Amino acid dipepetide frequency for Holospora obtusa F1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.643AlaAla: 3.643 ± 0.142
1.194AlaCys: 1.194 ± 0.066
2.076AlaAsp: 2.076 ± 0.09
2.923AlaGlu: 2.923 ± 0.106
3.445AlaPhe: 3.445 ± 0.108
3.753AlaGly: 3.753 ± 0.172
1.635AlaHis: 1.635 ± 0.074
3.75AlaIle: 3.75 ± 0.107
4.087AlaLys: 4.087 ± 0.117
8.871AlaLeu: 8.871 ± 0.219
1.505AlaMet: 1.505 ± 0.082
1.859AlaAsn: 1.859 ± 0.09
2.251AlaPro: 2.251 ± 0.093
3.441AlaGln: 3.441 ± 0.181
2.806AlaArg: 2.806 ± 0.116
4.304AlaSer: 4.304 ± 0.125
2.261AlaThr: 2.261 ± 0.107
3.72AlaVal: 3.72 ± 0.141
0.788AlaTrp: 0.788 ± 0.053
2.105AlaTyr: 2.105 ± 0.086
0.0AlaXaa: 0.0 ± 0.0
Cys
1.22CysAla: 1.22 ± 0.067
0.367CysCys: 0.367 ± 0.042
0.863CysAsp: 0.863 ± 0.055
0.895CysGlu: 0.895 ± 0.056
1.09CysPhe: 1.09 ± 0.062
1.103CysGly: 1.103 ± 0.074
0.441CysHis: 0.441 ± 0.037
1.518CysIle: 1.518 ± 0.065
0.973CysLys: 0.973 ± 0.07
1.881CysLeu: 1.881 ± 0.085
0.36CysMet: 0.36 ± 0.028
0.506CysAsn: 0.506 ± 0.047
0.717CysPro: 0.717 ± 0.049
0.834CysGln: 0.834 ± 0.056
0.548CysArg: 0.548 ± 0.041
1.307CysSer: 1.307 ± 0.069
0.717CysThr: 0.717 ± 0.045
1.489CysVal: 1.489 ± 0.075
0.201CysTrp: 0.201 ± 0.023
0.529CysTyr: 0.529 ± 0.041
0.0CysXaa: 0.0 ± 0.0
Asp
3.143AspAla: 3.143 ± 0.124
0.577AspCys: 0.577 ± 0.054
2.018AspAsp: 2.018 ± 0.096
2.65AspGlu: 2.65 ± 0.092
2.997AspPhe: 2.997 ± 0.118
2.368AspGly: 2.368 ± 0.116
1.366AspHis: 1.366 ± 0.067
3.341AspIle: 3.341 ± 0.113
2.524AspLys: 2.524 ± 0.105
5.485AspLeu: 5.485 ± 0.152
0.876AspMet: 0.876 ± 0.053
1.398AspAsn: 1.398 ± 0.066
2.164AspPro: 2.164 ± 0.08
2.189AspGln: 2.189 ± 0.112
1.94AspArg: 1.94 ± 0.098
3.052AspSer: 3.052 ± 0.14
2.436AspThr: 2.436 ± 0.13
3.179AspVal: 3.179 ± 0.118
0.678AspTrp: 0.678 ± 0.059
1.479AspTyr: 1.479 ± 0.065
0.0AspXaa: 0.0 ± 0.0
Glu
3.785GluAla: 3.785 ± 0.103
0.931GluCys: 0.931 ± 0.051
3.101GluAsp: 3.101 ± 0.114
4.502GluGlu: 4.502 ± 0.187
2.848GluPhe: 2.848 ± 0.108
3.195GluGly: 3.195 ± 0.118
1.651GluHis: 1.651 ± 0.078
5.112GluIle: 5.112 ± 0.139
6.529GluLys: 6.529 ± 0.206
5.329GluLeu: 5.329 ± 0.147
1.625GluMet: 1.625 ± 0.074
3.568GluAsn: 3.568 ± 0.121
1.495GluPro: 1.495 ± 0.079
2.718GluGln: 2.718 ± 0.098
3.299GluArg: 3.299 ± 0.117
3.928GluSer: 3.928 ± 0.13
2.605GluThr: 2.605 ± 0.093
3.519GluVal: 3.519 ± 0.121
0.636GluTrp: 0.636 ± 0.048
1.855GluTyr: 1.855 ± 0.083
0.0GluXaa: 0.0 ± 0.0
Phe
2.459PheAla: 2.459 ± 0.092
1.262PheCys: 1.262 ± 0.078
2.527PheAsp: 2.527 ± 0.108
3.065PheGlu: 3.065 ± 0.139
4.395PhePhe: 4.395 ± 0.185
3.01PheGly: 3.01 ± 0.12
1.083PheHis: 1.083 ± 0.06
3.286PheIle: 3.286 ± 0.118
3.101PheLys: 3.101 ± 0.115
7.269PheLeu: 7.269 ± 0.217
1.21PheMet: 1.21 ± 0.072
2.164PheAsn: 2.164 ± 0.103
2.141PhePro: 2.141 ± 0.095
2.426PheGln: 2.426 ± 0.109
2.031PheArg: 2.031 ± 0.077
5.962PheSer: 5.962 ± 0.169
1.982PheThr: 1.982 ± 0.071
3.163PheVal: 3.163 ± 0.116
0.924PheTrp: 0.924 ± 0.056
1.904PheTyr: 1.904 ± 0.076
0.0PheXaa: 0.0 ± 0.0
Gly
4.308GlyAla: 4.308 ± 0.165
1.035GlyCys: 1.035 ± 0.053
2.381GlyAsp: 2.381 ± 0.095
3.107GlyGlu: 3.107 ± 0.106
2.867GlyPhe: 2.867 ± 0.115
3.568GlyGly: 3.568 ± 0.146
1.44GlyHis: 1.44 ± 0.069
5.433GlyIle: 5.433 ± 0.154
4.363GlyLys: 4.363 ± 0.149
5.683GlyLeu: 5.683 ± 0.187
1.716GlyMet: 1.716 ± 0.075
2.151GlyAsn: 2.151 ± 0.081
1.752GlyPro: 1.752 ± 0.069
2.05GlyGln: 2.05 ± 0.091
2.699GlyArg: 2.699 ± 0.121
3.759GlySer: 3.759 ± 0.115
2.838GlyThr: 2.838 ± 0.101
4.418GlyVal: 4.418 ± 0.15
0.908GlyTrp: 0.908 ± 0.062
2.121GlyTyr: 2.121 ± 0.096
0.0GlyXaa: 0.0 ± 0.0
His
1.531HisAla: 1.531 ± 0.087
0.451HisCys: 0.451 ± 0.034
1.019HisAsp: 1.019 ± 0.054
1.129HisGlu: 1.129 ± 0.061
1.343HisPhe: 1.343 ± 0.064
1.443HisGly: 1.443 ± 0.07
1.048HisHis: 1.048 ± 0.065
1.914HisIle: 1.914 ± 0.096
1.599HisLys: 1.599 ± 0.063
2.848HisLeu: 2.848 ± 0.111
0.655HisMet: 0.655 ± 0.049
0.947HisAsn: 0.947 ± 0.062
1.375HisPro: 1.375 ± 0.079
1.275HisGln: 1.275 ± 0.067
1.379HisArg: 1.379 ± 0.074
1.667HisSer: 1.667 ± 0.083
1.061HisThr: 1.061 ± 0.061
1.625HisVal: 1.625 ± 0.074
0.399HisTrp: 0.399 ± 0.036
0.983HisTyr: 0.983 ± 0.057
0.0HisXaa: 0.0 ± 0.0
Ile
4.421IleAla: 4.421 ± 0.119
1.207IleCys: 1.207 ± 0.059
3.445IleAsp: 3.445 ± 0.124
4.554IleGlu: 4.554 ± 0.122
4.632IlePhe: 4.632 ± 0.156
3.847IleGly: 3.847 ± 0.151
1.81IleHis: 1.81 ± 0.078
4.382IleIle: 4.382 ± 0.164
5.115IleLys: 5.115 ± 0.157
8.391IleLeu: 8.391 ± 0.174
1.443IleMet: 1.443 ± 0.077
2.997IleAsn: 2.997 ± 0.146
3.234IlePro: 3.234 ± 0.127
3.711IleGln: 3.711 ± 0.107
2.942IleArg: 2.942 ± 0.11
5.67IleSer: 5.67 ± 0.155
3.257IleThr: 3.257 ± 0.124
4.249IleVal: 4.249 ± 0.131
0.866IleTrp: 0.866 ± 0.074
2.092IleTyr: 2.092 ± 0.102
0.0IleXaa: 0.0 ± 0.0
Lys
4.343LysAla: 4.343 ± 0.108
0.701LysCys: 0.701 ± 0.047
4.106LysAsp: 4.106 ± 0.222
6.234LysGlu: 6.234 ± 0.177
3.124LysPhe: 3.124 ± 0.127
4.035LysGly: 4.035 ± 0.122
1.606LysHis: 1.606 ± 0.08
7.483LysIle: 7.483 ± 0.206
7.674LysLys: 7.674 ± 0.247
5.89LysLeu: 5.89 ± 0.161
1.784LysMet: 1.784 ± 0.091
5.702LysAsn: 5.702 ± 0.217
1.898LysPro: 1.898 ± 0.076
2.608LysGln: 2.608 ± 0.102
3.296LysArg: 3.296 ± 0.106
5.047LysSer: 5.047 ± 0.155
3.944LysThr: 3.944 ± 0.138
3.639LysVal: 3.639 ± 0.112
0.681LysTrp: 0.681 ± 0.044
2.047LysTyr: 2.047 ± 0.088
0.0LysXaa: 0.0 ± 0.0
Leu
6.448LeuAla: 6.448 ± 0.183
2.241LeuCys: 2.241 ± 0.084
5.407LeuAsp: 5.407 ± 0.147
7.859LeuGlu: 7.859 ± 0.192
5.167LeuPhe: 5.167 ± 0.152
6.727LeuGly: 6.727 ± 0.194
2.517LeuHis: 2.517 ± 0.096
6.361LeuIle: 6.361 ± 0.18
9.533LeuLys: 9.533 ± 0.215
9.838LeuLeu: 9.838 ± 0.218
2.592LeuMet: 2.592 ± 0.094
5.135LeuAsn: 5.135 ± 0.167
4.385LeuPro: 4.385 ± 0.133
4.301LeuGln: 4.301 ± 0.118
4.778LeuArg: 4.778 ± 0.145
9.429LeuSer: 9.429 ± 0.197
4.804LeuThr: 4.804 ± 0.147
4.995LeuVal: 4.995 ± 0.133
1.606LeuTrp: 1.606 ± 0.088
3.03LeuTyr: 3.03 ± 0.1
0.0LeuXaa: 0.0 ± 0.0
Met
1.411MetAla: 1.411 ± 0.085
0.396MetCys: 0.396 ± 0.035
0.983MetAsp: 0.983 ± 0.057
1.317MetGlu: 1.317 ± 0.075
0.95MetPhe: 0.95 ± 0.056
1.437MetGly: 1.437 ± 0.073
0.639MetHis: 0.639 ± 0.046
1.836MetIle: 1.836 ± 0.086
1.778MetLys: 1.778 ± 0.087
2.627MetLeu: 2.627 ± 0.105
0.645MetMet: 0.645 ± 0.052
1.22MetAsn: 1.22 ± 0.072
0.772MetPro: 0.772 ± 0.054
0.95MetGln: 0.95 ± 0.051
1.155MetArg: 1.155 ± 0.062
1.657MetSer: 1.657 ± 0.069
1.268MetThr: 1.268 ± 0.068
1.288MetVal: 1.288 ± 0.066
0.263MetTrp: 0.263 ± 0.029
0.636MetTyr: 0.636 ± 0.048
0.0MetXaa: 0.0 ± 0.0
Asn
2.887AsnAla: 2.887 ± 0.102
0.561AsnCys: 0.561 ± 0.041
1.667AsnAsp: 1.667 ± 0.084
2.235AsnGlu: 2.235 ± 0.105
3.377AsnPhe: 3.377 ± 0.168
1.872AsnGly: 1.872 ± 0.082
1.281AsnHis: 1.281 ± 0.075
3.714AsnIle: 3.714 ± 0.138
2.828AsnLys: 2.828 ± 0.142
4.797AsnLeu: 4.797 ± 0.182
0.886AsnMet: 0.886 ± 0.054
1.914AsnAsn: 1.914 ± 0.105
1.829AsnPro: 1.829 ± 0.088
2.131AsnGln: 2.131 ± 0.084
1.778AsnArg: 1.778 ± 0.082
3.195AsnSer: 3.195 ± 0.143
2.404AsnThr: 2.404 ± 0.112
2.725AsnVal: 2.725 ± 0.091
0.558AsnTrp: 0.558 ± 0.071
1.317AsnTyr: 1.317 ± 0.069
0.0AsnXaa: 0.0 ± 0.0
Pro
1.745ProAla: 1.745 ± 0.086
0.723ProCys: 0.723 ± 0.05
1.752ProAsp: 1.752 ± 0.069
2.9ProGlu: 2.9 ± 0.098
2.115ProPhe: 2.115 ± 0.081
2.361ProGly: 2.361 ± 0.093
0.989ProHis: 0.989 ± 0.06
2.309ProIle: 2.309 ± 0.096
2.832ProLys: 2.832 ± 0.096
4.191ProLeu: 4.191 ± 0.127
0.73ProMet: 0.73 ± 0.049
1.466ProAsn: 1.466 ± 0.065
1.025ProPro: 1.025 ± 0.06
1.262ProGln: 1.262 ± 0.066
1.2ProArg: 1.2 ± 0.06
2.825ProSer: 2.825 ± 0.101
1.414ProThr: 1.414 ± 0.069
2.702ProVal: 2.702 ± 0.107
0.629ProTrp: 0.629 ± 0.049
1.43ProTyr: 1.43 ± 0.074
0.0ProXaa: 0.0 ± 0.0
Gln
2.952GlnAla: 2.952 ± 0.118
0.684GlnCys: 0.684 ± 0.041
2.498GlnAsp: 2.498 ± 0.093
3.935GlnGlu: 3.935 ± 0.147
1.732GlnPhe: 1.732 ± 0.07
3.033GlnGly: 3.033 ± 0.109
1.164GlnHis: 1.164 ± 0.062
2.738GlnIle: 2.738 ± 0.1
4.528GlnLys: 4.528 ± 0.16
3.321GlnLeu: 3.321 ± 0.103
0.827GlnMet: 0.827 ± 0.052
2.657GlnAsn: 2.657 ± 0.124
0.886GlnPro: 0.886 ± 0.055
1.404GlnGln: 1.404 ± 0.069
2.141GlnArg: 2.141 ± 0.094
2.893GlnSer: 2.893 ± 0.112
1.969GlnThr: 1.969 ± 0.128
2.316GlnVal: 2.316 ± 0.093
0.694GlnTrp: 0.694 ± 0.053
1.343GlnTyr: 1.343 ± 0.068
0.0GlnXaa: 0.0 ± 0.0
Arg
2.799ArgAla: 2.799 ± 0.104
0.937ArgCys: 0.937 ± 0.061
1.752ArgAsp: 1.752 ± 0.084
2.361ArgGlu: 2.361 ± 0.092
2.238ArgPhe: 2.238 ± 0.097
2.099ArgGly: 2.099 ± 0.085
1.249ArgHis: 1.249 ± 0.074
3.63ArgIle: 3.63 ± 0.111
3.237ArgLys: 3.237 ± 0.106
4.499ArgLeu: 4.499 ± 0.165
1.119ArgMet: 1.119 ± 0.07
1.898ArgAsn: 1.898 ± 0.081
1.56ArgPro: 1.56 ± 0.08
1.593ArgGln: 1.593 ± 0.082
2.056ArgArg: 2.056 ± 0.105
3.179ArgSer: 3.179 ± 0.103
1.923ArgThr: 1.923 ± 0.086
3.068ArgVal: 3.068 ± 0.109
0.778ArgTrp: 0.778 ± 0.05
1.732ArgTyr: 1.732 ± 0.077
0.0ArgXaa: 0.0 ± 0.0
Ser
4.622SerAla: 4.622 ± 0.134
1.417SerCys: 1.417 ± 0.08
3.571SerAsp: 3.571 ± 0.11
4.197SerGlu: 4.197 ± 0.163
4.603SerPhe: 4.603 ± 0.132
5.44SerGly: 5.44 ± 0.144
1.745SerHis: 1.745 ± 0.082
5.167SerIle: 5.167 ± 0.13
5.203SerLys: 5.203 ± 0.167
8.232SerLeu: 8.232 ± 0.173
1.732SerMet: 1.732 ± 0.072
2.77SerAsn: 2.77 ± 0.102
2.585SerPro: 2.585 ± 0.1
3.085SerGln: 3.085 ± 0.107
2.64SerArg: 2.64 ± 0.099
6.371SerSer: 6.371 ± 0.166
3.085SerThr: 3.085 ± 0.106
5.472SerVal: 5.472 ± 0.159
1.093SerTrp: 1.093 ± 0.064
2.488SerTyr: 2.488 ± 0.108
0.0SerXaa: 0.0 ± 0.0
Thr
2.676ThrAla: 2.676 ± 0.113
0.678ThrCys: 0.678 ± 0.044
1.875ThrAsp: 1.875 ± 0.1
2.407ThrGlu: 2.407 ± 0.088
2.562ThrPhe: 2.562 ± 0.108
2.741ThrGly: 2.741 ± 0.113
1.301ThrHis: 1.301 ± 0.07
2.835ThrIle: 2.835 ± 0.101
2.803ThrLys: 2.803 ± 0.1
5.997ThrLeu: 5.997 ± 0.136
0.921ThrMet: 0.921 ± 0.059
1.437ThrAsn: 1.437 ± 0.084
2.339ThrPro: 2.339 ± 0.082
2.682ThrGln: 2.682 ± 0.1
1.842ThrArg: 1.842 ± 0.087
3.052ThrSer: 3.052 ± 0.108
1.972ThrThr: 1.972 ± 0.093
2.806ThrVal: 2.806 ± 0.102
0.603ThrTrp: 0.603 ± 0.052
1.434ThrTyr: 1.434 ± 0.08
0.0ThrXaa: 0.0 ± 0.0
Val
3.192ValAla: 3.192 ± 0.112
1.369ValCys: 1.369 ± 0.074
2.686ValAsp: 2.686 ± 0.115
3.516ValGlu: 3.516 ± 0.12
3.503ValPhe: 3.503 ± 0.114
3.448ValGly: 3.448 ± 0.134
1.515ValHis: 1.515 ± 0.083
4.016ValIle: 4.016 ± 0.129
3.951ValLys: 3.951 ± 0.121
7.616ValLeu: 7.616 ± 0.166
1.492ValMet: 1.492 ± 0.085
2.368ValAsn: 2.368 ± 0.101
2.407ValPro: 2.407 ± 0.097
2.932ValGln: 2.932 ± 0.119
2.773ValArg: 2.773 ± 0.104
4.995ValSer: 4.995 ± 0.12
2.751ValThr: 2.751 ± 0.104
3.896ValVal: 3.896 ± 0.138
0.889ValTrp: 0.889 ± 0.056
2.063ValTyr: 2.063 ± 0.083
0.0ValXaa: 0.0 ± 0.0
Trp
0.782TrpAla: 0.782 ± 0.05
0.295TrpCys: 0.295 ± 0.032
0.662TrpAsp: 0.662 ± 0.061
0.743TrpGlu: 0.743 ± 0.049
0.444TrpPhe: 0.444 ± 0.05
0.973TrpGly: 0.973 ± 0.059
0.263TrpHis: 0.263 ± 0.031
1.427TrpIle: 1.427 ± 0.077
1.151TrpLys: 1.151 ± 0.064
1.158TrpLeu: 1.158 ± 0.066
0.425TrpMet: 0.425 ± 0.042
0.756TrpAsn: 0.756 ± 0.055
0.496TrpPro: 0.496 ± 0.043
0.405TrpGln: 0.405 ± 0.042
0.694TrpArg: 0.694 ± 0.054
1.061TrpSer: 1.061 ± 0.057
0.668TrpThr: 0.668 ± 0.049
0.973TrpVal: 0.973 ± 0.064
0.221TrpTrp: 0.221 ± 0.028
0.324TrpTyr: 0.324 ± 0.039
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.053TyrAla: 2.053 ± 0.072
0.532TyrCys: 0.532 ± 0.043
1.473TyrAsp: 1.473 ± 0.079
1.703TyrGlu: 1.703 ± 0.071
1.93TyrPhe: 1.93 ± 0.094
2.144TyrGly: 2.144 ± 0.091
0.947TyrHis: 0.947 ± 0.052
2.014TyrIle: 2.014 ± 0.08
2.034TyrLys: 2.034 ± 0.091
3.227TyrLeu: 3.227 ± 0.117
0.681TyrMet: 0.681 ± 0.047
1.044TyrAsn: 1.044 ± 0.06
1.291TyrPro: 1.291 ± 0.063
1.716TyrGln: 1.716 ± 0.082
1.713TyrArg: 1.713 ± 0.083
2.164TyrSer: 2.164 ± 0.095
1.606TyrThr: 1.606 ± 0.07
2.134TyrVal: 2.134 ± 0.092
0.506TyrTrp: 0.506 ± 0.041
1.129TyrTyr: 1.129 ± 0.07
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1116 proteins (308297 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski