Amino acid dipepetide frequency for Firmicutes bacterium CAG:102

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.441AlaAla: 10.441 ± 0.175
1.163AlaCys: 1.163 ± 0.043
5.259AlaAsp: 5.259 ± 0.12
8.927AlaGlu: 8.927 ± 0.176
3.623AlaPhe: 3.623 ± 0.086
6.312AlaGly: 6.312 ± 0.13
1.288AlaHis: 1.288 ± 0.05
5.297AlaIle: 5.297 ± 0.108
5.982AlaLys: 5.982 ± 0.109
8.471AlaLeu: 8.471 ± 0.126
2.792AlaMet: 2.792 ± 0.072
2.87AlaAsn: 2.87 ± 0.069
2.382AlaPro: 2.382 ± 0.078
2.694AlaGln: 2.694 ± 0.07
3.314AlaArg: 3.314 ± 0.082
3.633AlaSer: 3.633 ± 0.076
3.833AlaThr: 3.833 ± 0.087
7.504AlaVal: 7.504 ± 0.132
0.701AlaTrp: 0.701 ± 0.04
3.075AlaTyr: 3.075 ± 0.073
0.003AlaXaa: 0.003 ± 0.002
Cys
1.059CysAla: 1.059 ± 0.041
0.326CysCys: 0.326 ± 0.027
0.771CysAsp: 0.771 ± 0.034
0.886CysGlu: 0.886 ± 0.041
0.595CysPhe: 0.595 ± 0.035
1.672CysGly: 1.672 ± 0.062
0.321CysHis: 0.321 ± 0.023
1.07CysIle: 1.07 ± 0.048
0.761CysLys: 0.761 ± 0.035
1.158CysLeu: 1.158 ± 0.04
0.422CysMet: 0.422 ± 0.025
0.522CysAsn: 0.522 ± 0.032
0.655CysPro: 0.655 ± 0.038
0.382CysGln: 0.382 ± 0.024
0.801CysArg: 0.801 ± 0.04
0.74CysSer: 0.74 ± 0.038
0.736CysThr: 0.736 ± 0.038
0.997CysVal: 0.997 ± 0.047
0.098CysTrp: 0.098 ± 0.013
0.474CysTyr: 0.474 ± 0.026
0.002CysXaa: 0.002 ± 0.002
Asp
5.275AspAla: 5.275 ± 0.097
0.863AspCys: 0.863 ± 0.038
2.39AspAsp: 2.39 ± 0.085
4.187AspGlu: 4.187 ± 0.083
2.629AspPhe: 2.629 ± 0.059
4.489AspGly: 4.489 ± 0.102
0.818AspHis: 0.818 ± 0.038
4.065AspIle: 4.065 ± 0.082
3.173AspLys: 3.173 ± 0.066
4.459AspLeu: 4.459 ± 0.103
1.78AspMet: 1.78 ± 0.056
1.787AspAsn: 1.787 ± 0.06
1.491AspPro: 1.491 ± 0.058
0.889AspGln: 0.889 ± 0.044
2.285AspArg: 2.285 ± 0.059
2.664AspSer: 2.664 ± 0.075
3.174AspThr: 3.174 ± 0.07
3.789AspVal: 3.789 ± 0.09
0.602AspTrp: 0.602 ± 0.032
2.27AspTyr: 2.27 ± 0.06
0.0AspXaa: 0.0 ± 0.0
Glu
6.028GluAla: 6.028 ± 0.118
0.663GluCys: 0.663 ± 0.035
4.099GluAsp: 4.099 ± 0.092
7.845GluGlu: 7.845 ± 0.15
2.36GluPhe: 2.36 ± 0.06
5.363GluGly: 5.363 ± 0.108
1.23GluHis: 1.23 ± 0.049
5.802GluIle: 5.802 ± 0.103
7.552GluLys: 7.552 ± 0.137
6.663GluLeu: 6.663 ± 0.11
2.887GluMet: 2.887 ± 0.076
4.118GluAsn: 4.118 ± 0.091
1.915GluPro: 1.915 ± 0.059
3.096GluGln: 3.096 ± 0.089
4.236GluArg: 4.236 ± 0.095
3.002GluSer: 3.002 ± 0.076
4.506GluThr: 4.506 ± 0.109
4.627GluVal: 4.627 ± 0.09
0.656GluTrp: 0.656 ± 0.034
2.766GluTyr: 2.766 ± 0.071
0.0GluXaa: 0.0 ± 0.0
Phe
3.733PheAla: 3.733 ± 0.081
0.824PheCys: 0.824 ± 0.043
2.395PheAsp: 2.395 ± 0.06
2.358PheGlu: 2.358 ± 0.058
2.019PhePhe: 2.019 ± 0.078
3.301PheGly: 3.301 ± 0.085
0.838PheHis: 0.838 ± 0.035
2.442PheIle: 2.442 ± 0.074
1.722PheLys: 1.722 ± 0.058
4.308PheLeu: 4.308 ± 0.103
1.162PheMet: 1.162 ± 0.05
1.215PheAsn: 1.215 ± 0.046
1.436PhePro: 1.436 ± 0.045
1.19PheGln: 1.19 ± 0.048
2.043PheArg: 2.043 ± 0.058
2.761PheSer: 2.761 ± 0.075
2.338PheThr: 2.338 ± 0.063
2.729PheVal: 2.729 ± 0.068
0.419PheTrp: 0.419 ± 0.031
1.622PheTyr: 1.622 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
5.852GlyAla: 5.852 ± 0.134
1.33GlyCys: 1.33 ± 0.049
3.528GlyAsp: 3.528 ± 0.091
5.312GlyGlu: 5.312 ± 0.097
3.169GlyPhe: 3.169 ± 0.072
6.03GlyGly: 6.03 ± 0.172
1.232GlyHis: 1.232 ± 0.047
5.734GlyIle: 5.734 ± 0.107
5.84GlyLys: 5.84 ± 0.105
6.289GlyLeu: 6.289 ± 0.123
2.669GlyMet: 2.669 ± 0.074
2.824GlyAsn: 2.824 ± 0.076
1.133GlyPro: 1.133 ± 0.053
2.061GlyGln: 2.061 ± 0.063
3.592GlyArg: 3.592 ± 0.089
3.715GlySer: 3.715 ± 0.079
4.695GlyThr: 4.695 ± 0.108
5.525GlyVal: 5.525 ± 0.106
0.76GlyTrp: 0.76 ± 0.039
3.095GlyTyr: 3.095 ± 0.08
0.0GlyXaa: 0.0 ± 0.0
His
1.355HisAla: 1.355 ± 0.053
0.359HisCys: 0.359 ± 0.026
0.765HisAsp: 0.765 ± 0.038
1.05HisGlu: 1.05 ± 0.043
0.833HisPhe: 0.833 ± 0.036
1.251HisGly: 1.251 ± 0.044
0.445HisHis: 0.445 ± 0.031
1.454HisIle: 1.454 ± 0.051
0.956HisLys: 0.956 ± 0.042
1.542HisLeu: 1.542 ± 0.054
0.429HisMet: 0.429 ± 0.027
0.58HisAsn: 0.58 ± 0.036
0.931HisPro: 0.931 ± 0.042
0.479HisGln: 0.479 ± 0.027
0.789HisArg: 0.789 ± 0.038
1.002HisSer: 1.002 ± 0.044
0.952HisThr: 0.952 ± 0.044
1.037HisVal: 1.037 ± 0.043
0.206HisTrp: 0.206 ± 0.015
0.663HisTyr: 0.663 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
6.228IleAla: 6.228 ± 0.104
1.205IleCys: 1.205 ± 0.047
3.608IleAsp: 3.608 ± 0.082
4.358IleGlu: 4.358 ± 0.104
2.787IlePhe: 2.787 ± 0.082
5.269IleGly: 5.269 ± 0.091
1.26IleHis: 1.26 ± 0.046
4.416IleIle: 4.416 ± 0.113
3.341IleLys: 3.341 ± 0.085
6.869IleLeu: 6.869 ± 0.129
1.624IleMet: 1.624 ± 0.059
2.372IleAsn: 2.372 ± 0.069
2.983IlePro: 2.983 ± 0.069
1.971IleGln: 1.971 ± 0.061
3.49IleArg: 3.49 ± 0.085
4.19IleSer: 4.19 ± 0.098
3.886IleThr: 3.886 ± 0.089
4.627IleVal: 4.627 ± 0.103
0.499IleTrp: 0.499 ± 0.032
2.29IleTyr: 2.29 ± 0.059
0.002IleXaa: 0.002 ± 0.002
Lys
5.686LysAla: 5.686 ± 0.113
0.66LysCys: 0.66 ± 0.04
3.603LysAsp: 3.603 ± 0.098
6.743LysGlu: 6.743 ± 0.108
1.833LysPhe: 1.833 ± 0.057
4.752LysGly: 4.752 ± 0.094
1.069LysHis: 1.069 ± 0.048
4.424LysIle: 4.424 ± 0.094
6.164LysLys: 6.164 ± 0.107
5.305LysLeu: 5.305 ± 0.086
2.338LysMet: 2.338 ± 0.064
3.479LysAsn: 3.479 ± 0.086
2.004LysPro: 2.004 ± 0.063
2.458LysGln: 2.458 ± 0.067
3.414LysArg: 3.414 ± 0.075
2.837LysSer: 2.837 ± 0.077
4.123LysThr: 4.123 ± 0.082
4.027LysVal: 4.027 ± 0.101
0.55LysTrp: 0.55 ± 0.031
2.591LysTyr: 2.591 ± 0.062
0.002LysXaa: 0.002 ± 0.002
Leu
8.41LeuAla: 8.41 ± 0.136
1.526LeuCys: 1.526 ± 0.055
4.958LeuAsp: 4.958 ± 0.095
6.701LeuGlu: 6.701 ± 0.116
4.087LeuPhe: 4.087 ± 0.091
6.253LeuGly: 6.253 ± 0.115
1.689LeuHis: 1.689 ± 0.058
5.072LeuIle: 5.072 ± 0.104
5.736LeuLys: 5.736 ± 0.095
10.055LeuLeu: 10.055 ± 0.196
2.692LeuMet: 2.692 ± 0.073
3.106LeuAsn: 3.106 ± 0.075
4.05LeuPro: 4.05 ± 0.077
3.509LeuGln: 3.509 ± 0.094
4.472LeuArg: 4.472 ± 0.105
5.802LeuSer: 5.802 ± 0.112
5.418LeuThr: 5.418 ± 0.095
5.52LeuVal: 5.52 ± 0.097
0.864LeuTrp: 0.864 ± 0.043
3.022LeuTyr: 3.022 ± 0.077
0.002LeuXaa: 0.002 ± 0.002
Met
2.927MetAla: 2.927 ± 0.075
0.307MetCys: 0.307 ± 0.022
1.991MetAsp: 1.991 ± 0.054
2.771MetGlu: 2.771 ± 0.064
0.828MetPhe: 0.828 ± 0.036
2.32MetGly: 2.32 ± 0.077
0.414MetHis: 0.414 ± 0.025
1.797MetIle: 1.797 ± 0.06
2.53MetLys: 2.53 ± 0.057
2.764MetLeu: 2.764 ± 0.079
0.937MetMet: 0.937 ± 0.05
1.343MetAsn: 1.343 ± 0.046
1.132MetPro: 1.132 ± 0.045
1.366MetGln: 1.366 ± 0.051
1.355MetArg: 1.355 ± 0.053
1.606MetSer: 1.606 ± 0.047
1.893MetThr: 1.893 ± 0.049
1.886MetVal: 1.886 ± 0.063
0.175MetTrp: 0.175 ± 0.019
0.738MetTyr: 0.738 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
3.291AsnAla: 3.291 ± 0.071
0.557AsnCys: 0.557 ± 0.034
1.915AsnAsp: 1.915 ± 0.067
2.546AsnGlu: 2.546 ± 0.061
1.421AsnPhe: 1.421 ± 0.053
3.633AsnGly: 3.633 ± 0.092
0.743AsnHis: 0.743 ± 0.036
2.892AsnIle: 2.892 ± 0.068
2.382AsnLys: 2.382 ± 0.074
3.279AsnLeu: 3.279 ± 0.074
1.133AsnMet: 1.133 ± 0.046
1.419AsnAsn: 1.419 ± 0.06
1.991AsnPro: 1.991 ± 0.062
1.17AsnGln: 1.17 ± 0.041
1.92AsnArg: 1.92 ± 0.067
1.895AsnSer: 1.895 ± 0.061
2.081AsnThr: 2.081 ± 0.071
2.568AsnVal: 2.568 ± 0.072
0.361AsnTrp: 0.361 ± 0.023
1.341AsnTyr: 1.341 ± 0.051
0.0AsnXaa: 0.0 ± 0.0
Pro
2.943ProAla: 2.943 ± 0.076
0.485ProCys: 0.485 ± 0.031
2.001ProAsp: 2.001 ± 0.061
2.922ProGlu: 2.922 ± 0.068
1.705ProPhe: 1.705 ± 0.056
1.861ProGly: 1.861 ± 0.064
0.637ProHis: 0.637 ± 0.035
2.225ProIle: 2.225 ± 0.069
2.102ProLys: 2.102 ± 0.07
3.135ProLeu: 3.135 ± 0.08
0.996ProMet: 0.996 ± 0.044
1.315ProAsn: 1.315 ± 0.049
0.834ProPro: 0.834 ± 0.04
1.165ProGln: 1.165 ± 0.047
1.112ProArg: 1.112 ± 0.049
1.604ProSer: 1.604 ± 0.059
1.891ProThr: 1.891 ± 0.062
2.815ProVal: 2.815 ± 0.075
0.309ProTrp: 0.309 ± 0.024
1.346ProTyr: 1.346 ± 0.044
0.002ProXaa: 0.002 ± 0.002
Gln
3.023GlnAla: 3.023 ± 0.079
0.359GlnCys: 0.359 ± 0.03
1.431GlnAsp: 1.431 ± 0.049
3.065GlnGlu: 3.065 ± 0.077
1.099GlnPhe: 1.099 ± 0.036
1.921GlnGly: 1.921 ± 0.057
0.46GlnHis: 0.46 ± 0.031
2.149GlnIle: 2.149 ± 0.05
2.814GlnLys: 2.814 ± 0.072
2.797GlnLeu: 2.797 ± 0.064
1.192GlnMet: 1.192 ± 0.043
1.461GlnAsn: 1.461 ± 0.052
0.971GlnPro: 0.971 ± 0.041
1.168GlnGln: 1.168 ± 0.052
1.589GlnArg: 1.589 ± 0.055
1.393GlnSer: 1.393 ± 0.052
1.81GlnThr: 1.81 ± 0.059
1.828GlnVal: 1.828 ± 0.059
0.312GlnTrp: 0.312 ± 0.026
1.127GlnTyr: 1.127 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
3.455ArgAla: 3.455 ± 0.086
0.58ArgCys: 0.58 ± 0.034
2.137ArgAsp: 2.137 ± 0.065
4.09ArgGlu: 4.09 ± 0.089
1.92ArgPhe: 1.92 ± 0.061
2.774ArgGly: 2.774 ± 0.07
0.766ArgHis: 0.766 ± 0.044
3.582ArgIle: 3.582 ± 0.085
3.743ArgLys: 3.743 ± 0.081
4.514ArgLeu: 4.514 ± 0.108
1.728ArgMet: 1.728 ± 0.055
2.021ArgAsn: 2.021 ± 0.059
1.381ArgPro: 1.381 ± 0.046
1.735ArgGln: 1.735 ± 0.058
2.801ArgArg: 2.801 ± 0.083
2.141ArgSer: 2.141 ± 0.055
2.46ArgThr: 2.46 ± 0.061
2.988ArgVal: 2.988 ± 0.072
0.381ArgTrp: 0.381 ± 0.024
1.768ArgTyr: 1.768 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
4.562SerAla: 4.562 ± 0.093
0.741SerCys: 0.741 ± 0.038
2.586SerAsp: 2.586 ± 0.073
3.203SerGlu: 3.203 ± 0.084
2.491SerPhe: 2.491 ± 0.07
4.364SerGly: 4.364 ± 0.104
0.901SerHis: 0.901 ± 0.039
3.593SerIle: 3.593 ± 0.083
2.844SerLys: 2.844 ± 0.068
4.773SerLeu: 4.773 ± 0.1
1.581SerMet: 1.581 ± 0.047
1.775SerAsn: 1.775 ± 0.062
1.649SerPro: 1.649 ± 0.057
1.323SerGln: 1.323 ± 0.05
2.48SerArg: 2.48 ± 0.061
2.671SerSer: 2.671 ± 0.083
2.506SerThr: 2.506 ± 0.074
4.004SerVal: 4.004 ± 0.085
0.412SerTrp: 0.412 ± 0.028
1.963SerTyr: 1.963 ± 0.068
0.002SerXaa: 0.002 ± 0.002
Thr
5.91ThrAla: 5.91 ± 0.104
0.613ThrCys: 0.613 ± 0.035
3.128ThrAsp: 3.128 ± 0.092
4.532ThrGlu: 4.532 ± 0.099
2.26ThrPhe: 2.26 ± 0.073
4.695ThrGly: 4.695 ± 0.1
0.902ThrHis: 0.902 ± 0.039
3.784ThrIle: 3.784 ± 0.09
3.504ThrLys: 3.504 ± 0.079
5.299ThrLeu: 5.299 ± 0.098
1.539ThrMet: 1.539 ± 0.046
1.888ThrAsn: 1.888 ± 0.064
2.355ThrPro: 2.355 ± 0.066
1.524ThrGln: 1.524 ± 0.047
2.024ThrArg: 2.024 ± 0.068
2.377ThrSer: 2.377 ± 0.059
3.003ThrThr: 3.003 ± 0.103
4.723ThrVal: 4.723 ± 0.115
0.432ThrTrp: 0.432 ± 0.027
1.923ThrTyr: 1.923 ± 0.064
0.0ThrXaa: 0.0 ± 0.0
Val
5.749ValAla: 5.749 ± 0.117
1.195ValCys: 1.195 ± 0.05
3.68ValAsp: 3.68 ± 0.083
4.64ValGlu: 4.64 ± 0.094
3.11ValPhe: 3.11 ± 0.082
4.645ValGly: 4.645 ± 0.115
1.077ValHis: 1.077 ± 0.044
4.584ValIle: 4.584 ± 0.1
4.453ValLys: 4.453 ± 0.097
7.019ValLeu: 7.019 ± 0.13
1.931ValMet: 1.931 ± 0.056
2.541ValAsn: 2.541 ± 0.067
2.616ValPro: 2.616 ± 0.063
2.121ValGln: 2.121 ± 0.063
2.962ValArg: 2.962 ± 0.073
4.217ValSer: 4.217 ± 0.084
4.401ValThr: 4.401 ± 0.113
5.034ValVal: 5.034 ± 0.113
0.547ValTrp: 0.547 ± 0.03
2.443ValTyr: 2.443 ± 0.061
0.0ValXaa: 0.0 ± 0.0
Trp
0.72TrpAla: 0.72 ± 0.034
0.14TrpCys: 0.14 ± 0.017
0.495TrpAsp: 0.495 ± 0.03
0.66TrpGlu: 0.66 ± 0.033
0.351TrpPhe: 0.351 ± 0.025
0.655TrpGly: 0.655 ± 0.034
0.146TrpHis: 0.146 ± 0.016
0.489TrpIle: 0.489 ± 0.032
0.69TrpLys: 0.69 ± 0.036
0.838TrpLeu: 0.838 ± 0.046
0.344TrpMet: 0.344 ± 0.025
0.437TrpAsn: 0.437 ± 0.025
0.131TrpPro: 0.131 ± 0.016
0.362TrpGln: 0.362 ± 0.025
0.444TrpArg: 0.444 ± 0.026
0.366TrpSer: 0.366 ± 0.026
0.455TrpThr: 0.455 ± 0.031
0.538TrpVal: 0.538 ± 0.026
0.081TrpTrp: 0.081 ± 0.012
0.319TrpTyr: 0.319 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.915TyrAla: 2.915 ± 0.066
0.552TyrCys: 0.552 ± 0.031
2.34TyrAsp: 2.34 ± 0.07
2.618TyrGlu: 2.618 ± 0.071
1.733TyrPhe: 1.733 ± 0.059
2.82TyrGly: 2.82 ± 0.077
0.844TyrHis: 0.844 ± 0.039
2.402TyrIle: 2.402 ± 0.061
1.777TyrLys: 1.777 ± 0.058
3.405TyrLeu: 3.405 ± 0.07
0.899TyrMet: 0.899 ± 0.04
1.464TyrAsn: 1.464 ± 0.056
1.366TyrPro: 1.366 ± 0.049
1.303TyrGln: 1.303 ± 0.049
1.84TyrArg: 1.84 ± 0.058
1.812TyrSer: 1.812 ± 0.054
2.254TyrThr: 2.254 ± 0.059
2.196TyrVal: 2.196 ± 0.063
0.296TyrTrp: 0.296 ± 0.023
1.607TyrTyr: 1.607 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.003XaaAla: 0.003 ± 0.002
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.002XaaGlu: 0.002 ± 0.002
0.0XaaPhe: 0.0 ± 0.0
0.002XaaGly: 0.002 ± 0.002
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.002XaaPro: 0.002 ± 0.002
0.002XaaGln: 0.002 ± 0.002
0.003XaaArg: 0.003 ± 0.002
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.018XaaXaa: 0.018 ± 0.007
Statistics based on 2021 proteins (601679 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski