Amino acid dipepetide frequency for Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.722AlaAla: 24.722 ± 0.199	0.913AlaCys: 0.913 ± 0.024	8.535AlaAsp: 8.535 ± 0.083	8.173AlaGlu: 8.173 ± 0.087	3.364AlaPhe: 3.364 ± 0.052	15.667AlaGly: 15.667 ± 0.13	2.931AlaHis: 2.931 ± 0.053	3.01AlaIle: 3.01 ± 0.052	1.938AlaLys: 1.938 ± 0.046	15.795AlaLeu: 15.795 ± 0.123	2.263AlaMet: 2.263 ± 0.039	1.696AlaAsn: 1.696 ± 0.037	7.968AlaPro: 7.968 ± 0.091	4.231AlaGln: 4.231 ± 0.059	11.75AlaArg: 11.75 ± 0.108	6.344AlaSer: 6.344 ± 0.076	8.192AlaThr: 8.192 ± 0.084	14.829AlaVal: 14.829 ± 0.124	1.994AlaTrp: 1.994 ± 0.043	2.042AlaTyr: 2.042 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.916CysAla: 0.916 ± 0.026	0.085CysCys: 0.085 ± 0.007	0.41CysAsp: 0.41 ± 0.015	0.306CysGlu: 0.306 ± 0.015	0.189CysPhe: 0.189 ± 0.012	0.74CysGly: 0.74 ± 0.02	0.144CysHis: 0.144 ± 0.01	0.118CysIle: 0.118 ± 0.009	0.06CysLys: 0.06 ± 0.005	0.645CysLeu: 0.645 ± 0.02	0.072CysMet: 0.072 ± 0.007	0.077CysAsn: 0.077 ± 0.008	0.406CysPro: 0.406 ± 0.018	0.131CysGln: 0.131 ± 0.01	0.51CysArg: 0.51 ± 0.019	0.395CysSer: 0.395 ± 0.016	0.431CysThr: 0.431 ± 0.017	0.583CysVal: 0.583 ± 0.02	0.109CysTrp: 0.109 ± 0.009	0.121CysTyr: 0.121 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.612AspAla: 8.612 ± 0.082	0.314AspCys: 0.314 ± 0.015	3.949AspAsp: 3.949 ± 0.062	3.773AspGlu: 3.773 ± 0.06	1.329AspPhe: 1.329 ± 0.032	6.081AspGly: 6.081 ± 0.073	1.391AspHis: 1.391 ± 0.032	1.156AspIle: 1.156 ± 0.031	0.605AspLys: 0.605 ± 0.023	7.621AspLeu: 7.621 ± 0.071	0.602AspMet: 0.602 ± 0.022	0.639AspAsn: 0.639 ± 0.021	4.905AspPro: 4.905 ± 0.058	1.335AspGln: 1.335 ± 0.032	4.614AspArg: 4.614 ± 0.058	2.076AspSer: 2.076 ± 0.04	2.712AspThr: 2.712 ± 0.04	6.836AspVal: 6.836 ± 0.084	0.836AspTrp: 0.836 ± 0.025	0.927AspTyr: 0.927 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	7.107GluAla: 7.107 ± 0.083	0.245GluCys: 0.245 ± 0.013	3.218GluAsp: 3.218 ± 0.046	3.384GluGlu: 3.384 ± 0.056	1.468GluPhe: 1.468 ± 0.031	4.254GluGly: 4.254 ± 0.055	1.749GluHis: 1.749 ± 0.035	1.531GluIle: 1.531 ± 0.04	0.875GluLys: 0.875 ± 0.025	6.2GluLeu: 6.2 ± 0.07	0.642GluMet: 0.642 ± 0.024	0.854GluAsn: 0.854 ± 0.025	2.983GluPro: 2.983 ± 0.049	2.268GluGln: 2.268 ± 0.045	5.262GluArg: 5.262 ± 0.072	1.943GluSer: 1.943 ± 0.035	2.61GluThr: 2.61 ± 0.043	5.755GluVal: 5.755 ± 0.074	0.642GluTrp: 0.642 ± 0.02	0.748GluTyr: 0.748 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	3.821PheAla: 3.821 ± 0.05	0.218PheCys: 0.218 ± 0.012	1.812PheAsp: 1.812 ± 0.039	1.328PheGlu: 1.328 ± 0.032	0.758PhePhe: 0.758 ± 0.028	2.686PheGly: 2.686 ± 0.055	0.521PheHis: 0.521 ± 0.019	0.558PheIle: 0.558 ± 0.02	0.351PheLys: 0.351 ± 0.017	2.505PheLeu: 2.505 ± 0.043	0.304PheMet: 0.304 ± 0.016	0.443PheAsn: 0.443 ± 0.018	1.26PhePro: 1.26 ± 0.026	0.592PheGln: 0.592 ± 0.019	1.662PheArg: 1.662 ± 0.034	1.509PheSer: 1.509 ± 0.031	1.88PheThr: 1.88 ± 0.03	2.393PheVal: 2.393 ± 0.044	0.357PheTrp: 0.357 ± 0.015	0.477PheTyr: 0.477 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	12.179GlyAla: 12.179 ± 0.106	0.731GlyCys: 0.731 ± 0.023	5.371GlyAsp: 5.371 ± 0.064	5.205GlyGlu: 5.205 ± 0.059	3.002GlyPhe: 3.002 ± 0.041	8.936GlyGly: 8.936 ± 0.101	2.115GlyHis: 2.115 ± 0.042	3.016GlyIle: 3.016 ± 0.044	1.605GlyLys: 1.605 ± 0.038	9.715GlyLeu: 9.715 ± 0.091	1.59GlyMet: 1.59 ± 0.033	1.462GlyAsn: 1.462 ± 0.036	5.446GlyPro: 5.446 ± 0.063	2.515GlyGln: 2.515 ± 0.042	8.016GlyArg: 8.016 ± 0.077	5.525GlySer: 5.525 ± 0.063	6.419GlyThr: 6.419 ± 0.075	8.825GlyVal: 8.825 ± 0.081	1.837GlyTrp: 1.837 ± 0.04	1.938GlyTyr: 1.938 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.744HisAla: 2.744 ± 0.051	0.147HisCys: 0.147 ± 0.012	1.594HisAsp: 1.594 ± 0.032	1.206HisGlu: 1.206 ± 0.028	0.496HisPhe: 0.496 ± 0.021	2.283HisGly: 2.283 ± 0.042	0.724HisHis: 0.724 ± 0.024	0.307HisIle: 0.307 ± 0.019	0.179HisLys: 0.179 ± 0.011	2.756HisLeu: 2.756 ± 0.048	0.196HisMet: 0.196 ± 0.011	0.247HisAsn: 0.247 ± 0.014	1.892HisPro: 1.892 ± 0.04	0.589HisGln: 0.589 ± 0.019	2.303HisArg: 2.303 ± 0.046	0.815HisSer: 0.815 ± 0.026	0.897HisThr: 0.897 ± 0.025	2.162HisVal: 2.162 ± 0.04	0.311HisTrp: 0.311 ± 0.015	0.363HisTyr: 0.363 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.199IleAla: 4.199 ± 0.057	0.181IleCys: 0.181 ± 0.012	1.837IleAsp: 1.837 ± 0.044	1.372IleGlu: 1.372 ± 0.033	0.507IlePhe: 0.507 ± 0.019	2.826IleGly: 2.826 ± 0.056	0.396IleHis: 0.396 ± 0.019	0.564IleIle: 0.564 ± 0.022	0.394IleLys: 0.394 ± 0.017	1.694IleLeu: 1.694 ± 0.045	0.262IleMet: 0.262 ± 0.011	0.442IleAsn: 0.442 ± 0.02	1.249IlePro: 1.249 ± 0.034	0.494IleGln: 0.494 ± 0.019	1.404IleArg: 1.404 ± 0.032	1.372IleSer: 1.372 ± 0.031	1.791IleThr: 1.791 ± 0.039	2.397IleVal: 2.397 ± 0.045	0.214IleTrp: 0.214 ± 0.015	0.376IleTyr: 0.376 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	1.78LysAla: 1.78 ± 0.042	0.048LysCys: 0.048 ± 0.005	0.777LysAsp: 0.777 ± 0.025	0.684LysGlu: 0.684 ± 0.024	0.326LysPhe: 0.326 ± 0.017	1.131LysGly: 1.131 ± 0.029	0.318LysHis: 0.318 ± 0.016	0.504LysIle: 0.504 ± 0.023	0.389LysLys: 0.389 ± 0.022	1.307LysLeu: 1.307 ± 0.029	0.2LysMet: 0.2 ± 0.011	0.317LysAsn: 0.317 ± 0.015	0.791LysPro: 0.791 ± 0.025	0.465LysGln: 0.465 ± 0.019	1.016LysArg: 1.016 ± 0.026	0.721LysSer: 0.721 ± 0.025	0.902LysThr: 0.902 ± 0.031	1.269LysVal: 1.269 ± 0.032	0.142LysTrp: 0.142 ± 0.009	0.271LysTyr: 0.271 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	16.773LeuAla: 16.773 ± 0.14	0.629LeuCys: 0.629 ± 0.021	7.401LeuAsp: 7.401 ± 0.085	5.083LeuGlu: 5.083 ± 0.076	2.293LeuPhe: 2.293 ± 0.049	9.65LeuGly: 9.65 ± 0.087	2.383LeuHis: 2.383 ± 0.044	2.195LeuIle: 2.195 ± 0.045	1.233LeuLys: 1.233 ± 0.034	12.6LeuLeu: 12.6 ± 0.143	1.15LeuMet: 1.15 ± 0.03	1.429LeuAsn: 1.429 ± 0.031	6.683LeuPro: 6.683 ± 0.081	2.865LeuGln: 2.865 ± 0.048	9.363LeuArg: 9.363 ± 0.1	5.459LeuSer: 5.459 ± 0.07	6.73LeuThr: 6.73 ± 0.065	11.161LeuVal: 11.161 ± 0.12	1.121LeuTrp: 1.121 ± 0.029	1.342LeuTyr: 1.342 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	1.799MetAla: 1.799 ± 0.039	0.081MetCys: 0.081 ± 0.007	0.728MetAsp: 0.728 ± 0.021	0.511MetGlu: 0.511 ± 0.019	0.318MetPhe: 0.318 ± 0.015	1.051MetGly: 1.051 ± 0.027	0.277MetHis: 0.277 ± 0.014	0.419MetIle: 0.419 ± 0.015	0.22MetLys: 0.22 ± 0.013	1.245MetLeu: 1.245 ± 0.031	0.171MetMet: 0.171 ± 0.013	0.332MetAsn: 0.332 ± 0.014	0.913MetPro: 0.913 ± 0.025	0.377MetGln: 0.377 ± 0.015	1.153MetArg: 1.153 ± 0.027	1.327MetSer: 1.327 ± 0.032	1.331MetThr: 1.331 ± 0.032	1.086MetVal: 1.086 ± 0.028	0.124MetTrp: 0.124 ± 0.01	0.208MetTyr: 0.208 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	1.969AsnAla: 1.969 ± 0.04	0.105AsnCys: 0.105 ± 0.009	0.816AsnAsp: 0.816 ± 0.028	0.584AsnGlu: 0.584 ± 0.018	0.402AsnPhe: 0.402 ± 0.018	1.38AsnGly: 1.38 ± 0.038	0.351AsnHis: 0.351 ± 0.016	0.404AsnIle: 0.404 ± 0.017	0.193AsnLys: 0.193 ± 0.011	1.575AsnLeu: 1.575 ± 0.039	0.172AsnMet: 0.172 ± 0.011	0.278AsnAsn: 0.278 ± 0.014	1.225AsnPro: 1.225 ± 0.032	0.394AsnGln: 0.394 ± 0.018	1.089AsnArg: 1.089 ± 0.029	0.687AsnSer: 0.687 ± 0.023	0.811AsnThr: 0.811 ± 0.024	1.376AsnVal: 1.376 ± 0.033	0.208AsnTrp: 0.208 ± 0.013	0.341AsnTyr: 0.341 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	10.197ProAla: 10.197 ± 0.125	0.31ProCys: 0.31 ± 0.018	4.154ProAsp: 4.154 ± 0.064	3.664ProGlu: 3.664 ± 0.052	1.42ProPhe: 1.42 ± 0.032	7.028ProGly: 7.028 ± 0.088	1.289ProHis: 1.289 ± 0.032	1.043ProIle: 1.043 ± 0.03	0.634ProLys: 0.634 ± 0.021	5.616ProLeu: 5.616 ± 0.067	0.82ProMet: 0.82 ± 0.023	0.725ProAsn: 0.725 ± 0.025	3.559ProPro: 3.559 ± 0.067	1.666ProGln: 1.666 ± 0.037	4.739ProArg: 4.739 ± 0.067	3.111ProSer: 3.111 ± 0.053	3.719ProThr: 3.719 ± 0.055	6.186ProVal: 6.186 ± 0.073	0.938ProTrp: 0.938 ± 0.029	0.885ProTyr: 0.885 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.631GlnAla: 3.631 ± 0.056	0.14GlnCys: 0.14 ± 0.011	1.423GlnAsp: 1.423 ± 0.035	1.388GlnGlu: 1.388 ± 0.034	0.693GlnPhe: 0.693 ± 0.023	2.019GlnGly: 2.019 ± 0.036	0.721GlnHis: 0.721 ± 0.025	0.8GlnIle: 0.8 ± 0.025	0.361GlnLys: 0.361 ± 0.015	3.095GlnLeu: 3.095 ± 0.049	0.403GlnMet: 0.403 ± 0.019	0.42GlnAsn: 0.42 ± 0.018	1.623GlnPro: 1.623 ± 0.033	1.281GlnGln: 1.281 ± 0.034	3.109GlnArg: 3.109 ± 0.055	1.113GlnSer: 1.113 ± 0.032	1.333GlnThr: 1.333 ± 0.027	2.936GlnVal: 2.936 ± 0.047	0.437GlnTrp: 0.437 ± 0.018	0.43GlnTyr: 0.43 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	11.571ArgAla: 11.571 ± 0.12	0.59ArgCys: 0.59 ± 0.022	4.457ArgAsp: 4.457 ± 0.062	4.841ArgGlu: 4.841 ± 0.059	2.421ArgPhe: 2.421 ± 0.044	6.848ArgGly: 6.848 ± 0.072	1.939ArgHis: 1.939 ± 0.039	2.439ArgIle: 2.439 ± 0.041	1.044ArgLys: 1.044 ± 0.029	8.539ArgLeu: 8.539 ± 0.084	1.551ArgMet: 1.551 ± 0.031	1.104ArgAsn: 1.104 ± 0.026	5.243ArgPro: 5.243 ± 0.071	2.082ArgGln: 2.082 ± 0.041	9.117ArgArg: 9.117 ± 0.095	4.709ArgSer: 4.709 ± 0.066	5.483ArgThr: 5.483 ± 0.059	7.285ArgVal: 7.285 ± 0.07	1.705ArgTrp: 1.705 ± 0.035	1.504ArgTyr: 1.504 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	7.266SerAla: 7.266 ± 0.081	0.372SerCys: 0.372 ± 0.013	2.479SerAsp: 2.479 ± 0.046	2.15SerGlu: 2.15 ± 0.037	1.43SerPhe: 1.43 ± 0.034	5.515SerGly: 5.515 ± 0.069	0.93SerHis: 0.93 ± 0.023	1.41SerIle: 1.41 ± 0.034	0.72SerLys: 0.72 ± 0.024	4.798SerLeu: 4.798 ± 0.055	0.932SerMet: 0.932 ± 0.028	0.766SerAsn: 0.766 ± 0.022	3.45SerPro: 3.45 ± 0.049	1.202SerGln: 1.202 ± 0.032	3.967SerArg: 3.967 ± 0.055	3.361SerSer: 3.361 ± 0.064	3.881SerThr: 3.881 ± 0.053	4.352SerVal: 4.352 ± 0.06	0.914SerTrp: 0.914 ± 0.026	0.965SerTyr: 0.965 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	9.428ThrAla: 9.428 ± 0.078	0.404ThrCys: 0.404 ± 0.018	3.229ThrAsp: 3.229 ± 0.048	2.561ThrGlu: 2.561 ± 0.044	1.659ThrPhe: 1.659 ± 0.035	6.882ThrGly: 6.882 ± 0.077	1.172ThrHis: 1.172 ± 0.027	1.609ThrIle: 1.609 ± 0.035	0.834ThrLys: 0.834 ± 0.028	5.681ThrLeu: 5.681 ± 0.057	0.799ThrMet: 0.799 ± 0.026	0.915ThrAsn: 0.915 ± 0.027	4.363ThrPro: 4.363 ± 0.06	1.233ThrGln: 1.233 ± 0.033	4.327ThrArg: 4.327 ± 0.055	3.748ThrSer: 3.748 ± 0.056	4.832ThrThr: 4.832 ± 0.066	5.942ThrVal: 5.942 ± 0.067	0.981ThrTrp: 0.981 ± 0.027	1.071ThrTyr: 1.071 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	13.669ValAla: 13.669 ± 0.12	0.664ValCys: 0.664 ± 0.021	6.264ValAsp: 6.264 ± 0.072	6.006ValGlu: 6.006 ± 0.064	2.422ValPhe: 2.422 ± 0.049	7.859ValGly: 7.859 ± 0.085	2.273ValHis: 2.273 ± 0.042	2.191ValIle: 2.191 ± 0.046	1.282ValLys: 1.282 ± 0.033	12.719ValLeu: 12.719 ± 0.109	1.157ValMet: 1.157 ± 0.031	1.559ValAsn: 1.559 ± 0.037	6.133ValPro: 6.133 ± 0.067	2.625ValGln: 2.625 ± 0.042	8.104ValArg: 8.104 ± 0.085	4.804ValSer: 4.804 ± 0.062	5.873ValThr: 5.873 ± 0.074	12.409ValVal: 12.409 ± 0.131	1.147ValTrp: 1.147 ± 0.031	1.297ValTyr: 1.297 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.757TrpAla: 1.757 ± 0.036	0.132TrpCys: 0.132 ± 0.01	0.736TrpAsp: 0.736 ± 0.022	0.662TrpGlu: 0.662 ± 0.022	0.477TrpPhe: 0.477 ± 0.02	1.037TrpGly: 1.037 ± 0.026	0.327TrpHis: 0.327 ± 0.016	0.457TrpIle: 0.457 ± 0.014	0.229TrpLys: 0.229 ± 0.012	1.665TrpLeu: 1.665 ± 0.041	0.245TrpMet: 0.245 ± 0.013	0.373TrpAsn: 0.373 ± 0.017	0.762TrpPro: 0.762 ± 0.024	0.515TrpGln: 0.515 ± 0.018	1.432TrpArg: 1.432 ± 0.034	1.025TrpSer: 1.025 ± 0.032	0.984TrpThr: 0.984 ± 0.026	1.186TrpVal: 1.186 ± 0.03	0.413TrpTrp: 0.413 ± 0.018	0.269TrpTyr: 0.269 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.213TyrAla: 2.213 ± 0.039	0.138TyrCys: 0.138 ± 0.009	1.123TyrAsp: 1.123 ± 0.028	0.854TyrGlu: 0.854 ± 0.024	0.459TyrPhe: 0.459 ± 0.02	1.573TyrGly: 1.573 ± 0.033	0.265TyrHis: 0.265 ± 0.013	0.24TyrIle: 0.24 ± 0.015	0.21TyrLys: 0.21 ± 0.012	1.775TyrLeu: 1.775 ± 0.039	0.141TyrMet: 0.141 ± 0.01	0.287TyrAsn: 0.287 ± 0.014	0.851TyrPro: 0.851 ± 0.025	0.494TyrGln: 0.494 ± 0.02	1.536TyrArg: 1.536 ± 0.031	0.816TyrSer: 0.816 ± 0.027	0.859TyrThr: 0.859 ± 0.025	1.489TyrVal: 1.489 ± 0.036	0.254TyrTrp: 0.254 ± 0.015	0.363TyrTyr: 0.363 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4674 proteins (1488609 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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