Amino acid dipepetide frequency for Pectobacterium phage DU_PP_III

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.808AlaAla: 1.808 ± 0.658
0.0AlaCys: 0.0 ± 0.0
4.069AlaAsp: 4.069 ± 1.34
4.973AlaGlu: 4.973 ± 1.184
2.712AlaPhe: 2.712 ± 0.878
2.712AlaGly: 2.712 ± 0.931
0.904AlaHis: 0.904 ± 0.519
4.069AlaIle: 4.069 ± 1.144
7.685AlaLys: 7.685 ± 2.395
5.425AlaLeu: 5.425 ± 1.753
1.356AlaMet: 1.356 ± 1.034
4.521AlaAsn: 4.521 ± 1.037
0.452AlaPro: 0.452 ± 0.448
0.452AlaGln: 0.452 ± 0.323
0.904AlaArg: 0.904 ± 0.519
3.165AlaSer: 3.165 ± 0.828
4.069AlaThr: 4.069 ± 1.507
4.973AlaVal: 4.973 ± 1.919
1.808AlaTrp: 1.808 ± 0.569
3.165AlaTyr: 3.165 ± 0.629
0.0AlaXaa: 0.0 ± 0.0
Cys
0.452CysAla: 0.452 ± 0.507
0.0CysCys: 0.0 ± 0.0
0.904CysAsp: 0.904 ± 0.519
2.26CysGlu: 2.26 ± 1.032
0.904CysPhe: 0.904 ± 0.388
0.452CysGly: 0.452 ± 0.323
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.452CysLys: 0.452 ± 0.391
0.452CysLeu: 0.452 ± 0.323
0.0CysMet: 0.0 ± 0.0
0.452CysAsn: 0.452 ± 0.391
0.452CysPro: 0.452 ± 0.391
0.0CysGln: 0.0 ± 0.0
0.452CysArg: 0.452 ± 0.448
0.452CysSer: 0.452 ± 0.323
0.452CysThr: 0.452 ± 0.323
0.452CysVal: 0.452 ± 0.323
0.0CysTrp: 0.0 ± 0.0
0.904CysTyr: 0.904 ± 0.519
0.0CysXaa: 0.0 ± 0.0
Asp
4.973AspAla: 4.973 ± 1.586
0.0AspCys: 0.0 ± 0.0
4.973AspAsp: 4.973 ± 1.754
4.521AspGlu: 4.521 ± 1.124
4.069AspPhe: 4.069 ± 1.196
5.877AspGly: 5.877 ± 2.32
0.904AspHis: 0.904 ± 0.519
6.781AspIle: 6.781 ± 1.434
3.617AspLys: 3.617 ± 0.652
5.425AspLeu: 5.425 ± 1.02
0.904AspMet: 0.904 ± 0.476
3.617AspAsn: 3.617 ± 0.581
0.0AspPro: 0.0 ± 0.0
1.356AspGln: 1.356 ± 0.738
1.808AspArg: 1.808 ± 1.594
3.165AspSer: 3.165 ± 0.745
2.712AspThr: 2.712 ± 0.803
7.233AspVal: 7.233 ± 1.39
0.904AspTrp: 0.904 ± 0.645
2.26AspTyr: 2.26 ± 0.912
0.0AspXaa: 0.0 ± 0.0
Glu
2.712GluAla: 2.712 ± 1.057
0.452GluCys: 0.452 ± 0.525
2.712GluAsp: 2.712 ± 1.259
2.712GluGlu: 2.712 ± 0.788
5.877GluPhe: 5.877 ± 1.612
5.877GluGly: 5.877 ± 1.155
1.356GluHis: 1.356 ± 0.805
2.712GluIle: 2.712 ± 0.85
3.165GluLys: 3.165 ± 0.613
9.494GluLeu: 9.494 ± 3.69
2.712GluMet: 2.712 ± 0.56
5.877GluAsn: 5.877 ± 1.304
0.0GluPro: 0.0 ± 0.0
2.26GluGln: 2.26 ± 0.891
3.165GluArg: 3.165 ± 1.682
4.069GluSer: 4.069 ± 0.641
5.425GluThr: 5.425 ± 1.152
5.877GluVal: 5.877 ± 0.985
