Amino acid dipepetide frequency for Roseivivax halotolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.541AlaAla: 16.541 ± 0.16	1.06AlaCys: 1.06 ± 0.034	6.921AlaAsp: 6.921 ± 0.092	9.561AlaGlu: 9.561 ± 0.104	4.397AlaPhe: 4.397 ± 0.069	10.444AlaGly: 10.444 ± 0.092	2.361AlaHis: 2.361 ± 0.047	6.072AlaIle: 6.072 ± 0.079	3.532AlaLys: 3.532 ± 0.06	14.271AlaLeu: 14.271 ± 0.164	3.733AlaMet: 3.733 ± 0.058	2.455AlaAsn: 2.455 ± 0.044	6.081AlaPro: 6.081 ± 0.085	4.058AlaGln: 4.058 ± 0.068	9.816AlaArg: 9.816 ± 0.13	6.094AlaSer: 6.094 ± 0.089	5.758AlaThr: 5.758 ± 0.079	7.877AlaVal: 7.877 ± 0.086	1.513AlaTrp: 1.513 ± 0.041	2.536AlaTyr: 2.536 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.01CysAla: 1.01 ± 0.031	0.102CysCys: 0.102 ± 0.01	0.581CysAsp: 0.581 ± 0.02	0.456CysGlu: 0.456 ± 0.019	0.299CysPhe: 0.299 ± 0.016	0.88CysGly: 0.88 ± 0.032	0.248CysHis: 0.248 ± 0.014	0.378CysIle: 0.378 ± 0.02	0.18CysLys: 0.18 ± 0.013	0.914CysLeu: 0.914 ± 0.031	0.147CysMet: 0.147 ± 0.013	0.195CysAsn: 0.195 ± 0.014	0.467CysPro: 0.467 ± 0.019	0.221CysGln: 0.221 ± 0.014	0.609CysArg: 0.609 ± 0.023	0.411CysSer: 0.411 ± 0.019	0.417CysThr: 0.417 ± 0.019	0.584CysVal: 0.584 ± 0.022	0.093CysTrp: 0.093 ± 0.01	0.193CysTyr: 0.193 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.061AspAla: 8.061 ± 0.102	0.448AspCys: 0.448 ± 0.019	3.484AspAsp: 3.484 ± 0.085	3.972AspGlu: 3.972 ± 0.07	2.287AspPhe: 2.287 ± 0.049	5.855AspGly: 5.855 ± 0.083	1.305AspHis: 1.305 ± 0.035	3.128AspIle: 3.128 ± 0.051	1.563AspLys: 1.563 ± 0.04	6.511AspLeu: 6.511 ± 0.092	1.664AspMet: 1.664 ± 0.037	1.212AspAsn: 1.212 ± 0.036	3.871AspPro: 3.871 ± 0.06	1.71AspGln: 1.71 ± 0.047	4.614AspArg: 4.614 ± 0.068	2.121AspSer: 2.121 ± 0.046	2.991AspThr: 2.991 ± 0.058	4.297AspVal: 4.297 ± 0.073	1.226AspTrp: 1.226 ± 0.031	1.469AspTyr: 1.469 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	9.627GluAla: 9.627 ± 0.125	0.385GluCys: 0.385 ± 0.019	4.172GluAsp: 4.172 ± 0.066	4.557GluGlu: 4.557 ± 0.084	1.789GluPhe: 1.789 ± 0.037	5.352GluGly: 5.352 ± 0.067	1.166GluHis: 1.166 ± 0.035	4.148GluIle: 4.148 ± 0.068	2.19GluLys: 2.19 ± 0.057	5.419GluLeu: 5.419 ± 0.075	2.086GluMet: 2.086 ± 0.043	1.822GluAsn: 1.822 ± 0.04	2.94GluPro: 2.94 ± 0.061	1.746GluGln: 1.746 ± 0.042	5.04GluArg: 5.04 ± 0.074	2.455GluSer: 2.455 ± 0.058	4.823GluThr: 4.823 ± 0.081	4.627GluVal: 4.627 ± 0.07	0.728GluTrp: 0.728 ± 0.027	1.154GluTyr: 1.154 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.58PheAla: 4.58 ± 0.065	0.413PheCys: 0.413 ± 0.02	2.808PheAsp: 2.808 ± 0.055	2.49PheGlu: 2.49 ± 0.046	1.398PhePhe: 1.398 ± 0.047	3.73PheGly: 3.73 ± 0.069	0.741PheHis: 0.741 ± 0.027	1.524PheIle: 1.524 ± 0.042	0.78PheLys: 0.78 ± 0.028	3.435PheLeu: 3.435 ± 0.071	0.799PheMet: 0.799 ± 0.027	0.958PheAsn: 0.958 ± 0.033	1.512PhePro: 1.512 ± 0.042	0.979PheGln: 0.979 ± 0.031	2.262PheArg: 2.262 ± 0.053	2.067PheSer: 2.067 ± 0.041	1.957PheThr: 1.957 ± 0.048	2.607PheVal: 2.607 ± 0.054	0.567PheTrp: 0.567 ± 0.025	0.91PheTyr: 0.91 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	10.112GlyAla: 10.112 ± 0.099	0.847GlyCys: 0.847 ± 0.031	4.904GlyAsp: 4.904 ± 0.068	5.289GlyGlu: 5.289 ± 0.075	3.577GlyPhe: 3.577 ± 0.065	7.599GlyGly: 7.599 ± 0.113	1.959GlyHis: 1.959 ± 0.051	4.513GlyIle: 4.513 ± 0.068	2.776GlyLys: 2.776 ± 0.059	9.32GlyLeu: 9.32 ± 0.104	2.454GlyMet: 2.454 ± 0.048	1.914GlyAsn: 1.914 ± 0.051	3.866GlyPro: 3.866 ± 0.057	3.063GlyGln: 3.063 ± 0.057	6.269GlyArg: 6.269 ± 0.089	4.434GlySer: 4.434 ± 0.078	4.814GlyThr: 4.814 ± 0.08	6.113GlyVal: 6.113 ± 0.073	1.54GlyTrp: 1.54 ± 0.037	2.272GlyTyr: 2.272 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.313HisAla: 2.313 ± 0.05	0.212HisCys: 0.212 ± 0.014	1.229HisAsp: 1.229 ± 0.036	1.127HisGlu: 1.127 ± 0.031	0.757HisPhe: 0.757 ± 0.025	1.984HisGly: 1.984 ± 0.044	0.49HisHis: 0.49 ± 0.027	0.883HisIle: 0.883 ± 0.031	0.474HisLys: 0.474 ± 0.023	2.071HisLeu: 2.071 ± 0.044	0.51HisMet: 0.51 ± 0.023	0.401HisAsn: 0.401 ± 0.018	1.279HisPro: 1.279 ± 0.041	0.513HisGln: 0.513 ± 0.019	1.419HisArg: 1.419 ± 0.035	0.861HisSer: 0.861 ± 0.029	0.734HisThr: 0.734 ± 0.026	1.619HisVal: 1.619 ± 0.034	0.306HisTrp: 0.306 ± 0.017	0.506HisTyr: 0.506 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.219IleAla: 7.219 ± 0.09	0.568IleCys: 0.568 ± 0.024	3.508IleAsp: 3.508 ± 0.062	3.827IleGlu: 3.827 ± 0.065	1.802IlePhe: 1.802 ± 0.049	4.836IleGly: 4.836 ± 0.067	0.818IleHis: 0.818 ± 0.028	1.984IleIle: 1.984 ± 0.058	1.195IleLys: 1.195 ± 0.036	4.993IleLeu: 4.993 ± 0.068	1.026IleMet: 1.026 ± 0.036	1.197IleAsn: 1.197 ± 0.032	2.196IlePro: 2.196 ± 0.046	1.068IleGln: 1.068 ± 0.031	3.347IleArg: 3.347 ± 0.052	2.843IleSer: 2.843 ± 0.054	2.618IleThr: 2.618 ± 0.055	3.974IleVal: 3.974 ± 0.071	0.703IleTrp: 0.703 ± 0.026	1.111IleTyr: 1.111 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.618LysAla: 3.618 ± 0.067	0.172LysCys: 0.172 ± 0.012	1.688LysAsp: 1.688 ± 0.042	1.539LysGlu: 1.539 ± 0.046	0.752LysPhe: 0.752 ± 0.026	2.502LysGly: 2.502 ± 0.051	0.556LysHis: 0.556 ± 0.023	1.519LysIle: 1.519 ± 0.041	1.144LysLys: 1.144 ± 0.041	2.68LysLeu: 2.68 ± 0.045	0.767LysMet: 0.767 ± 0.03	0.706LysAsn: 0.706 ± 0.025	1.678LysPro: 1.678 ± 0.038	0.738LysGln: 0.738 ± 0.023	2.184LysArg: 2.184 ± 0.047	1.728LysSer: 1.728 ± 0.041	1.932LysThr: 1.932 ± 0.039	2.044LysVal: 2.044 ± 0.046	0.32LysTrp: 0.32 ± 0.016	0.526LysTyr: 0.526 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	12.986LeuAla: 12.986 ± 0.138	0.96LeuCys: 0.96 ± 0.034	6.28LeuAsp: 6.28 ± 0.078	5.877LeuGlu: 5.877 ± 0.086	3.578LeuPhe: 3.578 ± 0.068	8.619LeuGly: 8.619 ± 0.096	1.744LeuHis: 1.744 ± 0.034	4.928LeuIle: 4.928 ± 0.087	2.98LeuLys: 2.98 ± 0.057	8.721LeuLeu: 8.721 ± 0.128	2.574LeuMet: 2.574 ± 0.055	2.391LeuAsn: 2.391 ± 0.05	5.465LeuPro: 5.465 ± 0.071	2.529LeuGln: 2.529 ± 0.052	7.025LeuArg: 7.025 ± 0.09	7.096LeuSer: 7.096 ± 0.085	5.841LeuThr: 5.841 ± 0.074	7.028LeuVal: 7.028 ± 0.086	1.396LeuTrp: 1.396 ± 0.037	2.027LeuTyr: 2.027 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.254MetAla: 3.254 ± 0.061	0.183MetCys: 0.183 ± 0.014	1.385MetAsp: 1.385 ± 0.038	1.354MetGlu: 1.354 ± 0.038	0.746MetPhe: 0.746 ± 0.029	2.181MetGly: 2.181 ± 0.048	0.446MetHis: 0.446 ± 0.023	1.468MetIle: 1.468 ± 0.04	1.037MetLys: 1.037 ± 0.033	2.415MetLeu: 2.415 ± 0.051	0.686MetMet: 0.686 ± 0.026	0.809MetAsn: 0.809 ± 0.026	1.569MetPro: 1.569 ± 0.035	0.932MetGln: 0.932 ± 0.027	2.037MetArg: 2.037 ± 0.04	1.914MetSer: 1.914 ± 0.037	2.01MetThr: 2.01 ± 0.041	1.654MetVal: 1.654 ± 0.04	0.232MetTrp: 0.232 ± 0.015	0.296MetTyr: 0.296 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.003AsnAla: 3.003 ± 0.048	0.217AsnCys: 0.217 ± 0.012	1.393AsnAsp: 1.393 ± 0.039	1.255AsnGlu: 1.255 ± 0.031	0.849AsnPhe: 0.849 ± 0.027	2.132AsnGly: 2.132 ± 0.048	0.445AsnHis: 0.445 ± 0.019	1.25AsnIle: 1.25 ± 0.035	0.555AsnLys: 0.555 ± 0.027	2.285AsnLeu: 2.285 ± 0.054	0.617AsnMet: 0.617 ± 0.026	0.58AsnAsn: 0.58 ± 0.025	1.682AsnPro: 1.682 ± 0.04	0.615AsnGln: 0.615 ± 0.028	1.682AsnArg: 1.682 ± 0.034	1.044AsnSer: 1.044 ± 0.027	1.219AsnThr: 1.219 ± 0.034	1.805AsnVal: 1.805 ± 0.047	0.406AsnTrp: 0.406 ± 0.023	0.589AsnTyr: 0.589 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.567ProAla: 5.567 ± 0.087	0.343ProCys: 0.343 ± 0.016	4.17ProAsp: 4.17 ± 0.054	4.833ProGlu: 4.833 ± 0.075	1.949ProPhe: 1.949 ± 0.046	4.617ProGly: 4.617 ± 0.067	1.022ProHis: 1.022 ± 0.031	2.266ProIle: 2.266 ± 0.045	1.584ProLys: 1.584 ± 0.041	4.535ProLeu: 4.535 ± 0.063	1.206ProMet: 1.206 ± 0.025	1.249ProAsn: 1.249 ± 0.035	2.259ProPro: 2.259 ± 0.051	1.524ProGln: 1.524 ± 0.041	3.129ProArg: 3.129 ± 0.058	2.66ProSer: 2.66 ± 0.047	2.246ProThr: 2.246 ± 0.05	4.063ProVal: 4.063 ± 0.072	0.667ProTrp: 0.667 ± 0.026	1.077ProTyr: 1.077 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.606GlnAla: 3.606 ± 0.052	0.192GlnCys: 0.192 ± 0.012	1.697GlnAsp: 1.697 ± 0.039	1.665GlnGlu: 1.665 ± 0.044	0.928GlnPhe: 0.928 ± 0.031	2.553GlnGly: 2.553 ± 0.055	0.494GlnHis: 0.494 ± 0.018	1.822GlnIle: 1.822 ± 0.044	0.971GlnLys: 0.971 ± 0.031	2.582GlnLeu: 2.582 ± 0.045	0.91GlnMet: 0.91 ± 0.028	0.865GlnAsn: 0.865 ± 0.031	1.547GlnPro: 1.547 ± 0.038	0.875GlnGln: 0.875 ± 0.041	2.015GlnArg: 2.015 ± 0.042	1.776GlnSer: 1.776 ± 0.041	1.657GlnThr: 1.657 ± 0.038	2.151GlnVal: 2.151 ± 0.048	0.334GlnTrp: 0.334 ± 0.019	0.495GlnTyr: 0.495 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	8.896ArgAla: 8.896 ± 0.105	0.483ArgCys: 0.483 ± 0.02	4.579ArgAsp: 4.579 ± 0.069	4.612ArgGlu: 4.612 ± 0.056	2.876ArgPhe: 2.876 ± 0.047	4.938ArgGly: 4.938 ± 0.064	1.652ArgHis: 1.652 ± 0.045	4.225ArgIle: 4.225 ± 0.069	2.206ArgLys: 2.206 ± 0.05	7.808ArgLeu: 7.808 ± 0.099	2.0ArgMet: 2.0 ± 0.04	1.696ArgAsn: 1.696 ± 0.042	3.496ArgPro: 3.496 ± 0.061	2.3ArgGln: 2.3 ± 0.045	5.588ArgArg: 5.588 ± 0.084	3.404ArgSer: 3.404 ± 0.052	3.165ArgThr: 3.165 ± 0.056	5.033ArgVal: 5.033 ± 0.071	0.981ArgTrp: 0.981 ± 0.032	1.615ArgTyr: 1.615 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.131SerAla: 6.131 ± 0.082	0.425SerCys: 0.425 ± 0.021	3.573SerAsp: 3.573 ± 0.068	3.663SerGlu: 3.663 ± 0.068	2.205SerPhe: 2.205 ± 0.048	5.575SerGly: 5.575 ± 0.072	1.052SerHis: 1.052 ± 0.036	2.386SerIle: 2.386 ± 0.047	1.448SerLys: 1.448 ± 0.041	5.045SerLeu: 5.045 ± 0.067	1.298SerMet: 1.298 ± 0.033	1.22SerAsn: 1.22 ± 0.032	2.433SerPro: 2.433 ± 0.049	1.648SerGln: 1.648 ± 0.041	3.54SerArg: 3.54 ± 0.062	2.669SerSer: 2.669 ± 0.061	2.44SerThr: 2.44 ± 0.046	3.973SerVal: 3.973 ± 0.055	0.703SerTrp: 0.703 ± 0.027	1.302SerTyr: 1.302 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	5.956ThrAla: 5.956 ± 0.074	0.432ThrCys: 0.432 ± 0.02	3.186ThrAsp: 3.186 ± 0.056	3.508ThrGlu: 3.508 ± 0.062	2.116ThrPhe: 2.116 ± 0.049	5.523ThrGly: 5.523 ± 0.065	1.097ThrHis: 1.097 ± 0.031	2.624ThrIle: 2.624 ± 0.056	1.304ThrLys: 1.304 ± 0.03	6.205ThrLeu: 6.205 ± 0.078	1.229ThrMet: 1.229 ± 0.034	1.206ThrAsn: 1.206 ± 0.032	3.263ThrPro: 3.263 ± 0.051	1.482ThrGln: 1.482 ± 0.036	3.769ThrArg: 3.769 ± 0.054	2.783ThrSer: 2.783 ± 0.05	2.645ThrThr: 2.645 ± 0.058	3.812ThrVal: 3.812 ± 0.059	0.694ThrTrp: 0.694 ± 0.026	1.203ThrTyr: 1.203 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	8.683ValAla: 8.683 ± 0.094	0.584ValCys: 0.584 ± 0.022	3.856ValAsp: 3.856 ± 0.068	4.647ValGlu: 4.647 ± 0.068	2.814ValPhe: 2.814 ± 0.056	5.185ValGly: 5.185 ± 0.074	1.308ValHis: 1.308 ± 0.035	4.06ValIle: 4.06 ± 0.068	1.943ValLys: 1.943 ± 0.044	6.995ValLeu: 6.995 ± 0.089	2.051ValMet: 2.051 ± 0.041	1.804ValAsn: 1.804 ± 0.043	3.624ValPro: 3.624 ± 0.059	1.928ValGln: 1.928 ± 0.043	4.422ValArg: 4.422 ± 0.065	4.394ValSer: 4.394 ± 0.062	4.876ValThr: 4.876 ± 0.077	5.306ValVal: 5.306 ± 0.085	0.943ValTrp: 0.943 ± 0.034	1.467ValTyr: 1.467 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.409TrpAla: 1.409 ± 0.038	0.138TrpCys: 0.138 ± 0.011	0.797TrpAsp: 0.797 ± 0.023	0.65TrpGlu: 0.65 ± 0.024	0.553TrpPhe: 0.553 ± 0.022	1.015TrpGly: 1.015 ± 0.032	0.317TrpHis: 0.317 ± 0.018	0.742TrpIle: 0.742 ± 0.028	0.42TrpLys: 0.42 ± 0.018	1.641TrpLeu: 1.641 ± 0.043	0.397TrpMet: 0.397 ± 0.019	0.4TrpAsn: 0.4 ± 0.02	0.71TrpPro: 0.71 ± 0.024	0.582TrpGln: 0.582 ± 0.023	1.15TrpArg: 1.15 ± 0.034	0.85TrpSer: 0.85 ± 0.028	0.825TrpThr: 0.825 ± 0.029	0.884TrpVal: 0.884 ± 0.029	0.21TrpTrp: 0.21 ± 0.013	0.252TrpTyr: 0.252 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.51TyrAla: 2.51 ± 0.047	0.22TyrCys: 0.22 ± 0.014	1.579TyrAsp: 1.579 ± 0.039	1.346TyrGlu: 1.346 ± 0.041	0.846TyrPhe: 0.846 ± 0.03	2.112TyrGly: 2.112 ± 0.045	0.467TyrHis: 0.467 ± 0.02	0.914TyrIle: 0.914 ± 0.028	0.509TyrLys: 0.509 ± 0.021	2.197TyrLeu: 2.197 ± 0.046	0.451TyrMet: 0.451 ± 0.02	0.544TyrAsn: 0.544 ± 0.021	1.029TyrPro: 1.029 ± 0.029	0.621TyrGln: 0.621 ± 0.022	1.637TyrArg: 1.637 ± 0.035	1.125TyrSer: 1.125 ± 0.029	1.071TyrThr: 1.071 ± 0.033	1.439TyrVal: 1.439 ± 0.036	0.383TyrTrp: 0.383 ± 0.019	0.519TyrTyr: 0.519 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3742 proteins (1142359 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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