Amino acid dipepetide frequency for Trichoderma harzianum (Hypocrea lixii)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.81AlaAla: 9.81 ± 0.064	1.059AlaCys: 1.059 ± 0.016	4.421AlaAsp: 4.421 ± 0.029	5.211AlaGlu: 5.211 ± 0.042	3.208AlaPhe: 3.208 ± 0.024	5.737AlaGly: 5.737 ± 0.047	1.75AlaHis: 1.75 ± 0.017	4.675AlaIle: 4.675 ± 0.035	4.324AlaLys: 4.324 ± 0.036	7.763AlaLeu: 7.763 ± 0.05	2.061AlaMet: 2.061 ± 0.021	3.182AlaAsn: 3.182 ± 0.027	4.737AlaPro: 4.737 ± 0.034	3.51AlaGln: 3.51 ± 0.031	4.633AlaArg: 4.633 ± 0.033	7.564AlaSer: 7.564 ± 0.046	5.376AlaThr: 5.376 ± 0.035	5.537AlaVal: 5.537 ± 0.034	1.204AlaTrp: 1.204 ± 0.018	2.182AlaTyr: 2.182 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	0.912CysAla: 0.912 ± 0.014	0.242CysCys: 0.242 ± 0.009	0.664CysAsp: 0.664 ± 0.013	0.578CysGlu: 0.578 ± 0.012	0.546CysPhe: 0.546 ± 0.013	0.927CysGly: 0.927 ± 0.015	0.319CysHis: 0.319 ± 0.007	0.731CysIle: 0.731 ± 0.014	0.494CysLys: 0.494 ± 0.01	1.21CysLeu: 1.21 ± 0.015	0.25CysMet: 0.25 ± 0.007	0.437CysAsn: 0.437 ± 0.009	0.628CysPro: 0.628 ± 0.014	0.456CysGln: 0.456 ± 0.01	0.694CysArg: 0.694 ± 0.012	0.883CysSer: 0.883 ± 0.015	0.656CysThr: 0.656 ± 0.012	0.769CysVal: 0.769 ± 0.015	0.204CysTrp: 0.204 ± 0.006	0.364CysTyr: 0.364 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	5.016AspAla: 5.016 ± 0.031	0.644AspCys: 0.644 ± 0.01	4.564AspAsp: 4.564 ± 0.041	4.72AspGlu: 4.72 ± 0.039	2.266AspPhe: 2.266 ± 0.022	4.294AspGly: 4.294 ± 0.034	1.214AspHis: 1.214 ± 0.016	3.329AspIle: 3.329 ± 0.025	2.655AspLys: 2.655 ± 0.026	4.971AspLeu: 4.971 ± 0.032	1.329AspMet: 1.329 ± 0.015	2.017AspAsn: 2.017 ± 0.022	3.14AspPro: 3.14 ± 0.026	1.882AspGln: 1.882 ± 0.019	2.873AspArg: 2.873 ± 0.03	4.198AspSer: 4.198 ± 0.036	2.917AspThr: 2.917 ± 0.024	3.845AspVal: 3.845 ± 0.03	0.896AspTrp: 0.896 ± 0.015	1.63AspTyr: 1.63 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	5.757GluAla: 5.757 ± 0.042	0.613GluCys: 0.613 ± 0.011	4.25GluAsp: 4.25 ± 0.04	5.522GluGlu: 5.522 ± 0.068	2.025GluPhe: 2.025 ± 0.019	3.539GluGly: 3.539 ± 0.028	1.364GluHis: 1.364 ± 0.018	3.154GluIle: 3.154 ± 0.027	3.7GluLys: 3.7 ± 0.035	5.284GluLeu: 5.284 ± 0.03	1.535GluMet: 1.535 ± 0.016	2.27GluAsn: 2.27 ± 0.021	2.768GluPro: 2.768 ± 0.03	2.504GluGln: 2.504 ± 0.023	3.663GluArg: 3.663 ± 0.035	4.267GluSer: 4.267 ± 0.031	3.526GluThr: 3.526 ± 0.029	3.449GluVal: 3.449 ± 0.031	0.901GluTrp: 0.901 ± 0.012	1.688GluTyr: 1.688 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.122PheAla: 3.122 ± 0.026	0.555PheCys: 0.555 ± 0.009	2.369PheAsp: 2.369 ± 0.021	2.15PheGlu: 2.15 ± 0.023	1.68PhePhe: 1.68 ± 0.019	2.909PheGly: 2.909 ± 0.029	0.897PheHis: 0.897 ± 0.014	1.982PheIle: 1.982 ± 0.022	1.551PheLys: 1.551 ± 0.017	3.435PheLeu: 3.435 ± 0.024	0.821PheMet: 0.821 ± 0.013	1.516PheAsn: 1.516 ± 0.015	1.921PhePro: 1.921 ± 0.022	1.448PheGln: 1.448 ± 0.017	1.908PheArg: 1.908 ± 0.018	3.044PheSer: 3.044 ± 0.024	2.187PheThr: 2.187 ± 0.02	2.414PheVal: 2.414 ± 0.022	0.65PheTrp: 0.65 ± 0.012	1.129PheTyr: 1.129 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	5.327GlyAla: 5.327 ± 0.038	0.843GlyCys: 0.843 ± 0.014	3.759GlyAsp: 3.759 ± 0.03	3.62GlyGlu: 3.62 ± 0.028	2.823GlyPhe: 2.823 ± 0.026	5.682GlyGly: 5.682 ± 0.059	1.721GlyHis: 1.721 ± 0.017	3.727GlyIle: 3.727 ± 0.032	3.468GlyLys: 3.468 ± 0.031	6.024GlyLeu: 6.024 ± 0.04	1.571GlyMet: 1.571 ± 0.019	2.635GlyAsn: 2.635 ± 0.028	3.242GlyPro: 3.242 ± 0.029	2.577GlyGln: 2.577 ± 0.022	3.961GlyArg: 3.961 ± 0.034	5.778GlySer: 5.778 ± 0.039	3.883GlyThr: 3.883 ± 0.028	4.283GlyVal: 4.283 ± 0.036	1.166GlyTrp: 1.166 ± 0.015	2.15GlyTyr: 2.15 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	1.74HisAla: 1.74 ± 0.018	0.315HisCys: 0.315 ± 0.008	1.351HisAsp: 1.351 ± 0.017	1.331HisGlu: 1.331 ± 0.017	0.919HisPhe: 0.919 ± 0.014	1.72HisGly: 1.72 ± 0.019	0.878HisHis: 0.878 ± 0.018	1.254HisIle: 1.254 ± 0.014	0.953HisLys: 0.953 ± 0.015	2.202HisLeu: 2.202 ± 0.024	0.518HisMet: 0.518 ± 0.01	0.856HisAsn: 0.856 ± 0.012	1.526HisPro: 1.526 ± 0.02	1.036HisGln: 1.036 ± 0.016	1.45HisArg: 1.45 ± 0.019	1.763HisSer: 1.763 ± 0.021	1.171HisThr: 1.171 ± 0.016	1.424HisVal: 1.424 ± 0.018	0.351HisTrp: 0.351 ± 0.009	0.689HisTyr: 0.689 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.412IleAla: 4.412 ± 0.031	0.753IleCys: 0.753 ± 0.014	3.054IleAsp: 3.054 ± 0.024	3.034IleGlu: 3.034 ± 0.025	2.11IlePhe: 2.11 ± 0.023	3.37IleGly: 3.37 ± 0.029	1.27IleHis: 1.27 ± 0.016	2.763IleIle: 2.763 ± 0.026	2.365IleLys: 2.365 ± 0.022	4.694IleLeu: 4.694 ± 0.035	1.077IleMet: 1.077 ± 0.012	1.988IleAsn: 1.988 ± 0.023	3.122IlePro: 3.122 ± 0.023	2.066IleGln: 2.066 ± 0.023	2.884IleArg: 2.884 ± 0.021	4.053IleSer: 4.053 ± 0.031	2.96IleThr: 2.96 ± 0.024	3.309IleVal: 3.309 ± 0.026	0.777IleTrp: 0.777 ± 0.013	1.451IleTyr: 1.451 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.482LysAla: 4.482 ± 0.038	0.484LysCys: 0.484 ± 0.011	2.895LysAsp: 2.895 ± 0.026	3.417LysGlu: 3.417 ± 0.033	1.567LysPhe: 1.567 ± 0.018	2.991LysGly: 2.991 ± 0.028	1.118LysHis: 1.118 ± 0.016	2.372LysIle: 2.372 ± 0.022	3.358LysLys: 3.358 ± 0.045	4.272LysLeu: 4.272 ± 0.029	1.077LysMet: 1.077 ± 0.013	1.771LysAsn: 1.771 ± 0.017	2.708LysPro: 2.708 ± 0.025	1.905LysGln: 1.905 ± 0.018	3.273LysArg: 3.273 ± 0.031	3.567LysSer: 3.567 ± 0.028	2.908LysThr: 2.908 ± 0.024	2.809LysVal: 2.809 ± 0.023	0.699LysTrp: 0.699 ± 0.013	1.399LysTyr: 1.399 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	7.972LeuAla: 7.972 ± 0.042	1.169LeuCys: 1.169 ± 0.017	5.361LeuAsp: 5.361 ± 0.03	5.519LeuGlu: 5.519 ± 0.041	3.367LeuPhe: 3.367 ± 0.027	5.93LeuGly: 5.93 ± 0.035	2.164LeuHis: 2.164 ± 0.02	4.151LeuIle: 4.151 ± 0.029	4.261LeuLys: 4.261 ± 0.031	8.426LeuLeu: 8.426 ± 0.056	1.822LeuMet: 1.822 ± 0.02	3.231LeuAsn: 3.231 ± 0.025	5.333LeuPro: 5.333 ± 0.032	3.931LeuGln: 3.931 ± 0.031	5.536LeuArg: 5.536 ± 0.034	7.279LeuSer: 7.279 ± 0.041	4.714LeuThr: 4.714 ± 0.03	5.41LeuVal: 5.41 ± 0.035	1.237LeuTrp: 1.237 ± 0.017	2.339LeuTyr: 2.339 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.415MetAla: 2.415 ± 0.021	0.24MetCys: 0.24 ± 0.006	1.312MetAsp: 1.312 ± 0.014	1.334MetGlu: 1.334 ± 0.015	0.738MetPhe: 0.738 ± 0.012	1.486MetGly: 1.486 ± 0.018	0.467MetHis: 0.467 ± 0.009	1.031MetIle: 1.031 ± 0.012	1.04MetLys: 1.04 ± 0.015	1.9MetLeu: 1.9 ± 0.017	0.621MetMet: 0.621 ± 0.011	0.828MetAsn: 0.828 ± 0.014	1.314MetPro: 1.314 ± 0.016	0.879MetGln: 0.879 ± 0.015	1.258MetArg: 1.258 ± 0.016	1.874MetSer: 1.874 ± 0.019	1.302MetThr: 1.302 ± 0.015	1.314MetVal: 1.314 ± 0.015	0.272MetTrp: 0.272 ± 0.006	0.526MetTyr: 0.526 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.211AsnAla: 3.211 ± 0.025	0.456AsnCys: 0.456 ± 0.01	2.065AsnAsp: 2.065 ± 0.02	2.014AsnGlu: 2.014 ± 0.021	1.416AsnPhe: 1.416 ± 0.016	3.124AsnGly: 3.124 ± 0.032	0.874AsnHis: 0.874 ± 0.013	2.183AsnIle: 2.183 ± 0.02	1.673AsnLys: 1.673 ± 0.019	3.316AsnLeu: 3.316 ± 0.024	0.911AsnMet: 0.911 ± 0.014	1.622AsnAsn: 1.622 ± 0.024	2.418AsnPro: 2.418 ± 0.022	1.379AsnGln: 1.379 ± 0.018	1.913AsnArg: 1.913 ± 0.018	2.831AsnSer: 2.831 ± 0.024	2.189AsnThr: 2.189 ± 0.018	2.324AsnVal: 2.324 ± 0.022	0.593AsnTrp: 0.593 ± 0.011	1.111AsnTyr: 1.111 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	5.019ProAla: 5.019 ± 0.042	0.506ProCys: 0.506 ± 0.011	3.231ProAsp: 3.231 ± 0.026	3.752ProGlu: 3.752 ± 0.03	2.048ProPhe: 2.048 ± 0.021	3.767ProGly: 3.767 ± 0.03	1.241ProHis: 1.241 ± 0.017	2.577ProIle: 2.577 ± 0.024	2.693ProLys: 2.693 ± 0.024	4.785ProLeu: 4.785 ± 0.031	1.122ProMet: 1.122 ± 0.015	2.234ProAsn: 2.234 ± 0.022	4.951ProPro: 4.951 ± 0.069	2.451ProGln: 2.451 ± 0.029	3.147ProArg: 3.147 ± 0.026	5.697ProSer: 5.697 ± 0.043	3.738ProThr: 3.738 ± 0.027	3.48ProVal: 3.48 ± 0.03	0.741ProTrp: 0.741 ± 0.011	1.462ProTyr: 1.462 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.583GlnAla: 3.583 ± 0.03	0.436GlnCys: 0.436 ± 0.01	2.181GlnAsp: 2.181 ± 0.019	2.43GlnGlu: 2.43 ± 0.024	1.377GlnPhe: 1.377 ± 0.015	2.468GlnGly: 2.468 ± 0.022	1.071GlnHis: 1.071 ± 0.015	1.935GlnIle: 1.935 ± 0.02	1.984GlnLys: 1.984 ± 0.023	3.64GlnLeu: 3.64 ± 0.027	0.912GlnMet: 0.912 ± 0.012	1.546GlnAsn: 1.546 ± 0.017	2.575GlnPro: 2.575 ± 0.029	2.675GlnGln: 2.675 ± 0.063	2.572GlnArg: 2.572 ± 0.026	3.104GlnSer: 3.104 ± 0.025	2.298GlnThr: 2.298 ± 0.02	2.183GlnVal: 2.183 ± 0.019	0.606GlnTrp: 0.606 ± 0.01	1.178GlnTyr: 1.178 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.443ArgAla: 4.443 ± 0.03	0.655ArgCys: 0.655 ± 0.012	3.338ArgAsp: 3.338 ± 0.032	3.62ArgGlu: 3.62 ± 0.035	2.104ArgPhe: 2.104 ± 0.019	3.603ArgGly: 3.603 ± 0.031	1.502ArgHis: 1.502 ± 0.016	2.919ArgIle: 2.919 ± 0.023	3.191ArgLys: 3.191 ± 0.029	5.409ArgLeu: 5.409 ± 0.034	1.258ArgMet: 1.258 ± 0.015	2.187ArgAsn: 2.187 ± 0.019	3.332ArgPro: 3.332 ± 0.033	2.565ArgGln: 2.565 ± 0.023	4.754ArgArg: 4.754 ± 0.041	4.467ArgSer: 4.467 ± 0.037	2.982ArgThr: 2.982 ± 0.024	3.222ArgVal: 3.222 ± 0.024	0.888ArgTrp: 0.888 ± 0.012	1.594ArgTyr: 1.594 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.61SerAla: 6.61 ± 0.042	0.87SerCys: 0.87 ± 0.012	4.252SerAsp: 4.252 ± 0.034	4.126SerGlu: 4.126 ± 0.034	3.079SerPhe: 3.079 ± 0.024	5.585SerGly: 5.585 ± 0.035	1.948SerHis: 1.948 ± 0.022	4.174SerIle: 4.174 ± 0.033	3.775SerLys: 3.775 ± 0.034	7.215SerLeu: 7.215 ± 0.04	1.746SerMet: 1.746 ± 0.018	3.039SerAsn: 3.039 ± 0.027	5.254SerPro: 5.254 ± 0.043	3.391SerGln: 3.391 ± 0.027	4.853SerArg: 4.853 ± 0.039	8.747SerSer: 8.747 ± 0.065	5.37SerThr: 5.37 ± 0.046	4.595SerVal: 4.595 ± 0.031	1.191SerTrp: 1.191 ± 0.016	2.074SerTyr: 2.074 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.288ThrAla: 5.288 ± 0.036	0.711ThrCys: 0.711 ± 0.013	2.847ThrAsp: 2.847 ± 0.024	3.138ThrGlu: 3.138 ± 0.026	2.224ThrPhe: 2.224 ± 0.019	4.119ThrGly: 4.119 ± 0.032	1.193ThrHis: 1.193 ± 0.013	3.219ThrIle: 3.219 ± 0.024	2.656ThrLys: 2.656 ± 0.021	5.162ThrLeu: 5.162 ± 0.029	1.189ThrMet: 1.189 ± 0.014	2.154ThrAsn: 2.154 ± 0.024	4.042ThrPro: 4.042 ± 0.036	2.051ThrGln: 2.051 ± 0.02	2.941ThrArg: 2.941 ± 0.021	5.129ThrSer: 5.129 ± 0.039	4.122ThrThr: 4.122 ± 0.042	3.711ThrVal: 3.711 ± 0.032	0.853ThrTrp: 0.853 ± 0.012	1.591ThrTyr: 1.591 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.436ValAla: 5.436 ± 0.037	0.805ValCys: 0.805 ± 0.017	3.803ValAsp: 3.803 ± 0.028	3.82ValGlu: 3.82 ± 0.032	2.446ValPhe: 2.446 ± 0.023	3.902ValGly: 3.902 ± 0.028	1.336ValHis: 1.336 ± 0.015	3.085ValIle: 3.085 ± 0.026	2.961ValLys: 2.961 ± 0.021	5.477ValLeu: 5.477 ± 0.032	1.321ValMet: 1.321 ± 0.014	2.293ValAsn: 2.293 ± 0.021	3.523ValPro: 3.523 ± 0.031	2.378ValGln: 2.378 ± 0.023	3.244ValArg: 3.244 ± 0.027	4.602ValSer: 4.602 ± 0.032	3.566ValThr: 3.566 ± 0.031	4.34ValVal: 4.34 ± 0.032	0.874ValTrp: 0.874 ± 0.015	1.7ValTyr: 1.7 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.218TrpAla: 1.218 ± 0.02	0.191TrpCys: 0.191 ± 0.006	0.975TrpAsp: 0.975 ± 0.015	0.874TrpGlu: 0.874 ± 0.012	0.558TrpPhe: 0.558 ± 0.01	0.942TrpGly: 0.942 ± 0.014	0.371TrpHis: 0.371 ± 0.008	0.821TrpIle: 0.821 ± 0.011	0.805TrpLys: 0.805 ± 0.012	1.358TrpLeu: 1.358 ± 0.015	0.371TrpMet: 0.371 ± 0.007	0.673TrpAsn: 0.673 ± 0.012	0.619TrpPro: 0.619 ± 0.012	0.581TrpGln: 0.581 ± 0.01	0.928TrpArg: 0.928 ± 0.013	1.042TrpSer: 1.042 ± 0.012	0.925TrpThr: 0.925 ± 0.014	0.885TrpVal: 0.885 ± 0.014	0.293TrpTrp: 0.293 ± 0.008	0.424TrpTyr: 0.424 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.171TyrAla: 2.171 ± 0.018	0.415TyrCys: 0.415 ± 0.01	1.706TyrAsp: 1.706 ± 0.018	1.569TyrGlu: 1.569 ± 0.018	1.189TyrPhe: 1.189 ± 0.016	2.147TyrGly: 2.147 ± 0.023	0.749TyrHis: 0.749 ± 0.014	1.426TyrIle: 1.426 ± 0.016	1.167TyrLys: 1.167 ± 0.014	2.61TyrLeu: 2.61 ± 0.023	0.637TyrMet: 0.637 ± 0.012	1.141TyrAsn: 1.141 ± 0.017	1.491TyrPro: 1.491 ± 0.019	1.089TyrGln: 1.089 ± 0.014	1.548TyrArg: 1.548 ± 0.017	2.007TyrSer: 2.007 ± 0.02	1.551TyrThr: 1.551 ± 0.018	1.611TyrVal: 1.611 ± 0.018	0.455TyrTrp: 0.455 ± 0.009	0.925TyrTyr: 0.925 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.001

Statistics based on 11497 proteins (5801780 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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