Amino acid dipepetide frequency for Streptococcus phage Javan553

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.68AlaAla: 5.68 ± 1.02
0.445AlaCys: 0.445 ± 0.248
4.121AlaAsp: 4.121 ± 0.708
5.346AlaGlu: 5.346 ± 0.93
2.562AlaPhe: 2.562 ± 0.565
3.787AlaGly: 3.787 ± 0.827
0.557AlaHis: 0.557 ± 0.231
5.68AlaIle: 5.68 ± 1.084
4.678AlaLys: 4.678 ± 0.663
6.571AlaLeu: 6.571 ± 0.96
2.896AlaMet: 2.896 ± 0.503
3.898AlaAsn: 3.898 ± 0.601
1.671AlaPro: 1.671 ± 0.396
3.007AlaGln: 3.007 ± 0.667
3.675AlaArg: 3.675 ± 0.531
5.123AlaSer: 5.123 ± 0.883
3.341AlaThr: 3.341 ± 0.66
5.123AlaVal: 5.123 ± 0.818
0.557AlaTrp: 0.557 ± 0.288
2.673AlaTyr: 2.673 ± 0.579
0.0AlaXaa: 0.0 ± 0.0
Cys
0.223CysAla: 0.223 ± 0.147
0.0CysCys: 0.0 ± 0.0
0.557CysAsp: 0.557 ± 0.246
0.557CysGlu: 0.557 ± 0.246
0.111CysPhe: 0.111 ± 0.117
0.223CysGly: 0.223 ± 0.181
0.223CysHis: 0.223 ± 0.147
0.445CysIle: 0.445 ± 0.202
0.111CysLys: 0.111 ± 0.1
0.334CysLeu: 0.334 ± 0.175
0.111CysMet: 0.111 ± 0.098
0.223CysAsn: 0.223 ± 0.154
0.0CysPro: 0.0 ± 0.0
0.223CysGln: 0.223 ± 0.165
0.223CysArg: 0.223 ± 0.16
0.334CysSer: 0.334 ± 0.174
0.223CysThr: 0.223 ± 0.146
0.557CysVal: 0.557 ± 0.252
0.0CysTrp: 0.0 ± 0.0
0.111CysTyr: 0.111 ± 0.1
0.0CysXaa: 0.0 ± 0.0
Asp
4.121AspAla: 4.121 ± 0.68
0.334AspCys: 0.334 ± 0.16
3.23AspAsp: 3.23 ± 0.849
4.678AspGlu: 4.678 ± 0.73
4.232AspPhe: 4.232 ± 0.733
4.121AspGly: 4.121 ± 0.651
0.445AspHis: 0.445 ± 0.174
4.232AspIle: 4.232 ± 0.834
5.123AspLys: 5.123 ± 0.712
4.121AspLeu: 4.121 ± 0.72
1.782AspMet: 1.782 ± 0.513
4.009AspAsn: 4.009 ± 0.709
1.893AspPro: 1.893 ± 0.337
1.336AspGln: 1.336 ± 0.351
2.227AspArg: 2.227 ± 0.518
3.118AspSer: 3.118 ± 0.627
2.896AspThr: 2.896 ± 0.502
2.784AspVal: 2.784 ± 0.464
1.671AspTrp: 1.671 ± 0.545
2.896AspTyr: 2.896 ± 0.51
0.0AspXaa: 0.0 ± 0.0
Glu
5.346GluAla: 5.346 ± 0.876
0.223GluCys: 0.223 ± 0.166
3.787GluAsp: 3.787 ± 0.554
6.125GluGlu: 6.125 ± 0.956
2.673GluPhe: 2.673 ± 0.478
4.9GluGly: 4.9 ± 0.53
1.114GluHis: 1.114 ± 0.314
6.014GluIle: 6.014 ± 0.783
6.682GluLys: 6.682 ± 0.99
8.687GluLeu: 8.687 ± 1.266
2.005GluMet: 2.005 ± 0.422
4.009GluAsn: 4.009 ± 0.615
1.893GluPro: 1.893 ± 0.544
4.9GluGln: 4.9 ± 0.782
4.121GluArg: 4.121 ± 0.783
4.009GluSer: 4.009 ± 0.825
3.453GluThr: 3.453 ± 0.636
5.791GluVal: 5.791 ± 0.701
1.336GluTrp: 1.336 ± 0.417
2.896GluTyr: 2.896 ± 0.696
0.0GluXaa: 0.0 ± 0.0
Phe
3.23PheAla: 3.23 ± 0.509
0.223PheCys: 0.223 ± 0.146
3.675PheAsp: 3.675 ± 0.617
3.898PheGlu: 3.898 ± 0.865
2.45PhePhe: 2.45 ± 0.673
2.673PheGly: 2.673 ± 0.614
0.78PheHis: 0.78 ± 0.259
2.227PheIle: 2.227 ± 0.722
4.566PheLys: 4.566 ± 0.764
3.341PheLeu: 3.341 ± 0.667
1.114PheMet: 1.114 ± 0.29
3.453PheAsn: 3.453 ± 0.422
1.114PhePro: 1.114 ± 0.403
1.782PheGln: 1.782 ± 0.422
1.782PheArg: 1.782 ± 0.51
2.227PheSer: 2.227 ± 0.537
2.562PheThr: 2.562 ± 0.515
2.005PheVal: 2.005 ± 0.359
0.334PheTrp: 0.334 ± 0.183
1.114PheTyr: 1.114 ± 0.431
0.0PheXaa: 0.0 ± 0.0
Gly
3.23GlyAla: 3.23 ± 0.766
0.223GlyCys: 0.223 ± 0.259
3.675GlyAsp: 3.675 ± 0.531
2.562GlyGlu: 2.562 ± 0.481
2.45GlyPhe: 2.45 ± 0.62
4.9GlyGly: 4.9 ± 0.866
0.78GlyHis: 0.78 ± 0.332
5.123GlyIle: 5.123 ± 0.691
6.237GlyLys: 6.237 ± 0.811
5.68GlyLeu: 5.68 ± 0.947
1.893GlyMet: 1.893 ± 0.54
3.007GlyAsn: 3.007 ± 0.532
0.78GlyPro: 0.78 ± 0.323
2.784GlyGln: 2.784 ± 0.651
3.23GlyArg: 3.23 ± 0.597
2.896GlySer: 2.896 ± 0.582
3.118GlyThr: 3.118 ± 0.544
3.564GlyVal: 3.564 ± 0.506
0.668GlyTrp: 0.668 ± 0.256
2.562GlyTyr: 2.562 ± 0.494
0.0GlyXaa: 0.0 ± 0.0
His
0.557HisAla: 0.557 ± 0.223
0.223HisCys: 0.223 ± 0.13
1.448HisAsp: 1.448 ± 0.434
1.336HisGlu: 1.336 ± 0.358
0.334HisPhe: 0.334 ± 0.192
0.668HisGly: 0.668 ± 0.275
0.334HisHis: 0.334 ± 0.205
1.893HisIle: 1.893 ± 0.365
0.223HisLys: 0.223 ± 0.144
1.448HisLeu: 1.448 ± 0.488
0.334HisMet: 0.334 ± 0.187
0.557HisAsn: 0.557 ± 0.238
0.111HisPro: 0.111 ± 0.104
0.78HisGln: 0.78 ± 0.32
0.445HisArg: 0.445 ± 0.264
1.336HisSer: 1.336 ± 0.373
1.002HisThr: 1.002 ± 0.283
0.668HisVal: 0.668 ± 0.297
0.111HisTrp: 0.111 ± 0.117
1.336HisTyr: 1.336 ± 0.417
0.0HisXaa: 0.0 ± 0.0
Ile
5.234IleAla: 5.234 ± 0.819
0.445IleCys: 0.445 ± 0.235
5.012IleAsp: 5.012 ± 0.739
6.348IleGlu: 6.348 ± 0.737
2.227IlePhe: 2.227 ± 0.482
4.121IleGly: 4.121 ± 0.61
1.114IleHis: 1.114 ± 0.277
4.343IleIle: 4.343 ± 0.698
6.682IleLys: 6.682 ± 0.801
6.571IleLeu: 6.571 ± 0.838
1.336IleMet: 1.336 ± 0.425
5.346IleAsn: 5.346 ± 0.866
2.339IlePro: 2.339 ± 0.676
3.898IleGln: 3.898 ± 0.607
3.341IleArg: 3.341 ± 0.669
3.341IleSer: 3.341 ± 0.719
3.118IleThr: 3.118 ± 0.59
4.9IleVal: 4.9 ± 0.884
0.891IleTrp: 0.891 ± 0.337
1.893IleTyr: 1.893 ± 0.527
0.0IleXaa: 0.0 ± 0.0
Lys
6.125LysAla: 6.125 ± 0.912
0.223LysCys: 0.223 ± 0.162
3.675LysAsp: 3.675 ± 0.548
7.239LysGlu: 7.239 ± 0.882
3.118LysPhe: 3.118 ± 0.606
4.9LysGly: 4.9 ± 0.48
1.336LysHis: 1.336 ± 0.413
4.9LysIle: 4.9 ± 0.536
6.348LysLys: 6.348 ± 1.09
6.46LysLeu: 6.46 ± 0.721
1.893LysMet: 1.893 ± 0.51
4.232LysAsn: 4.232 ± 1.05
3.341LysPro: 3.341 ± 0.576
4.343LysGln: 4.343 ± 0.798
4.009LysArg: 4.009 ± 0.75
5.234LysSer: 5.234 ± 0.839
4.232LysThr: 4.232 ± 0.664
3.675LysVal: 3.675 ± 0.801
1.114LysTrp: 1.114 ± 0.365
2.673LysTyr: 2.673 ± 0.591
0.0LysXaa: 0.0 ± 0.0
Leu
7.907LeuAla: 7.907 ± 0.942
0.445LeuCys: 0.445 ± 0.203
5.346LeuAsp: 5.346 ± 0.641
7.796LeuGlu: 7.796 ± 0.844
2.896LeuPhe: 2.896 ± 0.763
3.675LeuGly: 3.675 ± 0.554
1.671LeuHis: 1.671 ± 0.343
7.016LeuIle: 7.016 ± 1.101
7.573LeuLys: 7.573 ± 0.681
7.462LeuLeu: 7.462 ± 1.034
2.116LeuMet: 2.116 ± 0.413
4.566LeuAsn: 4.566 ± 0.698
2.784LeuPro: 2.784 ± 0.532
3.118LeuGln: 3.118 ± 0.726
3.453LeuArg: 3.453 ± 0.7
4.566LeuSer: 4.566 ± 0.786
6.682LeuThr: 6.682 ± 0.801
5.012LeuVal: 5.012 ± 0.611
0.78LeuTrp: 0.78 ± 0.285
2.896LeuTyr: 2.896 ± 0.667
0.0LeuXaa: 0.0 ± 0.0
Met
3.118MetAla: 3.118 ± 0.476
0.111MetCys: 0.111 ± 0.116
0.78MetAsp: 0.78 ± 0.276
1.782MetGlu: 1.782 ± 0.382
1.225MetPhe: 1.225 ± 0.365
1.002MetGly: 1.002 ± 0.278
0.223MetHis: 0.223 ± 0.13
2.005MetIle: 2.005 ± 0.448
2.673MetLys: 2.673 ± 0.57
1.782MetLeu: 1.782 ± 0.516
0.668MetMet: 0.668 ± 0.254
1.336MetAsn: 1.336 ± 0.403
1.002MetPro: 1.002 ± 0.321
0.334MetGln: 0.334 ± 0.188
0.891MetArg: 0.891 ± 0.287
2.896MetSer: 2.896 ± 0.623
2.784MetThr: 2.784 ± 0.522
0.891MetVal: 0.891 ± 0.331
0.111MetTrp: 0.111 ± 0.118
0.668MetTyr: 0.668 ± 0.252
0.0MetXaa: 0.0 ± 0.0
Asn
3.23AsnAla: 3.23 ± 0.671
0.111AsnCys: 0.111 ± 0.1
2.562AsnAsp: 2.562 ± 0.493
4.343AsnGlu: 4.343 ± 0.668
2.784AsnPhe: 2.784 ± 0.676
6.237AsnGly: 6.237 ± 0.937
1.002AsnHis: 1.002 ± 0.333
3.564AsnIle: 3.564 ± 0.684
4.455AsnLys: 4.455 ± 0.886
5.012AsnLeu: 5.012 ± 0.712
2.227AsnMet: 2.227 ± 0.445
2.339AsnAsn: 2.339 ± 0.517
1.782AsnPro: 1.782 ± 0.441
2.116AsnGln: 2.116 ± 0.464
1.893AsnArg: 1.893 ± 0.503
2.562AsnSer: 2.562 ± 0.452
4.232AsnThr: 4.232 ± 0.741
3.787AsnVal: 3.787 ± 0.657
1.002AsnTrp: 1.002 ± 0.306
1.671AsnTyr: 1.671 ± 0.502
0.0AsnXaa: 0.0 ± 0.0
Pro
2.116ProAla: 2.116 ± 0.499
0.223ProCys: 0.223 ± 0.18
1.559ProAsp: 1.559 ± 0.441
1.893ProGlu: 1.893 ± 0.457
1.002ProPhe: 1.002 ± 0.369
1.336ProGly: 1.336 ± 0.376
0.445ProHis: 0.445 ± 0.253
2.784ProIle: 2.784 ± 0.494
1.782ProLys: 1.782 ± 0.456
1.671ProLeu: 1.671 ± 0.363
0.223ProMet: 0.223 ± 0.16
1.782ProAsn: 1.782 ± 0.421
0.334ProPro: 0.334 ± 0.242
1.448ProGln: 1.448 ± 0.393
1.336ProArg: 1.336 ± 0.379
1.893ProSer: 1.893 ± 0.504
2.005ProThr: 2.005 ± 0.445
1.893ProVal: 1.893 ± 0.541
0.557ProTrp: 0.557 ± 0.263
0.891ProTyr: 0.891 ± 0.293
0.0ProXaa: 0.0 ± 0.0
Gln
4.566GlnAla: 4.566 ± 0.704
0.111GlnCys: 0.111 ± 0.112
2.562GlnAsp: 2.562 ± 0.533
4.009GlnGlu: 4.009 ± 0.742
2.339GlnPhe: 2.339 ± 0.529
1.671GlnGly: 1.671 ± 0.483
1.002GlnHis: 1.002 ± 0.49
2.227GlnIle: 2.227 ± 0.507
2.562GlnLys: 2.562 ± 0.481
4.121GlnLeu: 4.121 ± 0.788
1.002GlnMet: 1.002 ± 0.336
2.896GlnAsn: 2.896 ± 0.563
1.336GlnPro: 1.336 ± 0.448
2.45GlnGln: 2.45 ± 0.49
2.005GlnArg: 2.005 ± 0.456
2.339GlnSer: 2.339 ± 0.437
1.782GlnThr: 1.782 ± 0.492
2.784GlnVal: 2.784 ± 0.474
0.111GlnTrp: 0.111 ± 0.087
2.339GlnTyr: 2.339 ± 0.49
0.0GlnXaa: 0.0 ± 0.0
Arg
2.339ArgAla: 2.339 ± 0.47
0.0ArgCys: 0.0 ± 0.0
2.005ArgAsp: 2.005 ± 0.424
4.232ArgGlu: 4.232 ± 0.752
1.671ArgPhe: 1.671 ± 0.488
2.116ArgGly: 2.116 ± 0.426
0.891ArgHis: 0.891 ± 0.297
3.341ArgIle: 3.341 ± 0.631
4.789ArgLys: 4.789 ± 0.893
3.564ArgLeu: 3.564 ± 0.928
0.557ArgMet: 0.557 ± 0.197
2.896ArgAsn: 2.896 ± 0.572
1.002ArgPro: 1.002 ± 0.279
1.782ArgGln: 1.782 ± 0.588
1.893ArgArg: 1.893 ± 0.481
2.562ArgSer: 2.562 ± 0.483
2.673ArgThr: 2.673 ± 0.518
2.784ArgVal: 2.784 ± 0.752
0.445ArgTrp: 0.445 ± 0.198
2.673ArgTyr: 2.673 ± 0.542
0.0ArgXaa: 0.0 ± 0.0
Ser
3.341SerAla: 3.341 ± 0.668
0.111SerCys: 0.111 ± 0.116
3.564SerAsp: 3.564 ± 0.461
6.46SerGlu: 6.46 ± 1.215
2.784SerPhe: 2.784 ± 0.578
3.453SerGly: 3.453 ± 0.671
0.668SerHis: 0.668 ± 0.222
4.232SerIle: 4.232 ± 0.747
4.343SerLys: 4.343 ± 0.876
5.903SerLeu: 5.903 ± 0.645
2.116SerMet: 2.116 ± 0.419
3.675SerAsn: 3.675 ± 0.657
1.559SerPro: 1.559 ± 0.489
2.673SerGln: 2.673 ± 0.528
2.005SerArg: 2.005 ± 0.433
3.898SerSer: 3.898 ± 0.743
3.118SerThr: 3.118 ± 0.593
3.564SerVal: 3.564 ± 0.676
0.223SerTrp: 0.223 ± 0.169
2.116SerTyr: 2.116 ± 0.555
0.0SerXaa: 0.0 ± 0.0
Thr
3.675ThrAla: 3.675 ± 0.698
0.223ThrCys: 0.223 ± 0.165
3.23ThrAsp: 3.23 ± 0.545
3.787ThrGlu: 3.787 ± 0.725
3.787ThrPhe: 3.787 ± 0.54
3.23ThrGly: 3.23 ± 0.524
1.002ThrHis: 1.002 ± 0.32
5.569ThrIle: 5.569 ± 0.869
2.784ThrLys: 2.784 ± 0.58
4.789ThrLeu: 4.789 ± 0.757
1.782ThrMet: 1.782 ± 0.384
2.562ThrAsn: 2.562 ± 0.523
1.559ThrPro: 1.559 ± 0.396
2.005ThrGln: 2.005 ± 0.43
2.673ThrArg: 2.673 ± 0.604
3.118ThrSer: 3.118 ± 0.69
3.118ThrThr: 3.118 ± 0.64
4.678ThrVal: 4.678 ± 0.834
1.002ThrTrp: 1.002 ± 0.375
2.339ThrTyr: 2.339 ± 0.51
0.0ThrXaa: 0.0 ± 0.0
Val
4.009ValAla: 4.009 ± 0.718
0.334ValCys: 0.334 ± 0.202
4.789ValAsp: 4.789 ± 0.59
4.455ValGlu: 4.455 ± 0.661
2.45ValPhe: 2.45 ± 0.483
3.23ValGly: 3.23 ± 0.591
0.891ValHis: 0.891 ± 0.358
4.343ValIle: 4.343 ± 0.724
4.232ValLys: 4.232 ± 0.736
5.234ValLeu: 5.234 ± 0.85
1.225ValMet: 1.225 ± 0.388
3.675ValAsn: 3.675 ± 0.604
1.671ValPro: 1.671 ± 0.452
1.893ValGln: 1.893 ± 0.439
2.339ValArg: 2.339 ± 0.464
5.012ValSer: 5.012 ± 0.761
4.009ValThr: 4.009 ± 0.7
3.898ValVal: 3.898 ± 0.766
0.78ValTrp: 0.78 ± 0.292
2.116ValTyr: 2.116 ± 0.533
0.0ValXaa: 0.0 ± 0.0
Trp
1.002TrpAla: 1.002 ± 0.33
0.111TrpCys: 0.111 ± 0.118
0.891TrpAsp: 0.891 ± 0.42
1.002TrpGlu: 1.002 ± 0.337
1.002TrpPhe: 1.002 ± 0.275
0.891TrpGly: 0.891 ± 0.333
0.0TrpHis: 0.0 ± 0.0
0.223TrpIle: 0.223 ± 0.217
0.557TrpLys: 0.557 ± 0.236
1.559TrpLeu: 1.559 ± 0.456
0.223TrpMet: 0.223 ± 0.14
0.78TrpAsn: 0.78 ± 0.33
0.223TrpPro: 0.223 ± 0.193
0.78TrpGln: 0.78 ± 0.248
0.0TrpArg: 0.0 ± 0.0
1.114TrpSer: 1.114 ± 0.322
1.225TrpThr: 1.225 ± 0.299
0.557TrpVal: 0.557 ± 0.242
0.334TrpTrp: 0.334 ± 0.222
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.339TyrAla: 2.339 ± 0.638
0.668TyrCys: 0.668 ± 0.335
2.784TyrAsp: 2.784 ± 0.582
2.116TyrGlu: 2.116 ± 0.66
2.45TyrPhe: 2.45 ± 0.664
2.227TyrGly: 2.227 ± 0.589
0.668TyrHis: 0.668 ± 0.245
2.339TyrIle: 2.339 ± 0.477
2.784TyrLys: 2.784 ± 0.666
3.453TyrLeu: 3.453 ± 0.522
0.668TyrMet: 0.668 ± 0.25
1.671TyrAsn: 1.671 ± 0.509
0.78TyrPro: 0.78 ± 0.337
2.562TyrGln: 2.562 ± 0.773
2.673TyrArg: 2.673 ± 0.606
2.227TyrSer: 2.227 ± 0.541
1.336TyrThr: 1.336 ± 0.409
1.671TyrVal: 1.671 ± 0.443
0.445TyrTrp: 0.445 ± 0.218
1.782TyrTyr: 1.782 ± 0.37
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 44 proteins (8980 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski