Amino acid dipepetide frequency for Staphylococcus phage tp310-2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.632AlaAla: 2.632 ± 0.719
0.213AlaCys: 0.213 ± 0.114
2.917AlaAsp: 2.917 ± 0.522
4.411AlaGlu: 4.411 ± 0.478
1.992AlaPhe: 1.992 ± 0.355
3.771AlaGly: 3.771 ± 0.686
0.996AlaHis: 0.996 ± 0.249
4.838AlaIle: 4.838 ± 0.79
6.403AlaLys: 6.403 ± 1.082
5.336AlaLeu: 5.336 ± 0.617
1.281AlaMet: 1.281 ± 0.293
4.197AlaAsn: 4.197 ± 0.805
1.494AlaPro: 1.494 ± 0.365
1.636AlaGln: 1.636 ± 0.392
2.775AlaArg: 2.775 ± 0.333
4.624AlaSer: 4.624 ± 0.805
3.273AlaThr: 3.273 ± 0.526
2.49AlaVal: 2.49 ± 0.534
1.138AlaTrp: 1.138 ± 0.381
2.632AlaTyr: 2.632 ± 0.489
0.0AlaXaa: 0.0 ± 0.0
Cys
0.142CysAla: 0.142 ± 0.092
0.071CysCys: 0.071 ± 0.073
0.285CysAsp: 0.285 ± 0.159
0.427CysGlu: 0.427 ± 0.189
0.356CysPhe: 0.356 ± 0.159
0.285CysGly: 0.285 ± 0.134
0.142CysHis: 0.142 ± 0.101
0.498CysIle: 0.498 ± 0.16
0.64CysLys: 0.64 ± 0.214
0.569CysLeu: 0.569 ± 0.242
0.213CysMet: 0.213 ± 0.156
0.142CysAsn: 0.142 ± 0.103
0.071CysPro: 0.071 ± 0.068
0.285CysGln: 0.285 ± 0.134
0.356CysArg: 0.356 ± 0.19
0.071CysSer: 0.071 ± 0.071
0.356CysThr: 0.356 ± 0.154
0.285CysVal: 0.285 ± 0.156
0.0CysTrp: 0.0 ± 0.0
0.213CysTyr: 0.213 ± 0.146
0.0CysXaa: 0.0 ± 0.0
Asp
2.419AspAla: 2.419 ± 0.53
0.427AspCys: 0.427 ± 0.174
4.197AspAsp: 4.197 ± 0.701
4.98AspGlu: 4.98 ± 0.752
3.699AspPhe: 3.699 ± 0.572
3.842AspGly: 3.842 ± 0.588
0.783AspHis: 0.783 ± 0.211
5.478AspIle: 5.478 ± 0.601
6.545AspLys: 6.545 ± 0.754
5.834AspLeu: 5.834 ± 0.594
1.85AspMet: 1.85 ± 0.338
2.917AspAsn: 2.917 ± 0.436
0.996AspPro: 0.996 ± 0.318
1.209AspGln: 1.209 ± 0.239
2.134AspArg: 2.134 ± 0.385
3.415AspSer: 3.415 ± 0.616
3.486AspThr: 3.486 ± 0.536
4.197AspVal: 4.197 ± 0.491
0.783AspTrp: 0.783 ± 0.238
3.059AspTyr: 3.059 ± 0.458
0.0AspXaa: 0.0 ± 0.0
Glu
5.336GluAla: 5.336 ± 0.517
0.64GluCys: 0.64 ± 0.236
4.624GluAsp: 4.624 ± 0.764
7.684GluGlu: 7.684 ± 1.256
3.13GluPhe: 3.13 ± 0.496
3.557GluGly: 3.557 ± 0.556
0.996GluHis: 0.996 ± 0.29
5.407GluIle: 5.407 ± 0.973
8.68GluLys: 8.68 ± 1.003
7.328GluLeu: 7.328 ± 0.78
2.561GluMet: 2.561 ± 0.485
4.98GluAsn: 4.98 ± 0.589
1.423GluPro: 1.423 ± 0.347
3.557GluGln: 3.557 ± 0.609
3.273GluArg: 3.273 ± 0.722
3.913GluSer: 3.913 ± 0.645
3.842GluThr: 3.842 ± 0.588
4.624GluVal: 4.624 ± 0.667
0.996GluTrp: 0.996 ± 0.198
2.917GluTyr: 2.917 ± 0.534
0.0GluXaa: 0.0 ± 0.0
Phe
2.063PheAla: 2.063 ± 0.437
0.427PheCys: 0.427 ± 0.154
3.415PheAsp: 3.415 ± 0.473
3.201PheGlu: 3.201 ± 0.588
1.067PhePhe: 1.067 ± 0.301
3.201PheGly: 3.201 ± 0.503
0.356PheHis: 0.356 ± 0.156
3.628PheIle: 3.628 ± 0.659
3.984PheLys: 3.984 ± 0.549
2.277PheLeu: 2.277 ± 0.387
1.138PheMet: 1.138 ± 0.268
3.557PheAsn: 3.557 ± 0.52
0.854PhePro: 0.854 ± 0.274
1.067PheGln: 1.067 ± 0.253
0.996PheArg: 0.996 ± 0.217
1.921PheSer: 1.921 ± 0.329
2.063PheThr: 2.063 ± 0.383
1.779PheVal: 1.779 ± 0.353
0.213PheTrp: 0.213 ± 0.106
1.992PheTyr: 1.992 ± 0.385
0.0PheXaa: 0.0 ± 0.0
Gly
4.411GlyAla: 4.411 ± 0.924
0.142GlyCys: 0.142 ± 0.089
3.842GlyAsp: 3.842 ± 0.457
3.771GlyGlu: 3.771 ± 0.467
2.49GlyPhe: 2.49 ± 0.36
4.696GlyGly: 4.696 ± 1.177
1.423GlyHis: 1.423 ± 0.405
3.699GlyIle: 3.699 ± 0.565
6.047GlyLys: 6.047 ± 0.67
5.549GlyLeu: 5.549 ± 0.952
1.281GlyMet: 1.281 ± 0.364
3.201GlyAsn: 3.201 ± 0.537
0.854GlyPro: 0.854 ± 0.227
1.423GlyGln: 1.423 ± 0.353
2.205GlyArg: 2.205 ± 0.416
3.699GlySer: 3.699 ± 0.646
3.699GlyThr: 3.699 ± 0.651
4.34GlyVal: 4.34 ± 0.692
0.854GlyTrp: 0.854 ± 0.274
2.561GlyTyr: 2.561 ± 0.528
0.0GlyXaa: 0.0 ± 0.0
His
0.925HisAla: 0.925 ± 0.231
0.071HisCys: 0.071 ± 0.068
0.925HisAsp: 0.925 ± 0.296
1.209HisGlu: 1.209 ± 0.236
0.854HisPhe: 0.854 ± 0.225
1.281HisGly: 1.281 ± 0.325
0.356HisHis: 0.356 ± 0.187
1.423HisIle: 1.423 ± 0.457
1.281HisLys: 1.281 ± 0.256
1.636HisLeu: 1.636 ± 0.277
0.213HisMet: 0.213 ± 0.117
0.925HisAsn: 0.925 ± 0.216
0.925HisPro: 0.925 ± 0.189
0.64HisGln: 0.64 ± 0.213
0.783HisArg: 0.783 ± 0.226
1.067HisSer: 1.067 ± 0.228
1.067HisThr: 1.067 ± 0.296
0.64HisVal: 0.64 ± 0.231
0.213HisTrp: 0.213 ± 0.134
1.138HisTyr: 1.138 ± 0.213
0.0HisXaa: 0.0 ± 0.0
Ile
4.34IleAla: 4.34 ± 0.612
0.427IleCys: 0.427 ± 0.172
4.767IleAsp: 4.767 ± 0.788
6.332IleGlu: 6.332 ± 0.73
2.49IlePhe: 2.49 ± 0.55
3.201IleGly: 3.201 ± 0.557
1.921IleHis: 1.921 ± 0.39
4.553IleIle: 4.553 ± 0.653
8.324IleLys: 8.324 ± 0.935
4.624IleLeu: 4.624 ± 0.673
1.707IleMet: 1.707 ± 0.356
5.336IleAsn: 5.336 ± 0.789
2.419IlePro: 2.419 ± 0.382
1.85IleGln: 1.85 ± 0.349
3.201IleArg: 3.201 ± 0.399
4.553IleSer: 4.553 ± 0.467
4.055IleThr: 4.055 ± 0.521
3.699IleVal: 3.699 ± 0.721
0.711IleTrp: 0.711 ± 0.241
2.988IleTyr: 2.988 ± 0.606
0.0IleXaa: 0.0 ± 0.0
Lys
7.47LysAla: 7.47 ± 1.098
0.285LysCys: 0.285 ± 0.153
5.478LysAsp: 5.478 ± 0.626
8.822LysGlu: 8.822 ± 0.809
2.348LysPhe: 2.348 ± 0.436
5.265LysGly: 5.265 ± 1.013
1.85LysHis: 1.85 ± 0.437
6.545LysIle: 6.545 ± 0.72
8.182LysLys: 8.182 ± 0.937
9.533LysLeu: 9.533 ± 1.006
2.49LysMet: 2.49 ± 0.456
5.265LysAsn: 5.265 ± 0.766
2.277LysPro: 2.277 ± 0.447
4.767LysGln: 4.767 ± 0.583
3.699LysArg: 3.699 ± 0.61
5.62LysSer: 5.62 ± 1.399
5.336LysThr: 5.336 ± 0.758
5.62LysVal: 5.62 ± 0.685
1.85LysTrp: 1.85 ± 0.397
5.549LysTyr: 5.549 ± 0.621
0.0LysXaa: 0.0 ± 0.0
Leu
4.767LeuAla: 4.767 ± 0.735
0.427LeuCys: 0.427 ± 0.165
5.407LeuAsp: 5.407 ± 0.895
6.901LeuGlu: 6.901 ± 0.842
2.846LeuPhe: 2.846 ± 0.436
4.482LeuGly: 4.482 ± 0.863
1.138LeuHis: 1.138 ± 0.359
5.194LeuIle: 5.194 ± 0.611
8.964LeuLys: 8.964 ± 1.267
6.616LeuLeu: 6.616 ± 0.795
2.419LeuMet: 2.419 ± 0.384
6.332LeuAsn: 6.332 ± 0.619
2.988LeuPro: 2.988 ± 0.492
2.703LeuGln: 2.703 ± 0.568
3.486LeuArg: 3.486 ± 0.506
5.478LeuSer: 5.478 ± 0.691
5.478LeuThr: 5.478 ± 0.754
4.34LeuVal: 4.34 ± 0.462
0.569LeuTrp: 0.569 ± 0.266
3.628LeuTyr: 3.628 ± 0.772
0.0LeuXaa: 0.0 ± 0.0
Met
1.281MetAla: 1.281 ± 0.277
0.142MetCys: 0.142 ± 0.11
1.067MetAsp: 1.067 ± 0.308
1.707MetGlu: 1.707 ± 0.351
0.711MetPhe: 0.711 ± 0.271
1.494MetGly: 1.494 ± 0.471
0.356MetHis: 0.356 ± 0.169
1.423MetIle: 1.423 ± 0.268
2.703MetLys: 2.703 ± 0.473
2.063MetLeu: 2.063 ± 0.488
0.427MetMet: 0.427 ± 0.201
1.423MetAsn: 1.423 ± 0.306
0.996MetPro: 0.996 ± 0.233
1.992MetGln: 1.992 ± 0.465
0.854MetArg: 0.854 ± 0.185
2.063MetSer: 2.063 ± 0.376
2.703MetThr: 2.703 ± 0.347
0.996MetVal: 0.996 ± 0.175
0.285MetTrp: 0.285 ± 0.125
0.925MetTyr: 0.925 ± 0.221
0.0MetXaa: 0.0 ± 0.0
Asn
3.628AsnAla: 3.628 ± 0.476
0.213AsnCys: 0.213 ± 0.123
4.126AsnAsp: 4.126 ± 0.533
4.34AsnGlu: 4.34 ± 0.53
1.85AsnPhe: 1.85 ± 0.27
4.269AsnGly: 4.269 ± 0.537
0.996AsnHis: 0.996 ± 0.299
4.126AsnIle: 4.126 ± 0.453
7.257AsnLys: 7.257 ± 0.707
5.407AsnLeu: 5.407 ± 0.646
0.996AsnMet: 0.996 ± 0.258
4.055AsnAsn: 4.055 ± 0.571
2.277AsnPro: 2.277 ± 0.314
2.348AsnGln: 2.348 ± 0.416
2.49AsnArg: 2.49 ± 0.416
4.055AsnSer: 4.055 ± 0.631
3.699AsnThr: 3.699 ± 0.401
3.13AsnVal: 3.13 ± 0.56
0.996AsnTrp: 0.996 ± 0.315
2.348AsnTyr: 2.348 ± 0.471
0.0AsnXaa: 0.0 ± 0.0
Pro
1.138ProAla: 1.138 ± 0.252
0.213ProCys: 0.213 ± 0.115
1.138ProAsp: 1.138 ± 0.317
2.277ProGlu: 2.277 ± 0.483
1.494ProPhe: 1.494 ± 0.344
1.707ProGly: 1.707 ± 0.329
0.285ProHis: 0.285 ± 0.157
1.779ProIle: 1.779 ± 0.306
2.063ProLys: 2.063 ± 0.464
2.134ProLeu: 2.134 ± 0.372
0.783ProMet: 0.783 ± 0.233
1.779ProAsn: 1.779 ± 0.366
0.569ProPro: 0.569 ± 0.208
1.209ProGln: 1.209 ± 0.264
1.352ProArg: 1.352 ± 0.264
2.205ProSer: 2.205 ± 0.356
1.779ProThr: 1.779 ± 0.407
1.209ProVal: 1.209 ± 0.35
0.285ProTrp: 0.285 ± 0.117
1.209ProTyr: 1.209 ± 0.365
0.0ProXaa: 0.0 ± 0.0
Gln
2.419GlnAla: 2.419 ± 0.331
0.285GlnCys: 0.285 ± 0.129
2.134GlnAsp: 2.134 ± 0.364
2.703GlnGlu: 2.703 ± 0.475
1.423GlnPhe: 1.423 ± 0.254
2.49GlnGly: 2.49 ± 0.433
0.64GlnHis: 0.64 ± 0.2
2.917GlnIle: 2.917 ± 0.503
3.13GlnLys: 3.13 ± 0.436
3.344GlnLeu: 3.344 ± 0.424
0.925GlnMet: 0.925 ± 0.33
1.85GlnAsn: 1.85 ± 0.332
1.067GlnPro: 1.067 ± 0.251
0.996GlnGln: 0.996 ± 0.261
1.707GlnArg: 1.707 ± 0.383
1.921GlnSer: 1.921 ± 0.295
1.281GlnThr: 1.281 ± 0.389
2.419GlnVal: 2.419 ± 0.465
0.498GlnTrp: 0.498 ± 0.192
1.565GlnTyr: 1.565 ± 0.32
0.0GlnXaa: 0.0 ± 0.0
Arg
2.348ArgAla: 2.348 ± 0.438
0.071ArgCys: 0.071 ± 0.074
3.273ArgAsp: 3.273 ± 0.347
2.49ArgGlu: 2.49 ± 0.428
2.063ArgPhe: 2.063 ± 0.432
2.134ArgGly: 2.134 ± 0.394
0.854ArgHis: 0.854 ± 0.244
3.557ArgIle: 3.557 ± 0.554
3.699ArgLys: 3.699 ± 0.501
3.557ArgLeu: 3.557 ± 0.621
1.138ArgMet: 1.138 ± 0.252
2.419ArgAsn: 2.419 ± 0.479
0.711ArgPro: 0.711 ± 0.294
1.352ArgGln: 1.352 ± 0.306
1.565ArgArg: 1.565 ± 0.402
1.779ArgSer: 1.779 ± 0.384
2.134ArgThr: 2.134 ± 0.401
2.419ArgVal: 2.419 ± 0.343
0.213ArgTrp: 0.213 ± 0.122
2.134ArgTyr: 2.134 ± 0.436
0.0ArgXaa: 0.0 ± 0.0
Ser
3.842SerAla: 3.842 ± 0.746
0.285SerCys: 0.285 ± 0.159
4.624SerAsp: 4.624 ± 0.487
4.624SerGlu: 4.624 ± 0.723
2.561SerPhe: 2.561 ± 0.495
4.126SerGly: 4.126 ± 0.725
0.925SerHis: 0.925 ± 0.22
4.055SerIle: 4.055 ± 0.445
5.692SerLys: 5.692 ± 1.113
4.696SerLeu: 4.696 ± 0.536
1.921SerMet: 1.921 ± 0.334
4.624SerAsn: 4.624 ± 0.616
1.85SerPro: 1.85 ± 0.401
2.703SerGln: 2.703 ± 0.404
2.419SerArg: 2.419 ± 0.354
4.197SerSer: 4.197 ± 0.744
2.917SerThr: 2.917 ± 0.529
3.913SerVal: 3.913 ± 0.594
0.996SerTrp: 0.996 ± 0.264
1.85SerTyr: 1.85 ± 0.378
0.0SerXaa: 0.0 ± 0.0
Thr
3.344ThrAla: 3.344 ± 0.594
0.356ThrCys: 0.356 ± 0.163
3.273ThrAsp: 3.273 ± 0.532
3.984ThrGlu: 3.984 ± 0.55
2.632ThrPhe: 2.632 ± 0.384
4.269ThrGly: 4.269 ± 0.563
1.423ThrHis: 1.423 ± 0.363
4.482ThrIle: 4.482 ± 0.527
5.62ThrLys: 5.62 ± 0.742
4.126ThrLeu: 4.126 ± 0.541
0.996ThrMet: 0.996 ± 0.273
3.13ThrAsn: 3.13 ± 0.531
2.205ThrPro: 2.205 ± 0.326
1.423ThrGln: 1.423 ± 0.303
1.779ThrArg: 1.779 ± 0.287
3.486ThrSer: 3.486 ± 0.477
3.486ThrThr: 3.486 ± 0.557
3.984ThrVal: 3.984 ± 0.437
0.569ThrTrp: 0.569 ± 0.288
2.277ThrTyr: 2.277 ± 0.398
0.0ThrXaa: 0.0 ± 0.0
Val
3.344ValAla: 3.344 ± 0.487
0.213ValCys: 0.213 ± 0.139
3.628ValAsp: 3.628 ± 0.604
5.407ValGlu: 5.407 ± 0.614
2.49ValPhe: 2.49 ± 0.45
3.486ValGly: 3.486 ± 0.565
1.067ValHis: 1.067 ± 0.287
4.197ValIle: 4.197 ± 0.575
4.767ValLys: 4.767 ± 0.665
4.34ValLeu: 4.34 ± 0.463
1.494ValMet: 1.494 ± 0.325
3.201ValAsn: 3.201 ± 0.493
1.423ValPro: 1.423 ± 0.339
2.063ValGln: 2.063 ± 0.378
2.348ValArg: 2.348 ± 0.426
4.34ValSer: 4.34 ± 0.594
2.988ValThr: 2.988 ± 0.557
3.13ValVal: 3.13 ± 0.457
0.711ValTrp: 0.711 ± 0.237
2.134ValTyr: 2.134 ± 0.534
0.0ValXaa: 0.0 ± 0.0
Trp
0.64TrpAla: 0.64 ± 0.211
0.0TrpCys: 0.0 ± 0.0
0.427TrpAsp: 0.427 ± 0.18
0.996TrpGlu: 0.996 ± 0.262
1.209TrpPhe: 1.209 ± 0.323
0.285TrpGly: 0.285 ± 0.13
0.071TrpHis: 0.071 ± 0.079
0.854TrpIle: 0.854 ± 0.3
0.783TrpLys: 0.783 ± 0.269
1.281TrpLeu: 1.281 ± 0.264
0.356TrpMet: 0.356 ± 0.234
0.854TrpAsn: 0.854 ± 0.236
0.285TrpPro: 0.285 ± 0.237
0.64TrpGln: 0.64 ± 0.153
0.427TrpArg: 0.427 ± 0.193
1.209TrpSer: 1.209 ± 0.432
0.569TrpThr: 0.569 ± 0.171
0.854TrpVal: 0.854 ± 0.24
0.142TrpTrp: 0.142 ± 0.121
0.711TrpTyr: 0.711 ± 0.233
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.561TyrAla: 2.561 ± 0.309
0.498TyrCys: 0.498 ± 0.131
2.703TyrAsp: 2.703 ± 0.543
3.201TyrGlu: 3.201 ± 0.662
1.494TyrPhe: 1.494 ± 0.335
2.348TyrGly: 2.348 ± 0.47
0.996TyrHis: 0.996 ± 0.269
2.917TyrIle: 2.917 ± 0.601
3.486TyrLys: 3.486 ± 0.407
3.913TyrLeu: 3.913 ± 0.656
1.352TyrMet: 1.352 ± 0.258
2.419TyrAsn: 2.419 ± 0.457
0.925TyrPro: 0.925 ± 0.213
1.85TyrGln: 1.85 ± 0.246
2.063TyrArg: 2.063 ± 0.564
3.201TyrSer: 3.201 ± 0.473
2.632TyrThr: 2.632 ± 0.538
2.703TyrVal: 2.703 ± 0.528
0.569TyrTrp: 0.569 ± 0.152
1.636TyrTyr: 1.636 ± 0.513
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 67 proteins (14057 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski