Amino acid dipepetide frequency for Porphyromonas macacae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.227AlaAla: 5.227 ± 0.118	0.904AlaCys: 0.904 ± 0.044	4.079AlaAsp: 4.079 ± 0.084	5.008AlaGlu: 5.008 ± 0.1	3.187AlaPhe: 3.187 ± 0.08	5.216AlaGly: 5.216 ± 0.1	1.328AlaHis: 1.328 ± 0.05	4.975AlaIle: 4.975 ± 0.101	4.358AlaLys: 4.358 ± 0.08	6.912AlaLeu: 6.912 ± 0.116	1.992AlaMet: 1.992 ± 0.062	2.831AlaAsn: 2.831 ± 0.068	2.362AlaPro: 2.362 ± 0.059	2.61AlaGln: 2.61 ± 0.063	3.405AlaArg: 3.405 ± 0.075	3.969AlaSer: 3.969 ± 0.09	3.219AlaThr: 3.219 ± 0.066	4.991AlaVal: 4.991 ± 0.085	0.614AlaTrp: 0.614 ± 0.033	2.76AlaTyr: 2.76 ± 0.066	0.003AlaXaa: 0.003 ± 0.002
Cys	0.622CysAla: 0.622 ± 0.031	0.175CysCys: 0.175 ± 0.017	0.509CysAsp: 0.509 ± 0.026	0.639CysGlu: 0.639 ± 0.031	0.555CysPhe: 0.555 ± 0.03	0.922CysGly: 0.922 ± 0.043	0.291CysHis: 0.291 ± 0.026	0.82CysIle: 0.82 ± 0.041	0.633CysLys: 0.633 ± 0.034	0.965CysLeu: 0.965 ± 0.042	0.251CysMet: 0.251 ± 0.019	0.575CysAsn: 0.575 ± 0.032	0.514CysPro: 0.514 ± 0.028	0.244CysGln: 0.244 ± 0.02	0.622CysArg: 0.622 ± 0.036	0.751CysSer: 0.751 ± 0.035	0.558CysThr: 0.558 ± 0.029	0.605CysVal: 0.605 ± 0.032	0.114CysTrp: 0.114 ± 0.013	0.45CysTyr: 0.45 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	3.646AspAla: 3.646 ± 0.074	0.583AspCys: 0.583 ± 0.03	2.379AspAsp: 2.379 ± 0.065	3.846AspGlu: 3.846 ± 0.093	2.913AspPhe: 2.913 ± 0.068	3.452AspGly: 3.452 ± 0.087	0.915AspHis: 0.915 ± 0.041	4.18AspIle: 4.18 ± 0.094	3.691AspLys: 3.691 ± 0.076	5.038AspLeu: 5.038 ± 0.1	1.587AspMet: 1.587 ± 0.053	2.431AspAsn: 2.431 ± 0.061	2.018AspPro: 2.018 ± 0.064	1.226AspGln: 1.226 ± 0.04	2.81AspArg: 2.81 ± 0.074	3.098AspSer: 3.098 ± 0.074	2.677AspThr: 2.677 ± 0.054	3.398AspVal: 3.398 ± 0.082	0.672AspTrp: 0.672 ± 0.033	2.57AspTyr: 2.57 ± 0.064	0.0AspXaa: 0.0 ± 0.0
Glu	5.08GluAla: 5.08 ± 0.104	0.575GluCys: 0.575 ± 0.028	3.259GluAsp: 3.259 ± 0.079	5.742GluGlu: 5.742 ± 0.122	2.304GluPhe: 2.304 ± 0.068	3.983GluGly: 3.983 ± 0.069	1.473GluHis: 1.473 ± 0.05	4.824GluIle: 4.824 ± 0.107	5.661GluLys: 5.661 ± 0.105	6.815GluLeu: 6.815 ± 0.105	1.91GluMet: 1.91 ± 0.048	3.529GluAsn: 3.529 ± 0.076	2.098GluPro: 2.098 ± 0.054	3.085GluGln: 3.085 ± 0.073	3.913GluArg: 3.913 ± 0.084	3.223GluSer: 3.223 ± 0.062	3.34GluThr: 3.34 ± 0.067	4.336GluVal: 4.336 ± 0.086	0.783GluTrp: 0.783 ± 0.037	2.524GluTyr: 2.524 ± 0.063	0.008GluXaa: 0.008 ± 0.003
Phe	2.979PheAla: 2.979 ± 0.074	0.525PheCys: 0.525 ± 0.025	2.899PheAsp: 2.899 ± 0.075	2.576PheGlu: 2.576 ± 0.067	2.485PhePhe: 2.485 ± 0.071	3.454PheGly: 3.454 ± 0.079	0.848PheHis: 0.848 ± 0.037	3.359PheIle: 3.359 ± 0.079	2.396PheLys: 2.396 ± 0.058	4.307PheLeu: 4.307 ± 0.116	1.322PheMet: 1.322 ± 0.054	2.348PheAsn: 2.348 ± 0.057	1.642PhePro: 1.642 ± 0.054	1.129PheGln: 1.129 ± 0.044	2.153PheArg: 2.153 ± 0.062	3.552PheSer: 3.552 ± 0.08	2.52PheThr: 2.52 ± 0.063	2.951PheVal: 2.951 ± 0.069	0.476PheTrp: 0.476 ± 0.026	1.875PheTyr: 1.875 ± 0.052	0.0PheXaa: 0.0 ± 0.0
Gly	4.68GlyAla: 4.68 ± 0.085	0.879GlyCys: 0.879 ± 0.036	3.076GlyAsp: 3.076 ± 0.068	4.124GlyGlu: 4.124 ± 0.084	3.251GlyPhe: 3.251 ± 0.085	4.818GlyGly: 4.818 ± 0.122	1.451GlyHis: 1.451 ± 0.051	5.438GlyIle: 5.438 ± 0.11	5.255GlyLys: 5.255 ± 0.105	6.262GlyLeu: 6.262 ± 0.104	2.09GlyMet: 2.09 ± 0.062	3.188GlyAsn: 3.188 ± 0.075	1.348GlyPro: 1.348 ± 0.049	1.964GlyGln: 1.964 ± 0.056	3.324GlyArg: 3.324 ± 0.077	4.068GlySer: 4.068 ± 0.086	3.651GlyThr: 3.651 ± 0.078	4.841GlyVal: 4.841 ± 0.096	0.811GlyTrp: 0.811 ± 0.036	3.123GlyTyr: 3.123 ± 0.089	0.0GlyXaa: 0.0 ± 0.0
His	1.287HisAla: 1.287 ± 0.045	0.264HisCys: 0.264 ± 0.022	0.906HisAsp: 0.906 ± 0.038	1.165HisGlu: 1.165 ± 0.039	1.067HisPhe: 1.067 ± 0.038	1.24HisGly: 1.24 ± 0.047	0.53HisHis: 0.53 ± 0.033	1.62HisIle: 1.62 ± 0.052	1.203HisLys: 1.203 ± 0.044	2.021HisLeu: 2.021 ± 0.065	0.395HisMet: 0.395 ± 0.026	0.986HisAsn: 0.986 ± 0.039	1.053HisPro: 1.053 ± 0.05	0.605HisGln: 0.605 ± 0.032	1.134HisArg: 1.134 ± 0.043	1.181HisSer: 1.181 ± 0.044	1.12HisThr: 1.12 ± 0.045	1.122HisVal: 1.122 ± 0.043	0.248HisTrp: 0.248 ± 0.021	0.89HisTyr: 0.89 ± 0.04	0.0HisXaa: 0.0 ± 0.0
Ile	5.433IleAla: 5.433 ± 0.098	0.884IleCys: 0.884 ± 0.042	4.536IleAsp: 4.536 ± 0.081	4.922IleGlu: 4.922 ± 0.093	3.041IlePhe: 3.041 ± 0.072	4.814IleGly: 4.814 ± 0.113	1.476IleHis: 1.476 ± 0.049	5.28IleIle: 5.28 ± 0.099	4.785IleLys: 4.785 ± 0.091	6.394IleLeu: 6.394 ± 0.119	1.596IleMet: 1.596 ± 0.054	3.43IleAsn: 3.43 ± 0.081	3.382IlePro: 3.382 ± 0.067	2.073IleGln: 2.073 ± 0.061	4.04IleArg: 4.04 ± 0.078	4.882IleSer: 4.882 ± 0.088	4.033IleThr: 4.033 ± 0.078	4.466IleVal: 4.466 ± 0.092	0.639IleTrp: 0.639 ± 0.032	2.662IleTyr: 2.662 ± 0.069	0.002IleXaa: 0.002 ± 0.002
Lys	4.797LysAla: 4.797 ± 0.087	0.467LysCys: 0.467 ± 0.031	3.766LysAsp: 3.766 ± 0.07	5.923LysGlu: 5.923 ± 0.12	2.089LysPhe: 2.089 ± 0.065	4.413LysGly: 4.413 ± 0.096	1.336LysHis: 1.336 ± 0.046	4.585LysIle: 4.585 ± 0.101	5.547LysLys: 5.547 ± 0.112	5.527LysLeu: 5.527 ± 0.103	2.129LysMet: 2.129 ± 0.067	3.652LysAsn: 3.652 ± 0.085	2.604LysPro: 2.604 ± 0.068	2.684LysGln: 2.684 ± 0.081	3.71LysArg: 3.71 ± 0.079	3.69LysSer: 3.69 ± 0.07	3.819LysThr: 3.819 ± 0.082	3.774LysVal: 3.774 ± 0.083	0.647LysTrp: 0.647 ± 0.033	2.71LysTyr: 2.71 ± 0.064	0.003LysXaa: 0.003 ± 0.002
Leu	6.286LeuAla: 6.286 ± 0.119	1.231LeuCys: 1.231 ± 0.043	4.71LeuAsp: 4.71 ± 0.108	5.456LeuGlu: 5.456 ± 0.109	5.089LeuPhe: 5.089 ± 0.103	6.144LeuGly: 6.144 ± 0.11	1.898LeuHis: 1.898 ± 0.058	6.517LeuIle: 6.517 ± 0.112	6.653LeuLys: 6.653 ± 0.1	9.81LeuLeu: 9.81 ± 0.183	2.596LeuMet: 2.596 ± 0.063	4.744LeuAsn: 4.744 ± 0.097	4.457LeuPro: 4.457 ± 0.085	3.171LeuGln: 3.171 ± 0.062	4.799LeuArg: 4.799 ± 0.098	7.462LeuSer: 7.462 ± 0.105	5.281LeuThr: 5.281 ± 0.11	5.049LeuVal: 5.049 ± 0.1	1.004LeuTrp: 1.004 ± 0.042	3.554LeuTyr: 3.554 ± 0.085	0.002LeuXaa: 0.002 ± 0.001
Met	2.195MetAla: 2.195 ± 0.059	0.23MetCys: 0.23 ± 0.018	1.473MetAsp: 1.473 ± 0.047	1.837MetGlu: 1.837 ± 0.051	0.906MetPhe: 0.906 ± 0.04	2.065MetGly: 2.065 ± 0.063	0.512MetHis: 0.512 ± 0.027	1.851MetIle: 1.851 ± 0.056	2.135MetLys: 2.135 ± 0.063	2.615MetLeu: 2.615 ± 0.056	0.789MetMet: 0.789 ± 0.037	1.512MetAsn: 1.512 ± 0.043	1.32MetPro: 1.32 ± 0.046	1.172MetGln: 1.172 ± 0.046	1.481MetArg: 1.481 ± 0.048	1.576MetSer: 1.576 ± 0.054	1.398MetThr: 1.398 ± 0.046	1.609MetVal: 1.609 ± 0.055	0.216MetTrp: 0.216 ± 0.02	0.701MetTyr: 0.701 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	3.173AsnAla: 3.173 ± 0.086	0.442AsnCys: 0.442 ± 0.022	2.301AsnAsp: 2.301 ± 0.063	3.024AsnGlu: 3.024 ± 0.07	2.07AsnPhe: 2.07 ± 0.053	3.329AsnGly: 3.329 ± 0.075	0.934AsnHis: 0.934 ± 0.037	3.863AsnIle: 3.863 ± 0.083	3.434AsnLys: 3.434 ± 0.08	4.371AsnLeu: 4.371 ± 0.082	1.336AsnMet: 1.336 ± 0.047	2.499AsnAsn: 2.499 ± 0.075	2.498AsnPro: 2.498 ± 0.055	1.328AsnGln: 1.328 ± 0.049	2.793AsnArg: 2.793 ± 0.07	2.677AsnSer: 2.677 ± 0.06	2.507AsnThr: 2.507 ± 0.061	2.799AsnVal: 2.799 ± 0.068	0.572AsnTrp: 0.572 ± 0.029	2.068AsnTyr: 2.068 ± 0.058	0.0AsnXaa: 0.0 ± 0.0
Pro	2.771ProAla: 2.771 ± 0.08	0.301ProCys: 0.301 ± 0.024	2.713ProAsp: 2.713 ± 0.071	3.832ProGlu: 3.832 ± 0.076	1.925ProPhe: 1.925 ± 0.058	2.679ProGly: 2.679 ± 0.07	0.85ProHis: 0.85 ± 0.038	2.32ProIle: 2.32 ± 0.06	2.235ProLys: 2.235 ± 0.063	3.573ProLeu: 3.573 ± 0.08	1.02ProMet: 1.02 ± 0.035	1.642ProAsn: 1.642 ± 0.049	1.025ProPro: 1.025 ± 0.046	1.434ProGln: 1.434 ± 0.054	1.473ProArg: 1.473 ± 0.04	2.29ProSer: 2.29 ± 0.057	1.712ProThr: 1.712 ± 0.053	3.251ProVal: 3.251 ± 0.073	0.401ProTrp: 0.401 ± 0.026	1.564ProTyr: 1.564 ± 0.047	0.003ProXaa: 0.003 ± 0.002
Gln	2.353GlnAla: 2.353 ± 0.063	0.255GlnCys: 0.255 ± 0.021	1.501GlnAsp: 1.501 ± 0.05	2.315GlnGlu: 2.315 ± 0.059	1.236GlnPhe: 1.236 ± 0.042	2.029GlnGly: 2.029 ± 0.063	0.584GlnHis: 0.584 ± 0.029	2.62GlnIle: 2.62 ± 0.061	2.473GlnLys: 2.473 ± 0.062	3.205GlnLeu: 3.205 ± 0.074	1.062GlnMet: 1.062 ± 0.037	1.65GlnAsn: 1.65 ± 0.049	1.222GlnPro: 1.222 ± 0.04	1.476GlnGln: 1.476 ± 0.047	1.679GlnArg: 1.679 ± 0.051	1.945GlnSer: 1.945 ± 0.055	1.915GlnThr: 1.915 ± 0.054	1.925GlnVal: 1.925 ± 0.049	0.434GlnTrp: 0.434 ± 0.028	1.32GlnTyr: 1.32 ± 0.046	0.003GlnXaa: 0.003 ± 0.002
Arg	3.091ArgAla: 3.091 ± 0.074	0.441ArgCys: 0.441 ± 0.025	2.248ArgAsp: 2.248 ± 0.06	3.573ArgGlu: 3.573 ± 0.08	2.473ArgPhe: 2.473 ± 0.059	2.766ArgGly: 2.766 ± 0.073	1.114ArgHis: 1.114 ± 0.043	4.444ArgIle: 4.444 ± 0.076	3.865ArgLys: 3.865 ± 0.078	5.303ArgLeu: 5.303 ± 0.102	1.587ArgMet: 1.587 ± 0.045	2.634ArgAsn: 2.634 ± 0.074	1.775ArgPro: 1.775 ± 0.052	1.948ArgGln: 1.948 ± 0.058	2.745ArgArg: 2.745 ± 0.072	2.973ArgSer: 2.973 ± 0.07	2.57ArgThr: 2.57 ± 0.062	2.924ArgVal: 2.924 ± 0.065	0.608ArgTrp: 0.608 ± 0.031	2.401ArgTyr: 2.401 ± 0.068	0.006ArgXaa: 0.006 ± 0.003
Ser	4.179SerAla: 4.179 ± 0.083	0.77SerCys: 0.77 ± 0.039	3.276SerAsp: 3.276 ± 0.082	3.933SerGlu: 3.933 ± 0.07	3.357SerPhe: 3.357 ± 0.085	4.594SerGly: 4.594 ± 0.079	1.24SerHis: 1.24 ± 0.044	4.549SerIle: 4.549 ± 0.084	3.669SerLys: 3.669 ± 0.086	6.591SerLeu: 6.591 ± 0.11	1.639SerMet: 1.639 ± 0.052	2.506SerAsn: 2.506 ± 0.059	2.424SerPro: 2.424 ± 0.06	1.745SerGln: 1.745 ± 0.051	2.965SerArg: 2.965 ± 0.071	3.958SerSer: 3.958 ± 0.096	3.04SerThr: 3.04 ± 0.064	4.138SerVal: 4.138 ± 0.09	0.684SerTrp: 0.684 ± 0.04	2.62SerTyr: 2.62 ± 0.074	0.0SerXaa: 0.0 ± 0.0
Thr	4.082ThrAla: 4.082 ± 0.073	0.453ThrCys: 0.453 ± 0.027	3.115ThrAsp: 3.115 ± 0.069	3.437ThrGlu: 3.437 ± 0.07	2.434ThrPhe: 2.434 ± 0.071	4.202ThrGly: 4.202 ± 0.078	1.003ThrHis: 1.003 ± 0.043	3.687ThrIle: 3.687 ± 0.083	2.588ThrLys: 2.588 ± 0.065	5.333ThrLeu: 5.333 ± 0.089	1.193ThrMet: 1.193 ± 0.044	2.139ThrAsn: 2.139 ± 0.063	2.752ThrPro: 2.752 ± 0.07	1.557ThrGln: 1.557 ± 0.052	2.22ThrArg: 2.22 ± 0.067	3.01ThrSer: 3.01 ± 0.068	2.64ThrThr: 2.64 ± 0.07	3.688ThrVal: 3.688 ± 0.073	0.455ThrTrp: 0.455 ± 0.029	2.081ThrTyr: 2.081 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	4.611ValAla: 4.611 ± 0.091	0.834ValCys: 0.834 ± 0.038	3.543ValAsp: 3.543 ± 0.071	4.054ValGlu: 4.054 ± 0.072	3.021ValPhe: 3.021 ± 0.067	3.966ValGly: 3.966 ± 0.093	1.139ValHis: 1.139 ± 0.043	4.349ValIle: 4.349 ± 0.098	4.035ValLys: 4.035 ± 0.091	6.022ValLeu: 6.022 ± 0.109	1.711ValMet: 1.711 ± 0.051	2.926ValAsn: 2.926 ± 0.076	2.484ValPro: 2.484 ± 0.062	2.009ValGln: 2.009 ± 0.063	3.266ValArg: 3.266 ± 0.076	4.427ValSer: 4.427 ± 0.082	3.198ValThr: 3.198 ± 0.077	4.327ValVal: 4.327 ± 0.084	0.68ValTrp: 0.68 ± 0.034	2.496ValTyr: 2.496 ± 0.067	0.011ValXaa: 0.011 ± 0.004
Trp	0.698TrpAla: 0.698 ± 0.038	0.123TrpCys: 0.123 ± 0.014	0.578TrpAsp: 0.578 ± 0.034	0.655TrpGlu: 0.655 ± 0.035	0.481TrpPhe: 0.481 ± 0.029	0.831TrpGly: 0.831 ± 0.037	0.272TrpHis: 0.272 ± 0.025	0.762TrpIle: 0.762 ± 0.035	0.662TrpLys: 0.662 ± 0.032	1.067TrpLeu: 1.067 ± 0.039	0.387TrpMet: 0.387 ± 0.024	0.55TrpAsn: 0.55 ± 0.027	0.269TrpPro: 0.269 ± 0.02	0.548TrpGln: 0.548 ± 0.029	0.52TrpArg: 0.52 ± 0.031	0.576TrpSer: 0.576 ± 0.029	0.497TrpThr: 0.497 ± 0.029	0.667TrpVal: 0.667 ± 0.033	0.155TrpTrp: 0.155 ± 0.016	0.381TrpTyr: 0.381 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.76TyrAla: 2.76 ± 0.062	0.476TyrCys: 0.476 ± 0.03	2.263TyrAsp: 2.263 ± 0.069	2.401TyrGlu: 2.401 ± 0.065	1.909TyrPhe: 1.909 ± 0.054	2.716TyrGly: 2.716 ± 0.068	0.844TyrHis: 0.844 ± 0.035	2.724TyrIle: 2.724 ± 0.073	2.59TyrLys: 2.59 ± 0.079	3.777TyrLeu: 3.777 ± 0.084	0.998TyrMet: 0.998 ± 0.033	2.246TyrAsn: 2.246 ± 0.069	1.767TyrPro: 1.767 ± 0.06	1.192TyrGln: 1.192 ± 0.046	2.435TyrArg: 2.435 ± 0.071	2.565TyrSer: 2.565 ± 0.063	2.367TyrThr: 2.367 ± 0.06	2.242TyrVal: 2.242 ± 0.061	0.469TyrTrp: 0.469 ± 0.027	1.775TyrTyr: 1.775 ± 0.06	0.006TyrXaa: 0.006 ± 0.003
Xaa	0.002XaaAla: 0.002 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.003XaaGlu: 0.003 ± 0.002	0.003XaaPhe: 0.003 ± 0.002	0.006XaaGly: 0.006 ± 0.004	0.0XaaHis: 0.0 ± 0.0	0.005XaaIle: 0.005 ± 0.003	0.003XaaLys: 0.003 ± 0.002	0.005XaaLeu: 0.005 ± 0.003	0.0XaaMet: 0.0 ± 0.0	0.002XaaAsn: 0.002 ± 0.001	0.002XaaPro: 0.002 ± 0.002	0.002XaaGln: 0.002 ± 0.001	0.0XaaArg: 0.0 ± 0.0	0.003XaaSer: 0.003 ± 0.002	0.006XaaThr: 0.006 ± 0.003	0.006XaaVal: 0.006 ± 0.004	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1843 proteins (640164 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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