Amino acid dipepetide frequency for Porphyromonadaceae bacterium COT-184 OH4590

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.001AlaAla: 4.001 ± 0.125	0.681AlaCys: 0.681 ± 0.037	3.8AlaAsp: 3.8 ± 0.087	4.283AlaGlu: 4.283 ± 0.097	3.132AlaPhe: 3.132 ± 0.077	4.258AlaGly: 4.258 ± 0.104	1.034AlaHis: 1.034 ± 0.038	5.876AlaIle: 5.876 ± 0.112	4.902AlaLys: 4.902 ± 0.088	5.898AlaLeu: 5.898 ± 0.103	1.77AlaMet: 1.77 ± 0.059	3.483AlaAsn: 3.483 ± 0.081	1.721AlaPro: 1.721 ± 0.059	2.352AlaGln: 2.352 ± 0.062	2.34AlaArg: 2.34 ± 0.076	3.76AlaSer: 3.76 ± 0.085	3.845AlaThr: 3.845 ± 0.089	4.157AlaVal: 4.157 ± 0.1	0.487AlaTrp: 0.487 ± 0.029	2.454AlaTyr: 2.454 ± 0.074	0.003AlaXaa: 0.003 ± 0.002
Cys	0.567CysAla: 0.567 ± 0.034	0.158CysCys: 0.158 ± 0.019	0.53CysAsp: 0.53 ± 0.029	0.555CysGlu: 0.555 ± 0.03	0.55CysPhe: 0.55 ± 0.028	0.914CysGly: 0.914 ± 0.045	0.219CysHis: 0.219 ± 0.021	0.802CysIle: 0.802 ± 0.04	0.761CysLys: 0.761 ± 0.037	0.842CysLeu: 0.842 ± 0.044	0.212CysMet: 0.212 ± 0.016	0.592CysAsn: 0.592 ± 0.03	0.427CysPro: 0.427 ± 0.029	0.334CysGln: 0.334 ± 0.026	0.502CysArg: 0.502 ± 0.029	0.706CysSer: 0.706 ± 0.035	0.499CysThr: 0.499 ± 0.033	0.63CysVal: 0.63 ± 0.034	0.107CysTrp: 0.107 ± 0.014	0.44CysTyr: 0.44 ± 0.028	0.0CysXaa: 0.0 ± 0.0
Asp	3.057AspAla: 3.057 ± 0.068	0.609AspCys: 0.609 ± 0.032	2.655AspAsp: 2.655 ± 0.087	3.649AspGlu: 3.649 ± 0.091	3.518AspPhe: 3.518 ± 0.077	3.234AspGly: 3.234 ± 0.082	0.656AspHis: 0.656 ± 0.035	5.414AspIle: 5.414 ± 0.092	4.847AspLys: 4.847 ± 0.087	4.313AspLeu: 4.313 ± 0.096	1.491AspMet: 1.491 ± 0.054	4.011AspAsn: 4.011 ± 0.082	1.306AspPro: 1.306 ± 0.053	1.006AspGln: 1.006 ± 0.039	2.133AspArg: 2.133 ± 0.066	3.331AspSer: 3.331 ± 0.087	3.182AspThr: 3.182 ± 0.078	3.346AspVal: 3.346 ± 0.078	0.637AspTrp: 0.637 ± 0.03	2.809AspTyr: 2.809 ± 0.074	0.003AspXaa: 0.003 ± 0.003
Glu	4.342GluAla: 4.342 ± 0.095	0.545GluCys: 0.545 ± 0.032	2.912GluAsp: 2.912 ± 0.071	4.142GluGlu: 4.142 ± 0.104	2.831GluPhe: 2.831 ± 0.073	3.449GluGly: 3.449 ± 0.078	1.101GluHis: 1.101 ± 0.045	5.579GluIle: 5.579 ± 0.113	5.254GluLys: 5.254 ± 0.113	5.806GluLeu: 5.806 ± 0.102	1.595GluMet: 1.595 ± 0.052	4.063GluAsn: 4.063 ± 0.084	1.526GluPro: 1.526 ± 0.046	2.946GluGln: 2.946 ± 0.064	3.059GluArg: 3.059 ± 0.082	2.959GluSer: 2.959 ± 0.064	2.952GluThr: 2.952 ± 0.063	4.015GluVal: 4.015 ± 0.102	0.632GluTrp: 0.632 ± 0.031	2.856GluTyr: 2.856 ± 0.072	0.003GluXaa: 0.003 ± 0.002
Phe	3.593PheAla: 3.593 ± 0.079	0.627PheCys: 0.627 ± 0.033	3.518PheAsp: 3.518 ± 0.068	3.196PheGlu: 3.196 ± 0.076	2.662PhePhe: 2.662 ± 0.087	3.454PheGly: 3.454 ± 0.087	0.749PheHis: 0.749 ± 0.038	3.888PheIle: 3.888 ± 0.104	2.914PheLys: 2.914 ± 0.073	4.153PheLeu: 4.153 ± 0.092	1.173PheMet: 1.173 ± 0.041	2.642PheAsn: 2.642 ± 0.071	1.636PhePro: 1.636 ± 0.054	1.103PheGln: 1.103 ± 0.053	2.047PheArg: 2.047 ± 0.057	3.705PheSer: 3.705 ± 0.098	2.784PheThr: 2.784 ± 0.069	3.815PheVal: 3.815 ± 0.101	0.554PheTrp: 0.554 ± 0.031	2.185PheTyr: 2.185 ± 0.074	0.005PheXaa: 0.005 ± 0.003
Gly	3.92GlyAla: 3.92 ± 0.098	0.724GlyCys: 0.724 ± 0.035	3.079GlyAsp: 3.079 ± 0.077	3.536GlyGlu: 3.536 ± 0.09	3.366GlyPhe: 3.366 ± 0.078	4.222GlyGly: 4.222 ± 0.109	0.996GlyHis: 0.996 ± 0.042	5.643GlyIle: 5.643 ± 0.107	5.224GlyLys: 5.224 ± 0.115	5.176GlyLeu: 5.176 ± 0.106	1.585GlyMet: 1.585 ± 0.059	3.745GlyAsn: 3.745 ± 0.095	0.767GlyPro: 0.767 ± 0.037	1.866GlyGln: 1.866 ± 0.06	2.392GlyArg: 2.392 ± 0.072	3.696GlySer: 3.696 ± 0.088	3.339GlyThr: 3.339 ± 0.08	4.338GlyVal: 4.338 ± 0.096	0.702GlyTrp: 0.702 ± 0.032	3.164GlyTyr: 3.164 ± 0.07	0.0GlyXaa: 0.0 ± 0.0
His	0.809HisAla: 0.809 ± 0.042	0.225HisCys: 0.225 ± 0.019	0.676HisAsp: 0.676 ± 0.034	0.686HisGlu: 0.686 ± 0.034	0.956HisPhe: 0.956 ± 0.043	0.916HisGly: 0.916 ± 0.045	0.407HisHis: 0.407 ± 0.027	1.686HisIle: 1.686 ± 0.054	1.284HisLys: 1.284 ± 0.045	1.586HisLeu: 1.586 ± 0.06	0.19HisMet: 0.19 ± 0.018	1.149HisAsn: 1.149 ± 0.044	0.749HisPro: 0.749 ± 0.038	0.577HisGln: 0.577 ± 0.033	0.714HisArg: 0.714 ± 0.033	1.259HisSer: 1.259 ± 0.056	1.077HisThr: 1.077 ± 0.043	0.635HisVal: 0.635 ± 0.036	0.17HisTrp: 0.17 ± 0.017	0.912HisTyr: 0.912 ± 0.038	0.0HisXaa: 0.0 ± 0.0
Ile	6.448IleAla: 6.448 ± 0.122	0.941IleCys: 0.941 ± 0.047	5.868IleAsp: 5.868 ± 0.104	6.085IleGlu: 6.085 ± 0.098	4.22IlePhe: 4.22 ± 0.115	5.341IleGly: 5.341 ± 0.104	1.314IleHis: 1.314 ± 0.054	6.859IleIle: 6.859 ± 0.132	6.3IleLys: 6.3 ± 0.122	7.157IleLeu: 7.157 ± 0.123	1.696IleMet: 1.696 ± 0.057	5.064IleAsn: 5.064 ± 0.101	3.239IlePro: 3.239 ± 0.08	2.237IleGln: 2.237 ± 0.063	3.219IleArg: 3.219 ± 0.071	5.978IleSer: 5.978 ± 0.102	4.902IleThr: 4.902 ± 0.09	5.988IleVal: 5.988 ± 0.1	0.647IleTrp: 0.647 ± 0.036	3.469IleTyr: 3.469 ± 0.088	0.003IleXaa: 0.003 ± 0.002
Lys	4.782LysAla: 4.782 ± 0.092	0.519LysCys: 0.519 ± 0.032	4.188LysAsp: 4.188 ± 0.096	5.734LysGlu: 5.734 ± 0.129	2.727LysPhe: 2.727 ± 0.067	4.427LysGly: 4.427 ± 0.094	1.336LysHis: 1.336 ± 0.048	6.812LysIle: 6.812 ± 0.117	6.203LysLys: 6.203 ± 0.123	5.891LysLeu: 5.891 ± 0.103	2.215LysMet: 2.215 ± 0.061	5.231LysAsn: 5.231 ± 0.101	2.432LysPro: 2.432 ± 0.061	2.887LysGln: 2.887 ± 0.084	3.388LysArg: 3.388 ± 0.084	4.458LysSer: 4.458 ± 0.094	4.537LysThr: 4.537 ± 0.083	4.365LysVal: 4.365 ± 0.084	0.681LysTrp: 0.681 ± 0.035	3.401LysTyr: 3.401 ± 0.081	0.0LysXaa: 0.0 ± 0.0
Leu	5.574LeuAla: 5.574 ± 0.099	0.984LeuCys: 0.984 ± 0.048	4.57LeuAsp: 4.57 ± 0.094	4.875LeuGlu: 4.875 ± 0.1	4.592LeuPhe: 4.592 ± 0.106	5.296LeuGly: 5.296 ± 0.107	1.494LeuHis: 1.494 ± 0.06	6.944LeuIle: 6.944 ± 0.137	6.9LeuLys: 6.9 ± 0.118	8.266LeuLeu: 8.266 ± 0.16	2.18LeuMet: 2.18 ± 0.062	5.219LeuAsn: 5.219 ± 0.112	3.684LeuPro: 3.684 ± 0.082	3.202LeuGln: 3.202 ± 0.083	3.489LeuArg: 3.489 ± 0.084	6.633LeuSer: 6.633 ± 0.135	4.839LeuThr: 4.839 ± 0.104	4.864LeuVal: 4.864 ± 0.095	0.901LeuTrp: 0.901 ± 0.044	3.569LeuTyr: 3.569 ± 0.082	0.007LeuXaa: 0.007 ± 0.003
Met	1.865MetAla: 1.865 ± 0.066	0.212MetCys: 0.212 ± 0.018	1.009MetAsp: 1.009 ± 0.043	1.389MetGlu: 1.389 ± 0.054	1.208MetPhe: 1.208 ± 0.057	1.54MetGly: 1.54 ± 0.055	0.379MetHis: 0.379 ± 0.028	1.763MetIle: 1.763 ± 0.058	1.957MetLys: 1.957 ± 0.053	2.435MetLeu: 2.435 ± 0.062	0.619MetMet: 0.619 ± 0.04	1.338MetAsn: 1.338 ± 0.047	1.154MetPro: 1.154 ± 0.05	0.892MetGln: 0.892 ± 0.038	1.084MetArg: 1.084 ± 0.041	1.63MetSer: 1.63 ± 0.047	1.203MetThr: 1.203 ± 0.05	1.424MetVal: 1.424 ± 0.056	0.197MetTrp: 0.197 ± 0.018	0.807MetTyr: 0.807 ± 0.035	0.0MetXaa: 0.0 ± 0.0
Asn	3.558AsnAla: 3.558 ± 0.088	0.569AsnCys: 0.569 ± 0.031	2.979AsnAsp: 2.979 ± 0.076	3.418AsnGlu: 3.418 ± 0.075	2.901AsnPhe: 2.901 ± 0.077	3.871AsnGly: 3.871 ± 0.11	0.962AsnHis: 0.962 ± 0.041	6.335AsnIle: 6.335 ± 0.121	4.523AsnLys: 4.523 ± 0.102	4.984AsnLeu: 4.984 ± 0.095	1.451AsnMet: 1.451 ± 0.054	4.167AsnAsn: 4.167 ± 0.102	2.605AsnPro: 2.605 ± 0.065	1.911AsnGln: 1.911 ± 0.064	2.769AsnArg: 2.769 ± 0.076	3.778AsnSer: 3.778 ± 0.09	3.489AsnThr: 3.489 ± 0.088	3.356AsnVal: 3.356 ± 0.07	0.614AsnTrp: 0.614 ± 0.035	2.774AsnTyr: 2.774 ± 0.088	0.0AsnXaa: 0.0 ± 0.0
Pro	1.893ProAla: 1.893 ± 0.062	0.284ProCys: 0.284 ± 0.024	2.2ProAsp: 2.2 ± 0.065	2.255ProGlu: 2.255 ± 0.065	1.825ProPhe: 1.825 ± 0.061	1.243ProGly: 1.243 ± 0.053	0.677ProHis: 0.677 ± 0.031	2.805ProIle: 2.805 ± 0.07	2.444ProLys: 2.444 ± 0.059	2.789ProLeu: 2.789 ± 0.062	0.822ProMet: 0.822 ± 0.039	2.278ProAsn: 2.278 ± 0.061	0.856ProPro: 0.856 ± 0.038	1.593ProGln: 1.593 ± 0.05	0.966ProArg: 0.966 ± 0.042	2.038ProSer: 2.038 ± 0.063	1.95ProThr: 1.95 ± 0.057	2.132ProVal: 2.132 ± 0.054	0.254ProTrp: 0.254 ± 0.021	1.526ProTyr: 1.526 ± 0.046	0.003ProXaa: 0.003 ± 0.002
Gln	1.977GlnAla: 1.977 ± 0.07	0.29GlnCys: 0.29 ± 0.024	1.453GlnAsp: 1.453 ± 0.049	1.998GlnGlu: 1.998 ± 0.055	1.298GlnPhe: 1.298 ± 0.049	1.713GlnGly: 1.713 ± 0.064	0.615GlnHis: 0.615 ± 0.031	3.064GlnIle: 3.064 ± 0.084	2.999GlnLys: 2.999 ± 0.067	3.011GlnLeu: 3.011 ± 0.079	0.956GlnMet: 0.956 ± 0.039	2.295GlnAsn: 2.295 ± 0.058	1.032GlnPro: 1.032 ± 0.05	1.458GlnGln: 1.458 ± 0.064	1.618GlnArg: 1.618 ± 0.048	2.087GlnSer: 2.087 ± 0.062	2.148GlnThr: 2.148 ± 0.066	1.685GlnVal: 1.685 ± 0.059	0.379GlnTrp: 0.379 ± 0.024	1.618GlnTyr: 1.618 ± 0.055	0.005GlnXaa: 0.005 ± 0.003
Arg	2.292ArgAla: 2.292 ± 0.067	0.387ArgCys: 0.387 ± 0.026	2.0ArgAsp: 2.0 ± 0.067	2.415ArgGlu: 2.415 ± 0.072	2.278ArgPhe: 2.278 ± 0.059	2.272ArgGly: 2.272 ± 0.069	0.827ArgHis: 0.827 ± 0.041	3.604ArgIle: 3.604 ± 0.062	3.082ArgLys: 3.082 ± 0.066	3.968ArgLeu: 3.968 ± 0.107	1.022ArgMet: 1.022 ± 0.043	2.389ArgAsn: 2.389 ± 0.06	1.281ArgPro: 1.281 ± 0.045	1.813ArgGln: 1.813 ± 0.055	1.901ArgArg: 1.901 ± 0.058	2.102ArgSer: 2.102 ± 0.059	2.03ArgThr: 2.03 ± 0.066	2.412ArgVal: 2.412 ± 0.065	0.459ArgTrp: 0.459 ± 0.027	2.142ArgTyr: 2.142 ± 0.064	0.002ArgXaa: 0.002 ± 0.001
Ser	3.84SerAla: 3.84 ± 0.085	0.669SerCys: 0.669 ± 0.035	3.608SerAsp: 3.608 ± 0.082	3.708SerGlu: 3.708 ± 0.081	3.429SerPhe: 3.429 ± 0.087	4.3SerGly: 4.3 ± 0.094	1.076SerHis: 1.076 ± 0.04	5.623SerIle: 5.623 ± 0.099	4.647SerLys: 4.647 ± 0.101	6.131SerLeu: 6.131 ± 0.118	1.366SerMet: 1.366 ± 0.06	3.596SerAsn: 3.596 ± 0.101	2.163SerPro: 2.163 ± 0.053	2.137SerGln: 2.137 ± 0.061	2.327SerArg: 2.327 ± 0.062	4.135SerSer: 4.135 ± 0.113	3.224SerThr: 3.224 ± 0.087	4.367SerVal: 4.367 ± 0.1	0.625SerTrp: 0.625 ± 0.035	2.844SerTyr: 2.844 ± 0.081	0.002SerXaa: 0.002 ± 0.002
Thr	3.738ThrAla: 3.738 ± 0.092	0.4ThrCys: 0.4 ± 0.026	3.528ThrAsp: 3.528 ± 0.09	3.378ThrGlu: 3.378 ± 0.07	2.54ThrPhe: 2.54 ± 0.081	3.554ThrGly: 3.554 ± 0.089	0.939ThrHis: 0.939 ± 0.039	5.096ThrIle: 5.096 ± 0.097	3.684ThrLys: 3.684 ± 0.083	5.277ThrLeu: 5.277 ± 0.107	1.108ThrMet: 1.108 ± 0.042	3.106ThrAsn: 3.106 ± 0.079	2.524ThrPro: 2.524 ± 0.062	1.77ThrGln: 1.77 ± 0.051	1.731ThrArg: 1.731 ± 0.049	3.464ThrSer: 3.464 ± 0.092	3.212ThrThr: 3.212 ± 0.077	3.498ThrVal: 3.498 ± 0.086	0.414ThrTrp: 0.414 ± 0.03	2.143ThrTyr: 2.143 ± 0.066	0.002ThrXaa: 0.002 ± 0.002
Val	4.72ValAla: 4.72 ± 0.119	0.837ValCys: 0.837 ± 0.038	3.653ValAsp: 3.653 ± 0.079	4.223ValGlu: 4.223 ± 0.083	3.409ValPhe: 3.409 ± 0.085	3.993ValGly: 3.993 ± 0.084	0.856ValHis: 0.856 ± 0.038	4.89ValIle: 4.89 ± 0.088	4.265ValLys: 4.265 ± 0.09	5.516ValLeu: 5.516 ± 0.111	1.469ValMet: 1.469 ± 0.046	3.124ValAsn: 3.124 ± 0.075	2.067ValPro: 2.067 ± 0.067	1.585ValGln: 1.585 ± 0.055	2.455ValArg: 2.455 ± 0.072	4.437ValSer: 4.437 ± 0.091	3.036ValThr: 3.036 ± 0.076	4.714ValVal: 4.714 ± 0.089	0.756ValTrp: 0.756 ± 0.046	2.499ValTyr: 2.499 ± 0.072	0.007ValXaa: 0.007 ± 0.003
Trp	0.63TrpAla: 0.63 ± 0.035	0.092TrpCys: 0.092 ± 0.012	0.552TrpAsp: 0.552 ± 0.032	0.587TrpGlu: 0.587 ± 0.037	0.507TrpPhe: 0.507 ± 0.025	0.754TrpGly: 0.754 ± 0.037	0.215TrpHis: 0.215 ± 0.02	0.724TrpIle: 0.724 ± 0.035	0.817TrpLys: 0.817 ± 0.047	1.041TrpLeu: 1.041 ± 0.05	0.203TrpMet: 0.203 ± 0.02	0.577TrpAsn: 0.577 ± 0.03	0.075TrpPro: 0.075 ± 0.01	0.542TrpGln: 0.542 ± 0.03	0.455TrpArg: 0.455 ± 0.032	0.46TrpSer: 0.46 ± 0.023	0.462TrpThr: 0.462 ± 0.034	0.632TrpVal: 0.632 ± 0.03	0.135TrpTrp: 0.135 ± 0.017	0.377TrpTyr: 0.377 ± 0.022	0.002TrpXaa: 0.002 ± 0.002
Tyr	2.625TyrAla: 2.625 ± 0.066	0.595TyrCys: 0.595 ± 0.033	2.43TyrAsp: 2.43 ± 0.067	2.45TyrGlu: 2.45 ± 0.06	2.45TyrPhe: 2.45 ± 0.061	2.729TyrGly: 2.729 ± 0.069	0.812TyrHis: 0.812 ± 0.037	3.563TyrIle: 3.563 ± 0.076	3.204TyrLys: 3.204 ± 0.084	3.836TyrLeu: 3.836 ± 0.096	0.977TyrMet: 0.977 ± 0.04	2.946TyrAsn: 2.946 ± 0.082	1.586TyrPro: 1.586 ± 0.054	1.486TyrGln: 1.486 ± 0.057	2.087TyrArg: 2.087 ± 0.058	3.196TyrSer: 3.196 ± 0.08	2.394TyrThr: 2.394 ± 0.07	2.133TyrVal: 2.133 ± 0.068	0.492TyrTrp: 0.492 ± 0.031	2.185TyrTyr: 2.185 ± 0.062	0.002TyrXaa: 0.002 ± 0.002
Xaa	0.005XaaAla: 0.005 ± 0.003	0.0XaaCys: 0.0 ± 0.0	0.002XaaAsp: 0.002 ± 0.002	0.003XaaGlu: 0.003 ± 0.002	0.002XaaPhe: 0.002 ± 0.002	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.005XaaIle: 0.005 ± 0.003	0.003XaaLys: 0.003 ± 0.002	0.007XaaLeu: 0.007 ± 0.003	0.002XaaMet: 0.002 ± 0.002	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.002XaaGln: 0.002 ± 0.002	0.002XaaArg: 0.002 ± 0.002	0.005XaaSer: 0.005 ± 0.003	0.002XaaThr: 0.002 ± 0.001	0.005XaaVal: 0.005 ± 0.003	0.0XaaTrp: 0.0 ± 0.0	0.005XaaTyr: 0.005 ± 0.003	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1856 proteins (599540 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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