0.452GluTrp: 0.452 ± 0.323
3.617GluTyr: 3.617 ± 0.596
0.0GluXaa: 0.0 ± 0.0
Phe
3.165PheAla: 3.165 ± 1.04
0.0PheCys: 0.0 ± 0.0
3.165PheAsp: 3.165 ± 0.912
2.712PheGlu: 2.712 ± 0.715
1.356PhePhe: 1.356 ± 0.842
2.26PheGly: 2.26 ± 0.935
0.452PheHis: 0.452 ± 0.399
4.973PheIle: 4.973 ± 1.591
4.069PheLys: 4.069 ± 1.257
3.165PheLeu: 3.165 ± 0.591
1.808PheMet: 1.808 ± 0.878
5.877PheAsn: 5.877 ± 0.837
2.712PhePro: 2.712 ± 0.641
0.452PheGln: 0.452 ± 0.323
0.452PheArg: 0.452 ± 0.323
2.26PheSer: 2.26 ± 0.784
4.973PheThr: 4.973 ± 1.357
2.712PheVal: 2.712 ± 0.741
0.0PheTrp: 0.0 ± 0.0
0.904PheTyr: 0.904 ± 0.522
0.0PheXaa: 0.0 ± 0.0
Gly
1.808GlyAla: 1.808 ± 0.747
0.0GlyCys: 0.0 ± 0.0
4.973GlyAsp: 4.973 ± 1.343
7.685GlyGlu: 7.685 ± 2.039
2.26GlyPhe: 2.26 ± 0.891
2.26GlyGly: 2.26 ± 0.62
0.452GlyHis: 0.452 ± 0.323
6.329GlyIle: 6.329 ± 0.975
5.425GlyLys: 5.425 ± 1.215
4.069GlyLeu: 4.069 ± 0.827
0.904GlyMet: 0.904 ± 0.645
4.521GlyAsn: 4.521 ± 1.807
0.0GlyPro: 0.0 ± 0.0
1.356GlyGln: 1.356 ± 1.061
2.712GlyArg: 2.712 ± 1.122
4.069GlySer: 4.069 ± 1.482
3.165GlyThr: 3.165 ± 0.814
4.973GlyVal: 4.973 ± 1.185
0.0GlyTrp: 0.0 ± 0.0
3.165GlyTyr: 3.165 ± 0.698
0.0GlyXaa: 0.0 ± 0.0
His
0.452HisAla: 0.452 ± 0.323
0.0HisCys: 0.0 ± 0.0
1.808HisAsp: 1.808 ± 0.299
0.452HisGlu: 0.452 ± 0.323
0.0HisPhe: 0.0 ± 0.0
1.356HisGly: 1.356 ± 0.722
0.0HisHis: 0.0 ± 0.0
2.712HisIle: 2.712 ± 1.149
1.808HisLys: 1.808 ± 0.672
1.356HisLeu: 1.356 ± 0.597
0.0HisMet: 0.0 ± 0.0
0.452HisAsn: 0.452 ± 0.323
0.0HisPro: 0.0 ± 0.0
0.452HisGln: 0.452 ± 0.399
0.452HisArg: 0.452 ± 0.323
0.904HisSer: 0.904 ± 0.519
0.904HisThr: 0.904 ± 0.434
0.904HisVal: 0.904 ± 0.519
0.0HisTrp: 0.0 ± 0.0
0.452HisTyr: 0.452 ± 0.391
0.0HisXaa: 0.0 ± 0.0
Ile
3.617IleAla: 3.617 ± 0.862
0.452IleCys: 0.452 ± 0.391
5.425IleAsp: 5.425 ± 0.948
4.521IleGlu: 4.521 ± 1.039
3.165IlePhe: 3.165 ± 1.433
4.069IleGly: 4.069 ± 1.658
0.904IleHis: 0.904 ± 0.712
5.425IleIle: 5.425 ± 1.815
7.685IleLys: 7.685 ± 2.263
4.973IleLeu: 4.973 ± 1.124
1.356IleMet: 1.356 ± 0.768
5.425IleAsn: 5.425 ± 1.383
2.26IlePro: 2.26 ± 0.359
2.26IleGln: 2.26 ± 0.712
1.808IleArg: 1.808 ± 0.556
6.329IleSer: 6.329 ± 1.969
5.425IleThr: 5.425 ± 0.957
2.26IleVal: 2.26 ± 0.675
1.808IleTrp: 1.808 ± 0.716
3.165IleTyr: 3.165 ± 2.229
0.0IleXaa: 0.0 ± 0.0
Lys
6.781LysAla: 6.781 ± 1.289
0.904LysCys: 0.904 ± 0.461
2.26LysAsp: 2.26 ± 0.73
5.425LysGlu: 5.425 ± 1.558
1.808LysPhe: 1.808 ± 0.678
4.069LysGly: 4.069 ± 2.527
1.356LysHis: 1.356 ± 0.722
4.973LysIle: 4.973 ± 0.876
3.165LysLys: 3.165 ± 1.291
8.59LysLeu: 8.59 ± 1.796
3.165LysMet: 3.165 ± 1.033
5.425LysAsn: 5.425 ± 1.155
2.712LysPro: 2.712 ± 1.165
3.165LysGln: 3.165 ± 0.573
3.165LysArg: 3.165 ± 1.272
4.069LysSer: 4.069 ± 1.668
8.137LysThr: 8.137 ± 1.549
7.685LysVal: 7.685 ± 2.035
0.452LysTrp: 0.452 ± 0.391
6.329LysTyr: 6.329 ± 1.468
0.0LysXaa: 0.0 ± 0.0
Leu
4.069LeuAla: 4.069 ± 1.72
1.356LeuCys: 1.356 ± 0.597
5.425LeuAsp: 5.425 ± 1.756
6.781LeuGlu: 6.781 ± 1.825
4.069LeuPhe: 4.069 ± 1.012
3.617LeuGly: 3.617 ± 1.047
0.452LeuHis: 0.452 ± 0.399
4.521LeuIle: 4.521 ± 0.479
7.685LeuLys: 7.685 ± 1.442
4.069LeuLeu: 4.069 ± 0.891
2.26LeuMet: 2.26 ± 1.227
5.425LeuAsn: 5.425 ± 0.86
3.617LeuPro: 3.617 ± 0.908
3.165LeuGln: 3.165 ± 1.003
0.904LeuArg: 0.904 ± 1.049
7.685LeuSer: 7.685 ± 2.114
4.973LeuThr: 4.973 ± 1.086
3.165LeuVal: 3.165 ± 1.178
0.904LeuTrp: 0.904 ± 0.388
5.877LeuTyr: 5.877 ± 1.301
0.0LeuXaa: 0.0 ± 0.0
Met
1.356MetAla: 1.356 ± 0.801
0.904MetCys: 0.904 ± 0.645
1.808MetAsp: 1.808 ± 0.844
1.356MetGlu: 1.356 ± 0.7
1.356MetPhe: 1.356 ± 0.61
2.26MetGly: 2.26 ± 0.88
0.0MetHis: 0.0 ± 0.0
2.26MetIle: 2.26 ± 0.792
1.356MetLys: 1.356 ± 0.834
2.26MetLeu: 2.26 ± 0.784
1.808MetMet: 1.808 ± 1.277
0.904MetAsn: 0.904 ± 0.657
1.356MetPro: 1.356 ± 0.405
0.452MetGln: 0.452 ± 0.399
1.808MetArg: 1.808 ± 0.658
1.356MetSer: 1.356 ± 0.442
2.712MetThr: 2.712 ± 0.884
1.808MetVal: 1.808 ± 0.928
0.452MetTrp: 0.452 ± 0.448
0.452MetTyr: 0.452 ± 0.323
0.0MetXaa: 0.0 ± 0.0
Asn
6.329AsnAla: 6.329 ± 1.735
1.808AsnCys: 1.808 ± 0.686
3.617AsnAsp: 3.617 ± 0.819
3.165AsnGlu: 3.165 ± 0.595
1.356AsnPhe: 1.356 ± 0.405
5.425AsnGly: 5.425 ± 1.041
1.356AsnHis: 1.356 ± 0.653
4.521AsnIle: 4.521 ± 1.876
3.617AsnLys: 3.617 ± 0.711
4.521AsnLeu: 4.521 ± 1.571
2.26AsnMet: 2.26 ± 1.148
5.877AsnAsn: 5.877 ± 1.466
1.808AsnPro: 1.808 ± 0.997
0.904AsnGln: 0.904 ± 0.461
1.808AsnArg: 1.808 ± 0.965
4.521AsnSer: 4.521 ± 0.617
4.521AsnThr: 4.521 ± 0.743
4.069AsnVal: 4.069 ± 1.431
1.356AsnTrp: 1.356 ± 0.974
5.877AsnTyr: 5.877 ± 1.45
0.0AsnXaa: 0.0 ± 0.0
Pro
1.356ProAla: 1.356 ± 0.609
0.452ProCys: 0.452 ± 0.323
2.712ProAsp: 2.712 ± 1.659
2.26ProGlu: 2.26 ± 0.986
2.26ProPhe: 2.26 ± 1.432
0.0ProGly: 0.0 ± 0.0
0.452ProHis: 0.452 ± 0.391
1.356ProIle: 1.356 ± 0.597
3.165ProLys: 3.165 ± 1.365
1.356ProLeu: 1.356 ± 0.658
1.808ProMet: 1.808 ± 0.572
0.904ProAsn: 0.904 ± 0.522
0.0ProPro: 0.0 ± 0.0
0.904ProGln: 0.904 ± 0.476
0.0ProArg: 0.0 ± 0.0
0.904ProSer: 0.904 ± 0.434
0.452ProThr: 0.452 ± 0.323
0.904ProVal: 0.904 ± 0.519
0.0ProTrp: 0.0 ± 0.0
2.26ProTyr: 2.26 ± 0.912
0.0ProXaa: 0.0 ± 0.0
Gln
1.808GlnAla: 1.808 ± 0.988
0.452GlnCys: 0.452 ± 0.391
2.712GlnAsp: 2.712 ± 0.694
0.452GlnGlu: 0.452 ± 0.588
1.356GlnPhe: 1.356 ± 0.7
1.808GlnGly: 1.808 ± 0.299
0.904GlnHis: 0.904 ± 0.642
0.904GlnIle: 0.904 ± 0.434
0.904GlnLys: 0.904 ± 0.461
3.165GlnLeu: 3.165 ± 0.904
0.904GlnMet: 0.904 ± 0.521
1.808GlnAsn: 1.808 ± 0.515
1.808GlnPro: 1.808 ± 0.921
0.904GlnGln: 0.904 ± 0.895
0.452GlnArg: 0.452 ± 0.399
1.808GlnSer: 1.808 ± 0.793
0.452GlnThr: 0.452 ± 0.448
1.808GlnVal: 1.808 ± 0.833
0.0GlnTrp: 0.0 ± 0.0
1.356GlnTyr: 1.356 ± 0.635
0.0GlnXaa: 0.0 ± 0.0
Arg
3.165ArgAla: 3.165 ± 1.008
0.0ArgCys: 0.0 ± 0.0
2.712ArgAsp: 2.712 ± 1.476
2.26ArgGlu: 2.26 ± 1.405
1.808ArgPhe: 1.808 ± 0.868
0.904ArgGly: 0.904 ± 0.673
0.452ArgHis: 0.452 ± 0.507
1.356ArgIle: 1.356 ± 1.061
4.973ArgLys: 4.973 ± 1.646
1.808ArgLeu: 1.808 ± 0.669
0.452ArgMet: 0.452 ± 0.399
1.356ArgAsn: 1.356 ± 0.658
0.0ArgPro: 0.0 ± 0.0
0.0ArgGln: 0.0 ± 0.0
3.617ArgArg: 3.617 ± 1.426
1.808ArgSer: 1.808 ± 0.669
0.904ArgThr: 0.904 ± 0.645
1.808ArgVal: 1.808 ± 0.868
0.452ArgTrp: 0.452 ± 0.391
0.452ArgTyr: 0.452 ± 0.323
0.0ArgXaa: 0.0 ± 0.0
Ser
3.617SerAla: 3.617 ± 1.845
0.0SerCys: 0.0 ± 0.0
4.521SerAsp: 4.521 ± 0.967
4.069SerGlu: 4.069 ± 1.357
2.712SerPhe: 2.712 ± 1.215
3.165SerGly: 3.165 ± 0.801
0.904SerHis: 0.904 ± 0.388
3.165SerIle: 3.165 ± 0.843
7.685SerLys: 7.685 ± 2.464
5.877SerLeu: 5.877 ± 1.97
2.26SerMet: 2.26 ± 1.205
3.165SerAsn: 3.165 ± 1.009
1.808SerPro: 1.808 ± 1.019
1.356SerGln: 1.356 ± 1.061
2.26SerArg: 2.26 ± 0.618
4.069SerSer: 4.069 ± 1.364
2.712SerThr: 2.712 ± 1.0
6.329SerVal: 6.329 ± 1.539
0.452SerTrp: 0.452 ± 0.399
2.26SerTyr: 2.26 ± 1.225
0.0SerXaa: 0.0 ± 0.0
Thr
4.521ThrAla: 4.521 ± 1.112
0.0ThrCys: 0.0 ± 0.0
4.069ThrAsp: 4.069 ± 1.312
2.712ThrGlu: 2.712 ± 1.065
2.26ThrPhe: 2.26 ± 0.904
4.973ThrGly: 4.973 ± 0.974
1.808ThrHis: 1.808 ± 1.291
5.425ThrIle: 5.425 ± 1.691
5.877ThrLys: 5.877 ± 1.177
3.165ThrLeu: 3.165 ± 1.016
0.0ThrMet: 0.0 ± 0.0
3.617ThrAsn: 3.617 ± 0.924
2.26ThrPro: 2.26 ± 1.127
2.26ThrGln: 2.26 ± 0.912
0.0ThrArg: 0.0 ± 0.0
4.069ThrSer: 4.069 ± 0.791
3.617ThrThr: 3.617 ± 0.785
6.781ThrVal: 6.781 ± 1.445
0.452ThrTrp: 0.452 ± 0.323
4.521ThrTyr: 4.521 ± 1.101
0.0ThrXaa: 0.0 ± 0.0
Val
2.26ValAla: 2.26 ± 0.792
0.0ValCys: 0.0 ± 0.0
4.973ValAsp: 4.973 ± 1.076
5.877ValGlu: 5.877 ± 1.122
4.521ValPhe: 4.521 ± 1.143
4.973ValGly: 4.973 ± 1.738
1.356ValHis: 1.356 ± 0.597
6.329ValIle: 6.329 ± 1.737
6.781ValLys: 6.781 ± 1.549
5.425ValLeu: 5.425 ± 1.544
1.356ValMet: 1.356 ± 0.867
4.069ValAsn: 4.069 ± 1.099
0.904ValPro: 0.904 ± 0.797
0.452ValGln: 0.452 ± 0.588
2.712ValArg: 2.712 ± 0.783
4.973ValSer: 4.973 ± 1.02
5.425ValThr: 5.425 ± 2.004
4.069ValVal: 4.069 ± 1.588
0.452ValTrp: 0.452 ± 0.323
3.617ValTyr: 3.617 ± 1.095
0.0ValXaa: 0.0 ± 0.0
Trp
0.452TrpAla: 0.452 ± 0.391
0.452TrpCys: 0.452 ± 0.507
0.904TrpAsp: 0.904 ± 0.645
1.356TrpGlu: 1.356 ± 0.442
0.904TrpPhe: 0.904 ± 0.388
1.356TrpGly: 1.356 ± 0.658
0.452TrpHis: 0.452 ± 0.448
0.0TrpIle: 0.0 ± 0.0
0.904TrpLys: 0.904 ± 0.522
0.452TrpLeu: 0.452 ± 0.323
0.452TrpMet: 0.452 ± 0.323
0.452TrpAsn: 0.452 ± 0.507
0.452TrpPro: 0.452 ± 0.507
0.904TrpGln: 0.904 ± 0.642
0.0TrpArg: 0.0 ± 0.0
0.0TrpSer: 0.0 ± 0.0
0.452TrpThr: 0.452 ± 0.323
0.452TrpVal: 0.452 ± 0.323
0.0TrpTrp: 0.0 ± 0.0
0.452TrpTyr: 0.452 ± 0.391
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.521TyrAla: 4.521 ± 0.905
2.26TyrCys: 2.26 ± 0.84
1.356TyrAsp: 1.356 ± 0.805
4.973TyrGlu: 4.973 ± 1.543
2.712TyrPhe: 2.712 ± 1.544
2.712TyrGly: 2.712 ± 0.82
0.0TyrHis: 0.0 ± 0.0
4.521TyrIle: 4.521 ± 2.794
3.617TyrLys: 3.617 ± 0.846
4.973TyrLeu: 4.973 ± 1.251
1.808TyrMet: 1.808 ± 0.54
4.973TyrAsn: 4.973 ± 1.407
0.904TyrPro: 0.904 ± 0.388
2.712TyrGln: 2.712 ± 0.769
1.808TyrArg: 1.808 ± 0.686
2.712TyrSer: 2.712 ± 1.492
0.904TyrThr: 0.904 ± 0.645
2.712TyrVal: 2.712 ± 0.784
0.904TyrTrp: 0.904 ± 0.522
4.069TyrTyr: 4.069 ± 1.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (2213 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski