys
4.886LysAla: 4.886 ± 0.675
0.503LysCys: 0.503 ± 0.209
4.671LysAsp: 4.671 ± 0.509
8.191LysGlu: 8.191 ± 1.056
4.599LysPhe: 4.599 ± 0.488
4.311LysGly: 4.311 ± 0.671
1.581LysHis: 1.581 ± 0.386
7.114LysIle: 7.114 ± 0.988
9.413LysLys: 9.413 ± 1.256
7.545LysLeu: 7.545 ± 0.769
2.874LysMet: 2.874 ± 0.423
6.395LysAsn: 6.395 ± 0.942
2.587LysPro: 2.587 ± 0.55
3.88LysGln: 3.88 ± 0.722
4.527LysArg: 4.527 ± 0.69
6.108LysSer: 6.108 ± 0.708
4.527LysThr: 4.527 ± 0.635
4.599LysVal: 4.599 ± 0.374
0.719LysTrp: 0.719 ± 0.236
3.305LysTyr: 3.305 ± 0.44
0.0LysXaa: 0.0 ± 0.0
Leu
5.102LeuAla: 5.102 ± 0.605
0.79LeuCys: 0.79 ± 0.325
4.239LeuAsp: 4.239 ± 0.536
6.539LeuGlu: 6.539 ± 0.703
4.958LeuPhe: 4.958 ± 0.858
4.742LeuGly: 4.742 ± 0.67
2.084LeuHis: 2.084 ± 0.417
6.179LeuIle: 6.179 ± 0.637
9.269LeuLys: 9.269 ± 0.881
7.832LeuLeu: 7.832 ± 0.832
2.299LeuMet: 2.299 ± 0.402
7.042LeuAsn: 7.042 ± 0.865
3.018LeuPro: 3.018 ± 0.615
3.162LeuGln: 3.162 ± 0.51
3.162LeuArg: 3.162 ± 0.381
5.964LeuSer: 5.964 ± 0.635
4.455LeuThr: 4.455 ± 0.479
3.377LeuVal: 3.377 ± 0.631
0.647LeuTrp: 0.647 ± 0.188
3.736LeuTyr: 3.736 ± 0.569
0.0LeuXaa: 0.0 ± 0.0
Met
1.581MetAla: 1.581 ± 0.325
0.216MetCys: 0.216 ± 0.131
1.078MetAsp: 1.078 ± 0.254
1.15MetGlu: 1.15 ± 0.271
0.719MetPhe: 0.719 ± 0.242
1.078MetGly: 1.078 ± 0.257
0.575MetHis: 0.575 ± 0.2
2.73MetIle: 2.73 ± 0.472
2.443MetLys: 2.443 ± 0.518
2.084MetLeu: 2.084 ± 0.38
0.575MetMet: 0.575 ± 0.201
1.581MetAsn: 1.581 ± 0.326
0.719MetPro: 0.719 ± 0.225
1.365MetGln: 1.365 ± 0.291
0.79MetArg: 0.79 ± 0.203
2.874MetSer: 2.874 ± 0.334
1.15MetThr: 1.15 ± 0.251
1.293MetVal: 1.293 ± 0.274
0.144MetTrp: 0.144 ± 0.084
1.437MetTyr: 1.437 ± 0.316
0.0MetXaa: 0.0 ± 0.0
Asn
3.521AsnAla: 3.521 ± 0.573
0.719AsnCys: 0.719 ± 0.27
3.449AsnAsp: 3.449 ± 0.425
4.168AsnGlu: 4.168 ± 0.743
3.88AsnPhe: 3.88 ± 0.566
4.096AsnGly: 4.096 ± 0.771
1.15AsnHis: 1.15 ± 0.354
5.102AsnIle: 5.102 ± 0.686
5.82AsnLys: 5.82 ± 0.706
5.964AsnLeu: 5.964 ± 0.77
1.365AsnMet: 1.365 ± 0.239
3.593AsnAsn: 3.593 ± 0.524
3.449AsnPro: 3.449 ± 0.59
2.371AsnGln: 2.371 ± 0.43
2.515AsnArg: 2.515 ± 0.432
4.527AsnSer: 4.527 ± 0.8
2.587AsnThr: 2.587 ± 0.456
3.305AsnVal: 3.305 ± 0.571
1.078AsnTrp: 1.078 ± 0.199
2.802AsnTyr: 2.802 ± 0.555
0.0AsnXaa: 0.0 ± 0.0
Pro
1.725ProAla: 1.725 ± 0.417
0.503ProCys: 0.503 ± 0.167
1.868ProAsp: 1.868 ± 0.471
3.305ProGlu: 3.305 ± 0.408
2.515ProPhe: 2.515 ± 0.473
1.365ProGly: 1.365 ± 0.399
0.503ProHis: 0.503 ± 0.226
2.515ProIle: 2.515 ± 0.545
2.156ProLys: 2.156 ± 0.404
2.802ProLeu: 2.802 ± 0.514
0.431ProMet: 0.431 ± 0.161
1.653ProAsn: 1.653 ± 0.333
0.647ProPro: 0.647 ± 0.275
0.79ProGln: 0.79 ± 0.216
0.575ProArg: 0.575 ± 0.245
2.659ProSer: 2.659 ± 0.637
1.94ProThr: 1.94 ± 0.475
1.653ProVal: 1.653 ± 0.506
0.287ProTrp: 0.287 ± 0.125
1.15ProTyr: 1.15 ± 0.287
0.0ProXaa: 0.0 ± 0.0
Gln
1.94GlnAla: 1.94 ± 0.561
0.072GlnCys: 0.072 ± 0.07
1.581GlnAsp: 1.581 ± 0.258
3.018GlnGlu: 3.018 ± 0.601
2.371GlnPhe: 2.371 ± 0.374
1.509GlnGly: 1.509 ± 0.321
1.006GlnHis: 1.006 ± 0.334
3.018GlnIle: 3.018 ± 0.483
3.162GlnLys: 3.162 ± 0.552
3.305GlnLeu: 3.305 ± 0.66
1.653GlnMet: 1.653 ± 0.31
2.73GlnAsn: 2.73 ± 0.411
1.293GlnPro: 1.293 ± 0.359
1.293GlnGln: 1.293 ± 0.334
2.084GlnArg: 2.084 ± 0.374
1.509GlnSer: 1.509 ± 0.341
2.371GlnThr: 2.371 ± 0.469
1.868GlnVal: 1.868 ± 0.412
0.575GlnTrp: 0.575 ± 0.172
1.365GlnTyr: 1.365 ± 0.326
0.0GlnXaa: 0.0 ± 0.0
Arg
2.012ArgAla: 2.012 ± 0.404
0.144ArgCys: 0.144 ± 0.088
1.509ArgAsp: 1.509 ± 0.446
2.946ArgGlu: 2.946 ± 0.486
2.227ArgPhe: 2.227 ± 0.331
1.222ArgGly: 1.222 ± 0.304
0.503ArgHis: 0.503 ± 0.216
3.736ArgIle: 3.736 ± 0.49
3.593ArgLys: 3.593 ± 0.444
3.449ArgLeu: 3.449 ± 0.476
0.79ArgMet: 0.79 ± 0.236
2.156ArgAsn: 2.156 ± 0.295
0.934ArgPro: 0.934 ± 0.31
1.365ArgGln: 1.365 ± 0.28
1.15ArgArg: 1.15 ± 0.231
2.156ArgSer: 2.156 ± 0.434
1.868ArgThr: 1.868 ± 0.328
1.94ArgVal: 1.94 ± 0.339
0.287ArgTrp: 0.287 ± 0.169
1.293ArgTyr: 1.293 ± 0.306
0.0ArgXaa: 0.0 ± 0.0
Ser
3.808SerAla: 3.808 ± 0.527
0.431SerCys: 0.431 ± 0.2
4.311SerAsp: 4.311 ± 0.578
5.605SerGlu: 5.605 ± 0.654
4.599SerPhe: 4.599 ± 0.622
4.886SerGly: 4.886 ± 0.675
1.078SerHis: 1.078 ± 0.278
4.742SerIle: 4.742 ± 0.657
6.036SerLys: 6.036 ± 0.742
4.958SerLeu: 4.958 ± 0.465
1.581SerMet: 1.581 ± 0.265
4.599SerAsn: 4.599 ± 0.636
2.012SerPro: 2.012 ± 0.537
2.227SerGln: 2.227 ± 0.397
2.515SerArg: 2.515 ± 0.454
3.736SerSer: 3.736 ± 0.54
3.665SerThr: 3.665 ± 0.414
2.73SerVal: 2.73 ± 0.365
0.79SerTrp: 0.79 ± 0.294
2.659SerTyr: 2.659 ± 0.511
0.0SerXaa: 0.0 ± 0.0
Thr
4.311ThrAla: 4.311 ± 0.869
0.287ThrCys: 0.287 ± 0.132
3.377ThrAsp: 3.377 ± 0.563
3.665ThrGlu: 3.665 ± 0.596
3.593ThrPhe: 3.593 ± 0.579
2.587ThrGly: 2.587 ± 0.483
0.719ThrHis: 0.719 ± 0.227
5.245ThrIle: 5.245 ± 0.872
4.814ThrLys: 4.814 ± 0.546
4.886ThrLeu: 4.886 ± 0.494
0.79ThrMet: 0.79 ± 0.315
3.233ThrAsn: 3.233 ± 0.586
2.443ThrPro: 2.443 ± 0.584
1.94ThrGln: 1.94 ± 0.295
1.653ThrArg: 1.653 ± 0.327
3.09ThrSer: 3.09 ± 0.515
4.527ThrThr: 4.527 ± 0.74
1.796ThrVal: 1.796 ± 0.337
0.287ThrTrp: 0.287 ± 0.144
2.084ThrTyr: 2.084 ± 0.561
0.0ThrXaa: 0.0 ± 0.0
Val
3.162ValAla: 3.162 ± 0.76
0.287ValCys: 0.287 ± 0.143
3.521ValAsp: 3.521 ± 0.525
4.239ValGlu: 4.239 ± 0.592
2.371ValPhe: 2.371 ± 0.501
2.084ValGly: 2.084 ± 0.381
1.006ValHis: 1.006 ± 0.278
3.736ValIle: 3.736 ± 0.44
4.168ValLys: 4.168 ± 0.564
4.239ValLeu: 4.239 ± 0.644
1.365ValMet: 1.365 ± 0.332
3.162ValAsn: 3.162 ± 0.564
2.227ValPro: 2.227 ± 0.453
1.94ValGln: 1.94 ± 0.319
1.581ValArg: 1.581 ± 0.366
3.521ValSer: 3.521 ± 0.475
3.233ValThr: 3.233 ± 0.611
2.802ValVal: 2.802 ± 0.364
0.719ValTrp: 0.719 ± 0.229
2.299ValTyr: 2.299 ± 0.433
0.0ValXaa: 0.0 ± 0.0
Trp
0.575TrpAla: 0.575 ± 0.176
0.216TrpCys: 0.216 ± 0.115
0.503TrpAsp: 0.503 ± 0.191
0.431TrpGlu: 0.431 ± 0.184
0.79TrpPhe: 0.79 ± 0.211
0.647TrpGly: 0.647 ± 0.17
0.0TrpHis: 0.0 ± 0.0
0.79TrpIle: 0.79 ± 0.282
1.581TrpLys: 1.581 ± 0.306
1.293TrpLeu: 1.293 ± 0.312
0.359TrpMet: 0.359 ± 0.179
0.79TrpAsn: 0.79 ± 0.224
0.216TrpPro: 0.216 ± 0.123
0.431TrpGln: 0.431 ± 0.151
0.216TrpArg: 0.216 ± 0.16
0.862TrpSer: 0.862 ± 0.276
0.575TrpThr: 0.575 ± 0.174
0.647TrpVal: 0.647 ± 0.264
0.216TrpTrp: 0.216 ± 0.15
0.216TrpTyr: 0.216 ± 0.127
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.156TyrAla: 2.156 ± 0.462
0.072TyrCys: 0.072 ± 0.065
2.802TyrAsp: 2.802 ± 0.465
3.018TyrGlu: 3.018 ± 0.447
2.227TyrPhe: 2.227 ± 0.566
1.725TyrGly: 1.725 ± 0.421
1.006TyrHis: 1.006 ± 0.254
2.659TyrIle: 2.659 ± 0.5
3.162TyrLys: 3.162 ± 0.35
3.449TyrLeu: 3.449 ± 0.428
0.862TyrMet: 0.862 ± 0.268
2.443TyrAsn: 2.443 ± 0.467
1.581TyrPro: 1.581 ± 0.344
1.725TyrGln: 1.725 ± 0.448
1.293TyrArg: 1.293 ± 0.299
3.018TyrSer: 3.018 ± 0.494
2.227TyrThr: 2.227 ± 0.441
2.371TyrVal: 2.371 ± 0.469
0.359TyrTrp: 0.359 ± 0.169
1.94TyrTyr: 1.94 ± 0.425
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 57 proteins (13918 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski