Amino acid dipepetide frequency for Oscillibacter sp. CAG:241

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.632AlaAla: 13.632 ± 0.255
1.606AlaCys: 1.606 ± 0.049
5.919AlaAsp: 5.919 ± 0.111
5.975AlaGlu: 5.975 ± 0.118
3.244AlaPhe: 3.244 ± 0.081
8.418AlaGly: 8.418 ± 0.175
1.69AlaHis: 1.69 ± 0.071
4.856AlaIle: 4.856 ± 0.106
3.543AlaLys: 3.543 ± 0.089
10.666AlaLeu: 10.666 ± 0.182
3.048AlaMet: 3.048 ± 0.069
2.173AlaAsn: 2.173 ± 0.067
3.517AlaPro: 3.517 ± 0.09
3.954AlaGln: 3.954 ± 0.093
5.666AlaArg: 5.666 ± 0.118
4.248AlaSer: 4.248 ± 0.103
3.603AlaThr: 3.603 ± 0.102
8.819AlaVal: 8.819 ± 0.185
0.892AlaTrp: 0.892 ± 0.042
2.866AlaTyr: 2.866 ± 0.077
0.002AlaXaa: 0.002 ± 0.002
Cys
1.655CysAla: 1.655 ± 0.053
0.436CysCys: 0.436 ± 0.027
0.936CysAsp: 0.936 ± 0.041
0.702CysGlu: 0.702 ± 0.041
0.59CysPhe: 0.59 ± 0.033
2.026CysGly: 2.026 ± 0.07
0.373CysHis: 0.373 ± 0.026
0.971CysIle: 0.971 ± 0.041
0.586CysLys: 0.586 ± 0.029
1.533CysLeu: 1.533 ± 0.056
0.406CysMet: 0.406 ± 0.03
0.422CysAsn: 0.422 ± 0.029
0.929CysPro: 0.929 ± 0.046
0.6CysGln: 0.6 ± 0.031
1.402CysArg: 1.402 ± 0.053
0.929CysSer: 0.929 ± 0.04
0.966CysThr: 0.966 ± 0.045
1.23CysVal: 1.23 ± 0.046
0.194CysTrp: 0.194 ± 0.019
0.558CysTyr: 0.558 ± 0.032
0.0CysXaa: 0.0 ± 0.0
Asp
5.583AspAla: 5.583 ± 0.103
0.952AspCys: 0.952 ± 0.037
2.982AspAsp: 2.982 ± 0.078
3.499AspGlu: 3.499 ± 0.088
2.164AspPhe: 2.164 ± 0.068
5.512AspGly: 5.512 ± 0.128
1.104AspHis: 1.104 ± 0.042
3.421AspIle: 3.421 ± 0.081
2.586AspLys: 2.586 ± 0.085
5.503AspLeu: 5.503 ± 0.116
1.884AspMet: 1.884 ± 0.058
1.61AspAsn: 1.61 ± 0.051
2.691AspPro: 2.691 ± 0.067
1.944AspGln: 1.944 ± 0.058
3.701AspArg: 3.701 ± 0.081
2.779AspSer: 2.779 ± 0.077
3.246AspThr: 3.246 ± 0.085
4.087AspVal: 4.087 ± 0.092
0.71AspTrp: 0.71 ± 0.041
2.359AspTyr: 2.359 ± 0.075
0.0AspXaa: 0.0 ± 0.0
Glu
5.295GluAla: 5.295 ± 0.107
0.663GluCys: 0.663 ± 0.04
3.526GluAsp: 3.526 ± 0.079
4.6GluGlu: 4.6 ± 0.113
1.753GluPhe: 1.753 ± 0.055
4.033GluGly: 4.033 ± 0.091
1.211GluHis: 1.211 ± 0.051
3.508GluIle: 3.508 ± 0.079
4.133GluLys: 4.133 ± 0.101
6.614GluLeu: 6.614 ± 0.12
1.918GluMet: 1.918 ± 0.065
2.857GluAsn: 2.857 ± 0.076
2.313GluPro: 2.313 ± 0.081
2.749GluGln: 2.749 ± 0.081
3.471GluArg: 3.471 ± 0.086
2.941GluSer: 2.941 ± 0.073
3.277GluThr: 3.277 ± 0.081
3.555GluVal: 3.555 ± 0.081
0.486GluTrp: 0.486 ± 0.028
2.136GluTyr: 2.136 ± 0.072
0.002GluXaa: 0.002 ± 0.001
