Amino acid dipepetide frequency for Desulfosarcina ovata subsp. ovata

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.865AlaAla: 9.865 ± 0.115	1.342AlaCys: 1.342 ± 0.03	5.821AlaAsp: 5.821 ± 0.058	5.517AlaGlu: 5.517 ± 0.066	3.76AlaPhe: 3.76 ± 0.046	7.669AlaGly: 7.669 ± 0.072	1.825AlaHis: 1.825 ± 0.031	5.941AlaIle: 5.941 ± 0.067	3.808AlaLys: 3.808 ± 0.057	9.17AlaLeu: 9.17 ± 0.086	2.984AlaMet: 2.984 ± 0.044	2.658AlaAsn: 2.658 ± 0.039	3.368AlaPro: 3.368 ± 0.046	2.773AlaGln: 2.773 ± 0.036	5.573AlaArg: 5.573 ± 0.065	4.696AlaSer: 4.696 ± 0.05	4.616AlaThr: 4.616 ± 0.059	7.015AlaVal: 7.015 ± 0.057	1.05AlaTrp: 1.05 ± 0.027	2.529AlaTyr: 2.529 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	0.97CysAla: 0.97 ± 0.026	0.263CysCys: 0.263 ± 0.013	0.676CysAsp: 0.676 ± 0.019	0.628CysGlu: 0.628 ± 0.02	0.529CysPhe: 0.529 ± 0.016	1.329CysGly: 1.329 ± 0.03	0.42CysHis: 0.42 ± 0.016	0.729CysIle: 0.729 ± 0.02	0.483CysLys: 0.483 ± 0.018	1.261CysLeu: 1.261 ± 0.023	0.33CysMet: 0.33 ± 0.013	0.414CysAsn: 0.414 ± 0.015	0.792CysPro: 0.792 ± 0.021	0.451CysGln: 0.451 ± 0.013	1.01CysArg: 1.01 ± 0.023	0.73CysSer: 0.73 ± 0.021	0.643CysThr: 0.643 ± 0.018	0.75CysVal: 0.75 ± 0.022	0.138CysTrp: 0.138 ± 0.009	0.4CysTyr: 0.4 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.56AspAla: 5.56 ± 0.06	0.689AspCys: 0.689 ± 0.019	3.492AspAsp: 3.492 ± 0.06	3.592AspGlu: 3.592 ± 0.048	2.606AspPhe: 2.606 ± 0.038	4.527AspGly: 4.527 ± 0.061	1.4AspHis: 1.4 ± 0.029	3.927AspIle: 3.927 ± 0.043	2.351AspLys: 2.351 ± 0.042	6.16AspLeu: 6.16 ± 0.064	1.388AspMet: 1.388 ± 0.028	1.841AspAsn: 1.841 ± 0.031	3.303AspPro: 3.303 ± 0.045	2.128AspGln: 2.128 ± 0.034	4.133AspArg: 4.133 ± 0.056	2.688AspSer: 2.688 ± 0.042	2.972AspThr: 2.972 ± 0.04	3.719AspVal: 3.719 ± 0.048	0.718AspTrp: 0.718 ± 0.018	1.949AspTyr: 1.949 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	5.666GluAla: 5.666 ± 0.068	0.514GluCys: 0.514 ± 0.018	2.963GluAsp: 2.963 ± 0.041	3.558GluGlu: 3.558 ± 0.058	1.872GluPhe: 1.872 ± 0.031	3.484GluGly: 3.484 ± 0.048	1.062GluHis: 1.062 ± 0.025	4.46GluIle: 4.46 ± 0.05	4.658GluLys: 4.658 ± 0.067	5.289GluLeu: 5.289 ± 0.053	1.894GluMet: 1.894 ± 0.033	2.773GluAsn: 2.773 ± 0.041	2.139GluPro: 2.139 ± 0.031	2.225GluGln: 2.225 ± 0.036	3.756GluArg: 3.756 ± 0.042	3.297GluSer: 3.297 ± 0.042	4.039GluThr: 4.039 ± 0.047	3.453GluVal: 3.453 ± 0.04	0.567GluTrp: 0.567 ± 0.017	1.491GluTyr: 1.491 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	3.225PheAla: 3.225 ± 0.043	0.597PheCys: 0.597 ± 0.018	2.736PheAsp: 2.736 ± 0.038	2.292PheGlu: 2.292 ± 0.036	2.086PhePhe: 2.086 ± 0.04	3.19PheGly: 3.19 ± 0.046	0.877PheHis: 0.877 ± 0.022	2.48PheIle: 2.48 ± 0.038	1.918PheLys: 1.918 ± 0.035	3.888PheLeu: 3.888 ± 0.054	1.023PheMet: 1.023 ± 0.023	1.618PheAsn: 1.618 ± 0.031	1.712PhePro: 1.712 ± 0.03	1.314PheGln: 1.314 ± 0.022	2.202PheArg: 2.202 ± 0.036	3.133PheSer: 3.133 ± 0.046	2.163PheThr: 2.163 ± 0.032	2.646PheVal: 2.646 ± 0.04	0.509PheTrp: 0.509 ± 0.015	1.316PheTyr: 1.316 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	5.969GlyAla: 5.969 ± 0.06	1.227GlyCys: 1.227 ± 0.024	3.873GlyAsp: 3.873 ± 0.053	4.195GlyGlu: 4.195 ± 0.046	3.288GlyPhe: 3.288 ± 0.042	5.679GlyGly: 5.679 ± 0.079	1.671GlyHis: 1.671 ± 0.032	5.463GlyIle: 5.463 ± 0.054	4.286GlyLys: 4.286 ± 0.049	7.463GlyLeu: 7.463 ± 0.069	2.414GlyMet: 2.414 ± 0.036	2.605GlyAsn: 2.605 ± 0.041	2.528GlyPro: 2.528 ± 0.039	2.682GlyGln: 2.682 ± 0.037	4.882GlyArg: 4.882 ± 0.052	4.164GlySer: 4.164 ± 0.05	4.219GlyThr: 4.219 ± 0.05	5.188GlyVal: 5.188 ± 0.054	1.012GlyTrp: 1.012 ± 0.025	2.613GlyTyr: 2.613 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	1.811HisAla: 1.811 ± 0.035	0.357HisCys: 0.357 ± 0.013	1.136HisAsp: 1.136 ± 0.025	1.027HisGlu: 1.027 ± 0.023	1.024HisPhe: 1.024 ± 0.024	1.628HisGly: 1.628 ± 0.032	0.649HisHis: 0.649 ± 0.022	1.304HisIle: 1.304 ± 0.026	0.773HisLys: 0.773 ± 0.02	2.459HisLeu: 2.459 ± 0.037	0.506HisMet: 0.506 ± 0.016	0.65HisAsn: 0.65 ± 0.017	1.407HisPro: 1.407 ± 0.027	0.892HisGln: 0.892 ± 0.022	1.579HisArg: 1.579 ± 0.028	1.05HisSer: 1.05 ± 0.023	1.097HisThr: 1.097 ± 0.024	1.344HisVal: 1.344 ± 0.024	0.301HisTrp: 0.301 ± 0.014	0.721HisTyr: 0.721 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	5.865IleAla: 5.865 ± 0.059	0.895IleCys: 0.895 ± 0.022	4.672IleAsp: 4.672 ± 0.054	4.265IleGlu: 4.265 ± 0.051	2.593IlePhe: 2.593 ± 0.04	5.004IleGly: 5.004 ± 0.062	1.545IleHis: 1.545 ± 0.03	3.812IleIle: 3.812 ± 0.051	3.094IleLys: 3.094 ± 0.044	5.797IleLeu: 5.797 ± 0.056	1.46IleMet: 1.46 ± 0.027	2.486IleAsn: 2.486 ± 0.038	3.187IlePro: 3.187 ± 0.043	2.25IleGln: 2.25 ± 0.035	4.2IleArg: 4.2 ± 0.045	3.875IleSer: 3.875 ± 0.048	3.526IleThr: 3.526 ± 0.047	4.536IleVal: 4.536 ± 0.046	0.579IleTrp: 0.579 ± 0.017	1.746IleTyr: 1.746 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.719LysAla: 4.719 ± 0.065	0.45LysCys: 0.45 ± 0.016	2.668LysAsp: 2.668 ± 0.041	3.13LysGlu: 3.13 ± 0.052	1.327LysPhe: 1.327 ± 0.027	3.675LysGly: 3.675 ± 0.043	0.888LysHis: 0.888 ± 0.023	3.537LysIle: 3.537 ± 0.053	3.709LysLys: 3.709 ± 0.056	3.874LysLeu: 3.874 ± 0.05	1.479LysMet: 1.479 ± 0.029	2.221LysAsn: 2.221 ± 0.038	2.238LysPro: 2.238 ± 0.032	1.84LysGln: 1.84 ± 0.03	3.249LysArg: 3.249 ± 0.044	2.775LysSer: 2.775 ± 0.039	3.334LysThr: 3.334 ± 0.039	2.972LysVal: 2.972 ± 0.04	0.55LysTrp: 0.55 ± 0.017	1.298LysTyr: 1.298 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	9.611LeuAla: 9.611 ± 0.103	1.288LeuCys: 1.288 ± 0.025	5.869LeuAsp: 5.869 ± 0.06	5.984LeuGlu: 5.984 ± 0.051	4.232LeuPhe: 4.232 ± 0.046	6.892LeuGly: 6.892 ± 0.066	1.783LeuHis: 1.783 ± 0.029	5.953LeuIle: 5.953 ± 0.054	5.645LeuLys: 5.645 ± 0.058	9.267LeuLeu: 9.267 ± 0.096	2.509LeuMet: 2.509 ± 0.034	3.626LeuAsn: 3.626 ± 0.042	4.857LeuPro: 4.857 ± 0.057	2.887LeuGln: 2.887 ± 0.039	5.164LeuArg: 5.164 ± 0.054	6.641LeuSer: 6.641 ± 0.07	5.463LeuThr: 5.463 ± 0.05	6.567LeuVal: 6.567 ± 0.064	0.981LeuTrp: 0.981 ± 0.024	2.409LeuTyr: 2.409 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	3.279MetAla: 3.279 ± 0.045	0.244MetCys: 0.244 ± 0.012	1.773MetAsp: 1.773 ± 0.031	1.673MetGlu: 1.673 ± 0.031	0.74MetPhe: 0.74 ± 0.02	2.214MetGly: 2.214 ± 0.035	0.513MetHis: 0.513 ± 0.015	1.786MetIle: 1.786 ± 0.027	1.461MetLys: 1.461 ± 0.026	2.487MetLeu: 2.487 ± 0.037	0.714MetMet: 0.714 ± 0.018	1.089MetAsn: 1.089 ± 0.021	1.351MetPro: 1.351 ± 0.027	0.988MetGln: 0.988 ± 0.024	1.43MetArg: 1.43 ± 0.026	1.345MetSer: 1.345 ± 0.026	1.613MetThr: 1.613 ± 0.029	2.163MetVal: 2.163 ± 0.034	0.187MetTrp: 0.187 ± 0.009	0.416MetTyr: 0.416 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.033AsnAla: 3.033 ± 0.042	0.445AsnCys: 0.445 ± 0.014	1.881AsnAsp: 1.881 ± 0.033	1.783AsnGlu: 1.783 ± 0.03	1.295AsnPhe: 1.295 ± 0.031	2.741AsnGly: 2.741 ± 0.036	0.817AsnHis: 0.817 ± 0.022	2.365AsnIle: 2.365 ± 0.038	1.481AsnLys: 1.481 ± 0.029	3.655AsnLeu: 3.655 ± 0.042	0.852AsnMet: 0.852 ± 0.023	1.213AsnAsn: 1.213 ± 0.024	2.197AsnPro: 2.197 ± 0.039	1.375AsnGln: 1.375 ± 0.024	2.582AsnArg: 2.582 ± 0.038	1.61AsnSer: 1.61 ± 0.032	1.748AsnThr: 1.748 ± 0.032	2.28AsnVal: 2.28 ± 0.035	0.441AsnTrp: 0.441 ± 0.014	1.07AsnTyr: 1.07 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	4.278ProAla: 4.278 ± 0.046	0.496ProCys: 0.496 ± 0.017	3.443ProAsp: 3.443 ± 0.039	3.641ProGlu: 3.641 ± 0.044	2.059ProPhe: 2.059 ± 0.038	3.638ProGly: 3.638 ± 0.044	0.979ProHis: 0.979 ± 0.028	2.489ProIle: 2.489 ± 0.039	1.933ProLys: 1.933 ± 0.034	4.286ProLeu: 4.286 ± 0.046	1.263ProMet: 1.263 ± 0.021	1.251ProAsn: 1.251 ± 0.025	2.198ProPro: 2.198 ± 0.043	1.558ProGln: 1.558 ± 0.031	2.088ProArg: 2.088 ± 0.035	2.415ProSer: 2.415 ± 0.033	2.233ProThr: 2.233 ± 0.037	3.985ProVal: 3.985 ± 0.046	0.546ProTrp: 0.546 ± 0.019	1.299ProTyr: 1.299 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.659GlnAla: 3.659 ± 0.049	0.392GlnCys: 0.392 ± 0.015	1.591GlnAsp: 1.591 ± 0.024	1.834GlnGlu: 1.834 ± 0.027	1.226GlnPhe: 1.226 ± 0.026	2.324GlnGly: 2.324 ± 0.034	0.699GlnHis: 0.699 ± 0.017	2.345GlnIle: 2.345 ± 0.03	1.941GlnLys: 1.941 ± 0.032	3.41GlnLeu: 3.41 ± 0.04	1.104GlnMet: 1.104 ± 0.026	1.218GlnAsn: 1.218 ± 0.025	1.583GlnPro: 1.583 ± 0.028	1.428GlnGln: 1.428 ± 0.035	2.399GlnArg: 2.399 ± 0.044	1.916GlnSer: 1.916 ± 0.029	2.143GlnThr: 2.143 ± 0.035	2.49GlnVal: 2.49 ± 0.034	0.515GlnTrp: 0.515 ± 0.018	0.916GlnTyr: 0.916 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	4.397ArgAla: 4.397 ± 0.048	0.858ArgCys: 0.858 ± 0.021	3.048ArgAsp: 3.048 ± 0.037	3.761ArgGlu: 3.761 ± 0.049	3.138ArgPhe: 3.138 ± 0.036	3.245ArgGly: 3.245 ± 0.039	1.665ArgHis: 1.665 ± 0.028	4.644ArgIle: 4.644 ± 0.043	3.329ArgLys: 3.329 ± 0.04	6.976ArgLeu: 6.976 ± 0.069	1.922ArgMet: 1.922 ± 0.034	1.98ArgAsn: 1.98 ± 0.027	2.658ArgPro: 2.658 ± 0.034	3.017ArgGln: 3.017 ± 0.043	4.345ArgArg: 4.345 ± 0.055	3.332ArgSer: 3.332 ± 0.042	2.948ArgThr: 2.948 ± 0.042	4.083ArgVal: 4.083 ± 0.053	0.831ArgTrp: 0.831 ± 0.02	2.16ArgTyr: 2.16 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	4.926SerAla: 4.926 ± 0.053	0.633SerCys: 0.633 ± 0.019	3.315SerAsp: 3.315 ± 0.047	3.136SerGlu: 3.136 ± 0.046	2.18SerPhe: 2.18 ± 0.033	5.372SerGly: 5.372 ± 0.062	1.254SerHis: 1.254 ± 0.025	3.579SerIle: 3.579 ± 0.047	2.359SerLys: 2.359 ± 0.04	5.578SerLeu: 5.578 ± 0.06	1.568SerMet: 1.568 ± 0.03	1.647SerAsn: 1.647 ± 0.03	2.646SerPro: 2.646 ± 0.038	1.9SerGln: 1.9 ± 0.029	3.564SerArg: 3.564 ± 0.043	3.113SerSer: 3.113 ± 0.051	2.735SerThr: 2.735 ± 0.038	3.986SerVal: 3.986 ± 0.046	0.641SerTrp: 0.641 ± 0.018	1.517SerTyr: 1.517 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	5.335ThrAla: 5.335 ± 0.058	0.673ThrCys: 0.673 ± 0.019	3.324ThrAsp: 3.324 ± 0.05	2.794ThrGlu: 2.794 ± 0.038	2.108ThrPhe: 2.108 ± 0.036	4.995ThrGly: 4.995 ± 0.057	1.194ThrHis: 1.194 ± 0.025	3.92ThrIle: 3.92 ± 0.049	1.803ThrLys: 1.803 ± 0.03	5.667ThrLeu: 5.667 ± 0.058	1.31ThrMet: 1.31 ± 0.025	1.606ThrAsn: 1.606 ± 0.03	2.934ThrPro: 2.934 ± 0.035	1.586ThrGln: 1.586 ± 0.026	3.092ThrArg: 3.092 ± 0.038	2.568ThrSer: 2.568 ± 0.04	2.92ThrThr: 2.92 ± 0.043	4.516ThrVal: 4.516 ± 0.063	0.565ThrTrp: 0.565 ± 0.016	1.571ThrTyr: 1.571 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	6.624ValAla: 6.624 ± 0.071	0.984ValCys: 0.984 ± 0.024	4.516ValAsp: 4.516 ± 0.051	4.192ValGlu: 4.192 ± 0.049	3.043ValPhe: 3.043 ± 0.041	4.814ValGly: 4.814 ± 0.055	1.37ValHis: 1.37 ± 0.031	4.388ValIle: 4.388 ± 0.049	3.194ValLys: 3.194 ± 0.039	6.659ValLeu: 6.659 ± 0.066	1.803ValMet: 1.803 ± 0.03	2.528ValAsn: 2.528 ± 0.04	3.072ValPro: 3.072 ± 0.038	2.087ValGln: 2.087 ± 0.037	4.069ValArg: 4.069 ± 0.048	4.208ValSer: 4.208 ± 0.047	3.919ValThr: 3.919 ± 0.055	5.581ValVal: 5.581 ± 0.063	0.711ValTrp: 0.711 ± 0.021	1.9ValTyr: 1.9 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	0.842TrpAla: 0.842 ± 0.021	0.165TrpCys: 0.165 ± 0.009	0.637TrpAsp: 0.637 ± 0.022	0.665TrpGlu: 0.665 ± 0.018	0.493TrpPhe: 0.493 ± 0.016	0.774TrpGly: 0.774 ± 0.02	0.281TrpHis: 0.281 ± 0.012	0.75TrpIle: 0.75 ± 0.019	0.569TrpLys: 0.569 ± 0.015	1.236TrpLeu: 1.236 ± 0.027	0.34TrpMet: 0.34 ± 0.013	0.434TrpAsn: 0.434 ± 0.017	0.485TrpPro: 0.485 ± 0.016	0.579TrpGln: 0.579 ± 0.017	0.728TrpArg: 0.728 ± 0.021	0.602TrpSer: 0.602 ± 0.02	0.586TrpThr: 0.586 ± 0.018	0.763TrpVal: 0.763 ± 0.021	0.166TrpTrp: 0.166 ± 0.01	0.308TrpTyr: 0.308 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.347TyrAla: 2.347 ± 0.033	0.434TyrCys: 0.434 ± 0.016	1.709TyrAsp: 1.709 ± 0.036	1.494TyrGlu: 1.494 ± 0.029	1.327TyrPhe: 1.327 ± 0.03	2.229TyrGly: 2.229 ± 0.04	0.822TyrHis: 0.822 ± 0.018	1.512TyrIle: 1.512 ± 0.028	1.134TyrLys: 1.134 ± 0.03	3.046TyrLeu: 3.046 ± 0.042	0.603TyrMet: 0.603 ± 0.015	1.005TyrAsn: 1.005 ± 0.026	1.426TyrPro: 1.426 ± 0.027	1.175TyrGln: 1.175 ± 0.023	2.291TyrArg: 2.291 ± 0.032	1.492TyrSer: 1.492 ± 0.028	1.564TyrThr: 1.564 ± 0.03	1.625TyrVal: 1.625 ± 0.029	0.395TyrTrp: 0.395 ± 0.014	1.054TyrTyr: 1.054 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6391 proteins (2080000 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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