Amino acid dipepetide frequency for Prevotella buccae ATCC 33574

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.659AlaAla: 6.659 ± 0.117
1.108AlaCys: 1.108 ± 0.038
5.172AlaAsp: 5.172 ± 0.086
4.724AlaGlu: 4.724 ± 0.081
3.275AlaPhe: 3.275 ± 0.058
5.853AlaGly: 5.853 ± 0.092
1.583AlaHis: 1.583 ± 0.041
4.49AlaIle: 4.49 ± 0.077
4.426AlaLys: 4.426 ± 0.078
7.067AlaLeu: 7.067 ± 0.097
2.165AlaMet: 2.165 ± 0.046
3.394AlaAsn: 3.394 ± 0.063
2.633AlaPro: 2.633 ± 0.062
2.828AlaGln: 2.828 ± 0.056
4.091AlaArg: 4.091 ± 0.075
4.195AlaSer: 4.195 ± 0.069
4.503AlaThr: 4.503 ± 0.073
5.431AlaVal: 5.431 ± 0.089
0.887AlaTrp: 0.887 ± 0.031
3.095AlaTyr: 3.095 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
0.898CysAla: 0.898 ± 0.033
0.192CysCys: 0.192 ± 0.015
0.725CysAsp: 0.725 ± 0.033
0.679CysGlu: 0.679 ± 0.03
0.625CysPhe: 0.625 ± 0.024
1.101CysGly: 1.101 ± 0.036
0.402CysHis: 0.402 ± 0.022
0.777CysIle: 0.777 ± 0.029
0.696CysLys: 0.696 ± 0.028
1.145CysLeu: 1.145 ± 0.037
0.317CysMet: 0.317 ± 0.017
0.621CysAsn: 0.621 ± 0.026
0.55CysPro: 0.55 ± 0.028
0.329CysGln: 0.329 ± 0.021
0.861CysArg: 0.861 ± 0.033
0.771CysSer: 0.771 ± 0.034
0.702CysThr: 0.702 ± 0.028
0.809CysVal: 0.809 ± 0.03
0.167CysTrp: 0.167 ± 0.013
0.573CysTyr: 0.573 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
4.335AspAla: 4.335 ± 0.077
0.718AspCys: 0.718 ± 0.03
3.089AspAsp: 3.089 ± 0.061
3.9AspGlu: 3.9 ± 0.074
3.187AspPhe: 3.187 ± 0.059
4.812AspGly: 4.812 ± 0.1
1.081AspHis: 1.081 ± 0.041
3.953AspIle: 3.953 ± 0.077
3.748AspLys: 3.748 ± 0.061
4.485AspLeu: 4.485 ± 0.072
1.674AspMet: 1.674 ± 0.04
2.979AspAsn: 2.979 ± 0.058
1.832AspPro: 1.832 ± 0.045
1.173AspGln: 1.173 ± 0.035
3.191AspArg: 3.191 ± 0.059
3.149AspSer: 3.149 ± 0.067
2.884AspThr: 2.884 ± 0.055
3.449AspVal: 3.449 ± 0.061
0.855AspTrp: 0.855 ± 0.031
2.975AspTyr: 2.975 ± 0.048
0.0AspXaa: 0.0 ± 0.0
Glu
5.102GluAla: 5.102 ± 0.1
0.682GluCys: 0.682 ± 0.03
3.037GluAsp: 3.037 ± 0.062
4.336GluGlu: 4.336 ± 0.088
2.227GluPhe: 2.227 ± 0.047
4.088GluGly: 4.088 ± 0.065
1.351GluHis: 1.351 ± 0.037
3.546GluIle: 3.546 ± 0.072
4.326GluLys: 4.326 ± 0.083
5.323GluLeu: 5.323 ± 0.085
1.939GluMet: 1.939 ± 0.046
2.879GluAsn: 2.879 ± 0.059
1.779GluPro: 1.779 ± 0.05
2.604GluGln: 2.604 ± 0.056
3.592GluArg: 3.592 ± 0.063
2.796GluSer: 2.796 ± 0.056
3.254GluThr: 3.254 ± 0.053
4.154GluVal: 4.154 ± 0.07
0.776GluTrp: 0.776 ± 0.029
2.312GluTyr: 2.312 ± 0.049
0.0GluXaa: 0.0 ± 0.0
Phe
3.234PheAla: 3.234 ± 0.069
0.787PheCys: 0.787 ± 0.03
2.892PheAsp: 2.892 ± 0.054
2.239PheGlu: 2.239 ± 0.054
2.187PhePhe: 2.187 ± 0.054
3.49PheGly: 3.49 ± 0.067
1.023PheHis: 1.023 ± 0.029
2.602PheIle: 2.602 ± 0.063
2.36PheLys: 2.36 ± 0.05
3.839PheLeu: 3.839 ± 0.077
1.241PheMet: 1.241 ± 0.038
2.196PheAsn: 2.196 ± 0.045
1.659PhePro: 1.659 ± 0.046
1.146PheGln: 1.146 ± 0.031
2.324PheArg: 2.324 ± 0.043
3.153PheSer: 3.153 ± 0.056
2.701PheThr: 2.701 ± 0.063
3.077PheVal: 3.077 ± 0.056
0.539PheTrp: 0.539 ± 0.026
1.852PheTyr: 1.852 ± 0.045
0.0PheXaa: 0.0 ± 0.0
Gly
4.924GlyAla: 4.924 ± 0.087
1.064GlyCys: 1.064 ± 0.042
3.908GlyAsp: 3.908 ± 0.074
4.399GlyGlu: 4.399 ± 0.076
3.198GlyPhe: 3.198 ± 0.057
5.444GlyGly: 5.444 ± 0.091
1.653GlyHis: 1.653 ± 0.045
4.867GlyIle: 4.867 ± 0.081
5.179GlyLys: 5.179 ± 0.083
6.264GlyLeu: 6.264 ± 0.087
2.193GlyMet: 2.193 ± 0.044
3.588GlyAsn: 3.588 ± 0.071
1.613GlyPro: 1.613 ± 0.045
2.398GlyGln: 2.398 ± 0.052
4.287GlyArg: 4.287 ± 0.086
4.144GlySer: 4.144 ± 0.067
4.453GlyThr: 4.453 ± 0.083
5.088GlyVal: 5.088 ± 0.085
1.078GlyTrp: 1.078 ± 0.039
3.264GlyTyr: 3.264 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
1.487HisAla: 1.487 ± 0.041
0.368HisCys: 0.368 ± 0.021
1.183HisAsp: 1.183 ± 0.039
1.153HisGlu: 1.153 ± 0.036
1.159HisPhe: 1.159 ± 0.035
1.473HisGly: 1.473 ± 0.04
0.7HisHis: 0.7 ± 0.032
1.549HisIle: 1.549 ± 0.039
1.056HisLys: 1.056 ± 0.032
2.06HisLeu: 2.06 ± 0.052
0.322HisMet: 0.322 ± 0.018
1.061HisAsn: 1.061 ± 0.033
1.188HisPro: 1.188 ± 0.037
0.661HisGln: 0.661 ± 0.027
1.336HisArg: 1.336 ± 0.04
1.211HisSer: 1.211 ± 0.044
1.262HisThr: 1.262 ± 0.039
1.326HisVal: 1.326 ± 0.037
0.286HisTrp: 0.286 ± 0.017
1.038HisTyr: 1.038 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
4.914IleAla: 4.914 ± 0.081
0.848IleCys: 0.848 ± 0.029
4.201IleAsp: 4.201 ± 0.071
3.596IleGlu: 3.596 ± 0.068
2.443IlePhe: 2.443 ± 0.057
4.474IleGly: 4.474 ± 0.072
1.272IleHis: 1.272 ± 0.036
3.893IleIle: 3.893 ± 0.08
3.614IleLys: 3.614 ± 0.075
4.856IleLeu: 4.856 ± 0.078
1.465IleMet: 1.465 ± 0.04
2.938IleAsn: 2.938 ± 0.054
2.66IlePro: 2.66 ± 0.058
1.675IleGln: 1.675 ± 0.045
3.26IleArg: 3.26 ± 0.054
3.835IleSer: 3.835 ± 0.077
3.521IleThr: 3.521 ± 0.061
4.124IleVal: 4.124 ± 0.073
0.602IleTrp: 0.602 ± 0.029
2.373IleTyr: 2.373 ± 0.053
0.0IleXaa: 0.0 ± 0.0
Lys
5.154LysAla: 5.154 ± 0.076
0.555LysCys: 0.555 ± 0.026
3.612LysAsp: 3.612 ± 0.066
4.511LysGlu: 4.511 ± 0.081
2.103LysPhe: 2.103 ± 0.047
4.518LysGly: 4.518 ± 0.065
1.233LysHis: 1.233 ± 0.038
3.662LysIle: 3.662 ± 0.066
4.305LysLys: 4.305 ± 0.096
4.873LysLeu: 4.873 ± 0.085
2.06LysMet: 2.06 ± 0.053
3.049LysAsn: 3.049 ± 0.059
2.162LysPro: 2.162 ± 0.049
2.347LysGln: 2.347 ± 0.059
3.37LysArg: 3.37 ± 0.06
3.252LysSer: 3.252 ± 0.067
3.734LysThr: 3.734 ± 0.073
4.007LysVal: 4.007 ± 0.072
0.764LysTrp: 0.764 ± 0.026
2.664LysTyr: 2.664 ± 0.051
0.0LysXaa: 0.0 ± 0.0
Leu
6.883LeuAla: 6.883 ± 0.091
1.361LeuCys: 1.361 ± 0.045
4.871LeuAsp: 4.871 ± 0.069
4.45LeuGlu: 4.45 ± 0.073
4.21LeuPhe: 4.21 ± 0.069
5.914LeuGly: 5.914 ± 0.077
2.072LeuHis: 2.072 ± 0.051
4.704LeuIle: 4.704 ± 0.079
5.69LeuLys: 5.69 ± 0.078
8.854LeuLeu: 8.854 ± 0.132
2.606LeuMet: 2.606 ± 0.048
4.187LeuAsn: 4.187 ± 0.071
4.109LeuPro: 4.109 ± 0.071
3.267LeuGln: 3.267 ± 0.062
5.014LeuArg: 5.014 ± 0.086
6.389LeuSer: 6.389 ± 0.097
5.309LeuThr: 5.309 ± 0.092
5.386LeuVal: 5.386 ± 0.087
1.111LeuTrp: 1.111 ± 0.044
3.473LeuTyr: 3.473 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
2.52MetAla: 2.52 ± 0.054
0.244MetCys: 0.244 ± 0.018
1.471MetAsp: 1.471 ± 0.042
1.791MetGlu: 1.791 ± 0.04
1.043MetPhe: 1.043 ± 0.033
2.05MetGly: 2.05 ± 0.048
0.543MetHis: 0.543 ± 0.027
1.356MetIle: 1.356 ± 0.039
2.433MetLys: 2.433 ± 0.044
2.654MetLeu: 2.654 ± 0.062
0.946MetMet: 0.946 ± 0.031
1.423MetAsn: 1.423 ± 0.037
1.331MetPro: 1.331 ± 0.036
1.113MetGln: 1.113 ± 0.038
1.556MetArg: 1.556 ± 0.043
1.599MetSer: 1.599 ± 0.037
1.717MetThr: 1.717 ± 0.045
1.731MetVal: 1.731 ± 0.042
0.224MetTrp: 0.224 ± 0.016
0.758MetTyr: 0.758 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
3.529AsnAla: 3.529 ± 0.07
0.527AsnCys: 0.527 ± 0.023
2.708AsnAsp: 2.708 ± 0.056
2.594AsnGlu: 2.594 ± 0.062
2.028AsnPhe: 2.028 ± 0.047
3.966AsnGly: 3.966 ± 0.074
0.995AsnHis: 0.995 ± 0.033
3.433AsnIle: 3.433 ± 0.067
2.75AsnLys: 2.75 ± 0.055
4.066AsnLeu: 4.066 ± 0.077
1.263AsnMet: 1.263 ± 0.038
2.353AsnAsn: 2.353 ± 0.059
2.198AsnPro: 2.198 ± 0.048
1.4AsnGln: 1.4 ± 0.041
2.623AsnArg: 2.623 ± 0.063
2.566AsnSer: 2.566 ± 0.055
2.601AsnThr: 2.601 ± 0.062
3.143AsnVal: 3.143 ± 0.065
0.631AsnTrp: 0.631 ± 0.029
2.155AsnTyr: 2.155 ± 0.052
0.0AsnXaa: 0.0 ± 0.0
Pro
3.144ProAla: 3.144 ± 0.059
0.391ProCys: 0.391 ± 0.022
2.473ProAsp: 2.473 ± 0.054
2.867ProGlu: 2.867 ± 0.061
1.884ProPhe: 1.884 ± 0.044
2.536ProGly: 2.536 ± 0.06
0.854ProHis: 0.854 ± 0.029
2.168ProIle: 2.168 ± 0.045
2.025ProLys: 2.025 ± 0.048
3.32ProLeu: 3.32 ± 0.064
1.103ProMet: 1.103 ± 0.034
1.569ProAsn: 1.569 ± 0.044
0.914ProPro: 0.914 ± 0.034
1.455ProGln: 1.455 ± 0.039
1.651ProArg: 1.651 ± 0.043
2.288ProSer: 2.288 ± 0.049
2.286ProThr: 2.286 ± 0.046
2.982ProVal: 2.982 ± 0.057
0.467ProTrp: 0.467 ± 0.024
1.677ProTyr: 1.677 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
2.616GlnAla: 2.616 ± 0.056
0.352GlnCys: 0.352 ± 0.018
1.482GlnAsp: 1.482 ± 0.042
2.04GlnGlu: 2.04 ± 0.051
1.233GlnPhe: 1.233 ± 0.036
2.271GlnGly: 2.271 ± 0.053
0.682GlnHis: 0.682 ± 0.024
2.023GlnIle: 2.023 ± 0.049
2.217GlnLys: 2.217 ± 0.056
3.296GlnLeu: 3.296 ± 0.055
1.132GlnMet: 1.132 ± 0.033
1.649GlnAsn: 1.649 ± 0.047
1.398GlnPro: 1.398 ± 0.038
1.645GlnGln: 1.645 ± 0.049
1.948GlnArg: 1.948 ± 0.043
1.822GlnSer: 1.822 ± 0.043
2.107GlnThr: 2.107 ± 0.05
2.173GlnVal: 2.173 ± 0.044
0.511GlnTrp: 0.511 ± 0.029
1.394GlnTyr: 1.394 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
3.55ArgAla: 3.55 ± 0.06
0.62ArgCys: 0.62 ± 0.024
2.585ArgAsp: 2.585 ± 0.052
3.471ArgGlu: 3.471 ± 0.052
2.561ArgPhe: 2.561 ± 0.058
3.063ArgGly: 3.063 ± 0.062
1.498ArgHis: 1.498 ± 0.044
3.35ArgIle: 3.35 ± 0.061
3.702ArgLys: 3.702 ± 0.071
5.886ArgLeu: 5.886 ± 0.087
1.828ArgMet: 1.828 ± 0.051
2.561ArgAsn: 2.561 ± 0.056
2.235ArgPro: 2.235 ± 0.062
2.585ArgGln: 2.585 ± 0.056
3.498ArgArg: 3.498 ± 0.079
2.724ArgSer: 2.724 ± 0.052
2.651ArgThr: 2.651 ± 0.052
3.24ArgVal: 3.24 ± 0.061
0.788ArgTrp: 0.788 ± 0.03
2.508ArgTyr: 2.508 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
4.447SerAla: 4.447 ± 0.079
0.814SerCys: 0.814 ± 0.03
3.216SerAsp: 3.216 ± 0.062
3.168SerGlu: 3.168 ± 0.058
2.967SerPhe: 2.967 ± 0.059
4.48SerGly: 4.48 ± 0.082
1.336SerHis: 1.336 ± 0.038
3.552SerIle: 3.552 ± 0.065
3.18SerLys: 3.18 ± 0.063
5.661SerLeu: 5.661 ± 0.086
1.489SerMet: 1.489 ± 0.041
2.466SerAsn: 2.466 ± 0.056
2.39SerPro: 2.39 ± 0.047
1.859SerGln: 1.859 ± 0.042
3.031SerArg: 3.031 ± 0.058
3.375SerSer: 3.375 ± 0.077
3.18SerThr: 3.18 ± 0.057
4.122SerVal: 4.122 ± 0.068
0.744SerTrp: 0.744 ± 0.025
2.524SerTyr: 2.524 ± 0.063
0.0SerXaa: 0.0 ± 0.0
Thr
4.796ThrAla: 4.796 ± 0.084
0.615ThrCys: 0.615 ± 0.025
3.621ThrAsp: 3.621 ± 0.065
3.112ThrGlu: 3.112 ± 0.068
2.797ThrPhe: 2.797 ± 0.059
4.638ThrGly: 4.638 ± 0.072
1.189ThrHis: 1.189 ± 0.034
3.665ThrIle: 3.665 ± 0.062
2.833ThrLys: 2.833 ± 0.063
5.647ThrLeu: 5.647 ± 0.08
1.368ThrMet: 1.368 ± 0.038
2.322ThrAsn: 2.322 ± 0.059
2.747ThrPro: 2.747 ± 0.055
1.599ThrGln: 1.599 ± 0.039
2.533ThrArg: 2.533 ± 0.049
3.197ThrSer: 3.197 ± 0.064
3.486ThrThr: 3.486 ± 0.082
4.231ThrVal: 4.231 ± 0.07
0.694ThrTrp: 0.694 ± 0.028
2.364ThrTyr: 2.364 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
5.328ValAla: 5.328 ± 0.078
1.031ValCys: 1.031 ± 0.03
3.97ValAsp: 3.97 ± 0.068
4.216ValGlu: 4.216 ± 0.064
2.923ValPhe: 2.923 ± 0.063
4.721ValGly: 4.721 ± 0.078
1.117ValHis: 1.117 ± 0.035
3.835ValIle: 3.835 ± 0.068
4.298ValLys: 4.298 ± 0.066
5.559ValLeu: 5.559 ± 0.084
1.882ValMet: 1.882 ± 0.045
3.194ValAsn: 3.194 ± 0.063
2.607ValPro: 2.607 ± 0.053
1.86ValGln: 1.86 ± 0.046
3.384ValArg: 3.384 ± 0.06
4.415ValSer: 4.415 ± 0.072
3.914ValThr: 3.914 ± 0.073
5.071ValVal: 5.071 ± 0.082
0.836ValTrp: 0.836 ± 0.033
2.615ValTyr: 2.615 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
0.901TrpAla: 0.901 ± 0.029
0.153TrpCys: 0.153 ± 0.013
0.701TrpAsp: 0.701 ± 0.03
0.721TrpGlu: 0.721 ± 0.026
0.53TrpPhe: 0.53 ± 0.025
1.019TrpGly: 1.019 ± 0.04
0.303TrpHis: 0.303 ± 0.019
0.684TrpIle: 0.684 ± 0.031
0.799TrpLys: 0.799 ± 0.028
1.281TrpLeu: 1.281 ± 0.042
0.436TrpMet: 0.436 ± 0.021
0.813TrpAsn: 0.813 ± 0.033
0.335TrpPro: 0.335 ± 0.019
0.577TrpGln: 0.577 ± 0.026
0.7TrpArg: 0.7 ± 0.027
0.672TrpSer: 0.672 ± 0.03
0.684TrpThr: 0.684 ± 0.026
0.727TrpVal: 0.727 ± 0.031
0.237TrpTrp: 0.237 ± 0.017
0.508TrpTyr: 0.508 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.156TyrAla: 3.156 ± 0.055
0.51TyrCys: 0.51 ± 0.022
2.55TyrAsp: 2.55 ± 0.054
2.138TyrGlu: 2.138 ± 0.051
1.964TyrPhe: 1.964 ± 0.047
3.094TyrGly: 3.094 ± 0.068
0.993TyrHis: 0.993 ± 0.033
2.454TyrIle: 2.454 ± 0.05
2.295TyrLys: 2.295 ± 0.053
3.722TyrLeu: 3.722 ± 0.067
1.073TyrMet: 1.073 ± 0.032
2.291TyrAsn: 2.291 ± 0.049
1.715TyrPro: 1.715 ± 0.045
1.47TyrGln: 1.47 ± 0.044
2.655TyrArg: 2.655 ± 0.058
2.449TyrSer: 2.449 ± 0.053
2.503TyrThr: 2.503 ± 0.055
2.504TyrVal: 2.504 ± 0.051
0.584TyrTrp: 0.584 ± 0.025
2.017TyrTyr: 2.017 ± 0.055
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2896 proteins (957092 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski