Amino acid dipepetide frequency for Prevotella sp. CAG:1320

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.262AlaAla: 6.262 ± 0.123	1.261AlaCys: 1.261 ± 0.044	4.59AlaAsp: 4.59 ± 0.086	4.991AlaGlu: 4.991 ± 0.106	3.36AlaPhe: 3.36 ± 0.07	5.201AlaGly: 5.201 ± 0.091	1.65AlaHis: 1.65 ± 0.043	5.05AlaIle: 5.05 ± 0.098	4.68AlaLys: 4.68 ± 0.093	7.648AlaLeu: 7.648 ± 0.109	2.508AlaMet: 2.508 ± 0.064	3.438AlaAsn: 3.438 ± 0.069	2.435AlaPro: 2.435 ± 0.067	3.241AlaGln: 3.241 ± 0.078	3.895AlaArg: 3.895 ± 0.084	4.412AlaSer: 4.412 ± 0.085	4.184AlaThr: 4.184 ± 0.086	5.124AlaVal: 5.124 ± 0.085	1.005AlaTrp: 1.005 ± 0.037	3.135AlaTyr: 3.135 ± 0.058	0.003AlaXaa: 0.003 ± 0.002
Cys	1.092CysAla: 1.092 ± 0.042	0.214CysCys: 0.214 ± 0.019	0.777CysAsp: 0.777 ± 0.037	0.806CysGlu: 0.806 ± 0.037	0.557CysPhe: 0.557 ± 0.029	1.244CysGly: 1.244 ± 0.048	0.388CysHis: 0.388 ± 0.021	0.642CysIle: 0.642 ± 0.031	0.599CysLys: 0.599 ± 0.03	1.273CysLeu: 1.273 ± 0.044	0.325CysMet: 0.325 ± 0.021	0.45CysAsn: 0.45 ± 0.029	0.664CysPro: 0.664 ± 0.034	0.484CysGln: 0.484 ± 0.032	0.674CysArg: 0.674 ± 0.032	0.719CysSer: 0.719 ± 0.033	0.59CysThr: 0.59 ± 0.03	1.073CysVal: 1.073 ± 0.043	0.162CysTrp: 0.162 ± 0.016	0.558CysTyr: 0.558 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	3.963AspAla: 3.963 ± 0.073	0.732AspCys: 0.732 ± 0.034	3.008AspAsp: 3.008 ± 0.081	4.065AspGlu: 4.065 ± 0.074	3.19AspPhe: 3.19 ± 0.069	4.32AspGly: 4.32 ± 0.096	1.108AspHis: 1.108 ± 0.04	4.242AspIle: 4.242 ± 0.077	3.701AspLys: 3.701 ± 0.083	4.703AspLeu: 4.703 ± 0.079	1.773AspMet: 1.773 ± 0.051	2.929AspAsn: 2.929 ± 0.068	2.075AspPro: 2.075 ± 0.05	1.456AspGln: 1.456 ± 0.047	2.56AspArg: 2.56 ± 0.058	3.15AspSer: 3.15 ± 0.085	2.992AspThr: 2.992 ± 0.07	3.77AspVal: 3.77 ± 0.08	0.842AspTrp: 0.842 ± 0.034	2.975AspTyr: 2.975 ± 0.062	0.0AspXaa: 0.0 ± 0.0
Glu	5.468GluAla: 5.468 ± 0.11	0.709GluCys: 0.709 ± 0.035	3.588GluAsp: 3.588 ± 0.073	5.496GluGlu: 5.496 ± 0.131	2.158GluPhe: 2.158 ± 0.057	4.614GluGly: 4.614 ± 0.084	1.357GluHis: 1.357 ± 0.044	3.914GluIle: 3.914 ± 0.082	4.648GluLys: 4.648 ± 0.096	5.739GluLeu: 5.739 ± 0.105	2.161GluMet: 2.161 ± 0.059	2.959GluAsn: 2.959 ± 0.075	1.871GluPro: 1.871 ± 0.059	2.715GluGln: 2.715 ± 0.067	4.329GluArg: 4.329 ± 0.112	2.991GluSer: 2.991 ± 0.067	3.394GluThr: 3.394 ± 0.066	4.271GluVal: 4.271 ± 0.074	0.865GluTrp: 0.865 ± 0.04	2.534GluTyr: 2.534 ± 0.067	0.0GluXaa: 0.0 ± 0.0
Phe	3.0PheAla: 3.0 ± 0.063	0.716PheCys: 0.716 ± 0.032	2.684PheAsp: 2.684 ± 0.066	2.098PheGlu: 2.098 ± 0.06	1.896PhePhe: 1.896 ± 0.057	3.067PheGly: 3.067 ± 0.069	1.109PheHis: 1.109 ± 0.044	2.569PheIle: 2.569 ± 0.061	1.984PheLys: 1.984 ± 0.047	3.919PheLeu: 3.919 ± 0.087	1.2PheMet: 1.2 ± 0.043	1.974PheAsn: 1.974 ± 0.062	1.65PhePro: 1.65 ± 0.046	1.488PheGln: 1.488 ± 0.049	2.255PheArg: 2.255 ± 0.058	2.887PheSer: 2.887 ± 0.072	2.647PheThr: 2.647 ± 0.071	2.713PheVal: 2.713 ± 0.06	0.532PheTrp: 0.532 ± 0.034	1.673PheTyr: 1.673 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	4.726GlyAla: 4.726 ± 0.087	1.041GlyCys: 1.041 ± 0.043	3.99GlyAsp: 3.99 ± 0.08	4.602GlyGlu: 4.602 ± 0.085	3.108GlyPhe: 3.108 ± 0.075	5.101GlyGly: 5.101 ± 0.104	1.547GlyHis: 1.547 ± 0.056	4.974GlyIle: 4.974 ± 0.085	5.519GlyLys: 5.519 ± 0.1	6.013GlyLeu: 6.013 ± 0.1	2.337GlyMet: 2.337 ± 0.059	3.417GlyAsn: 3.417 ± 0.075	1.44GlyPro: 1.44 ± 0.055	2.477GlyGln: 2.477 ± 0.064	3.28GlyArg: 3.28 ± 0.077	3.82GlySer: 3.82 ± 0.085	4.0GlyThr: 4.0 ± 0.086	5.154GlyVal: 5.154 ± 0.078	1.017GlyTrp: 1.017 ± 0.038	3.312GlyTyr: 3.312 ± 0.081	0.003GlyXaa: 0.003 ± 0.002
His	1.484HisAla: 1.484 ± 0.051	0.364HisCys: 0.364 ± 0.023	1.283HisAsp: 1.283 ± 0.051	1.238HisGlu: 1.238 ± 0.046	1.004HisPhe: 1.004 ± 0.038	1.61HisGly: 1.61 ± 0.054	0.629HisHis: 0.629 ± 0.033	1.374HisIle: 1.374 ± 0.054	1.056HisLys: 1.056 ± 0.041	1.964HisLeu: 1.964 ± 0.051	0.447HisMet: 0.447 ± 0.025	0.885HisAsn: 0.885 ± 0.037	1.242HisPro: 1.242 ± 0.044	0.765HisGln: 0.765 ± 0.032	1.121HisArg: 1.121 ± 0.046	1.13HisSer: 1.13 ± 0.042	1.02HisThr: 1.02 ± 0.039	1.453HisVal: 1.453 ± 0.046	0.296HisTrp: 0.296 ± 0.022	1.079HisTyr: 1.079 ± 0.045	0.0HisXaa: 0.0 ± 0.0
Ile	5.172IleAla: 5.172 ± 0.098	0.975IleCys: 0.975 ± 0.038	4.139IleAsp: 4.139 ± 0.08	3.788IleGlu: 3.788 ± 0.087	2.265IlePhe: 2.265 ± 0.071	4.279IleGly: 4.279 ± 0.09	1.378IleHis: 1.378 ± 0.043	3.835IleIle: 3.835 ± 0.09	3.4IleLys: 3.4 ± 0.083	5.033IleLeu: 5.033 ± 0.098	1.484IleMet: 1.484 ± 0.048	2.842IleAsn: 2.842 ± 0.069	2.83IlePro: 2.83 ± 0.073	1.884IleGln: 1.884 ± 0.049	3.108IleArg: 3.108 ± 0.066	3.785IleSer: 3.785 ± 0.077	3.658IleThr: 3.658 ± 0.075	4.358IleVal: 4.358 ± 0.099	0.607IleTrp: 0.607 ± 0.03	2.398IleTyr: 2.398 ± 0.061	0.0IleXaa: 0.0 ± 0.0
Lys	5.098LysAla: 5.098 ± 0.103	0.518LysCys: 0.518 ± 0.028	3.608LysAsp: 3.608 ± 0.074	4.991LysGlu: 4.991 ± 0.107	1.851LysPhe: 1.851 ± 0.056	4.394LysGly: 4.394 ± 0.08	1.202LysHis: 1.202 ± 0.044	3.325LysIle: 3.325 ± 0.08	3.968LysLys: 3.968 ± 0.092	5.031LysLeu: 5.031 ± 0.094	1.952LysMet: 1.952 ± 0.059	2.586LysAsn: 2.586 ± 0.076	2.246LysPro: 2.246 ± 0.062	2.402LysGln: 2.402 ± 0.053	3.449LysArg: 3.449 ± 0.064	3.014LysSer: 3.014 ± 0.075	3.28LysThr: 3.28 ± 0.066	4.089LysVal: 4.089 ± 0.087	0.733LysTrp: 0.733 ± 0.038	2.531LysTyr: 2.531 ± 0.066	0.001LysXaa: 0.001 ± 0.001
Leu	7.499LeuAla: 7.499 ± 0.137	1.332LeuCys: 1.332 ± 0.042	4.893LeuAsp: 4.893 ± 0.087	5.034LeuGlu: 5.034 ± 0.094	3.973LeuPhe: 3.973 ± 0.078	6.275LeuGly: 6.275 ± 0.109	1.895LeuHis: 1.895 ± 0.06	4.68LeuIle: 4.68 ± 0.097	5.149LeuLys: 5.149 ± 0.094	8.91LeuLeu: 8.91 ± 0.16	2.744LeuMet: 2.744 ± 0.065	3.824LeuAsn: 3.824 ± 0.083	4.211LeuPro: 4.211 ± 0.088	3.065LeuGln: 3.065 ± 0.076	6.084LeuArg: 6.084 ± 0.118	6.391LeuSer: 6.391 ± 0.106	5.167LeuThr: 5.167 ± 0.088	5.823LeuVal: 5.823 ± 0.096	1.093LeuTrp: 1.093 ± 0.045	3.642LeuTyr: 3.642 ± 0.078	0.0LeuXaa: 0.0 ± 0.0
Met	2.905MetAla: 2.905 ± 0.065	0.296MetCys: 0.296 ± 0.022	1.709MetAsp: 1.709 ± 0.045	2.229MetGlu: 2.229 ± 0.061	0.905MetPhe: 0.905 ± 0.043	2.285MetGly: 2.285 ± 0.059	0.448MetHis: 0.448 ± 0.028	1.456MetIle: 1.456 ± 0.044	2.237MetLys: 2.237 ± 0.058	2.608MetLeu: 2.608 ± 0.061	0.989MetMet: 0.989 ± 0.042	1.322MetAsn: 1.322 ± 0.044	1.406MetPro: 1.406 ± 0.039	0.927MetGln: 0.927 ± 0.04	1.96MetArg: 1.96 ± 0.052	1.624MetSer: 1.624 ± 0.053	1.649MetThr: 1.649 ± 0.043	1.942MetVal: 1.942 ± 0.059	0.252MetTrp: 0.252 ± 0.017	0.775MetTyr: 0.775 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	3.549AsnAla: 3.549 ± 0.069	0.502AsnCys: 0.502 ± 0.03	2.434AsnAsp: 2.434 ± 0.066	2.655AsnGlu: 2.655 ± 0.067	1.792AsnPhe: 1.792 ± 0.049	3.295AsnGly: 3.295 ± 0.076	0.995AsnHis: 0.995 ± 0.035	3.024AsnIle: 3.024 ± 0.072	2.516AsnLys: 2.516 ± 0.063	3.75AsnLeu: 3.75 ± 0.084	1.206AsnMet: 1.206 ± 0.044	2.02AsnAsn: 2.02 ± 0.06	2.268AsnPro: 2.268 ± 0.063	1.54AsnGln: 1.54 ± 0.054	2.217AsnArg: 2.217 ± 0.056	2.262AsnSer: 2.262 ± 0.066	2.405AsnThr: 2.405 ± 0.071	3.159AsnVal: 3.159 ± 0.07	0.605AsnTrp: 0.605 ± 0.03	2.051AsnTyr: 2.051 ± 0.059	0.0AsnXaa: 0.0 ± 0.0
Pro	3.076ProAla: 3.076 ± 0.083	0.45ProCys: 0.45 ± 0.029	2.477ProAsp: 2.477 ± 0.059	3.216ProGlu: 3.216 ± 0.071	1.746ProPhe: 1.746 ± 0.049	2.657ProGly: 2.657 ± 0.06	0.806ProHis: 0.806 ± 0.035	2.217ProIle: 2.217 ± 0.063	2.062ProLys: 2.062 ± 0.053	3.474ProLeu: 3.474 ± 0.077	1.163ProMet: 1.163 ± 0.038	1.637ProAsn: 1.637 ± 0.046	0.881ProPro: 0.881 ± 0.037	1.56ProGln: 1.56 ± 0.054	1.762ProArg: 1.762 ± 0.052	2.191ProSer: 2.191 ± 0.058	2.129ProThr: 2.129 ± 0.058	2.9ProVal: 2.9 ± 0.065	0.528ProTrp: 0.528 ± 0.03	1.731ProTyr: 1.731 ± 0.058	0.001ProXaa: 0.001 ± 0.002
Gln	3.261GlnAla: 3.261 ± 0.08	0.366GlnCys: 0.366 ± 0.022	1.78GlnAsp: 1.78 ± 0.052	2.671GlnGlu: 2.671 ± 0.063	1.202GlnPhe: 1.202 ± 0.044	2.597GlnGly: 2.597 ± 0.062	0.615GlnHis: 0.615 ± 0.032	2.044GlnIle: 2.044 ± 0.054	2.067GlnLys: 2.067 ± 0.06	3.767GlnLeu: 3.767 ± 0.072	1.193GlnMet: 1.193 ± 0.04	1.388GlnAsn: 1.388 ± 0.045	1.401GlnPro: 1.401 ± 0.051	1.542GlnGln: 1.542 ± 0.058	2.096GlnArg: 2.096 ± 0.059	1.747GlnSer: 1.747 ± 0.048	1.896GlnThr: 1.896 ± 0.054	2.667GlnVal: 2.667 ± 0.059	0.531GlnTrp: 0.531 ± 0.027	1.433GlnTyr: 1.433 ± 0.054	0.0GlnXaa: 0.0 ± 0.0
Arg	3.306ArgAla: 3.306 ± 0.075	0.587ArgCys: 0.587 ± 0.032	2.853ArgAsp: 2.853 ± 0.065	3.873ArgGlu: 3.873 ± 0.091	2.505ArgPhe: 2.505 ± 0.062	3.111ArgGly: 3.111 ± 0.076	1.433ArgHis: 1.433 ± 0.05	3.026ArgIle: 3.026 ± 0.07	3.941ArgLys: 3.941 ± 0.087	5.406ArgLeu: 5.406 ± 0.098	1.871ArgMet: 1.871 ± 0.056	2.263ArgAsn: 2.263 ± 0.061	2.01ArgPro: 2.01 ± 0.058	2.754ArgGln: 2.754 ± 0.069	3.14ArgArg: 3.14 ± 0.081	2.49ArgSer: 2.49 ± 0.062	2.331ArgThr: 2.331 ± 0.062	3.53ArgVal: 3.53 ± 0.083	0.79ArgTrp: 0.79 ± 0.036	2.574ArgTyr: 2.574 ± 0.064	0.0ArgXaa: 0.0 ± 0.0
Ser	4.146SerAla: 4.146 ± 0.084	0.782SerCys: 0.782 ± 0.031	3.072SerAsp: 3.072 ± 0.071	3.212SerGlu: 3.212 ± 0.068	2.726SerPhe: 2.726 ± 0.068	4.038SerGly: 4.038 ± 0.086	1.261SerHis: 1.261 ± 0.041	3.472SerIle: 3.472 ± 0.077	2.846SerLys: 2.846 ± 0.06	6.029SerLeu: 6.029 ± 0.107	1.558SerMet: 1.558 ± 0.053	2.171SerAsn: 2.171 ± 0.07	2.443SerPro: 2.443 ± 0.061	2.048SerGln: 2.048 ± 0.055	2.9SerArg: 2.9 ± 0.073	3.251SerSer: 3.251 ± 0.085	3.04SerThr: 3.04 ± 0.073	4.227SerVal: 4.227 ± 0.077	0.762SerTrp: 0.762 ± 0.033	2.498SerTyr: 2.498 ± 0.068	0.0SerXaa: 0.0 ± 0.0
Thr	4.317ThrAla: 4.317 ± 0.094	0.657ThrCys: 0.657 ± 0.034	3.18ThrAsp: 3.18 ± 0.079	3.166ThrGlu: 3.166 ± 0.071	2.444ThrPhe: 2.444 ± 0.059	4.251ThrGly: 4.251 ± 0.072	1.16ThrHis: 1.16 ± 0.049	3.737ThrIle: 3.737 ± 0.069	2.542ThrLys: 2.542 ± 0.063	5.794ThrLeu: 5.794 ± 0.108	1.414ThrMet: 1.414 ± 0.049	2.169ThrAsn: 2.169 ± 0.07	2.78ThrPro: 2.78 ± 0.066	1.98ThrGln: 1.98 ± 0.062	2.462ThrArg: 2.462 ± 0.067	3.067ThrSer: 3.067 ± 0.057	3.067ThrThr: 3.067 ± 0.076	3.542ThrVal: 3.542 ± 0.08	0.654ThrTrp: 0.654 ± 0.031	2.313ThrTyr: 2.313 ± 0.059	0.0ThrXaa: 0.0 ± 0.0
Val	5.607ValAla: 5.607 ± 0.092	1.043ValCys: 1.043 ± 0.039	4.096ValAsp: 4.096 ± 0.087	4.528ValGlu: 4.528 ± 0.081	2.882ValPhe: 2.882 ± 0.081	4.564ValGly: 4.564 ± 0.094	1.092ValHis: 1.092 ± 0.037	4.456ValIle: 4.456 ± 0.098	4.331ValLys: 4.331 ± 0.085	5.513ValLeu: 5.513 ± 0.097	2.013ValMet: 2.013 ± 0.059	3.36ValAsn: 3.36 ± 0.064	2.648ValPro: 2.648 ± 0.07	1.601ValGln: 1.601 ± 0.047	3.368ValArg: 3.368 ± 0.076	4.563ValSer: 4.563 ± 0.083	4.133ValThr: 4.133 ± 0.083	4.981ValVal: 4.981 ± 0.105	0.748ValTrp: 0.748 ± 0.038	2.759ValTyr: 2.759 ± 0.07	0.001ValXaa: 0.001 ± 0.001
Trp	0.924TrpAla: 0.924 ± 0.038	0.163TrpCys: 0.163 ± 0.017	0.727TrpAsp: 0.727 ± 0.035	0.722TrpGlu: 0.722 ± 0.035	0.518TrpPhe: 0.518 ± 0.026	0.975TrpGly: 0.975 ± 0.037	0.315TrpHis: 0.315 ± 0.023	0.729TrpIle: 0.729 ± 0.04	0.813TrpLys: 0.813 ± 0.035	1.3TrpLeu: 1.3 ± 0.052	0.443TrpMet: 0.443 ± 0.023	0.686TrpAsn: 0.686 ± 0.034	0.366TrpPro: 0.366 ± 0.023	0.646TrpGln: 0.646 ± 0.035	0.727TrpArg: 0.727 ± 0.034	0.673TrpSer: 0.673 ± 0.03	0.618TrpThr: 0.618 ± 0.032	0.723TrpVal: 0.723 ± 0.031	0.239TrpTrp: 0.239 ± 0.02	0.512TrpTyr: 0.512 ± 0.03	0.001TrpXaa: 0.001 ± 0.001
Tyr	3.218TyrAla: 3.218 ± 0.061	0.578TyrCys: 0.578 ± 0.024	2.664TyrAsp: 2.664 ± 0.066	2.396TyrGlu: 2.396 ± 0.061	1.981TyrPhe: 1.981 ± 0.057	3.004TyrGly: 3.004 ± 0.071	1.054TyrHis: 1.054 ± 0.039	2.451TyrIle: 2.451 ± 0.063	2.211TyrLys: 2.211 ± 0.059	3.808TyrLeu: 3.808 ± 0.082	1.143TyrMet: 1.143 ± 0.041	1.925TyrAsn: 1.925 ± 0.065	1.793TyrPro: 1.793 ± 0.052	1.688TyrGln: 1.688 ± 0.054	2.411TyrArg: 2.411 ± 0.056	2.314TyrSer: 2.314 ± 0.058	2.493TyrThr: 2.493 ± 0.077	2.79TyrVal: 2.79 ± 0.067	0.56TyrTrp: 0.56 ± 0.029	2.054TyrTyr: 2.054 ± 0.064	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.003XaaCys: 0.003 ± 0.002	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.001XaaHis: 0.001 ± 0.001	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.003XaaSer: 0.003 ± 0.002	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.017XaaXaa: 0.017 ± 0.006

Statistics based on 2035 proteins (691449 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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