Amino acid dipepetide frequency for Dorea formicigenerans CAG:28

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.57AlaAla: 6.57 ± 0.116
1.177AlaCys: 1.177 ± 0.049
4.44AlaAsp: 4.44 ± 0.083
5.143AlaGlu: 5.143 ± 0.1
2.992AlaPhe: 2.992 ± 0.078
6.151AlaGly: 6.151 ± 0.101
1.142AlaHis: 1.142 ± 0.039
5.485AlaIle: 5.485 ± 0.088
5.452AlaLys: 5.452 ± 0.099
6.891AlaLeu: 6.891 ± 0.092
2.503AlaMet: 2.503 ± 0.066
2.665AlaAsn: 2.665 ± 0.065
1.934AlaPro: 1.934 ± 0.056
2.26AlaGln: 2.26 ± 0.066
2.855AlaArg: 2.855 ± 0.069
3.807AlaSer: 3.807 ± 0.081
3.472AlaThr: 3.472 ± 0.073
5.943AlaVal: 5.943 ± 0.097
0.574AlaTrp: 0.574 ± 0.032
2.801AlaTyr: 2.801 ± 0.061
0.003AlaXaa: 0.003 ± 0.002
Cys
1.099CysAla: 1.099 ± 0.041
0.248CysCys: 0.248 ± 0.019
0.866CysAsp: 0.866 ± 0.035
1.06CysGlu: 1.06 ± 0.036
0.567CysPhe: 0.567 ± 0.028
1.533CysGly: 1.533 ± 0.057
0.312CysHis: 0.312 ± 0.023
1.126CysIle: 1.126 ± 0.043
0.899CysLys: 0.899 ± 0.041
1.088CysLeu: 1.088 ± 0.04
0.531CysMet: 0.531 ± 0.03
0.621CysAsn: 0.621 ± 0.027
0.692CysPro: 0.692 ± 0.031
0.469CysGln: 0.469 ± 0.026
0.608CysArg: 0.608 ± 0.029
0.801CysSer: 0.801 ± 0.034
0.723CysThr: 0.723 ± 0.032
1.101CysVal: 1.101 ± 0.039
0.109CysTrp: 0.109 ± 0.013
0.61CysTyr: 0.61 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
4.02AspAla: 4.02 ± 0.079
0.818AspCys: 0.818 ± 0.035
3.107AspAsp: 3.107 ± 0.099
4.865AspGlu: 4.865 ± 0.107
2.495AspPhe: 2.495 ± 0.065
4.241AspGly: 4.241 ± 0.09
0.916AspHis: 0.916 ± 0.033
4.601AspIle: 4.601 ± 0.087
3.807AspLys: 3.807 ± 0.073
4.471AspLeu: 4.471 ± 0.08
1.918AspMet: 1.918 ± 0.053
2.211AspAsn: 2.211 ± 0.062
1.764AspPro: 1.764 ± 0.051
1.652AspGln: 1.652 ± 0.054
2.293AspArg: 2.293 ± 0.062
2.947AspSer: 2.947 ± 0.071
3.14AspThr: 3.14 ± 0.062
4.076AspVal: 4.076 ± 0.084
0.553AspTrp: 0.553 ± 0.025
2.94AspTyr: 2.94 ± 0.07
0.0AspXaa: 0.0 ± 0.0
Glu
5.848GluAla: 5.848 ± 0.09
0.867GluCys: 0.867 ± 0.038
4.522GluAsp: 4.522 ± 0.11
7.965GluGlu: 7.965 ± 0.168
2.536GluPhe: 2.536 ± 0.063
4.38GluGly: 4.38 ± 0.07
1.602GluHis: 1.602 ± 0.048
5.865GluIle: 5.865 ± 0.101
7.323GluLys: 7.323 ± 0.137
7.042GluLeu: 7.042 ± 0.109
2.605GluMet: 2.605 ± 0.055
4.269GluAsn: 4.269 ± 0.085
1.971GluPro: 1.971 ± 0.056
3.002GluGln: 3.002 ± 0.079
3.336GluArg: 3.336 ± 0.077
3.42GluSer: 3.42 ± 0.067
3.614GluThr: 3.614 ± 0.082
4.964GluVal: 4.964 ± 0.075
0.623GluTrp: 0.623 ± 0.036
3.231GluTyr: 3.231 ± 0.076
0.0GluXaa: 0.0 ± 0.0
Phe
2.921PheAla: 2.921 ± 0.066
0.68PheCys: 0.68 ± 0.03
2.413PheAsp: 2.413 ± 0.055
2.643PheGlu: 2.643 ± 0.07
1.562PhePhe: 1.562 ± 0.054
3.091PheGly: 3.091 ± 0.075
0.815PheHis: 0.815 ± 0.035
2.661PheIle: 2.661 ± 0.063
2.016PheLys: 2.016 ± 0.053
3.693PheLeu: 3.693 ± 0.095
1.179PheMet: 1.179 ± 0.041
1.309PheAsn: 1.309 ± 0.047
1.358PhePro: 1.358 ± 0.038
1.309PheGln: 1.309 ± 0.041
1.522PheArg: 1.522 ± 0.048
2.367PheSer: 2.367 ± 0.057
2.127PheThr: 2.127 ± 0.055
2.768PheVal: 2.768 ± 0.067
0.367PheTrp: 0.367 ± 0.022
1.514PheTyr: 1.514 ± 0.045
0.0PheXaa: 0.0 ± 0.0
Gly
5.354GlyAla: 5.354 ± 0.113
1.39GlyCys: 1.39 ± 0.054
3.43GlyAsp: 3.43 ± 0.077
4.83GlyGlu: 4.83 ± 0.086
2.916GlyPhe: 2.916 ± 0.064
4.964GlyGly: 4.964 ± 0.122
1.332GlyHis: 1.332 ± 0.04
6.556GlyIle: 6.556 ± 0.099
5.681GlyLys: 5.681 ± 0.094
5.925GlyLeu: 5.925 ± 0.097
2.597GlyMet: 2.597 ± 0.064
3.146GlyAsn: 3.146 ± 0.071
1.342GlyPro: 1.342 ± 0.045
2.167GlyGln: 2.167 ± 0.054
3.033GlyArg: 3.033 ± 0.059
3.934GlySer: 3.934 ± 0.085
4.384GlyThr: 4.384 ± 0.091
5.259GlyVal: 5.259 ± 0.09
0.617GlyTrp: 0.617 ± 0.043
3.361GlyTyr: 3.361 ± 0.063
0.0GlyXaa: 0.0 ± 0.0
His
1.173HisAla: 1.173 ± 0.037
0.327HisCys: 0.327 ± 0.023
0.942HisAsp: 0.942 ± 0.037
1.195HisGlu: 1.195 ± 0.048
0.823HisPhe: 0.823 ± 0.033
1.332HisGly: 1.332 ± 0.05
0.462HisHis: 0.462 ± 0.045
1.464HisIle: 1.464 ± 0.041
1.027HisLys: 1.027 ± 0.032
1.602HisLeu: 1.602 ± 0.044
0.617HisMet: 0.617 ± 0.027
0.727HisAsn: 0.727 ± 0.031
0.825HisPro: 0.825 ± 0.034
0.574HisGln: 0.574 ± 0.031
0.694HisArg: 0.694 ± 0.03
0.896HisSer: 0.896 ± 0.038
1.002HisThr: 1.002 ± 0.037
1.256HisVal: 1.256 ± 0.043
0.155HisTrp: 0.155 ± 0.017
0.717HisTyr: 0.717 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
5.934IleAla: 5.934 ± 0.111
1.476IleCys: 1.476 ± 0.044
4.25IleAsp: 4.25 ± 0.087
5.267IleGlu: 5.267 ± 0.097
3.109IlePhe: 3.109 ± 0.076
5.585IleGly: 5.585 ± 0.106
1.509IleHis: 1.509 ± 0.047
5.405IleIle: 5.405 ± 0.113
4.262IleLys: 4.262 ± 0.068
7.274IleLeu: 7.274 ± 0.134
2.188IleMet: 2.188 ± 0.053
2.694IleAsn: 2.694 ± 0.063
3.381IlePro: 3.381 ± 0.064
2.563IleGln: 2.563 ± 0.069
3.548IleArg: 3.548 ± 0.076
4.614IleSer: 4.614 ± 0.084
4.16IleThr: 4.16 ± 0.07
5.497IleVal: 5.497 ± 0.088
0.642IleTrp: 0.642 ± 0.031
2.854IleTyr: 2.854 ± 0.061
0.0IleXaa: 0.0 ± 0.0
Lys
5.336LysAla: 5.336 ± 0.088
0.798LysCys: 0.798 ± 0.031
4.099LysAsp: 4.099 ± 0.082
7.573LysGlu: 7.573 ± 0.127
1.909LysPhe: 1.909 ± 0.052
4.37LysGly: 4.37 ± 0.082
1.097LysHis: 1.097 ± 0.032
5.476LysIle: 5.476 ± 0.089
6.977LysLys: 6.977 ± 0.118
5.656LysLeu: 5.656 ± 0.078
2.522LysMet: 2.522 ± 0.058
3.945LysAsn: 3.945 ± 0.075
1.968LysPro: 1.968 ± 0.06
2.364LysGln: 2.364 ± 0.06
3.092LysArg: 3.092 ± 0.062
3.512LysSer: 3.512 ± 0.063
3.701LysThr: 3.701 ± 0.068
4.867LysVal: 4.867 ± 0.086
0.612LysTrp: 0.612 ± 0.031
2.915LysTyr: 2.915 ± 0.062
0.0LysXaa: 0.0 ± 0.0
Leu
6.764LeuAla: 6.764 ± 0.109
1.46LeuCys: 1.46 ± 0.042
5.066LeuAsp: 5.066 ± 0.089
6.453LeuGlu: 6.453 ± 0.098
3.402LeuPhe: 3.402 ± 0.079
6.268LeuGly: 6.268 ± 0.087
1.546LeuHis: 1.546 ± 0.044
6.331LeuIle: 6.331 ± 0.1
6.478LeuLys: 6.478 ± 0.099
7.851LeuLeu: 7.851 ± 0.153
2.68LeuMet: 2.68 ± 0.059
3.816LeuAsn: 3.816 ± 0.074
3.406LeuPro: 3.406 ± 0.071
2.624LeuGln: 2.624 ± 0.057
3.501LeuArg: 3.501 ± 0.075
5.545LeuSer: 5.545 ± 0.095
4.879LeuThr: 4.879 ± 0.086
5.611LeuVal: 5.611 ± 0.089
0.666LeuTrp: 0.666 ± 0.033
3.019LeuTyr: 3.019 ± 0.071
0.001LeuXaa: 0.001 ± 0.001
Met
2.496MetAla: 2.496 ± 0.057
0.414MetCys: 0.414 ± 0.026
1.976MetAsp: 1.976 ± 0.052
2.596MetGlu: 2.596 ± 0.056
0.998MetPhe: 0.998 ± 0.039
2.241MetGly: 2.241 ± 0.063
0.512MetHis: 0.512 ± 0.027
2.433MetIle: 2.433 ± 0.062
2.823MetLys: 2.823 ± 0.068
2.928MetLeu: 2.928 ± 0.067
1.036MetMet: 1.036 ± 0.036
1.68MetAsn: 1.68 ± 0.045
1.103MetPro: 1.103 ± 0.041
1.13MetGln: 1.13 ± 0.036
1.301MetArg: 1.301 ± 0.04
1.929MetSer: 1.929 ± 0.056
1.934MetThr: 1.934 ± 0.058
1.976MetVal: 1.976 ± 0.054
0.234MetTrp: 0.234 ± 0.016
1.021MetTyr: 1.021 ± 0.038
0.0MetXaa: 0.0 ± 0.0
Asn
3.031AsnAla: 3.031 ± 0.067
0.626AsnCys: 0.626 ± 0.026
2.135AsnAsp: 2.135 ± 0.051
2.857AsnGlu: 2.857 ± 0.063
1.424AsnPhe: 1.424 ± 0.044
3.356AsnGly: 3.356 ± 0.077
0.863AsnHis: 0.863 ± 0.034
3.45AsnIle: 3.45 ± 0.068
2.622AsnLys: 2.622 ± 0.071
3.787AsnLeu: 3.787 ± 0.061
1.418AsnMet: 1.418 ± 0.043
1.738AsnAsn: 1.738 ± 0.049
2.044AsnPro: 2.044 ± 0.055
1.592AsnGln: 1.592 ± 0.05
1.831AsnArg: 1.831 ± 0.057
2.213AsnSer: 2.213 ± 0.064
2.275AsnThr: 2.275 ± 0.058
3.251AsnVal: 3.251 ± 0.072
0.414AsnTrp: 0.414 ± 0.024
1.833AsnTyr: 1.833 ± 0.049
0.0AsnXaa: 0.0 ± 0.0
Pro
2.287ProAla: 2.287 ± 0.06
0.434ProCys: 0.434 ± 0.025
2.286ProAsp: 2.286 ± 0.062
3.308ProGlu: 3.308 ± 0.07
1.402ProPhe: 1.402 ± 0.049
2.413ProGly: 2.413 ± 0.066
0.535ProHis: 0.535 ± 0.028
2.301ProIle: 2.301 ± 0.062
2.148ProLys: 2.148 ± 0.053
2.598ProLeu: 2.598 ± 0.059
0.909ProMet: 0.909 ± 0.031
1.272ProAsn: 1.272 ± 0.039
0.661ProPro: 0.661 ± 0.032
1.031ProGln: 1.031 ± 0.035
0.939ProArg: 0.939 ± 0.037
1.618ProSer: 1.618 ± 0.053
1.541ProThr: 1.541 ± 0.04
3.015ProVal: 3.015 ± 0.066
0.261ProTrp: 0.261 ± 0.019
1.453ProTyr: 1.453 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
2.531GlnAla: 2.531 ± 0.061
0.4GlnCys: 0.4 ± 0.023
1.61GlnAsp: 1.61 ± 0.046
2.855GlnGlu: 2.855 ± 0.084
1.087GlnPhe: 1.087 ± 0.042
1.929GlnGly: 1.929 ± 0.054
0.429GlnHis: 0.429 ± 0.026
2.887GlnIle: 2.887 ± 0.06
2.936GlnLys: 2.936 ± 0.065
2.688GlnLeu: 2.688 ± 0.064
1.33GlnMet: 1.33 ± 0.042
1.725GlnAsn: 1.725 ± 0.057
0.867GlnPro: 0.867 ± 0.04
1.138GlnGln: 1.138 ± 0.045
1.239GlnArg: 1.239 ± 0.043
1.591GlnSer: 1.591 ± 0.049
1.677GlnThr: 1.677 ± 0.047
2.287GlnVal: 2.287 ± 0.051
0.269GlnTrp: 0.269 ± 0.019
1.349GlnTyr: 1.349 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
2.52ArgAla: 2.52 ± 0.061
0.54ArgCys: 0.54 ± 0.029
2.118ArgAsp: 2.118 ± 0.064
3.668ArgGlu: 3.668 ± 0.083
1.647ArgPhe: 1.647 ± 0.045
2.44ArgGly: 2.44 ± 0.06
0.735ArgHis: 0.735 ± 0.032
3.344ArgIle: 3.344 ± 0.07
3.46ArgLys: 3.46 ± 0.07
3.489ArgLeu: 3.489 ± 0.072
1.622ArgMet: 1.622 ± 0.047
1.811ArgAsn: 1.811 ± 0.051
1.205ArgPro: 1.205 ± 0.044
1.661ArgGln: 1.661 ± 0.057
2.143ArgArg: 2.143 ± 0.064
1.9ArgSer: 1.9 ± 0.051
2.098ArgThr: 2.098 ± 0.056
2.714ArgVal: 2.714 ± 0.066
0.34ArgTrp: 0.34 ± 0.021
1.75ArgTyr: 1.75 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
3.971SerAla: 3.971 ± 0.077
0.744SerCys: 0.744 ± 0.033
3.274SerAsp: 3.274 ± 0.064
4.028SerGlu: 4.028 ± 0.084
2.282SerPhe: 2.282 ± 0.065
4.935SerGly: 4.935 ± 0.092
0.968SerHis: 0.968 ± 0.034
3.778SerIle: 3.778 ± 0.076
3.423SerLys: 3.423 ± 0.07
4.535SerLeu: 4.535 ± 0.077
1.84SerMet: 1.84 ± 0.05
2.131SerAsn: 2.131 ± 0.066
1.541SerPro: 1.541 ± 0.042
1.813SerGln: 1.813 ± 0.047
2.314SerArg: 2.314 ± 0.062
3.304SerSer: 3.304 ± 0.088
2.662SerThr: 2.662 ± 0.072
4.167SerVal: 4.167 ± 0.086
0.512SerTrp: 0.512 ± 0.031
2.233SerTyr: 2.233 ± 0.052
0.0SerXaa: 0.0 ± 0.0
Thr
4.051ThrAla: 4.051 ± 0.077
0.696ThrCys: 0.696 ± 0.025
3.218ThrAsp: 3.218 ± 0.069
3.816ThrGlu: 3.816 ± 0.077
2.33ThrPhe: 2.33 ± 0.054
4.686ThrGly: 4.686 ± 0.089
0.876ThrHis: 0.876 ± 0.036
3.99ThrIle: 3.99 ± 0.072
3.321ThrLys: 3.321 ± 0.063
4.7ThrLeu: 4.7 ± 0.079
1.494ThrMet: 1.494 ± 0.043
2.009ThrAsn: 2.009 ± 0.056
2.076ThrPro: 2.076 ± 0.062
1.521ThrGln: 1.521 ± 0.049
1.876ThrArg: 1.876 ± 0.055
2.884ThrSer: 2.884 ± 0.071
2.916ThrThr: 2.916 ± 0.078
4.252ThrVal: 4.252 ± 0.082
0.478ThrTrp: 0.478 ± 0.024
2.037ThrTyr: 2.037 ± 0.055
0.0ThrXaa: 0.0 ± 0.0
Val
5.116ValAla: 5.116 ± 0.091
1.21ValCys: 1.21 ± 0.044
4.036ValAsp: 4.036 ± 0.071
5.095ValGlu: 5.095 ± 0.089
2.841ValPhe: 2.841 ± 0.061
4.711ValGly: 4.711 ± 0.099
1.145ValHis: 1.145 ± 0.038
5.524ValIle: 5.524 ± 0.094
4.886ValLys: 4.886 ± 0.084
6.677ValLeu: 6.677 ± 0.101
2.294ValMet: 2.294 ± 0.057
2.794ValAsn: 2.794 ± 0.057
2.669ValPro: 2.669 ± 0.06
2.14ValGln: 2.14 ± 0.052
2.932ValArg: 2.932 ± 0.068
4.509ValSer: 4.509 ± 0.081
4.313ValThr: 4.313 ± 0.083
5.251ValVal: 5.251 ± 0.104
0.597ValTrp: 0.597 ± 0.03
2.751ValTyr: 2.751 ± 0.061
0.0ValXaa: 0.0 ± 0.0
Trp
0.544TrpAla: 0.544 ± 0.024
0.15TrpCys: 0.15 ± 0.014
0.496TrpAsp: 0.496 ± 0.026
0.567TrpGlu: 0.567 ± 0.024
0.352TrpPhe: 0.352 ± 0.021
0.613TrpGly: 0.613 ± 0.028
0.135TrpHis: 0.135 ± 0.013
0.667TrpIle: 0.667 ± 0.032
0.822TrpLys: 0.822 ± 0.037
0.773TrpLeu: 0.773 ± 0.034
0.274TrpMet: 0.274 ± 0.021
0.469TrpAsn: 0.469 ± 0.026
0.183TrpPro: 0.183 ± 0.014
0.326TrpGln: 0.326 ± 0.022
0.338TrpArg: 0.338 ± 0.021
0.408TrpSer: 0.408 ± 0.025
0.379TrpThr: 0.379 ± 0.024
0.484TrpVal: 0.484 ± 0.027
0.083TrpTrp: 0.083 ± 0.012
0.369TrpTyr: 0.369 ± 0.031
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.692TyrAla: 2.692 ± 0.062
0.606TyrCys: 0.606 ± 0.031
2.551TyrAsp: 2.551 ± 0.061
3.202TyrGlu: 3.202 ± 0.066
1.644TyrPhe: 1.644 ± 0.053
2.981TyrGly: 2.981 ± 0.069
0.879TyrHis: 0.879 ± 0.033
2.867TyrIle: 2.867 ± 0.06
2.424TyrLys: 2.424 ± 0.06
3.697TyrLeu: 3.697 ± 0.067
1.203TyrMet: 1.203 ± 0.048
1.73TyrAsn: 1.73 ± 0.048
1.424TyrPro: 1.424 ± 0.041
1.487TyrGln: 1.487 ± 0.048
1.811TyrArg: 1.811 ± 0.055
2.257TyrSer: 2.257 ± 0.062
2.232TyrThr: 2.232 ± 0.064
2.748TyrVal: 2.748 ± 0.063
0.324TyrTrp: 0.324 ± 0.021
1.812TyrTyr: 1.812 ± 0.054
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.001XaaGly: 0.001 ± 0.001
0.0XaaHis: 0.0 ± 0.0
0.001XaaIle: 0.001 ± 0.001
0.0XaaLys: 0.0 ± 0.0
0.001XaaLeu: 0.001 ± 0.001
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.008XaaXaa: 0.008 ± 0.005
Statistics based on 2461 proteins (755461 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski