Amino acid dipepetide frequency for Enterococcus columbae DSM 7374 = ATCC 51263

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.606AlaAla: 5.606 ± 0.116
0.666AlaCys: 0.666 ± 0.027
4.021AlaAsp: 4.021 ± 0.078
4.504AlaGlu: 4.504 ± 0.091
3.403AlaPhe: 3.403 ± 0.073
4.768AlaGly: 4.768 ± 0.105
1.349AlaHis: 1.349 ± 0.04
6.369AlaIle: 6.369 ± 0.096
6.138AlaLys: 6.138 ± 0.114
7.736AlaLeu: 7.736 ± 0.122
2.077AlaMet: 2.077 ± 0.058
3.873AlaAsn: 3.873 ± 0.086
2.051AlaPro: 2.051 ± 0.053
3.775AlaGln: 3.775 ± 0.083
2.456AlaArg: 2.456 ± 0.064
4.556AlaSer: 4.556 ± 0.089
4.454AlaThr: 4.454 ± 0.098
4.842AlaVal: 4.842 ± 0.101
0.593AlaTrp: 0.593 ± 0.028
2.782AlaTyr: 2.782 ± 0.073
0.0AlaXaa: 0.0 ± 0.0
Cys
0.485CysAla: 0.485 ± 0.026
0.106CysCys: 0.106 ± 0.012
0.372CysAsp: 0.372 ± 0.026
0.389CysGlu: 0.389 ± 0.027
0.436CysPhe: 0.436 ± 0.026
0.652CysGly: 0.652 ± 0.034
0.2CysHis: 0.2 ± 0.017
0.517CysIle: 0.517 ± 0.028
0.359CysLys: 0.359 ± 0.025
0.865CysLeu: 0.865 ± 0.035
0.177CysMet: 0.177 ± 0.015
0.251CysAsn: 0.251 ± 0.019
0.333CysPro: 0.333 ± 0.024
0.431CysGln: 0.431 ± 0.025
0.271CysArg: 0.271 ± 0.02
0.526CysSer: 0.526 ± 0.027
0.341CysThr: 0.341 ± 0.024
0.465CysVal: 0.465 ± 0.027
0.065CysTrp: 0.065 ± 0.009
0.399CysTyr: 0.399 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
3.384AspAla: 3.384 ± 0.086
0.459AspCys: 0.459 ± 0.028
2.36AspAsp: 2.36 ± 0.076
4.478AspGlu: 4.478 ± 0.099
2.789AspPhe: 2.789 ± 0.069
3.315AspGly: 3.315 ± 0.202
0.978AspHis: 0.978 ± 0.035
3.5AspIle: 3.5 ± 0.075
3.018AspLys: 3.018 ± 0.085
5.337AspLeu: 5.337 ± 0.086
1.157AspMet: 1.157 ± 0.041
2.046AspAsn: 2.046 ± 0.082
1.75AspPro: 1.75 ± 0.107
2.476AspGln: 2.476 ± 0.053
1.844AspArg: 1.844 ± 0.052
2.648AspSer: 2.648 ± 0.084
2.695AspThr: 2.695 ± 0.111
3.161AspVal: 3.161 ± 0.072
0.624AspTrp: 0.624 ± 0.031
2.586AspTyr: 2.586 ± 0.064
0.0AspXaa: 0.0 ± 0.0
Glu
5.022GluAla: 5.022 ± 0.108
0.376GluCys: 0.376 ± 0.023
3.034GluAsp: 3.034 ± 0.064
5.417GluGlu: 5.417 ± 0.116
2.229GluPhe: 2.229 ± 0.059
3.384GluGly: 3.384 ± 0.078
1.254GluHis: 1.254 ± 0.04
5.49GluIle: 5.49 ± 0.104
6.177GluLys: 6.177 ± 0.097
6.873GluLeu: 6.873 ± 0.12
2.019GluMet: 2.019 ± 0.051
3.675GluAsn: 3.675 ± 0.08
1.511GluPro: 1.511 ± 0.061
3.975GluGln: 3.975 ± 0.099
2.62GluArg: 2.62 ± 0.069
2.938GluSer: 2.938 ± 0.062
3.231GluThr: 3.231 ± 0.076
4.766GluVal: 4.766 ± 0.087
0.572GluTrp: 0.572 ± 0.032
2.197GluTyr: 2.197 ± 0.064
0.0GluXaa: 0.0 ± 0.0
Phe
3.394PheAla: 3.394 ± 0.075
0.431PheCys: 0.431 ± 0.024
2.681PheAsp: 2.681 ± 0.062
2.88PheGlu: 2.88 ± 0.065
2.179PhePhe: 2.179 ± 0.064
3.115PheGly: 3.115 ± 0.076
0.96PheHis: 0.96 ± 0.041
3.717PheIle: 3.717 ± 0.11
2.485PheLys: 2.485 ± 0.065
4.507PheLeu: 4.507 ± 0.098
1.116PheMet: 1.116 ± 0.044
2.043PheAsn: 2.043 ± 0.052
1.551PhePro: 1.551 ± 0.053
1.732PheGln: 1.732 ± 0.053
1.394PheArg: 1.394 ± 0.05
3.174PheSer: 3.174 ± 0.074
2.66PheThr: 2.66 ± 0.067
3.152PheVal: 3.152 ± 0.073
0.439PheTrp: 0.439 ± 0.026
1.871PheTyr: 1.871 ± 0.053
0.0PheXaa: 0.0 ± 0.0
Gly
4.157GlyAla: 4.157 ± 0.086
0.557GlyCys: 0.557 ± 0.027
2.744GlyAsp: 2.744 ± 0.092
3.787GlyGlu: 3.787 ± 0.084
3.04GlyPhe: 3.04 ± 0.078
4.01GlyGly: 4.01 ± 0.089
1.197GlyHis: 1.197 ± 0.048
5.33GlyIle: 5.33 ± 0.1
4.623GlyLys: 4.623 ± 0.082
6.242GlyLeu: 6.242 ± 0.121
1.851GlyMet: 1.851 ± 0.051
2.708GlyAsn: 2.708 ± 0.062
1.278GlyPro: 1.278 ± 0.045
2.711GlyGln: 2.711 ± 0.065
2.153GlyArg: 2.153 ± 0.059
3.407GlySer: 3.407 ± 0.083
3.577GlyThr: 3.577 ± 0.104
4.338GlyVal: 4.338 ± 0.089
0.691GlyTrp: 0.691 ± 0.042
2.65GlyTyr: 2.65 ± 0.066
0.0GlyXaa: 0.0 ± 0.0
His
1.238HisAla: 1.238 ± 0.042
0.18HisCys: 0.18 ± 0.015
0.927HisAsp: 0.927 ± 0.037
1.203HisGlu: 1.203 ± 0.044
1.253HisPhe: 1.253 ± 0.045
1.278HisGly: 1.278 ± 0.046
0.642HisHis: 0.642 ± 0.035
1.24HisIle: 1.24 ± 0.044
0.796HisLys: 0.796 ± 0.034
2.499HisLeu: 2.499 ± 0.056
0.418HisMet: 0.418 ± 0.025
0.645HisAsn: 0.645 ± 0.033
1.091HisPro: 1.091 ± 0.044
1.378HisGln: 1.378 ± 0.049
0.854HisArg: 0.854 ± 0.037
1.061HisSer: 1.061 ± 0.039
1.059HisThr: 1.059 ± 0.036
1.102HisVal: 1.102 ± 0.041
0.202HisTrp: 0.202 ± 0.017
1.003HisTyr: 1.003 ± 0.046
0.0HisXaa: 0.0 ± 0.0
Ile
6.228IleAla: 6.228 ± 0.104
0.798IleCys: 0.798 ± 0.037
4.545IleAsp: 4.545 ± 0.082
5.226IleGlu: 5.226 ± 0.085
3.725IlePhe: 3.725 ± 0.09
5.225IleGly: 5.225 ± 0.105
1.655IleHis: 1.655 ± 0.052
5.538IleIle: 5.538 ± 0.113
4.461IleLys: 4.461 ± 0.096
7.483IleLeu: 7.483 ± 0.131
1.65IleMet: 1.65 ± 0.052
3.366IleAsn: 3.366 ± 0.078
2.936IlePro: 2.936 ± 0.063
3.845IleGln: 3.845 ± 0.086
2.83IleArg: 2.83 ± 0.063
4.478IleSer: 4.478 ± 0.094
4.117IleThr: 4.117 ± 0.09
5.24IleVal: 5.24 ± 0.087
0.561IleTrp: 0.561 ± 0.031
2.88IleTyr: 2.88 ± 0.056
0.0IleXaa: 0.0 ± 0.0
Lys
5.501LysAla: 5.501 ± 0.106
0.307LysCys: 0.307 ± 0.023
3.504LysAsp: 3.504 ± 0.081
6.033LysGlu: 6.033 ± 0.111
2.018LysPhe: 2.018 ± 0.054
3.574LysGly: 3.574 ± 0.079
1.255LysHis: 1.255 ± 0.039
5.282LysIle: 5.282 ± 0.089
5.771LysLys: 5.771 ± 0.108
5.91LysLeu: 5.91 ± 0.097
2.221LysMet: 2.221 ± 0.053
3.882LysAsn: 3.882 ± 0.086
1.849LysPro: 1.849 ± 0.057
4.088LysGln: 4.088 ± 0.08
3.059LysArg: 3.059 ± 0.067
3.166LysSer: 3.166 ± 0.084
3.579LysThr: 3.579 ± 0.075
4.561LysVal: 4.561 ± 0.094
0.58LysTrp: 0.58 ± 0.027
2.581LysTyr: 2.581 ± 0.072
0.0LysXaa: 0.0 ± 0.0
Leu
9.9LeuAla: 9.9 ± 0.152
0.829LeuCys: 0.829 ± 0.038
5.124LeuAsp: 5.124 ± 0.11
5.573LeuGlu: 5.573 ± 0.101
4.974LeuPhe: 4.974 ± 0.121
6.148LeuGly: 6.148 ± 0.121
1.867LeuHis: 1.867 ± 0.054
7.168LeuIle: 7.168 ± 0.126
6.871LeuLys: 6.871 ± 0.118
10.786LeuLeu: 10.786 ± 0.189
2.402LeuMet: 2.402 ± 0.061
4.769LeuAsn: 4.769 ± 0.09
4.359LeuPro: 4.359 ± 0.082
4.516LeuGln: 4.516 ± 0.103
3.492LeuArg: 3.492 ± 0.082
7.143LeuSer: 7.143 ± 0.104
6.493LeuThr: 6.493 ± 0.099
6.5LeuVal: 6.5 ± 0.101
0.746LeuTrp: 0.746 ± 0.032
3.338LeuTyr: 3.338 ± 0.064
0.0LeuXaa: 0.0 ± 0.0
Met
1.917MetAla: 1.917 ± 0.058
0.142MetCys: 0.142 ± 0.014
1.345MetAsp: 1.345 ± 0.048
1.472MetGlu: 1.472 ± 0.045
0.895MetPhe: 0.895 ± 0.036
1.475MetGly: 1.475 ± 0.04
0.482MetHis: 0.482 ± 0.024
2.22MetIle: 2.22 ± 0.063
2.126MetLys: 2.126 ± 0.056
2.381MetLeu: 2.381 ± 0.054
0.762MetMet: 0.762 ± 0.032
1.486MetAsn: 1.486 ± 0.051
0.878MetPro: 0.878 ± 0.036
1.424MetGln: 1.424 ± 0.048
0.945MetArg: 0.945 ± 0.031
1.467MetSer: 1.467 ± 0.046
1.497MetThr: 1.497 ± 0.037
1.667MetVal: 1.667 ± 0.055
0.163MetTrp: 0.163 ± 0.016
0.71MetTyr: 0.71 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
2.978AsnAla: 2.978 ± 0.073
0.32AsnCys: 0.32 ± 0.023
2.478AsnAsp: 2.478 ± 0.07
3.363AsnGlu: 3.363 ± 0.069
1.855AsnPhe: 1.855 ± 0.056
3.051AsnGly: 3.051 ± 0.077
1.329AsnHis: 1.329 ± 0.048
3.3AsnIle: 3.3 ± 0.066
2.747AsnLys: 2.747 ± 0.066
4.309AsnLeu: 4.309 ± 0.093
0.994AsnMet: 0.994 ± 0.037
2.05AsnAsn: 2.05 ± 0.072
2.218AsnPro: 2.218 ± 0.079
3.71AsnGln: 3.71 ± 0.08
2.043AsnArg: 2.043 ± 0.051
2.239AsnSer: 2.239 ± 0.065
2.225AsnThr: 2.225 ± 0.066
2.862AsnVal: 2.862 ± 0.076
0.59AsnTrp: 0.59 ± 0.031
2.098AsnTyr: 2.098 ± 0.055
0.0AsnXaa: 0.0 ± 0.0
Pro
2.344ProAla: 2.344 ± 0.063
0.199ProCys: 0.199 ± 0.017
1.854ProAsp: 1.854 ± 0.111
2.673ProGlu: 2.673 ± 0.063
1.761ProPhe: 1.761 ± 0.057
1.825ProGly: 1.825 ± 0.068
0.555ProHis: 0.555 ± 0.031
2.769ProIle: 2.769 ± 0.06
2.475ProLys: 2.475 ± 0.055
3.289ProLeu: 3.289 ± 0.079
0.762ProMet: 0.762 ± 0.03
1.838ProAsn: 1.838 ± 0.067
0.591ProPro: 0.591 ± 0.031
1.334ProGln: 1.334 ± 0.04
0.963ProArg: 0.963 ± 0.043
2.054ProSer: 2.054 ± 0.062
2.453ProThr: 2.453 ± 0.116
2.434ProVal: 2.434 ± 0.06
0.296ProTrp: 0.296 ± 0.023
1.399ProTyr: 1.399 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
5.323GlnAla: 5.323 ± 0.099
0.247GlnCys: 0.247 ± 0.018
1.88GlnAsp: 1.88 ± 0.05
3.362GlnGlu: 3.362 ± 0.069
2.072GlnPhe: 2.072 ± 0.061
2.516GlnGly: 2.516 ± 0.06
0.902GlnHis: 0.902 ± 0.035
3.787GlnIle: 3.787 ± 0.078
3.842GlnLys: 3.842 ± 0.091
6.576GlnLeu: 6.576 ± 0.135
1.385GlnMet: 1.385 ± 0.044
2.269GlnAsn: 2.269 ± 0.061
1.818GlnPro: 1.818 ± 0.057
3.445GlnGln: 3.445 ± 0.108
2.032GlnArg: 2.032 ± 0.048
2.769GlnSer: 2.769 ± 0.072
3.112GlnThr: 3.112 ± 0.074
3.525GlnVal: 3.525 ± 0.078
0.523GlnTrp: 0.523 ± 0.031
1.751GlnTyr: 1.751 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
2.193ArgAla: 2.193 ± 0.069
0.285ArgCys: 0.285 ± 0.02
1.576ArgAsp: 1.576 ± 0.048
2.599ArgGlu: 2.599 ± 0.068
1.869ArgPhe: 1.869 ± 0.049
1.892ArgGly: 1.892 ± 0.055
0.711ArgHis: 0.711 ± 0.03
2.925ArgIle: 2.925 ± 0.063
2.97ArgLys: 2.97 ± 0.073
4.351ArgLeu: 4.351 ± 0.087
1.099ArgMet: 1.099 ± 0.037
1.686ArgAsn: 1.686 ± 0.051
1.177ArgPro: 1.177 ± 0.044
2.155ArgGln: 2.155 ± 0.073
1.671ArgArg: 1.671 ± 0.059
1.877ArgSer: 1.877 ± 0.056
1.736ArgThr: 1.736 ± 0.051
2.329ArgVal: 2.329 ± 0.071
0.34ArgTrp: 0.34 ± 0.023
1.626ArgTyr: 1.626 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
3.954SerAla: 3.954 ± 0.084
0.38SerCys: 0.38 ± 0.028
2.782SerAsp: 2.782 ± 0.086
3.355SerGlu: 3.355 ± 0.085
2.986SerPhe: 2.986 ± 0.079
3.903SerGly: 3.903 ± 0.091
1.105SerHis: 1.105 ± 0.042
4.471SerIle: 4.471 ± 0.073
3.753SerLys: 3.753 ± 0.084
6.034SerLeu: 6.034 ± 0.098
1.482SerMet: 1.482 ± 0.048
2.42SerAsn: 2.42 ± 0.057
1.739SerPro: 1.739 ± 0.059
3.007SerGln: 3.007 ± 0.066
2.04SerArg: 2.04 ± 0.059
3.523SerSer: 3.523 ± 0.109
3.266SerThr: 3.266 ± 0.091
3.784SerVal: 3.784 ± 0.083
0.53SerTrp: 0.53 ± 0.027
2.405SerTyr: 2.405 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
3.852ThrAla: 3.852 ± 0.095
0.383ThrCys: 0.383 ± 0.021
3.191ThrAsp: 3.191 ± 0.195
3.258ThrGlu: 3.258 ± 0.067
2.572ThrPhe: 2.572 ± 0.065
3.78ThrGly: 3.78 ± 0.118
1.155ThrHis: 1.155 ± 0.043
5.03ThrIle: 5.03 ± 0.089
3.678ThrLys: 3.678 ± 0.075
5.649ThrLeu: 5.649 ± 0.093
1.236ThrMet: 1.236 ± 0.034
2.905ThrAsn: 2.905 ± 0.09
2.521ThrPro: 2.521 ± 0.093
2.441ThrGln: 2.441 ± 0.064
1.681ThrArg: 1.681 ± 0.051
3.266ThrSer: 3.266 ± 0.076
3.63ThrThr: 3.63 ± 0.111
3.823ThrVal: 3.823 ± 0.083
0.485ThrTrp: 0.485 ± 0.027
2.05ThrTyr: 2.05 ± 0.057
0.0ThrXaa: 0.0 ± 0.0
Val
5.389ValAla: 5.389 ± 0.096
0.579ValCys: 0.579 ± 0.03
3.863ValAsp: 3.863 ± 0.075
4.3ValGlu: 4.3 ± 0.092
2.869ValPhe: 2.869 ± 0.068
4.335ValGly: 4.335 ± 0.101
1.206ValHis: 1.206 ± 0.044
5.117ValIle: 5.117 ± 0.106
4.257ValLys: 4.257 ± 0.09
6.385ValLeu: 6.385 ± 0.102
1.677ValMet: 1.677 ± 0.05
3.0ValAsn: 3.0 ± 0.073
2.424ValPro: 2.424 ± 0.058
2.74ValGln: 2.74 ± 0.076
2.38ValArg: 2.38 ± 0.06
3.989ValSer: 3.989 ± 0.093
3.938ValThr: 3.938 ± 0.116
4.853ValVal: 4.853 ± 0.097
0.5ValTrp: 0.5 ± 0.028
2.403ValTyr: 2.403 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
0.512TrpAla: 0.512 ± 0.029
0.057TrpCys: 0.057 ± 0.008
0.354TrpAsp: 0.354 ± 0.025
0.456TrpGlu: 0.456 ± 0.025
0.472TrpPhe: 0.472 ± 0.03
0.504TrpGly: 0.504 ± 0.03
0.235TrpHis: 0.235 ± 0.021
0.634TrpIle: 0.634 ± 0.028
0.494TrpLys: 0.494 ± 0.027
1.186TrpLeu: 1.186 ± 0.043
0.26TrpMet: 0.26 ± 0.02
0.414TrpAsn: 0.414 ± 0.021
0.24TrpPro: 0.24 ± 0.017
0.913TrpGln: 0.913 ± 0.046
0.394TrpArg: 0.394 ± 0.02
0.528TrpSer: 0.528 ± 0.027
0.41TrpThr: 0.41 ± 0.025
0.457TrpVal: 0.457 ± 0.026
0.104TrpTrp: 0.104 ± 0.012
0.376TrpTyr: 0.376 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.641TyrAla: 2.641 ± 0.061
0.343TyrCys: 0.343 ± 0.02
1.97TyrAsp: 1.97 ± 0.068
2.432TyrGlu: 2.432 ± 0.064
2.083TyrPhe: 2.083 ± 0.059
2.302TyrGly: 2.302 ± 0.06
1.029TyrHis: 1.029 ± 0.036
2.387TyrIle: 2.387 ± 0.06
1.682TyrLys: 1.682 ± 0.052
4.602TyrLeu: 4.602 ± 0.094
0.706TyrMet: 0.706 ± 0.035
1.431TyrAsn: 1.431 ± 0.052
1.551TyrPro: 1.551 ± 0.048
3.04TyrGln: 3.04 ± 0.091
1.947TyrArg: 1.947 ± 0.06
2.11TyrSer: 2.11 ± 0.058
2.11TyrThr: 2.11 ± 0.081
2.341TyrVal: 2.341 ± 0.054
0.398TyrTrp: 0.398 ± 0.024
1.778TyrTyr: 1.778 ± 0.053
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2315 proteins (724025 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski