Human papillomavirus type 18

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Alphapapillomavirus; Alphapapillomavirus 7

Average proteome isoelectric point is 6.88

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 9 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>sp|P06789|VE1_HPV18 Replication protein E1 OS=Human papillomavirus type 18 OX=333761 GN=E1 PE=1 SV=1
MM1 pKa = 7.6HH2 pKa = 7.32GPKK5 pKa = 9.22ATLQDD10 pKa = 3.22IVLHH14 pKa = 6.26LEE16 pKa = 4.12PQNEE20 pKa = 4.09IPVDD24 pKa = 4.27LLCHH28 pKa = 5.79EE29 pKa = 4.49QLSDD33 pKa = 3.96SEE35 pKa = 4.54EE36 pKa = 4.2EE37 pKa = 3.76NDD39 pKa = 4.31EE40 pKa = 3.95IDD42 pKa = 4.47GVNHH46 pKa = 4.58QHH48 pKa = 6.4LPARR52 pKa = 11.84RR53 pKa = 11.84AEE55 pKa = 4.23PQRR58 pKa = 11.84HH59 pKa = 5.18TMLCMCCKK67 pKa = 10.23CEE69 pKa = 4.04ARR71 pKa = 11.84IKK73 pKa = 10.88LVVEE77 pKa = 4.77SSADD81 pKa = 3.47DD82 pKa = 3.63LRR84 pKa = 11.84AFQQLFLNTLSFVCPWCASQQQ105 pKa = 3.38

Molecular weight: 11.99 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>sp|P06792|VE5_HPV18 Probable protein E5 OS=Human papillomavirus type 18 OX=333761 GN=E5 PE=3 SV=1
MM1 pKa = 8.13ADD3 pKa = 3.42PEE5 pKa = 4.72VPVTTRR11 pKa = 11.84YY12 pKa = 9.53PLLSLLNSYY21 pKa = 7.41STPPHH26 pKa = 7.35RR27 pKa = 11.84IPAPCPWAPQRR38 pKa = 11.84PTARR42 pKa = 11.84RR43 pKa = 11.84RR44 pKa = 11.84LLHH47 pKa = 7.19DD48 pKa = 5.26LDD50 pKa = 4.46TVDD53 pKa = 4.03SRR55 pKa = 11.84RR56 pKa = 11.84SSIVDD61 pKa = 3.82LSTHH65 pKa = 6.51FSVQLHH71 pKa = 5.86LQATTKK77 pKa = 10.6DD78 pKa = 3.68GNSVVVTLRR87 pKa = 11.84LL88 pKa = 3.37

Molecular weight: 9.88 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

9

0

9

2647

73

657

294.1

32.91

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.893 ± 0.189

2.985 ± 0.625

5.818 ± 0.433

4.193 ± 0.786

4.118 ± 0.566

6.082 ± 0.628

3.06 ± 0.495

4.949 ± 0.307

4.647 ± 0.62

8.462 ± 0.771

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.776 ± 0.254

4.08 ± 0.626

6.233 ± 1.158

4.231 ± 0.417

5.138 ± 0.74

7.669 ± 0.765

8.689 ± 0.877

6.611 ± 0.709

1.511 ± 0.225

3.853 ± 0.5
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski