Amino acid dipepetide frequency for Sphingobacterium composti Yoo et al. 2007 non Ten et al. 2007

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.546AlaAla: 6.546 ± 0.101	0.694AlaCys: 0.694 ± 0.026	4.662AlaAsp: 4.662 ± 0.059	4.827AlaGlu: 4.827 ± 0.064	3.545AlaPhe: 3.545 ± 0.053	5.597AlaGly: 5.597 ± 0.083	1.466AlaHis: 1.466 ± 0.039	5.435AlaIle: 5.435 ± 0.074	4.452AlaLys: 4.452 ± 0.069	7.31AlaLeu: 7.31 ± 0.088	1.709AlaMet: 1.709 ± 0.041	3.394AlaAsn: 3.394 ± 0.059	2.425AlaPro: 2.425 ± 0.053	2.993AlaGln: 2.993 ± 0.05	3.201AlaArg: 3.201 ± 0.059	4.75AlaSer: 4.75 ± 0.065	4.041AlaThr: 4.041 ± 0.054	5.582AlaVal: 5.582 ± 0.075	0.904AlaTrp: 0.904 ± 0.026	3.281AlaTyr: 3.281 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.548CysAla: 0.548 ± 0.02	0.146CysCys: 0.146 ± 0.011	0.384CysAsp: 0.384 ± 0.018	0.379CysGlu: 0.379 ± 0.018	0.377CysPhe: 0.377 ± 0.018	0.604CysGly: 0.604 ± 0.021	0.205CysHis: 0.205 ± 0.015	0.543CysIle: 0.543 ± 0.021	0.348CysLys: 0.348 ± 0.018	0.777CysLeu: 0.777 ± 0.027	0.179CysMet: 0.179 ± 0.012	0.289CysAsn: 0.289 ± 0.014	0.336CysPro: 0.336 ± 0.019	0.243CysGln: 0.243 ± 0.014	0.389CysArg: 0.389 ± 0.021	0.541CysSer: 0.541 ± 0.023	0.442CysThr: 0.442 ± 0.019	0.473CysVal: 0.473 ± 0.02	0.077CysTrp: 0.077 ± 0.007	0.305CysTyr: 0.305 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.14AspAla: 4.14 ± 0.06	0.34AspCys: 0.34 ± 0.016	2.821AspAsp: 2.821 ± 0.052	3.527AspGlu: 3.527 ± 0.057	3.125AspPhe: 3.125 ± 0.05	4.364AspGly: 4.364 ± 0.065	1.061AspHis: 1.061 ± 0.03	4.25AspIle: 4.25 ± 0.058	3.373AspLys: 3.373 ± 0.057	5.157AspLeu: 5.157 ± 0.062	1.319AspMet: 1.319 ± 0.035	2.707AspAsn: 2.707 ± 0.044	2.289AspPro: 2.289 ± 0.045	1.762AspGln: 1.762 ± 0.039	3.046AspArg: 3.046 ± 0.059	2.87AspSer: 2.87 ± 0.05	2.664AspThr: 2.664 ± 0.046	3.905AspVal: 3.905 ± 0.064	0.856AspTrp: 0.856 ± 0.029	2.685AspTyr: 2.685 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	4.868GluAla: 4.868 ± 0.071	0.309GluCys: 0.309 ± 0.015	3.144GluAsp: 3.144 ± 0.06	4.654GluGlu: 4.654 ± 0.074	2.321GluPhe: 2.321 ± 0.042	4.061GluGly: 4.061 ± 0.056	1.369GluHis: 1.369 ± 0.032	4.287GluIle: 4.287 ± 0.067	4.43GluLys: 4.43 ± 0.075	5.835GluLeu: 5.835 ± 0.075	1.452GluMet: 1.452 ± 0.031	3.249GluAsn: 3.249 ± 0.06	1.773GluPro: 1.773 ± 0.034	2.764GluGln: 2.764 ± 0.049	3.613GluArg: 3.613 ± 0.061	3.025GluSer: 3.025 ± 0.043	3.083GluThr: 3.083 ± 0.048	4.195GluVal: 4.195 ± 0.056	0.706GluTrp: 0.706 ± 0.025	2.034GluTyr: 2.034 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.386PheAla: 3.386 ± 0.058	0.444PheCys: 0.444 ± 0.018	3.032PheAsp: 3.032 ± 0.055	2.791PheGlu: 2.791 ± 0.052	2.494PhePhe: 2.494 ± 0.055	3.603PheGly: 3.603 ± 0.06	0.954PheHis: 0.954 ± 0.028	2.982PheIle: 2.982 ± 0.054	2.45PheLys: 2.45 ± 0.048	4.502PheLeu: 4.502 ± 0.067	1.106PheMet: 1.106 ± 0.029	2.416PheAsn: 2.416 ± 0.045	1.779PhePro: 1.779 ± 0.037	1.599PheGln: 1.599 ± 0.036	2.345PheArg: 2.345 ± 0.047	3.503PheSer: 3.503 ± 0.059	2.718PheThr: 2.718 ± 0.054	3.118PheVal: 3.118 ± 0.047	0.61PheTrp: 0.61 ± 0.023	1.975PheTyr: 1.975 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	5.147GlyAla: 5.147 ± 0.081	0.607GlyCys: 0.607 ± 0.026	3.75GlyAsp: 3.75 ± 0.064	3.908GlyGlu: 3.908 ± 0.054	3.533GlyPhe: 3.533 ± 0.059	5.282GlyGly: 5.282 ± 0.081	1.431GlyHis: 1.431 ± 0.038	5.167GlyIle: 5.167 ± 0.07	4.672GlyLys: 4.672 ± 0.063	6.446GlyLeu: 6.446 ± 0.073	1.798GlyMet: 1.798 ± 0.041	3.48GlyAsn: 3.48 ± 0.062	1.715GlyPro: 1.715 ± 0.045	2.574GlyGln: 2.574 ± 0.039	3.697GlyArg: 3.697 ± 0.062	4.332GlySer: 4.332 ± 0.07	4.237GlyThr: 4.237 ± 0.055	4.933GlyVal: 4.933 ± 0.064	1.039GlyTrp: 1.039 ± 0.028	3.295GlyTyr: 3.295 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.432HisAla: 1.432 ± 0.034	0.186HisCys: 0.186 ± 0.013	1.062HisAsp: 1.062 ± 0.033	1.054HisGlu: 1.054 ± 0.029	1.113HisPhe: 1.113 ± 0.032	1.41HisGly: 1.41 ± 0.034	0.629HisHis: 0.629 ± 0.024	1.591HisIle: 1.591 ± 0.036	0.917HisLys: 0.917 ± 0.026	2.015HisLeu: 2.015 ± 0.043	0.453HisMet: 0.453 ± 0.019	0.929HisAsn: 0.929 ± 0.03	1.101HisPro: 1.101 ± 0.033	0.768HisGln: 0.768 ± 0.025	1.104HisArg: 1.104 ± 0.029	1.024HisSer: 1.024 ± 0.033	1.16HisThr: 1.16 ± 0.03	1.394HisVal: 1.394 ± 0.037	0.294HisTrp: 0.294 ± 0.016	0.957HisTyr: 0.957 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.639IleAla: 5.639 ± 0.074	0.609IleCys: 0.609 ± 0.024	4.179IleAsp: 4.179 ± 0.059	4.115IleGlu: 4.115 ± 0.063	2.895IlePhe: 2.895 ± 0.059	4.87IleGly: 4.87 ± 0.062	1.373IleHis: 1.373 ± 0.035	4.168IleIle: 4.168 ± 0.081	3.808IleLys: 3.808 ± 0.06	5.889IleLeu: 5.889 ± 0.081	1.267IleMet: 1.267 ± 0.029	3.318IleAsn: 3.318 ± 0.048	3.011IlePro: 3.011 ± 0.054	2.507IleGln: 2.507 ± 0.045	3.522IleArg: 3.522 ± 0.053	4.305IleSer: 4.305 ± 0.073	3.587IleThr: 3.587 ± 0.053	4.424IleVal: 4.424 ± 0.066	0.723IleTrp: 0.723 ± 0.025	2.478IleTyr: 2.478 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	4.499LysAla: 4.499 ± 0.075	0.251LysCys: 0.251 ± 0.013	3.594LysAsp: 3.594 ± 0.05	4.547LysGlu: 4.547 ± 0.075	2.141LysPhe: 2.141 ± 0.043	4.012LysGly: 4.012 ± 0.055	1.302LysHis: 1.302 ± 0.035	4.046LysIle: 4.046 ± 0.069	4.36LysLys: 4.36 ± 0.087	5.262LysLeu: 5.262 ± 0.064	1.548LysMet: 1.548 ± 0.035	3.24LysAsn: 3.24 ± 0.052	2.232LysPro: 2.232 ± 0.05	2.354LysGln: 2.354 ± 0.049	3.081LysArg: 3.081 ± 0.053	3.285LysSer: 3.285 ± 0.049	3.324LysThr: 3.324 ± 0.061	3.869LysVal: 3.869 ± 0.059	0.694LysTrp: 0.694 ± 0.024	2.242LysTyr: 2.242 ± 0.042	0.0LysXaa: 0.0 ± 0.0
Leu	7.273LeuAla: 7.273 ± 0.084	0.874LeuCys: 0.874 ± 0.03	5.083LeuAsp: 5.083 ± 0.06	5.426LeuGlu: 5.426 ± 0.07	4.633LeuPhe: 4.633 ± 0.072	6.264LeuGly: 6.264 ± 0.075	1.994LeuHis: 1.994 ± 0.043	5.724LeuIle: 5.724 ± 0.077	5.794LeuLys: 5.794 ± 0.068	9.653LeuLeu: 9.653 ± 0.11	2.099LeuMet: 2.099 ± 0.041	4.594LeuAsn: 4.594 ± 0.068	4.188LeuPro: 4.188 ± 0.059	3.85LeuGln: 3.85 ± 0.063	4.829LeuArg: 4.829 ± 0.067	6.993LeuSer: 6.993 ± 0.068	5.387LeuThr: 5.387 ± 0.058	5.877LeuVal: 5.877 ± 0.075	1.009LeuTrp: 1.009 ± 0.026	3.606LeuTyr: 3.606 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	1.803MetAla: 1.803 ± 0.036	0.136MetCys: 0.136 ± 0.011	1.308MetAsp: 1.308 ± 0.033	1.505MetGlu: 1.505 ± 0.036	0.842MetPhe: 0.842 ± 0.025	1.553MetGly: 1.553 ± 0.036	0.423MetHis: 0.423 ± 0.019	1.293MetIle: 1.293 ± 0.034	1.727MetLys: 1.727 ± 0.039	2.224MetLeu: 2.224 ± 0.046	0.586MetMet: 0.586 ± 0.022	1.183MetAsn: 1.183 ± 0.029	0.976MetPro: 0.976 ± 0.027	0.941MetGln: 0.941 ± 0.027	1.151MetArg: 1.151 ± 0.03	1.4MetSer: 1.4 ± 0.034	1.225MetThr: 1.225 ± 0.032	1.474MetVal: 1.474 ± 0.039	0.23MetTrp: 0.23 ± 0.014	0.736MetTyr: 0.736 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.562AsnAla: 3.562 ± 0.051	0.298AsnCys: 0.298 ± 0.015	2.462AsnAsp: 2.462 ± 0.041	2.786AsnGlu: 2.786 ± 0.054	2.334AsnPhe: 2.334 ± 0.049	3.613AsnGly: 3.613 ± 0.066	0.936AsnHis: 0.936 ± 0.028	3.552AsnIle: 3.552 ± 0.057	2.87AsnLys: 2.87 ± 0.05	4.457AsnLeu: 4.457 ± 0.06	1.212AsnMet: 1.212 ± 0.036	2.682AsnAsn: 2.682 ± 0.052	2.484AsnPro: 2.484 ± 0.05	1.75AsnGln: 1.75 ± 0.039	2.696AsnArg: 2.696 ± 0.053	2.75AsnSer: 2.75 ± 0.047	2.811AsnThr: 2.811 ± 0.046	3.145AsnVal: 3.145 ± 0.057	0.686AsnTrp: 0.686 ± 0.022	2.169AsnTyr: 2.169 ± 0.06	0.0AsnXaa: 0.0 ± 0.0
Pro	3.116ProAla: 3.116 ± 0.058	0.226ProCys: 0.226 ± 0.013	2.59ProAsp: 2.59 ± 0.049	2.866ProGlu: 2.866 ± 0.045	1.974ProPhe: 1.974 ± 0.038	2.542ProGly: 2.542 ± 0.053	0.824ProHis: 0.824 ± 0.027	2.455ProIle: 2.455 ± 0.045	2.056ProLys: 2.056 ± 0.041	3.554ProLeu: 3.554 ± 0.06	0.803ProMet: 0.803 ± 0.027	1.836ProAsn: 1.836 ± 0.039	1.068ProPro: 1.068 ± 0.034	1.438ProGln: 1.438 ± 0.031	1.517ProArg: 1.517 ± 0.041	2.419ProSer: 2.419 ± 0.044	2.21ProThr: 2.21 ± 0.038	2.88ProVal: 2.88 ± 0.055	0.512ProTrp: 0.512 ± 0.023	1.673ProTyr: 1.673 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	2.879GlnAla: 2.879 ± 0.052	0.197GlnCys: 0.197 ± 0.012	1.869GlnAsp: 1.869 ± 0.036	2.535GlnGlu: 2.535 ± 0.047	1.588GlnPhe: 1.588 ± 0.036	2.361GlnGly: 2.361 ± 0.038	0.985GlnHis: 0.985 ± 0.027	2.427GlnIle: 2.427 ± 0.049	2.238GlnLys: 2.238 ± 0.047	3.998GlnLeu: 3.998 ± 0.063	0.853GlnMet: 0.853 ± 0.024	1.757GlnAsn: 1.757 ± 0.042	1.44GlnPro: 1.44 ± 0.037	2.087GlnGln: 2.087 ± 0.047	2.183GlnArg: 2.183 ± 0.046	1.959GlnSer: 1.959 ± 0.042	2.094GlnThr: 2.094 ± 0.042	2.296GlnVal: 2.296 ± 0.044	0.504GlnTrp: 0.504 ± 0.018	1.556GlnTyr: 1.556 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	3.516ArgAla: 3.516 ± 0.052	0.292ArgCys: 0.292 ± 0.015	2.599ArgAsp: 2.599 ± 0.052	3.108ArgGlu: 3.108 ± 0.054	2.709ArgPhe: 2.709 ± 0.052	3.056ArgGly: 3.056 ± 0.058	1.032ArgHis: 1.032 ± 0.029	3.562ArgIle: 3.562 ± 0.056	3.241ArgLys: 3.241 ± 0.052	4.961ArgLeu: 4.961 ± 0.068	1.333ArgMet: 1.333 ± 0.033	2.612ArgAsn: 2.612 ± 0.047	1.909ArgPro: 1.909 ± 0.04	1.985ArgGln: 1.985 ± 0.035	2.704ArgArg: 2.704 ± 0.051	2.929ArgSer: 2.929 ± 0.048	2.769ArgThr: 2.769 ± 0.05	3.115ArgVal: 3.115 ± 0.054	0.817ArgTrp: 0.817 ± 0.03	2.487ArgTyr: 2.487 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	4.655SerAla: 4.655 ± 0.063	0.601SerCys: 0.601 ± 0.026	3.221SerAsp: 3.221 ± 0.05	3.167SerGlu: 3.167 ± 0.048	3.389SerPhe: 3.389 ± 0.056	4.758SerGly: 4.758 ± 0.066	1.126SerHis: 1.126 ± 0.029	4.121SerIle: 4.121 ± 0.059	3.289SerLys: 3.289 ± 0.059	6.083SerLeu: 6.083 ± 0.066	1.355SerMet: 1.355 ± 0.032	2.854SerAsn: 2.854 ± 0.047	2.438SerPro: 2.438 ± 0.044	1.848SerGln: 1.848 ± 0.037	3.054SerArg: 3.054 ± 0.046	4.07SerSer: 4.07 ± 0.068	3.461SerThr: 3.461 ± 0.059	4.273SerVal: 4.273 ± 0.06	0.811SerTrp: 0.811 ± 0.025	2.783SerTyr: 2.783 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	4.542ThrAla: 4.542 ± 0.06	0.352ThrCys: 0.352 ± 0.018	3.274ThrAsp: 3.274 ± 0.05	2.952ThrGlu: 2.952 ± 0.044	2.868ThrPhe: 2.868 ± 0.049	4.458ThrGly: 4.458 ± 0.062	0.998ThrHis: 0.998 ± 0.024	3.664ThrIle: 3.664 ± 0.06	2.931ThrLys: 2.931 ± 0.049	5.346ThrLeu: 5.346 ± 0.068	1.001ThrMet: 1.001 ± 0.029	2.429ThrAsn: 2.429 ± 0.046	2.521ThrPro: 2.521 ± 0.051	1.752ThrGln: 1.752 ± 0.038	2.193ThrArg: 2.193 ± 0.044	3.467ThrSer: 3.467 ± 0.062	3.094ThrThr: 3.094 ± 0.055	4.046ThrVal: 4.046 ± 0.059	0.703ThrTrp: 0.703 ± 0.025	2.323ThrTyr: 2.323 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	5.182ValAla: 5.182 ± 0.071	0.597ValCys: 0.597 ± 0.021	4.107ValAsp: 4.107 ± 0.059	4.044ValGlu: 4.044 ± 0.059	3.191ValPhe: 3.191 ± 0.054	4.608ValGly: 4.608 ± 0.067	1.282ValHis: 1.282 ± 0.034	4.148ValIle: 4.148 ± 0.061	3.833ValLys: 3.833 ± 0.062	6.571ValLeu: 6.571 ± 0.088	1.397ValMet: 1.397 ± 0.038	3.375ValAsn: 3.375 ± 0.05	2.756ValPro: 2.756 ± 0.053	2.386ValGln: 2.386 ± 0.044	3.33ValArg: 3.33 ± 0.052	4.505ValSer: 4.505 ± 0.066	3.472ValThr: 3.472 ± 0.053	5.058ValVal: 5.058 ± 0.065	0.795ValTrp: 0.795 ± 0.028	2.677ValTyr: 2.677 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.886TrpAla: 0.886 ± 0.027	0.106TrpCys: 0.106 ± 0.01	0.736TrpAsp: 0.736 ± 0.025	0.781TrpGlu: 0.781 ± 0.027	0.534TrpPhe: 0.534 ± 0.024	0.94TrpGly: 0.94 ± 0.03	0.283TrpHis: 0.283 ± 0.014	0.767TrpIle: 0.767 ± 0.026	0.806TrpLys: 0.806 ± 0.021	1.197TrpLeu: 1.197 ± 0.031	0.377TrpMet: 0.377 ± 0.02	0.729TrpAsn: 0.729 ± 0.025	0.375TrpPro: 0.375 ± 0.017	0.545TrpGln: 0.545 ± 0.021	0.699TrpArg: 0.699 ± 0.023	0.784TrpSer: 0.784 ± 0.023	0.714TrpThr: 0.714 ± 0.028	0.749TrpVal: 0.749 ± 0.029	0.194TrpTrp: 0.194 ± 0.012	0.503TrpTyr: 0.503 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.192TyrAla: 3.192 ± 0.062	0.319TyrCys: 0.319 ± 0.017	2.384TyrAsp: 2.384 ± 0.044	2.202TyrGlu: 2.202 ± 0.038	2.202TyrPhe: 2.202 ± 0.045	3.086TyrGly: 3.086 ± 0.051	0.922TyrHis: 0.922 ± 0.026	2.505TyrIle: 2.505 ± 0.046	2.289TyrLys: 2.289 ± 0.043	3.914TyrLeu: 3.914 ± 0.052	0.866TyrMet: 0.866 ± 0.025	2.179TyrAsn: 2.179 ± 0.052	1.744TyrPro: 1.744 ± 0.04	1.661TyrGln: 1.661 ± 0.036	2.383TyrArg: 2.383 ± 0.049	2.448TyrSer: 2.448 ± 0.049	2.421TyrThr: 2.421 ± 0.047	2.506TyrVal: 2.506 ± 0.044	0.541TyrTrp: 0.541 ± 0.024	1.883TyrTyr: 1.883 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3756 proteins (1277210 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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