Amino acid dipepetide frequency for Sneathia vaginalis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.444AlaAla: 2.444 ± 0.115
0.577AlaCys: 0.577 ± 0.039
2.314AlaAsp: 2.314 ± 0.093
2.345AlaGlu: 2.345 ± 0.083
2.309AlaPhe: 2.309 ± 0.084
3.16AlaGly: 3.16 ± 0.106
0.705AlaHis: 0.705 ± 0.041
5.571AlaIle: 5.571 ± 0.159
5.775AlaLys: 5.775 ± 0.149
5.267AlaLeu: 5.267 ± 0.129
1.389AlaMet: 1.389 ± 0.07
3.116AlaAsn: 3.116 ± 0.112
0.991AlaPro: 0.991 ± 0.054
1.216AlaGln: 1.216 ± 0.058
1.913AlaArg: 1.913 ± 0.084
3.218AlaSer: 3.218 ± 0.096
2.891AlaThr: 2.891 ± 0.1
3.471AlaVal: 3.471 ± 0.117
0.225AlaTrp: 0.225 ± 0.027
2.276AlaTyr: 2.276 ± 0.08
0.0AlaXaa: 0.0 ± 0.0
Cys
0.429CysAla: 0.429 ± 0.033
0.087CysCys: 0.087 ± 0.016
0.572CysAsp: 0.572 ± 0.042
0.501CysGlu: 0.501 ± 0.039
0.388CysPhe: 0.388 ± 0.033
0.713CysGly: 0.713 ± 0.051
0.138CysHis: 0.138 ± 0.021
1.014CysIle: 1.014 ± 0.051
0.759CysLys: 0.759 ± 0.047
0.636CysLeu: 0.636 ± 0.047
0.281CysMet: 0.281 ± 0.027
0.485CysAsn: 0.485 ± 0.036
0.268CysPro: 0.268 ± 0.027
0.117CysGln: 0.117 ± 0.018
0.286CysArg: 0.286 ± 0.026
0.582CysSer: 0.582 ± 0.04
0.396CysThr: 0.396 ± 0.04
0.562CysVal: 0.562 ± 0.042
0.046CysTrp: 0.046 ± 0.01
0.375CysTyr: 0.375 ± 0.035
0.0CysXaa: 0.0 ± 0.0
Asp
2.649AspAla: 2.649 ± 0.084
0.485AspCys: 0.485 ± 0.045
3.226AspAsp: 3.226 ± 0.109
5.037AspGlu: 5.037 ± 0.122
2.792AspPhe: 2.792 ± 0.09
3.267AspGly: 3.267 ± 0.128
0.552AspHis: 0.552 ± 0.039
6.715AspIle: 6.715 ± 0.156
6.97AspLys: 6.97 ± 0.16
5.231AspLeu: 5.231 ± 0.124
1.451AspMet: 1.451 ± 0.065
3.635AspAsn: 3.635 ± 0.108
1.149AspPro: 1.149 ± 0.055
0.774AspGln: 0.774 ± 0.053
1.865AspArg: 1.865 ± 0.071
2.838AspSer: 2.838 ± 0.087
2.866AspThr: 2.866 ± 0.095
3.788AspVal: 3.788 ± 0.107
0.281AspTrp: 0.281 ± 0.03
2.978AspTyr: 2.978 ± 0.106
0.0AspXaa: 0.0 ± 0.0
Glu
3.275GluAla: 3.275 ± 0.102
0.447GluCys: 0.447 ± 0.04
4.005GluAsp: 4.005 ± 0.102
5.647GluGlu: 5.647 ± 0.166
3.04GluPhe: 3.04 ± 0.1
3.336GluGly: 3.336 ± 0.099
0.996GluHis: 0.996 ± 0.048
7.315GluIle: 7.315 ± 0.137
9.205GluLys: 9.205 ± 0.204
6.753GluLeu: 6.753 ± 0.149
1.668GluMet: 1.668 ± 0.065
5.729GluAsn: 5.729 ± 0.13
1.313GluPro: 1.313 ± 0.067
1.711GluGln: 1.711 ± 0.067
2.189GluArg: 2.189 ± 0.088
2.963GluSer: 2.963 ± 0.092
2.789GluThr: 2.789 ± 0.093
4.6GluVal: 4.6 ± 0.131
0.401GluTrp: 0.401 ± 0.029
4.094GluTyr: 4.094 ± 0.119
0.0GluXaa: 0.0 ± 0.0
Phe
2.079PheAla: 2.079 ± 0.081
0.462PheCys: 0.462 ± 0.036
2.733PheAsp: 2.733 ± 0.077
2.782PheGlu: 2.782 ± 0.089
2.181PhePhe: 2.181 ± 0.086
2.779PheGly: 2.779 ± 0.091
0.485PheHis: 0.485 ± 0.035
3.64PheIle: 3.64 ± 0.11
4.181PheLys: 4.181 ± 0.117
4.309PheLeu: 4.309 ± 0.133
1.144PheMet: 1.144 ± 0.055
3.193PheAsn: 3.193 ± 0.099
0.996PhePro: 0.996 ± 0.055
0.769PheGln: 0.769 ± 0.049
1.229PheArg: 1.229 ± 0.054
3.548PheSer: 3.548 ± 0.107
2.335PheThr: 2.335 ± 0.075
2.991PheVal: 2.991 ± 0.091
0.209PheTrp: 0.209 ± 0.026
1.706PheTyr: 1.706 ± 0.075
0.0PheXaa: 0.0 ± 0.0
Gly
3.492GlyAla: 3.492 ± 0.127
0.49GlyCys: 0.49 ± 0.038
3.126GlyAsp: 3.126 ± 0.13
3.727GlyGlu: 3.727 ± 0.108
2.603GlyPhe: 2.603 ± 0.083
3.653GlyGly: 3.653 ± 0.119
0.986GlyHis: 0.986 ± 0.05
6.357GlyIle: 6.357 ± 0.147
5.903GlyLys: 5.903 ± 0.168
5.313GlyLeu: 5.313 ± 0.136
1.392GlyMet: 1.392 ± 0.06
3.221GlyAsn: 3.221 ± 0.132
1.07GlyPro: 1.07 ± 0.054
1.535GlyGln: 1.535 ± 0.061
2.059GlyArg: 2.059 ± 0.082
3.573GlySer: 3.573 ± 0.124
3.425GlyThr: 3.425 ± 0.12
4.541GlyVal: 4.541 ± 0.139
0.322GlyTrp: 0.322 ± 0.031
3.172GlyTyr: 3.172 ± 0.092
0.0GlyXaa: 0.0 ± 0.0
His
0.743HisAla: 0.743 ± 0.051
0.133HisCys: 0.133 ± 0.019
0.789HisAsp: 0.789 ± 0.046
0.858HisGlu: 0.858 ± 0.052
0.616HisPhe: 0.616 ± 0.043
0.932HisGly: 0.932 ± 0.047
0.286HisHis: 0.286 ± 0.029
1.298HisIle: 1.298 ± 0.054
1.183HisLys: 1.183 ± 0.058
1.116HisLeu: 1.116 ± 0.055
0.271HisMet: 0.271 ± 0.027
0.787HisAsn: 0.787 ± 0.045
0.473HisPro: 0.473 ± 0.036
0.258HisGln: 0.258 ± 0.027
0.457HisArg: 0.457 ± 0.035
0.851HisSer: 0.851 ± 0.054
0.69HisThr: 0.69 ± 0.044
0.621HisVal: 0.621 ± 0.042
0.072HisTrp: 0.072 ± 0.013
0.529HisTyr: 0.529 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
5.346IleAla: 5.346 ± 0.135
1.068IleCys: 1.068 ± 0.062
6.199IleAsp: 6.199 ± 0.143
6.771IleGlu: 6.771 ± 0.152
4.462IlePhe: 4.462 ± 0.145
5.79IleGly: 5.79 ± 0.178
1.239IleHis: 1.239 ± 0.058
8.007IleIle: 8.007 ± 0.206
9.537IleLys: 9.537 ± 0.142
10.222IleLeu: 10.222 ± 0.244
1.859IleMet: 1.859 ± 0.079
6.225IleAsn: 6.225 ± 0.152
2.868IlePro: 2.868 ± 0.1
2.444IleGln: 2.444 ± 0.073
3.085IleArg: 3.085 ± 0.094
6.914IleSer: 6.914 ± 0.169
5.062IleThr: 5.062 ± 0.136
5.852IleVal: 5.852 ± 0.144
0.416IleTrp: 0.416 ± 0.036
4.181IleTyr: 4.181 ± 0.135
0.0IleXaa: 0.0 ± 0.0
Lys
4.932LysAla: 4.932 ± 0.133
0.641LysCys: 0.641 ± 0.04
7.091LysAsp: 7.091 ± 0.156
9.56LysGlu: 9.56 ± 0.18
3.849LysPhe: 3.849 ± 0.097
5.778LysGly: 5.778 ± 0.151
1.114LysHis: 1.114 ± 0.052
9.803LysIle: 9.803 ± 0.167
11.66LysLys: 11.66 ± 0.217
9.228LysLeu: 9.228 ± 0.182
2.741LysMet: 2.741 ± 0.094
7.642LysAsn: 7.642 ± 0.184
2.202LysPro: 2.202 ± 0.082
2.539LysGln: 2.539 ± 0.091
3.402LysArg: 3.402 ± 0.107
4.986LysSer: 4.986 ± 0.127
5.047LysThr: 5.047 ± 0.129
6.49LysVal: 6.49 ± 0.147
0.539LysTrp: 0.539 ± 0.035
5.903LysTyr: 5.903 ± 0.136
0.003LysXaa: 0.003 ± 0.003
Leu
5.515LeuAla: 5.515 ± 0.138
0.907LeuCys: 0.907 ± 0.05
5.977LeuAsp: 5.977 ± 0.146
7.024LeuGlu: 7.024 ± 0.154
3.647LeuPhe: 3.647 ± 0.115
6.309LeuGly: 6.309 ± 0.166
1.195LeuHis: 1.195 ± 0.061
8.133LeuIle: 8.133 ± 0.215
10.01LeuLys: 10.01 ± 0.168
8.314LeuLeu: 8.314 ± 0.216
1.913LeuMet: 1.913 ± 0.077
6.301LeuAsn: 6.301 ± 0.126
2.81LeuPro: 2.81 ± 0.076
2.033LeuGln: 2.033 ± 0.064
2.866LeuArg: 2.866 ± 0.083
6.84LeuSer: 6.84 ± 0.147
5.019LeuThr: 5.019 ± 0.129
5.655LeuVal: 5.655 ± 0.122
0.462LeuTrp: 0.462 ± 0.036
3.188LeuTyr: 3.188 ± 0.095
0.0LeuXaa: 0.0 ± 0.0
Met
1.379MetAla: 1.379 ± 0.06
0.189MetCys: 0.189 ± 0.024
1.272MetAsp: 1.272 ± 0.059
1.543MetGlu: 1.543 ± 0.068
0.937MetPhe: 0.937 ± 0.055
1.512MetGly: 1.512 ± 0.061
0.332MetHis: 0.332 ± 0.029
2.008MetIle: 2.008 ± 0.092
2.628MetLys: 2.628 ± 0.078
2.508MetLeu: 2.508 ± 0.092
0.521MetMet: 0.521 ± 0.036
1.407MetAsn: 1.407 ± 0.063
0.759MetPro: 0.759 ± 0.048
0.626MetGln: 0.626 ± 0.041
0.759MetArg: 0.759 ± 0.046
1.387MetSer: 1.387 ± 0.058
1.088MetThr: 1.088 ± 0.048
1.359MetVal: 1.359 ± 0.069
0.128MetTrp: 0.128 ± 0.018
1.096MetTyr: 1.096 ± 0.049
0.0MetXaa: 0.0 ± 0.0
Asn
3.06AsnAla: 3.06 ± 0.107
0.434AsnCys: 0.434 ± 0.033
3.433AsnAsp: 3.433 ± 0.116
4.792AsnGlu: 4.792 ± 0.136
2.845AsnPhe: 2.845 ± 0.1
3.893AsnGly: 3.893 ± 0.159
0.771AsnHis: 0.771 ± 0.047
7.864AsnIle: 7.864 ± 0.192
6.889AsnLys: 6.889 ± 0.2
6.13AsnLeu: 6.13 ± 0.147
1.655AsnMet: 1.655 ± 0.078
4.419AsnAsn: 4.419 ± 0.176
1.801AsnPro: 1.801 ± 0.065
1.31AsnGln: 1.31 ± 0.057
2.028AsnArg: 2.028 ± 0.072
3.836AsnSer: 3.836 ± 0.133
3.4AsnThr: 3.4 ± 0.118
4.312AsnVal: 4.312 ± 0.137
0.307AsnTrp: 0.307 ± 0.03
2.787AsnTyr: 2.787 ± 0.095
0.0AsnXaa: 0.0 ± 0.0
Pro
1.116ProAla: 1.116 ± 0.062
0.235ProCys: 0.235 ± 0.026
1.336ProAsp: 1.336 ± 0.054
1.775ProGlu: 1.775 ± 0.074
1.254ProPhe: 1.254 ± 0.057
1.234ProGly: 1.234 ± 0.063
0.391ProHis: 0.391 ± 0.031
2.301ProIle: 2.301 ± 0.083
2.409ProLys: 2.409 ± 0.086
2.197ProLeu: 2.197 ± 0.082
0.572ProMet: 0.572 ± 0.034
1.52ProAsn: 1.52 ± 0.068
0.386ProPro: 0.386 ± 0.032
0.6ProGln: 0.6 ± 0.038
0.702ProArg: 0.702 ± 0.044
1.655ProSer: 1.655 ± 0.065
1.502ProThr: 1.502 ± 0.053
1.798ProVal: 1.798 ± 0.063
0.151ProTrp: 0.151 ± 0.017
1.257ProTyr: 1.257 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
1.282GlnAla: 1.282 ± 0.064
0.146GlnCys: 0.146 ± 0.022
1.305GlnAsp: 1.305 ± 0.054
1.571GlnGlu: 1.571 ± 0.064
0.84GlnPhe: 0.84 ± 0.048
1.277GlnGly: 1.277 ± 0.061
0.284GlnHis: 0.284 ± 0.029
2.074GlnIle: 2.074 ± 0.069
2.401GlnLys: 2.401 ± 0.088
2.074GlnLeu: 2.074 ± 0.082
0.57GlnMet: 0.57 ± 0.046
1.441GlnAsn: 1.441 ± 0.065
0.429GlnPro: 0.429 ± 0.038
0.501GlnGln: 0.501 ± 0.037
0.881GlnArg: 0.881 ± 0.048
1.142GlnSer: 1.142 ± 0.05
1.111GlnThr: 1.111 ± 0.053
1.584GlnVal: 1.584 ± 0.059
0.123GlnTrp: 0.123 ± 0.018
1.042GlnTyr: 1.042 ± 0.057
0.0GlnXaa: 0.0 ± 0.0
Arg
1.706ArgAla: 1.706 ± 0.06
0.25ArgCys: 0.25 ± 0.025
1.601ArgAsp: 1.601 ± 0.064
2.457ArgGlu: 2.457 ± 0.084
1.264ArgPhe: 1.264 ± 0.058
1.798ArgGly: 1.798 ± 0.078
0.521ArgHis: 0.521 ± 0.041
3.349ArgIle: 3.349 ± 0.098
3.315ArgLys: 3.315 ± 0.09
2.996ArgLeu: 2.996 ± 0.102
0.902ArgMet: 0.902 ± 0.048
1.939ArgAsn: 1.939 ± 0.085
0.789ArgPro: 0.789 ± 0.043
0.999ArgGln: 0.999 ± 0.05
1.303ArgArg: 1.303 ± 0.069
1.586ArgSer: 1.586 ± 0.069
1.423ArgThr: 1.423 ± 0.056
2.181ArgVal: 2.181 ± 0.076
0.179ArgTrp: 0.179 ± 0.022
1.617ArgTyr: 1.617 ± 0.071
0.0ArgXaa: 0.0 ± 0.0
Ser
2.789SerAla: 2.789 ± 0.103
0.562SerCys: 0.562 ± 0.034
3.315SerAsp: 3.315 ± 0.103
3.63SerGlu: 3.63 ± 0.103
3.034SerPhe: 3.034 ± 0.095
3.813SerGly: 3.813 ± 0.11
0.822SerHis: 0.822 ± 0.05
6.243SerIle: 6.243 ± 0.141
6.235SerLys: 6.235 ± 0.15
5.813SerLeu: 5.813 ± 0.136
1.504SerMet: 1.504 ± 0.064
3.954SerAsn: 3.954 ± 0.131
1.382SerPro: 1.382 ± 0.064
1.246SerGln: 1.246 ± 0.056
1.739SerArg: 1.739 ± 0.06
3.752SerSer: 3.752 ± 0.114
3.101SerThr: 3.101 ± 0.109
4.097SerVal: 4.097 ± 0.11
0.35SerTrp: 0.35 ± 0.031
3.05SerTyr: 3.05 ± 0.088
0.0SerXaa: 0.0 ± 0.0
Thr
2.552ThrAla: 2.552 ± 0.091
0.355ThrCys: 0.355 ± 0.032
2.866ThrAsp: 2.866 ± 0.094
3.009ThrGlu: 3.009 ± 0.093
2.386ThrPhe: 2.386 ± 0.086
3.747ThrGly: 3.747 ± 0.129
0.805ThrHis: 0.805 ± 0.05
4.654ThrIle: 4.654 ± 0.128
5.195ThrLys: 5.195 ± 0.133
4.884ThrLeu: 4.884 ± 0.123
1.068ThrMet: 1.068 ± 0.058
3.303ThrAsn: 3.303 ± 0.113
1.737ThrPro: 1.737 ± 0.067
1.206ThrGln: 1.206 ± 0.052
1.683ThrArg: 1.683 ± 0.068
2.935ThrSer: 2.935 ± 0.094
2.873ThrThr: 2.873 ± 0.107
3.441ThrVal: 3.441 ± 0.106
0.238ThrTrp: 0.238 ± 0.027
2.373ThrTyr: 2.373 ± 0.082
0.0ThrXaa: 0.0 ± 0.0
Val
3.739ValAla: 3.739 ± 0.132
0.679ValCys: 0.679 ± 0.046
4.115ValAsp: 4.115 ± 0.102
4.728ValGlu: 4.728 ± 0.137
2.873ValPhe: 2.873 ± 0.097
3.859ValGly: 3.859 ± 0.11
0.7ValHis: 0.7 ± 0.044
5.997ValIle: 5.997 ± 0.139
6.294ValLys: 6.294 ± 0.164
6.217ValLeu: 6.217 ± 0.146
1.272ValMet: 1.272 ± 0.063
4.084ValAsn: 4.084 ± 0.131
1.655ValPro: 1.655 ± 0.078
1.157ValGln: 1.157 ± 0.06
2.005ValArg: 2.005 ± 0.082
4.582ValSer: 4.582 ± 0.118
3.3ValThr: 3.3 ± 0.108
4.503ValVal: 4.503 ± 0.112
0.322ValTrp: 0.322 ± 0.029
2.889ValTyr: 2.889 ± 0.087
0.0ValXaa: 0.0 ± 0.0
Trp
0.289TrpAla: 0.289 ± 0.03
0.049TrpCys: 0.049 ± 0.013
0.307TrpAsp: 0.307 ± 0.025
0.355TrpGlu: 0.355 ± 0.031
0.273TrpPhe: 0.273 ± 0.028
0.327TrpGly: 0.327 ± 0.032
0.092TrpHis: 0.092 ± 0.016
0.457TrpIle: 0.457 ± 0.033
0.411TrpLys: 0.411 ± 0.031
0.534TrpLeu: 0.534 ± 0.038
0.115TrpMet: 0.115 ± 0.015
0.299TrpAsn: 0.299 ± 0.025
0.117TrpPro: 0.117 ± 0.023
0.128TrpGln: 0.128 ± 0.021
0.156TrpArg: 0.156 ± 0.022
0.314TrpSer: 0.314 ± 0.035
0.261TrpThr: 0.261 ± 0.028
0.273TrpVal: 0.273 ± 0.027
0.087TrpTrp: 0.087 ± 0.018
0.248TrpTyr: 0.248 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.358TyrAla: 2.358 ± 0.085
0.439TyrCys: 0.439 ± 0.033
2.968TyrAsp: 2.968 ± 0.098
3.366TyrGlu: 3.366 ± 0.113
2.156TyrPhe: 2.156 ± 0.084
2.784TyrGly: 2.784 ± 0.09
0.547TyrHis: 0.547 ± 0.04
4.751TyrIle: 4.751 ± 0.142
4.189TyrLys: 4.189 ± 0.125
4.375TyrLeu: 4.375 ± 0.119
1.147TyrMet: 1.147 ± 0.059
3.267TyrAsn: 3.267 ± 0.116
1.195TyrPro: 1.195 ± 0.067
0.904TyrGln: 0.904 ± 0.047
1.568TyrArg: 1.568 ± 0.067
2.93TyrSer: 2.93 ± 0.095
2.728TyrThr: 2.728 ± 0.08
2.853TyrVal: 2.853 ± 0.09
0.235TyrTrp: 0.235 ± 0.025
2.066TyrTyr: 2.066 ± 0.081
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.003XaaGln: 0.003 ± 0.003
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1182 proteins (391510 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski