Amino acid dipepetide frequency for Campylobacter showae RM3277

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.055AlaAla: 9.055 ± 0.158	1.228AlaCys: 1.228 ± 0.065	4.376AlaAsp: 4.376 ± 0.096	4.243AlaGlu: 4.243 ± 0.091	4.035AlaPhe: 4.035 ± 0.085	5.983AlaGly: 5.983 ± 0.128	1.478AlaHis: 1.478 ± 0.052	5.785AlaIle: 5.785 ± 0.101	8.556AlaLys: 8.556 ± 0.134	9.59AlaLeu: 9.59 ± 0.149	2.476AlaMet: 2.476 ± 0.068	4.655AlaAsn: 4.655 ± 0.107	2.586AlaPro: 2.586 ± 0.066	3.665AlaGln: 3.665 ± 0.086	4.163AlaArg: 4.163 ± 0.109	5.463AlaSer: 5.463 ± 0.093	3.736AlaThr: 3.736 ± 0.08	6.422AlaVal: 6.422 ± 0.118	0.67AlaTrp: 0.67 ± 0.041	2.781AlaTyr: 2.781 ± 0.075	0.0AlaXaa: 0.0 ± 0.0
Cys	1.231CysAla: 1.231 ± 0.053	0.163CysCys: 0.163 ± 0.015	0.813CysAsp: 0.813 ± 0.039	1.251CysGlu: 1.251 ± 0.05	0.596CysPhe: 0.596 ± 0.036	1.17CysGly: 1.17 ± 0.05	0.21CysHis: 0.21 ± 0.026	0.657CysIle: 0.657 ± 0.035	0.763CysLys: 0.763 ± 0.036	0.915CysLeu: 0.915 ± 0.037	0.231CysMet: 0.231 ± 0.02	0.307CysAsn: 0.307 ± 0.025	0.4CysPro: 0.4 ± 0.032	0.19CysGln: 0.19 ± 0.017	0.383CysArg: 0.383 ± 0.026	0.652CysSer: 0.652 ± 0.034	0.395CysThr: 0.395 ± 0.022	0.975CysVal: 0.975 ± 0.044	0.063CysTrp: 0.063 ± 0.01	0.408CysTyr: 0.408 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	5.149AspAla: 5.149 ± 0.103	0.479AspCys: 0.479 ± 0.027	2.984AspAsp: 2.984 ± 0.079	5.652AspGlu: 5.652 ± 0.109	3.217AspPhe: 3.217 ± 0.067	3.933AspGly: 3.933 ± 0.087	0.617AspHis: 0.617 ± 0.036	4.085AspIle: 4.085 ± 0.084	4.469AspLys: 4.469 ± 0.088	4.276AspLeu: 4.276 ± 0.092	1.344AspMet: 1.344 ± 0.046	1.785AspAsn: 1.785 ± 0.06	1.562AspPro: 1.562 ± 0.055	0.897AspGln: 0.897 ± 0.04	1.835AspArg: 1.835 ± 0.058	2.586AspSer: 2.586 ± 0.067	2.256AspThr: 2.256 ± 0.065	4.072AspVal: 4.072 ± 0.092	0.341AspTrp: 0.341 ± 0.022	2.05AspTyr: 2.05 ± 0.062	0.0AspXaa: 0.0 ± 0.0
Glu	5.551GluAla: 5.551 ± 0.109	0.712GluCys: 0.712 ± 0.035	2.87GluAsp: 2.87 ± 0.064	3.814GluGlu: 3.814 ± 0.108	3.975GluPhe: 3.975 ± 0.098	3.738GluGly: 3.738 ± 0.083	1.039GluHis: 1.039 ± 0.039	6.613GluIle: 6.613 ± 0.122	5.549GluLys: 5.549 ± 0.108	7.523GluLeu: 7.523 ± 0.124	1.533GluMet: 1.533 ± 0.049	4.334GluAsn: 4.334 ± 0.09	2.04GluPro: 2.04 ± 0.065	2.597GluGln: 2.597 ± 0.073	3.314GluArg: 3.314 ± 0.076	3.33GluSer: 3.33 ± 0.088	2.442GluThr: 2.442 ± 0.074	3.728GluVal: 3.728 ± 0.075	0.512GluTrp: 0.512 ± 0.027	2.255GluTyr: 2.255 ± 0.059	0.0GluXaa: 0.0 ± 0.0
Phe	5.112PheAla: 5.112 ± 0.106	0.902PheCys: 0.902 ± 0.045	3.951PheAsp: 3.951 ± 0.083	4.108PheGlu: 4.108 ± 0.096	2.918PhePhe: 2.918 ± 0.097	3.916PheGly: 3.916 ± 0.09	0.657PheHis: 0.657 ± 0.032	4.008PheIle: 4.008 ± 0.094	4.279PheLys: 4.279 ± 0.085	5.181PheLeu: 5.181 ± 0.106	1.315PheMet: 1.315 ± 0.042	2.458PheAsn: 2.458 ± 0.069	0.997PhePro: 0.997 ± 0.043	0.865PheGln: 0.865 ± 0.035	1.821PheArg: 1.821 ± 0.058	4.267PheSer: 4.267 ± 0.088	2.511PheThr: 2.511 ± 0.066	3.293PheVal: 3.293 ± 0.083	0.592PheTrp: 0.592 ± 0.034	2.413PheTyr: 2.413 ± 0.069	0.0PheXaa: 0.0 ± 0.0
Gly	6.687GlyAla: 6.687 ± 0.132	0.938GlyCys: 0.938 ± 0.046	3.646GlyAsp: 3.646 ± 0.094	5.439GlyGlu: 5.439 ± 0.104	3.937GlyPhe: 3.937 ± 0.082	5.63GlyGly: 5.63 ± 0.11	1.031GlyHis: 1.031 ± 0.045	4.755GlyIle: 4.755 ± 0.093	5.349GlyLys: 5.349 ± 0.097	6.082GlyLeu: 6.082 ± 0.104	1.604GlyMet: 1.604 ± 0.049	2.3GlyAsn: 2.3 ± 0.076	0.883GlyPro: 0.883 ± 0.04	1.704GlyGln: 1.704 ± 0.058	2.649GlyArg: 2.649 ± 0.073	3.998GlySer: 3.998 ± 0.072	2.8GlyThr: 2.8 ± 0.093	5.767GlyVal: 5.767 ± 0.112	0.533GlyTrp: 0.533 ± 0.029	2.766GlyTyr: 2.766 ± 0.066	0.0GlyXaa: 0.0 ± 0.0
His	1.256HisAla: 1.256 ± 0.05	0.19HisCys: 0.19 ± 0.018	0.721HisAsp: 0.721 ± 0.036	0.994HisGlu: 0.994 ± 0.044	0.831HisPhe: 0.831 ± 0.04	1.238HisGly: 1.238 ± 0.05	0.316HisHis: 0.316 ± 0.023	1.023HisIle: 1.023 ± 0.045	1.151HisLys: 1.151 ± 0.048	1.377HisLeu: 1.377 ± 0.045	0.305HisMet: 0.305 ± 0.023	0.528HisAsn: 0.528 ± 0.033	0.652HisPro: 0.652 ± 0.037	0.389HisGln: 0.389 ± 0.027	0.518HisArg: 0.518 ± 0.029	0.912HisSer: 0.912 ± 0.038	0.678HisThr: 0.678 ± 0.035	0.928HisVal: 0.928 ± 0.039	0.111HisTrp: 0.111 ± 0.015	0.579HisTyr: 0.579 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.829IleAla: 6.829 ± 0.104	1.193IleCys: 1.193 ± 0.05	4.274IleAsp: 4.274 ± 0.096	4.605IleGlu: 4.605 ± 0.099	4.18IlePhe: 4.18 ± 0.107	4.782IleGly: 4.782 ± 0.104	0.851IleHis: 0.851 ± 0.04	4.419IleIle: 4.419 ± 0.113	6.019IleLys: 6.019 ± 0.116	7.353IleLeu: 7.353 ± 0.137	1.578IleMet: 1.578 ± 0.052	3.843IleAsn: 3.843 ± 0.084	1.976IlePro: 1.976 ± 0.062	1.214IleGln: 1.214 ± 0.049	2.424IleArg: 2.424 ± 0.061	5.112IleSer: 5.112 ± 0.098	3.301IleThr: 3.301 ± 0.094	4.713IleVal: 4.713 ± 0.103	0.573IleTrp: 0.573 ± 0.034	3.222IleTyr: 3.222 ± 0.081	0.0IleXaa: 0.0 ± 0.0
Lys	6.261LysAla: 6.261 ± 0.136	0.613LysCys: 0.613 ± 0.034	4.727LysAsp: 4.727 ± 0.093	5.965LysGlu: 5.965 ± 0.115	7.165LysPhe: 7.165 ± 0.135	4.264LysGly: 4.264 ± 0.087	0.96LysHis: 0.96 ± 0.039	7.589LysIle: 7.589 ± 0.124	6.29LysLys: 6.29 ± 0.126	6.059LysLeu: 6.059 ± 0.107	2.14LysMet: 2.14 ± 0.064	5.581LysAsn: 5.581 ± 0.104	2.497LysPro: 2.497 ± 0.066	2.342LysGln: 2.342 ± 0.073	3.339LysArg: 3.339 ± 0.078	5.108LysSer: 5.108 ± 0.101	4.311LysThr: 4.311 ± 0.081	3.694LysVal: 3.694 ± 0.087	0.476LysTrp: 0.476 ± 0.029	2.403LysTyr: 2.403 ± 0.07	0.0LysXaa: 0.0 ± 0.0
Leu	9.335LeuAla: 9.335 ± 0.149	1.259LeuCys: 1.259 ± 0.051	5.091LeuAsp: 5.091 ± 0.089	6.103LeuGlu: 6.103 ± 0.128	4.737LeuPhe: 4.737 ± 0.116	6.955LeuGly: 6.955 ± 0.132	1.375LeuHis: 1.375 ± 0.051	6.159LeuIle: 6.159 ± 0.113	9.038LeuLys: 9.038 ± 0.133	8.012LeuLeu: 8.012 ± 0.145	2.085LeuMet: 2.085 ± 0.06	6.027LeuAsn: 6.027 ± 0.116	3.373LeuPro: 3.373 ± 0.079	2.728LeuGln: 2.728 ± 0.068	4.101LeuArg: 4.101 ± 0.081	7.161LeuSer: 7.161 ± 0.125	4.327LeuThr: 4.327 ± 0.081	5.423LeuVal: 5.423 ± 0.1	0.604LeuTrp: 0.604 ± 0.028	2.952LeuTyr: 2.952 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	1.829MetAla: 1.829 ± 0.059	0.218MetCys: 0.218 ± 0.022	1.141MetAsp: 1.141 ± 0.042	1.057MetGlu: 1.057 ± 0.045	0.954MetPhe: 0.954 ± 0.04	1.643MetGly: 1.643 ± 0.063	0.41MetHis: 0.41 ± 0.028	1.866MetIle: 1.866 ± 0.065	2.03MetLys: 2.03 ± 0.059	2.389MetLeu: 2.389 ± 0.064	0.625MetMet: 0.625 ± 0.036	1.054MetAsn: 1.054 ± 0.037	1.07MetPro: 1.07 ± 0.044	1.041MetGln: 1.041 ± 0.04	1.341MetArg: 1.341 ± 0.048	1.754MetSer: 1.754 ± 0.053	0.967MetThr: 0.967 ± 0.038	1.122MetVal: 1.122 ± 0.048	0.173MetTrp: 0.173 ± 0.015	0.437MetTyr: 0.437 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	4.669AsnAla: 4.669 ± 0.098	0.423AsnCys: 0.423 ± 0.027	2.592AsnAsp: 2.592 ± 0.075	3.812AsnGlu: 3.812 ± 0.083	3.202AsnPhe: 3.202 ± 0.082	3.465AsnGly: 3.465 ± 0.086	0.696AsnHis: 0.696 ± 0.035	3.57AsnIle: 3.57 ± 0.091	3.165AsnLys: 3.165 ± 0.078	8.036AsnLeu: 8.036 ± 0.137	0.878AsnMet: 0.878 ± 0.041	1.691AsnAsn: 1.691 ± 0.069	1.905AsnPro: 1.905 ± 0.057	1.272AsnGln: 1.272 ± 0.044	1.679AsnArg: 1.679 ± 0.048	3.018AsnSer: 3.018 ± 0.078	1.854AsnThr: 1.854 ± 0.07	3.012AsnVal: 3.012 ± 0.077	0.245AsnTrp: 0.245 ± 0.02	1.598AsnTyr: 1.598 ± 0.058	0.0AsnXaa: 0.0 ± 0.0
Pro	2.332ProAla: 2.332 ± 0.069	0.331ProCys: 0.331 ± 0.026	1.461ProAsp: 1.461 ± 0.052	1.929ProGlu: 1.929 ± 0.053	1.724ProPhe: 1.724 ± 0.052	1.456ProGly: 1.456 ± 0.052	0.659ProHis: 0.659 ± 0.034	2.03ProIle: 2.03 ± 0.065	2.476ProLys: 2.476 ± 0.069	2.844ProLeu: 2.844 ± 0.063	0.671ProMet: 0.671 ± 0.035	1.693ProAsn: 1.693 ± 0.054	0.938ProPro: 0.938 ± 0.045	1.204ProGln: 1.204 ± 0.051	1.177ProArg: 1.177 ± 0.048	2.252ProSer: 2.252 ± 0.059	1.451ProThr: 1.451 ± 0.047	2.043ProVal: 2.043 ± 0.056	0.25ProTrp: 0.25 ± 0.02	1.24ProTyr: 1.24 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	2.237GlnAla: 2.237 ± 0.054	0.182GlnCys: 0.182 ± 0.016	1.403GlnAsp: 1.403 ± 0.05	1.633GlnGlu: 1.633 ± 0.053	0.834GlnPhe: 0.834 ± 0.04	1.616GlnGly: 1.616 ± 0.054	0.324GlnHis: 0.324 ± 0.022	3.593GlnIle: 3.593 ± 0.072	3.038GlnLys: 3.038 ± 0.076	1.893GlnLeu: 1.893 ± 0.052	0.789GlnMet: 0.789 ± 0.037	2.786GlnAsn: 2.786 ± 0.079	0.739GlnPro: 0.739 ± 0.035	0.592GlnGln: 0.592 ± 0.038	1.169GlnArg: 1.169 ± 0.043	1.896GlnSer: 1.896 ± 0.062	1.838GlnThr: 1.838 ± 0.061	1.277GlnVal: 1.277 ± 0.05	0.171GlnTrp: 0.171 ± 0.016	0.654GlnTyr: 0.654 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	3.625ArgAla: 3.625 ± 0.093	0.376ArgCys: 0.376 ± 0.027	2.174ArgAsp: 2.174 ± 0.062	3.339ArgGlu: 3.339 ± 0.087	2.137ArgPhe: 2.137 ± 0.063	2.663ArgGly: 2.663 ± 0.073	0.662ArgHis: 0.662 ± 0.032	2.907ArgIle: 2.907 ± 0.077	2.684ArgLys: 2.684 ± 0.073	4.264ArgLeu: 4.264 ± 0.085	0.907ArgMet: 0.907 ± 0.036	1.796ArgAsn: 1.796 ± 0.053	1.152ArgPro: 1.152 ± 0.043	1.346ArgGln: 1.346 ± 0.048	2.005ArgArg: 2.005 ± 0.065	2.242ArgSer: 2.242 ± 0.061	1.595ArgThr: 1.595 ± 0.051	2.904ArgVal: 2.904 ± 0.065	0.328ArgTrp: 0.328 ± 0.023	1.654ArgTyr: 1.654 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	5.901SerAla: 5.901 ± 0.098	0.744SerCys: 0.744 ± 0.034	3.343SerAsp: 3.343 ± 0.076	4.582SerGlu: 4.582 ± 0.099	3.357SerPhe: 3.357 ± 0.08	5.3SerGly: 5.3 ± 0.099	0.993SerHis: 0.993 ± 0.042	3.611SerIle: 3.611 ± 0.089	4.837SerLys: 4.837 ± 0.091	6.204SerLeu: 6.204 ± 0.117	1.251SerMet: 1.251 ± 0.048	3.068SerAsn: 3.068 ± 0.08	1.901SerPro: 1.901 ± 0.057	1.94SerGln: 1.94 ± 0.064	2.55SerArg: 2.55 ± 0.066	4.041SerSer: 4.041 ± 0.094	2.326SerThr: 2.326 ± 0.078	4.724SerVal: 4.724 ± 0.094	0.515SerTrp: 0.515 ± 0.034	2.203SerTyr: 2.203 ± 0.066	0.0SerXaa: 0.0 ± 0.0
Thr	4.067ThrAla: 4.067 ± 0.084	0.371ThrCys: 0.371 ± 0.025	2.39ThrAsp: 2.39 ± 0.071	1.948ThrGlu: 1.948 ± 0.063	1.906ThrPhe: 1.906 ± 0.066	3.025ThrGly: 3.025 ± 0.08	0.947ThrHis: 0.947 ± 0.044	2.908ThrIle: 2.908 ± 0.084	3.264ThrLys: 3.264 ± 0.075	4.685ThrLeu: 4.685 ± 0.093	0.922ThrMet: 0.922 ± 0.035	2.0ThrAsn: 2.0 ± 0.078	2.156ThrPro: 2.156 ± 0.056	1.851ThrGln: 1.851 ± 0.053	1.84ThrArg: 1.84 ± 0.062	2.778ThrSer: 2.778 ± 0.069	2.253ThrThr: 2.253 ± 0.08	2.587ThrVal: 2.587 ± 0.072	0.274ThrTrp: 0.274 ± 0.023	1.356ThrTyr: 1.356 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	5.982ValAla: 5.982 ± 0.122	1.023ValCys: 1.023 ± 0.047	2.942ValAsp: 2.942 ± 0.076	3.641ValGlu: 3.641 ± 0.099	3.341ValPhe: 3.341 ± 0.09	4.524ValGly: 4.524 ± 0.104	0.749ValHis: 0.749 ± 0.035	4.422ValIle: 4.422 ± 0.099	5.68ValLys: 5.68 ± 0.098	6.17ValLeu: 6.17 ± 0.111	1.54ValMet: 1.54 ± 0.058	3.226ValAsn: 3.226 ± 0.087	2.042ValPro: 2.042 ± 0.057	1.556ValGln: 1.556 ± 0.046	2.742ValArg: 2.742 ± 0.064	4.44ValSer: 4.44 ± 0.087	2.831ValThr: 2.831 ± 0.082	4.777ValVal: 4.777 ± 0.104	0.492ValTrp: 0.492 ± 0.028	1.995ValTyr: 1.995 ± 0.065	0.0ValXaa: 0.0 ± 0.0
Trp	0.655TrpAla: 0.655 ± 0.032	0.082TrpCys: 0.082 ± 0.012	0.445TrpAsp: 0.445 ± 0.029	0.36TrpGlu: 0.36 ± 0.026	0.366TrpPhe: 0.366 ± 0.025	0.55TrpGly: 0.55 ± 0.034	0.171TrpHis: 0.171 ± 0.016	0.52TrpIle: 0.52 ± 0.029	0.328TrpLys: 0.328 ± 0.024	0.933TrpLeu: 0.933 ± 0.041	0.245TrpMet: 0.245 ± 0.021	0.27TrpAsn: 0.27 ± 0.021	0.124TrpPro: 0.124 ± 0.013	0.345TrpGln: 0.345 ± 0.023	0.373TrpArg: 0.373 ± 0.03	0.418TrpSer: 0.418 ± 0.028	0.273TrpThr: 0.273 ± 0.022	0.481TrpVal: 0.481 ± 0.027	0.113TrpTrp: 0.113 ± 0.012	0.266TrpTyr: 0.266 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.184TyrAla: 3.184 ± 0.082	0.345TyrCys: 0.345 ± 0.025	2.245TyrAsp: 2.245 ± 0.062	2.992TyrGlu: 2.992 ± 0.065	2.151TyrPhe: 2.151 ± 0.059	2.645TyrGly: 2.645 ± 0.068	0.554TyrHis: 0.554 ± 0.029	1.94TyrIle: 1.94 ± 0.059	2.823TyrLys: 2.823 ± 0.066	3.059TyrLeu: 3.059 ± 0.073	0.678TyrMet: 0.678 ± 0.032	1.382TyrAsn: 1.382 ± 0.054	1.165TyrPro: 1.165 ± 0.046	0.925TyrGln: 0.925 ± 0.044	1.34TyrArg: 1.34 ± 0.046	1.963TyrSer: 1.963 ± 0.064	1.383TyrThr: 1.383 ± 0.048	2.174TyrVal: 2.174 ± 0.056	0.284TyrTrp: 0.284 ± 0.024	1.294TyrTyr: 1.294 ± 0.053	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2361 proteins (619577 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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