Amino acid dipepetide frequency for [Ruminococcus] gnavus CAG:126

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.204AlaAla: 7.204 ± 0.117	1.046AlaCys: 1.046 ± 0.035	4.167AlaAsp: 4.167 ± 0.072	5.759AlaGlu: 5.759 ± 0.1	2.924AlaPhe: 2.924 ± 0.067	6.141AlaGly: 6.141 ± 0.097	1.144AlaHis: 1.144 ± 0.043	4.906AlaIle: 4.906 ± 0.09	5.22AlaLys: 5.22 ± 0.084	6.797AlaLeu: 6.797 ± 0.108	2.488AlaMet: 2.488 ± 0.062	2.518AlaAsn: 2.518 ± 0.055	1.963AlaPro: 1.963 ± 0.046	2.452AlaGln: 2.452 ± 0.059	2.919AlaArg: 2.919 ± 0.063	3.717AlaSer: 3.717 ± 0.069	2.874AlaThr: 2.874 ± 0.065	6.521AlaVal: 6.521 ± 0.092	0.639AlaTrp: 0.639 ± 0.029	2.717AlaTyr: 2.717 ± 0.065	0.001AlaXaa: 0.001 ± 0.001
Cys	1.048CysAla: 1.048 ± 0.042	0.263CysCys: 0.263 ± 0.018	0.762CysAsp: 0.762 ± 0.03	1.03CysGlu: 1.03 ± 0.041	0.67CysPhe: 0.67 ± 0.029	1.503CysGly: 1.503 ± 0.049	0.299CysHis: 0.299 ± 0.019	1.123CysIle: 1.123 ± 0.039	0.815CysLys: 0.815 ± 0.033	1.163CysLeu: 1.163 ± 0.038	0.517CysMet: 0.517 ± 0.027	0.548CysAsn: 0.548 ± 0.029	0.612CysPro: 0.612 ± 0.029	0.462CysGln: 0.462 ± 0.025	0.786CysArg: 0.786 ± 0.033	0.882CysSer: 0.882 ± 0.037	0.789CysThr: 0.789 ± 0.03	1.152CysVal: 1.152 ± 0.038	0.107CysTrp: 0.107 ± 0.011	0.561CysTyr: 0.561 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	4.098AspAla: 4.098 ± 0.084	0.785AspCys: 0.785 ± 0.029	2.412AspAsp: 2.412 ± 0.067	4.272AspGlu: 4.272 ± 0.081	2.363AspPhe: 2.363 ± 0.059	4.012AspGly: 4.012 ± 0.071	0.925AspHis: 0.925 ± 0.039	3.946AspIle: 3.946 ± 0.079	3.026AspLys: 3.026 ± 0.065	4.458AspLeu: 4.458 ± 0.071	1.856AspMet: 1.856 ± 0.044	1.661AspAsn: 1.661 ± 0.048	1.757AspPro: 1.757 ± 0.048	1.502AspGln: 1.502 ± 0.052	2.217AspArg: 2.217 ± 0.062	2.798AspSer: 2.798 ± 0.068	2.98AspThr: 2.98 ± 0.067	3.948AspVal: 3.948 ± 0.059	0.536AspTrp: 0.536 ± 0.027	2.479AspTyr: 2.479 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	5.707GluAla: 5.707 ± 0.103	0.98GluCys: 0.98 ± 0.041	4.29GluAsp: 4.29 ± 0.078	8.825GluGlu: 8.825 ± 0.141	2.874GluPhe: 2.874 ± 0.066	4.635GluGly: 4.635 ± 0.087	1.61GluHis: 1.61 ± 0.049	6.317GluIle: 6.317 ± 0.109	7.621GluLys: 7.621 ± 0.108	7.143GluLeu: 7.143 ± 0.093	2.84GluMet: 2.84 ± 0.062	4.186GluAsn: 4.186 ± 0.076	1.839GluPro: 1.839 ± 0.05	3.584GluGln: 3.584 ± 0.084	3.608GluArg: 3.608 ± 0.074	3.504GluSer: 3.504 ± 0.076	4.269GluThr: 4.269 ± 0.079	5.08GluVal: 5.08 ± 0.103	0.704GluTrp: 0.704 ± 0.033	3.279GluTyr: 3.279 ± 0.063	0.0GluXaa: 0.0 ± 0.0
Phe	2.988PheAla: 2.988 ± 0.073	0.828PheCys: 0.828 ± 0.035	2.282PheAsp: 2.282 ± 0.056	2.935PheGlu: 2.935 ± 0.064	1.777PhePhe: 1.777 ± 0.047	3.242PheGly: 3.242 ± 0.071	0.867PheHis: 0.867 ± 0.039	2.567PheIle: 2.567 ± 0.057	1.788PheLys: 1.788 ± 0.051	4.16PheLeu: 4.16 ± 0.083	1.265PheMet: 1.265 ± 0.042	1.259PheAsn: 1.259 ± 0.046	1.416PhePro: 1.416 ± 0.047	1.569PheGln: 1.569 ± 0.036	1.692PheArg: 1.692 ± 0.051	2.701PheSer: 2.701 ± 0.057	2.22PheThr: 2.22 ± 0.053	2.949PheVal: 2.949 ± 0.066	0.426PheTrp: 0.426 ± 0.024	1.652PheTyr: 1.652 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	5.037GlyAla: 5.037 ± 0.099	1.403GlyCys: 1.403 ± 0.047	3.236GlyAsp: 3.236 ± 0.08	5.063GlyGlu: 5.063 ± 0.09	3.101GlyPhe: 3.101 ± 0.061	4.768GlyGly: 4.768 ± 0.096	1.259GlyHis: 1.259 ± 0.044	6.51GlyIle: 6.51 ± 0.107	5.508GlyLys: 5.508 ± 0.083	5.678GlyLeu: 5.678 ± 0.112	2.67GlyMet: 2.67 ± 0.052	3.076GlyAsn: 3.076 ± 0.07	1.328GlyPro: 1.328 ± 0.046	2.16GlyGln: 2.16 ± 0.057	3.097GlyArg: 3.097 ± 0.072	3.898GlySer: 3.898 ± 0.069	4.234GlyThr: 4.234 ± 0.095	5.284GlyVal: 5.284 ± 0.088	0.663GlyTrp: 0.663 ± 0.036	3.292GlyTyr: 3.292 ± 0.07	0.0GlyXaa: 0.0 ± 0.0
His	1.245HisAla: 1.245 ± 0.038	0.324HisCys: 0.324 ± 0.022	0.863HisAsp: 0.863 ± 0.035	1.095HisGlu: 1.095 ± 0.036	0.824HisPhe: 0.824 ± 0.032	1.284HisGly: 1.284 ± 0.042	0.445HisHis: 0.445 ± 0.037	1.432HisIle: 1.432 ± 0.048	0.933HisLys: 0.933 ± 0.035	1.658HisLeu: 1.658 ± 0.044	0.573HisMet: 0.573 ± 0.029	0.648HisAsn: 0.648 ± 0.025	0.956HisPro: 0.956 ± 0.035	0.645HisGln: 0.645 ± 0.028	0.793HisArg: 0.793 ± 0.033	0.941HisSer: 0.941 ± 0.038	1.059HisThr: 1.059 ± 0.039	1.28HisVal: 1.28 ± 0.047	0.159HisTrp: 0.159 ± 0.015	0.771HisTyr: 0.771 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.588IleAla: 5.588 ± 0.094	1.429IleCys: 1.429 ± 0.044	3.609IleAsp: 3.609 ± 0.072	5.199IleGlu: 5.199 ± 0.094	2.854IlePhe: 2.854 ± 0.072	5.353IleGly: 5.353 ± 0.089	1.403IleHis: 1.403 ± 0.045	4.297IleIle: 4.297 ± 0.084	3.729IleLys: 3.729 ± 0.078	7.769IleLeu: 7.769 ± 0.125	1.895IleMet: 1.895 ± 0.052	2.432IleAsn: 2.432 ± 0.065	3.371IlePro: 3.371 ± 0.066	2.897IleGln: 2.897 ± 0.054	3.859IleArg: 3.859 ± 0.086	4.666IleSer: 4.666 ± 0.086	3.942IleThr: 3.942 ± 0.073	5.186IleVal: 5.186 ± 0.085	0.66IleTrp: 0.66 ± 0.029	2.701IleTyr: 2.701 ± 0.064	0.001IleXaa: 0.001 ± 0.001
Lys	5.061LysAla: 5.061 ± 0.089	0.697LysCys: 0.697 ± 0.03	3.637LysAsp: 3.637 ± 0.068	7.915LysGlu: 7.915 ± 0.118	1.894LysPhe: 1.894 ± 0.049	4.247LysGly: 4.247 ± 0.072	1.106LysHis: 1.106 ± 0.039	4.984LysIle: 4.984 ± 0.081	6.523LysLys: 6.523 ± 0.09	5.305LysLeu: 5.305 ± 0.077	2.38LysMet: 2.38 ± 0.058	3.42LysAsn: 3.42 ± 0.078	1.845LysPro: 1.845 ± 0.056	2.702LysGln: 2.702 ± 0.067	3.283LysArg: 3.283 ± 0.065	3.309LysSer: 3.309 ± 0.071	3.705LysThr: 3.705 ± 0.066	4.475LysVal: 4.475 ± 0.079	0.626LysTrp: 0.626 ± 0.026	2.692LysTyr: 2.692 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	6.705LeuAla: 6.705 ± 0.105	1.497LeuCys: 1.497 ± 0.044	4.923LeuAsp: 4.923 ± 0.088	7.182LeuGlu: 7.182 ± 0.113	3.832LeuPhe: 3.832 ± 0.082	6.09LeuGly: 6.09 ± 0.113	1.624LeuHis: 1.624 ± 0.044	6.287LeuIle: 6.287 ± 0.102	6.63LeuLys: 6.63 ± 0.102	8.948LeuLeu: 8.948 ± 0.155	2.682LeuMet: 2.682 ± 0.057	3.832LeuAsn: 3.832 ± 0.071	3.562LeuPro: 3.562 ± 0.074	3.043LeuGln: 3.043 ± 0.068	3.613LeuArg: 3.613 ± 0.075	5.885LeuSer: 5.885 ± 0.089	4.946LeuThr: 4.946 ± 0.08	5.346LeuVal: 5.346 ± 0.091	0.742LeuTrp: 0.742 ± 0.03	3.331LeuTyr: 3.331 ± 0.07	0.0LeuXaa: 0.0 ± 0.0
Met	2.394MetAla: 2.394 ± 0.056	0.396MetCys: 0.396 ± 0.023	1.805MetAsp: 1.805 ± 0.051	2.95MetGlu: 2.95 ± 0.064	1.089MetPhe: 1.089 ± 0.035	2.147MetGly: 2.147 ± 0.054	0.514MetHis: 0.514 ± 0.022	2.32MetIle: 2.32 ± 0.058	2.801MetLys: 2.801 ± 0.063	2.935MetLeu: 2.935 ± 0.066	0.996MetMet: 0.996 ± 0.037	1.554MetAsn: 1.554 ± 0.039	1.159MetPro: 1.159 ± 0.033	1.297MetGln: 1.297 ± 0.044	1.424MetArg: 1.424 ± 0.043	1.759MetSer: 1.759 ± 0.054	1.813MetThr: 1.813 ± 0.047	1.9MetVal: 1.9 ± 0.055	0.25MetTrp: 0.25 ± 0.018	0.977MetTyr: 0.977 ± 0.036	0.0MetXaa: 0.0 ± 0.0
Asn	2.954AsnAla: 2.954 ± 0.059	0.586AsnCys: 0.586 ± 0.027	1.789AsnAsp: 1.789 ± 0.05	2.714AsnGlu: 2.714 ± 0.069	1.483AsnPhe: 1.483 ± 0.047	3.344AsnGly: 3.344 ± 0.067	0.779AsnHis: 0.779 ± 0.032	3.017AsnIle: 3.017 ± 0.06	2.136AsnLys: 2.136 ± 0.051	3.843AsnLeu: 3.843 ± 0.076	1.328AsnMet: 1.328 ± 0.044	1.445AsnAsn: 1.445 ± 0.051	1.991AsnPro: 1.991 ± 0.055	1.609AsnGln: 1.609 ± 0.052	1.926AsnArg: 1.926 ± 0.057	2.039AsnSer: 2.039 ± 0.054	2.174AsnThr: 2.174 ± 0.06	2.758AsnVal: 2.758 ± 0.062	0.393AsnTrp: 0.393 ± 0.02	1.624AsnTyr: 1.624 ± 0.045	0.001AsnXaa: 0.001 ± 0.001
Pro	2.338ProAla: 2.338 ± 0.057	0.441ProCys: 0.441 ± 0.023	2.184ProAsp: 2.184 ± 0.054	3.276ProGlu: 3.276 ± 0.071	1.549ProPhe: 1.549 ± 0.048	2.344ProGly: 2.344 ± 0.059	0.556ProHis: 0.556 ± 0.029	2.176ProIle: 2.176 ± 0.052	2.14ProLys: 2.14 ± 0.055	2.706ProLeu: 2.706 ± 0.058	0.896ProMet: 0.896 ± 0.036	1.202ProAsn: 1.202 ± 0.045	0.698ProPro: 0.698 ± 0.035	1.135ProGln: 1.135 ± 0.038	0.99ProArg: 0.99 ± 0.041	1.697ProSer: 1.697 ± 0.054	1.503ProThr: 1.503 ± 0.042	3.009ProVal: 3.009 ± 0.061	0.306ProTrp: 0.306 ± 0.023	1.418ProTyr: 1.418 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	2.59GlnAla: 2.59 ± 0.058	0.401GlnCys: 0.401 ± 0.027	1.76GlnAsp: 1.76 ± 0.05	3.31GlnGlu: 3.31 ± 0.077	1.343GlnPhe: 1.343 ± 0.04	2.131GlnGly: 2.131 ± 0.054	0.483GlnHis: 0.483 ± 0.026	3.167GlnIle: 3.167 ± 0.066	3.4GlnLys: 3.4 ± 0.076	2.937GlnLeu: 2.937 ± 0.06	1.43GlnMet: 1.43 ± 0.043	1.697GlnAsn: 1.697 ± 0.052	0.852GlnPro: 0.852 ± 0.032	1.217GlnGln: 1.217 ± 0.046	1.466GlnArg: 1.466 ± 0.05	1.778GlnSer: 1.778 ± 0.049	1.893GlnThr: 1.893 ± 0.054	2.406GlnVal: 2.406 ± 0.056	0.329GlnTrp: 0.329 ± 0.021	1.444GlnTyr: 1.444 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	2.806ArgAla: 2.806 ± 0.071	0.568ArgCys: 0.568 ± 0.027	2.033ArgAsp: 2.033 ± 0.048	4.174ArgGlu: 4.174 ± 0.081	1.86ArgPhe: 1.86 ± 0.049	2.551ArgGly: 2.551 ± 0.067	0.775ArgHis: 0.775 ± 0.033	3.552ArgIle: 3.552 ± 0.062	3.661ArgLys: 3.661 ± 0.078	3.74ArgLeu: 3.74 ± 0.086	1.641ArgMet: 1.641 ± 0.04	1.899ArgAsn: 1.899 ± 0.05	1.317ArgPro: 1.317 ± 0.046	1.903ArgGln: 1.903 ± 0.047	2.382ArgArg: 2.382 ± 0.062	2.06ArgSer: 2.06 ± 0.053	2.319ArgThr: 2.319 ± 0.05	2.693ArgVal: 2.693 ± 0.058	0.392ArgTrp: 0.392 ± 0.025	1.844ArgTyr: 1.844 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	4.159SerAla: 4.159 ± 0.071	0.867SerCys: 0.867 ± 0.035	2.905SerAsp: 2.905 ± 0.064	4.015SerGlu: 4.015 ± 0.072	2.471SerPhe: 2.471 ± 0.059	4.826SerGly: 4.826 ± 0.077	0.994SerHis: 0.994 ± 0.037	3.777SerIle: 3.777 ± 0.071	3.1SerLys: 3.1 ± 0.068	4.782SerLeu: 4.782 ± 0.08	1.807SerMet: 1.807 ± 0.054	1.954SerAsn: 1.954 ± 0.051	1.684SerPro: 1.684 ± 0.049	1.787SerGln: 1.787 ± 0.055	2.688SerArg: 2.688 ± 0.063	3.221SerSer: 3.221 ± 0.065	2.54SerThr: 2.54 ± 0.053	4.404SerVal: 4.404 ± 0.069	0.519SerTrp: 0.519 ± 0.029	2.331SerTyr: 2.331 ± 0.057	0.001SerXaa: 0.001 ± 0.001
Thr	4.224ThrAla: 4.224 ± 0.079	0.644ThrCys: 0.644 ± 0.029	2.944ThrAsp: 2.944 ± 0.061	4.111ThrGlu: 4.111 ± 0.072	2.227ThrPhe: 2.227 ± 0.058	4.605ThrGly: 4.605 ± 0.094	0.906ThrHis: 0.906 ± 0.035	3.711ThrIle: 3.711 ± 0.081	3.256ThrLys: 3.256 ± 0.06	4.746ThrLeu: 4.746 ± 0.078	1.513ThrMet: 1.513 ± 0.052	1.859ThrAsn: 1.859 ± 0.053	2.077ThrPro: 2.077 ± 0.06	1.598ThrGln: 1.598 ± 0.049	2.005ThrArg: 2.005 ± 0.045	2.733ThrSer: 2.733 ± 0.06	2.799ThrThr: 2.799 ± 0.067	4.325ThrVal: 4.325 ± 0.076	0.476ThrTrp: 0.476 ± 0.025	2.054ThrTyr: 2.054 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	4.692ValAla: 4.692 ± 0.089	1.208ValCys: 1.208 ± 0.037	3.662ValAsp: 3.662 ± 0.065	5.1ValGlu: 5.1 ± 0.098	3.217ValPhe: 3.217 ± 0.079	4.389ValGly: 4.389 ± 0.079	1.191ValHis: 1.191 ± 0.041	5.414ValIle: 5.414 ± 0.091	4.608ValLys: 4.608 ± 0.08	7.299ValLeu: 7.299 ± 0.113	2.228ValMet: 2.228 ± 0.053	2.68ValAsn: 2.68 ± 0.056	2.501ValPro: 2.501 ± 0.052	2.321ValGln: 2.321 ± 0.053	3.066ValArg: 3.066 ± 0.066	4.617ValSer: 4.617 ± 0.088	4.157ValThr: 4.157 ± 0.09	4.978ValVal: 4.978 ± 0.097	0.703ValTrp: 0.703 ± 0.037	2.716ValTyr: 2.716 ± 0.061	0.001ValXaa: 0.001 ± 0.001
Trp	0.509TrpAla: 0.509 ± 0.024	0.159TrpCys: 0.159 ± 0.015	0.486TrpAsp: 0.486 ± 0.027	0.708TrpGlu: 0.708 ± 0.031	0.417TrpPhe: 0.417 ± 0.026	0.649TrpGly: 0.649 ± 0.031	0.144TrpHis: 0.144 ± 0.014	0.709TrpIle: 0.709 ± 0.033	0.784TrpLys: 0.784 ± 0.034	0.82TrpLeu: 0.82 ± 0.03	0.41TrpMet: 0.41 ± 0.021	0.531TrpAsn: 0.531 ± 0.029	0.202TrpPro: 0.202 ± 0.016	0.353TrpGln: 0.353 ± 0.02	0.334TrpArg: 0.334 ± 0.022	0.51TrpSer: 0.51 ± 0.025	0.415TrpThr: 0.415 ± 0.024	0.47TrpVal: 0.47 ± 0.026	0.102TrpTrp: 0.102 ± 0.012	0.41TrpTyr: 0.41 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.77TyrAla: 2.77 ± 0.066	0.571TyrCys: 0.571 ± 0.027	2.28TyrAsp: 2.28 ± 0.057	3.261TyrGlu: 3.261 ± 0.068	1.813TyrPhe: 1.813 ± 0.054	3.004TyrGly: 3.004 ± 0.063	0.905TyrHis: 0.905 ± 0.037	2.627TyrIle: 2.627 ± 0.057	2.127TyrLys: 2.127 ± 0.054	3.812TyrLeu: 3.812 ± 0.071	1.062TyrMet: 1.062 ± 0.036	1.534TyrAsn: 1.534 ± 0.048	1.433TyrPro: 1.433 ± 0.042	1.797TyrGln: 1.797 ± 0.057	2.023TyrArg: 2.023 ± 0.052	2.116TyrSer: 2.116 ± 0.056	2.18TyrThr: 2.18 ± 0.057	2.586TyrVal: 2.586 ± 0.062	0.388TyrTrp: 0.388 ± 0.025	1.739TyrTyr: 1.739 ± 0.048	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.001XaaAla: 0.001 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.003XaaGlu: 0.003 ± 0.002	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.009XaaXaa: 0.009 ± 0.006

Statistics based on 2588 proteins (793556 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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