Phe
3.289PheAla: 3.289 ± 0.078
0.793PheCys: 0.793 ± 0.04
2.507PheAsp: 2.507 ± 0.063
1.627PheGlu: 1.627 ± 0.055
1.482PhePhe: 1.482 ± 0.052
2.915PheGly: 2.915 ± 0.071
0.73PheHis: 0.73 ± 0.033
1.758PheIle: 1.758 ± 0.058
1.041PheLys: 1.041 ± 0.046
3.331PheLeu: 3.331 ± 0.082
0.828PheMet: 0.828 ± 0.038
1.06PheAsn: 1.06 ± 0.045
1.468PhePro: 1.468 ± 0.051
1.092PheGln: 1.092 ± 0.047
2.217PheArg: 2.217 ± 0.069
2.206PheSer: 2.206 ± 0.068
2.159PheThr: 2.159 ± 0.055
2.439PheVal: 2.439 ± 0.064
0.395PheTrp: 0.395 ± 0.029
1.353PheTyr: 1.353 ± 0.05
0.0PheXaa: 0.0 ± 0.0
Gly
7.2GlyAla: 7.2 ± 0.176
1.634GlyCys: 1.634 ± 0.054
4.562GlyAsp: 4.562 ± 0.133
4.532GlyGlu: 4.532 ± 0.085
3.01GlyPhe: 3.01 ± 0.072
7.242GlyGly: 7.242 ± 0.231
1.86GlyHis: 1.86 ± 0.099
4.794GlyIle: 4.794 ± 0.121
4.521GlyLys: 4.521 ± 0.096
7.746GlyLeu: 7.746 ± 0.165
2.465GlyMet: 2.465 ± 0.068
2.353GlyAsn: 2.353 ± 0.078
2.22GlyPro: 2.22 ± 0.076
3.307GlyGln: 3.307 ± 0.092
5.008GlyArg: 5.008 ± 0.104
4.595GlySer: 4.595 ± 0.121
4.514GlyThr: 4.514 ± 0.092
6.534GlyVal: 6.534 ± 0.171
0.913GlyTrp: 0.913 ± 0.043
3.043GlyTyr: 3.043 ± 0.086
0.0GlyXaa: 0.0 ± 0.0
His
1.51HisAla: 1.51 ± 0.06
0.362HisCys: 0.362 ± 0.025
1.081HisAsp: 1.081 ± 0.053
0.948HisGlu: 0.948 ± 0.041
0.744HisPhe: 0.744 ± 0.037
1.827HisGly: 1.827 ± 0.11
0.586HisHis: 0.586 ± 0.057
1.344HisIle: 1.344 ± 0.056
0.686HisLys: 0.686 ± 0.034
1.926HisLeu: 1.926 ± 0.062
0.548HisMet: 0.548 ± 0.032
0.66HisAsn: 0.66 ± 0.03
1.202HisPro: 1.202 ± 0.051
0.7HisGln: 0.7 ± 0.04
1.386HisArg: 1.386 ± 0.064
0.989HisSer: 0.989 ± 0.039
1.122HisThr: 1.122 ± 0.042
1.398HisVal: 1.398 ± 0.06
0.212HisTrp: 0.212 ± 0.018
0.696HisTyr: 0.696 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
5.268IleAla: 5.268 ± 0.106
0.973IleCys: 0.973 ± 0.04
3.174IleAsp: 3.174 ± 0.069
2.528IleGlu: 2.528 ± 0.078
1.879IlePhe: 1.879 ± 0.063
4.143IleGly: 4.143 ± 0.107
1.118IleHis: 1.118 ± 0.048
2.926IleIle: 2.926 ± 0.093
1.858IleLys: 1.858 ± 0.066
5.13IleLeu: 5.13 ± 0.117
1.255IleMet: 1.255 ± 0.055
1.671IleAsn: 1.671 ± 0.062
2.773IlePro: 2.773 ± 0.074
1.793IleGln: 1.793 ± 0.061
3.813IleArg: 3.813 ± 0.082
3.192IleSer: 3.192 ± 0.084
3.295IleThr: 3.295 ± 0.077
3.89IleVal: 3.89 ± 0.102
0.527IleTrp: 0.527 ± 0.033
1.704IleTyr: 1.704 ± 0.058
0.002IleXaa: 0.002 ± 0.002
Lys
3.961LysAla: 3.961 ± 0.095
0.551LysCys: 0.551 ± 0.035
2.436LysAsp: 2.436 ± 0.068
2.845LysGlu: 2.845 ± 0.08
1.043LysPhe: 1.043 ± 0.047
3.006LysGly: 3.006 ± 0.089
0.689LysHis: 0.689 ± 0.039
2.278LysIle: 2.278 ± 0.069
3.139LysLys: 3.139 ± 0.092
4.007LysLeu: 4.007 ± 0.09
1.423LysMet: 1.423 ± 0.059
1.837LysAsn: 1.837 ± 0.071
1.802LysPro: 1.802 ± 0.061
1.542LysGln: 1.542 ± 0.063
2.598LysArg: 2.598 ± 0.07
2.157LysSer: 2.157 ± 0.07
2.681LysThr: 2.681 ± 0.077
2.714LysVal: 2.714 ± 0.079
0.369LysTrp: 0.369 ± 0.025
1.568LysTyr: 1.568 ± 0.06
0.0LysXaa: 0.0 ± 0.0
Leu
9.951LeuAla: 9.951 ± 0.175
2.182LeuCys: 2.182 ± 0.059
5.865LeuAsp: 5.865 ± 0.105
5.785LeuGlu: 5.785 ± 0.102
3.571LeuPhe: 3.571 ± 0.093
7.499LeuGly: 7.499 ± 0.164
2.212LeuHis: 2.212 ± 0.087
4.458LeuIle: 4.458 ± 0.105
3.694LeuLys: 3.694 ± 0.088
11.681LeuLeu: 11.681 ± 0.247
2.663LeuMet: 2.663 ± 0.067
2.894LeuAsn: 2.894 ± 0.075
5.058LeuPro: 5.058 ± 0.1
3.12LeuGln: 3.12 ± 0.084
7.065LeuArg: 7.065 ± 0.14
6.394LeuSer: 6.394 ± 0.122
6.682LeuThr: 6.682 ± 0.128
6.568LeuVal: 6.568 ± 0.138
1.116LeuTrp: 1.116 ± 0.047
3.293LeuTyr: 3.293 ± 0.086
0.002LeuXaa: 0.002 ± 0.001
Met
3.06MetAla: 3.06 ± 0.071
0.322MetCys: 0.322 ± 0.023
2.045MetAsp: 2.045 ± 0.064
2.152MetGlu: 2.152 ± 0.072
0.744MetPhe: 0.744 ± 0.034
2.164MetGly: 2.164 ± 0.068
0.434MetHis: 0.434 ± 0.03
1.323MetIle: 1.323 ± 0.048
1.608MetLys: 1.608 ± 0.056
2.693MetLeu: 2.693 ± 0.085
0.793MetMet: 0.793 ± 0.039
1.076MetAsn: 1.076 ± 0.043
1.207MetPro: 1.207 ± 0.05
1.048MetGln: 1.048 ± 0.047
1.403MetArg: 1.403 ± 0.044
1.657MetSer: 1.657 ± 0.049
1.909MetThr: 1.909 ± 0.058
1.837MetVal: 1.837 ± 0.059
0.191MetTrp: 0.191 ± 0.019
0.7MetTyr: 0.7 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
3.073AsnAla: 3.073 ± 0.079
0.483AsnCys: 0.483 ± 0.03
1.582AsnAsp: 1.582 ± 0.058
1.54AsnGlu: 1.54 ± 0.053
0.973AsnPhe: 0.973 ± 0.048
3.071AsnGly: 3.071 ± 0.101
0.605AsnHis: 0.605 ± 0.03
1.94AsnIle: 1.94 ± 0.063
1.197AsnLys: 1.197 ± 0.047
2.733AsnLeu: 2.733 ± 0.071
0.889AsnMet: 0.889 ± 0.033
1.025AsnAsn: 1.025 ± 0.049
1.608AsnPro: 1.608 ± 0.051
1.039AsnGln: 1.039 ± 0.046
1.877AsnArg: 1.877 ± 0.056
1.41AsnSer: 1.41 ± 0.057
1.776AsnThr: 1.776 ± 0.058
2.257AsnVal: 2.257 ± 0.067
0.304AsnTrp: 0.304 ± 0.025
1.055AsnTyr: 1.055 ± 0.046
0.0AsnXaa: 0.0 ± 0.0
Pro
4.371ProAla: 4.371 ± 0.092
0.679ProCys: 0.679 ± 0.037
2.938ProAsp: 2.938 ± 0.068
4.073ProGlu: 4.073 ± 0.101
1.421ProPhe: 1.421 ± 0.048
3.66ProGly: 3.66 ± 0.086
0.801ProHis: 0.801 ± 0.04
1.979ProIle: 1.979 ± 0.072
1.473ProLys: 1.473 ± 0.057
3.646ProLeu: 3.646 ± 0.096
1.038ProMet: 1.038 ± 0.04
1.123ProAsn: 1.123 ± 0.041
1.433ProPro: 1.433 ± 0.052
1.904ProGln: 1.904 ± 0.062
2.245ProArg: 2.245 ± 0.069
1.849ProSer: 1.849 ± 0.055
2.016ProThr: 2.016 ± 0.062
3.716ProVal: 3.716 ± 0.078
0.472ProTrp: 0.472 ± 0.028
1.491ProTyr: 1.491 ± 0.054
0.0ProXaa: 0.0 ± 0.0
Gln
4.058GlnAla: 4.058 ± 0.095
0.471GlnCys: 0.471 ± 0.031
1.884GlnAsp: 1.884 ± 0.056
2.878GlnGlu: 2.878 ± 0.077
1.094GlnPhe: 1.094 ± 0.047
2.945GlnGly: 2.945 ± 0.081
0.67GlnHis: 0.67 ± 0.041
1.87GlnIle: 1.87 ± 0.055
1.779GlnLys: 1.779 ± 0.057
4.226GlnLeu: 4.226 ± 0.103
1.109GlnMet: 1.109 ± 0.048
1.137GlnAsn: 1.137 ± 0.048
1.47GlnPro: 1.47 ± 0.058
1.911GlnGln: 1.911 ± 0.07
2.635GlnArg: 2.635 ± 0.078
1.592GlnSer: 1.592 ± 0.047
1.8GlnThr: 1.8 ± 0.058
2.929GlnVal: 2.929 ± 0.08
0.439GlnTrp: 0.439 ± 0.028
1.253GlnTyr: 1.253 ± 0.048
0.002GlnXaa: 0.002 ± 0.002
Arg
4.99ArgAla: 4.99 ± 0.116
1.141ArgCys: 1.141 ± 0.044
3.545ArgAsp: 3.545 ± 0.078
4.656ArgGlu: 4.656 ± 0.111
2.301ArgPhe: 2.301 ± 0.066
4.213ArgGly: 4.213 ± 0.096
1.354ArgHis: 1.354 ± 0.05
3.428ArgIle: 3.428 ± 0.084
2.612ArgLys: 2.612 ± 0.077
6.614ArgLeu: 6.614 ± 0.125
1.923ArgMet: 1.923 ± 0.055
1.709ArgAsn: 1.709 ± 0.052
2.598ArgPro: 2.598 ± 0.077
3.618ArgGln: 3.618 ± 0.099
5.653ArgArg: 5.653 ± 0.137
3.186ArgSer: 3.186 ± 0.083
3.069ArgThr: 3.069 ± 0.076
4.336ArgVal: 4.336 ± 0.1
0.712ArgTrp: 0.712 ± 0.033
2.275ArgTyr: 2.275 ± 0.077
0.0ArgXaa: 0.0 ± 0.0
Ser
5.118SerAla: 5.118 ± 0.101
0.934SerCys: 0.934 ± 0.038
2.819SerAsp: 2.819 ± 0.074
2.408SerGlu: 2.408 ± 0.072
2.205SerPhe: 2.205 ± 0.07
5.193SerGly: 5.193 ± 0.118
1.011SerHis: 1.011 ± 0.045
2.779SerIle: 2.779 ± 0.077
1.83SerLys: 1.83 ± 0.066
5.107SerLeu: 5.107 ± 0.106
1.545SerMet: 1.545 ± 0.057
1.417SerAsn: 1.417 ± 0.052
2.131SerPro: 2.131 ± 0.055
1.888SerGln: 1.888 ± 0.068
3.592SerArg: 3.592 ± 0.091
2.661SerSer: 2.661 ± 0.083
2.507SerThr: 2.507 ± 0.077
4.299SerVal: 4.299 ± 0.092
0.607SerTrp: 0.607 ± 0.035
2.037SerTyr: 2.037 ± 0.064
0.0SerXaa: 0.0 ± 0.0
Thr
6.096ThrAla: 6.096 ± 0.129
0.824ThrCys: 0.824 ± 0.042
3.302ThrAsp: 3.302 ± 0.085
3.246ThrGlu: 3.246 ± 0.083
1.914ThrPhe: 1.914 ± 0.062
5.125ThrGly: 5.125 ± 0.099
1.034ThrHis: 1.034 ± 0.045
2.854ThrIle: 2.854 ± 0.081
1.736ThrLys: 1.736 ± 0.052
5.683ThrLeu: 5.683 ± 0.107
1.486ThrMet: 1.486 ± 0.057
1.452ThrAsn: 1.452 ± 0.065
2.807ThrPro: 2.807 ± 0.078
1.713ThrGln: 1.713 ± 0.055
2.644ThrArg: 2.644 ± 0.071
2.413ThrSer: 2.413 ± 0.078
2.721ThrThr: 2.721 ± 0.078
5.75ThrVal: 5.75 ± 0.134
0.576ThrTrp: 0.576 ± 0.034
1.94ThrTyr: 1.94 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
6.18ValAla: 6.18 ± 0.145
1.591ValCys: 1.591 ± 0.053
4.213ValAsp: 4.213 ± 0.107
4.362ValGlu: 4.362 ± 0.106
2.791ValPhe: 2.791 ± 0.067
5.316ValGly: 5.316 ± 0.157
1.517ValHis: 1.517 ± 0.069
4.205ValIle: 4.205 ± 0.093
2.948ValLys: 2.948 ± 0.084
8.234ValLeu: 8.234 ± 0.146
2.009ValMet: 2.009 ± 0.061
2.415ValAsn: 2.415 ± 0.069
3.272ValPro: 3.272 ± 0.07
2.451ValGln: 2.451 ± 0.065
4.556ValArg: 4.556 ± 0.107
4.518ValSer: 4.518 ± 0.102
5.251ValThr: 5.251 ± 0.118
5.736ValVal: 5.736 ± 0.128
0.782ValTrp: 0.782 ± 0.045
2.679ValTyr: 2.679 ± 0.07
0.0ValXaa: 0.0 ± 0.0
Trp
0.894TrpAla: 0.894 ± 0.043
0.184TrpCys: 0.184 ± 0.02
0.626TrpAsp: 0.626 ± 0.029
0.654TrpGlu: 0.654 ± 0.035
0.378TrpPhe: 0.378 ± 0.027
0.838TrpGly: 0.838 ± 0.04
0.213TrpHis: 0.213 ± 0.019
0.404TrpIle: 0.404 ± 0.026
0.43TrpLys: 0.43 ± 0.027
1.256TrpLeu: 1.256 ± 0.056
0.322TrpMet: 0.322 ± 0.023
0.359TrpAsn: 0.359 ± 0.025
0.334TrpPro: 0.334 ± 0.025
0.507TrpGln: 0.507 ± 0.033
0.637TrpArg: 0.637 ± 0.033
0.611TrpSer: 0.611 ± 0.037
0.56TrpThr: 0.56 ± 0.038
0.665TrpVal: 0.665 ± 0.031
0.157TrpTrp: 0.157 ± 0.021
0.39TrpTyr: 0.39 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.151TyrAla: 3.151 ± 0.074
0.663TyrCys: 0.663 ± 0.034
2.374TyrAsp: 2.374 ± 0.078
2.031TyrGlu: 2.031 ± 0.069
1.393TyrPhe: 1.393 ± 0.05
2.903TyrGly: 2.903 ± 0.087
0.712TyrHis: 0.712 ± 0.038
1.816TyrIle: 1.816 ± 0.057
1.242TyrLys: 1.242 ± 0.057
3.422TyrLeu: 3.422 ± 0.079
0.815TyrMet: 0.815 ± 0.042
1.186TyrAsn: 1.186 ± 0.05
1.494TyrPro: 1.494 ± 0.054
1.272TyrGln: 1.272 ± 0.048
2.366TyrArg: 2.366 ± 0.066
1.762TyrSer: 1.762 ± 0.063
2.161TyrThr: 2.161 ± 0.075
2.266TyrVal: 2.266 ± 0.066
0.364TyrTrp: 0.364 ± 0.027
1.386TyrTyr: 1.386 ± 0.059
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.002XaaAla: 0.002 ± 0.002
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.005XaaGly: 0.005 ± 0.003
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.002XaaLys: 0.002 ± 0.002
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.012XaaXaa: 0.012 ± 0.006
Statistics based on 1823 proteins (571517 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski