Amino acid dipepetide frequency for Prevotella sp. CAG:474

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.164AlaAla: 7.164 ± 0.132
1.144AlaCys: 1.144 ± 0.041
5.612AlaAsp: 5.612 ± 0.098
5.03AlaGlu: 5.03 ± 0.097
3.092AlaPhe: 3.092 ± 0.068
5.213AlaGly: 5.213 ± 0.082
1.826AlaHis: 1.826 ± 0.054
5.29AlaIle: 5.29 ± 0.102
4.627AlaLys: 4.627 ± 0.088
7.621AlaLeu: 7.621 ± 0.128
2.42AlaMet: 2.42 ± 0.058
3.601AlaAsn: 3.601 ± 0.076
2.739AlaPro: 2.739 ± 0.07
3.445AlaGln: 3.445 ± 0.069
4.154AlaArg: 4.154 ± 0.081
4.428AlaSer: 4.428 ± 0.084
4.874AlaThr: 4.874 ± 0.089
5.449AlaVal: 5.449 ± 0.085
0.959AlaTrp: 0.959 ± 0.036
3.183AlaTyr: 3.183 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
0.964CysAla: 0.964 ± 0.041
0.244CysCys: 0.244 ± 0.019
0.844CysAsp: 0.844 ± 0.034
0.686CysGlu: 0.686 ± 0.029
0.555CysPhe: 0.555 ± 0.029
1.22CysGly: 1.22 ± 0.04
0.471CysHis: 0.471 ± 0.026
0.877CysIle: 0.877 ± 0.035
0.668CysLys: 0.668 ± 0.029
1.137CysLeu: 1.137 ± 0.038
0.412CysMet: 0.412 ± 0.023
0.618CysAsn: 0.618 ± 0.028
0.608CysPro: 0.608 ± 0.031
0.493CysGln: 0.493 ± 0.026
0.802CysArg: 0.802 ± 0.033
0.816CysSer: 0.816 ± 0.036
0.697CysThr: 0.697 ± 0.026
0.879CysVal: 0.879 ± 0.038
0.17CysTrp: 0.17 ± 0.016
0.639CysTyr: 0.639 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
4.935AspAla: 4.935 ± 0.08
0.833AspCys: 0.833 ± 0.029
3.717AspAsp: 3.717 ± 0.083
4.091AspGlu: 4.091 ± 0.079
2.86AspPhe: 2.86 ± 0.058
4.555AspGly: 4.555 ± 0.088
1.302AspHis: 1.302 ± 0.038
4.265AspIle: 4.265 ± 0.075
3.714AspLys: 3.714 ± 0.079
4.363AspLeu: 4.363 ± 0.081
1.943AspMet: 1.943 ± 0.045
3.175AspAsn: 3.175 ± 0.068
1.862AspPro: 1.862 ± 0.058
1.429AspGln: 1.429 ± 0.04
3.095AspArg: 3.095 ± 0.06
3.352AspSer: 3.352 ± 0.073
3.147AspThr: 3.147 ± 0.072
3.975AspVal: 3.975 ± 0.078
0.821AspTrp: 0.821 ± 0.03
3.187AspTyr: 3.187 ± 0.064
0.0AspXaa: 0.0 ± 0.0
Glu
4.925GluAla: 4.925 ± 0.093
0.663GluCys: 0.663 ± 0.033
2.946GluAsp: 2.946 ± 0.072
3.718GluGlu: 3.718 ± 0.081
2.082GluPhe: 2.082 ± 0.058
3.945GluGly: 3.945 ± 0.073
1.332GluHis: 1.332 ± 0.046
3.855GluIle: 3.855 ± 0.08
3.632GluLys: 3.632 ± 0.089
5.065GluLeu: 5.065 ± 0.091
2.002GluMet: 2.002 ± 0.046
2.511GluAsn: 2.511 ± 0.071
1.804GluPro: 1.804 ± 0.059
2.564GluGln: 2.564 ± 0.064
3.456GluArg: 3.456 ± 0.074
2.808GluSer: 2.808 ± 0.057
2.823GluThr: 2.823 ± 0.065
4.057GluVal: 4.057 ± 0.077
0.807GluTrp: 0.807 ± 0.032
2.46GluTyr: 2.46 ± 0.063
0.0GluXaa: 0.0 ± 0.0
Phe
3.454PheAla: 3.454 ± 0.068
0.672PheCys: 0.672 ± 0.03
2.916PheAsp: 2.916 ± 0.058
2.086PheGlu: 2.086 ± 0.053
1.894PhePhe: 1.894 ± 0.054
3.158PheGly: 3.158 ± 0.077
0.876PheHis: 0.876 ± 0.033
2.452PheIle: 2.452 ± 0.059
2.071PheLys: 2.071 ± 0.054
3.183PheLeu: 3.183 ± 0.079
1.209PheMet: 1.209 ± 0.042
1.873PheAsn: 1.873 ± 0.052
1.431PhePro: 1.431 ± 0.039
1.018PheGln: 1.018 ± 0.038
1.965PheArg: 1.965 ± 0.051
2.776PheSer: 2.776 ± 0.063
2.553PheThr: 2.553 ± 0.068
3.056PheVal: 3.056 ± 0.064
0.477PheTrp: 0.477 ± 0.028
1.674PheTyr: 1.674 ± 0.038
0.0PheXaa: 0.0 ± 0.0
Gly
4.974GlyAla: 4.974 ± 0.097
1.111GlyCys: 1.111 ± 0.037
4.089GlyAsp: 4.089 ± 0.086
3.954GlyGlu: 3.954 ± 0.079
2.907GlyPhe: 2.907 ± 0.066
4.981GlyGly: 4.981 ± 0.11
1.559GlyHis: 1.559 ± 0.049
4.912GlyIle: 4.912 ± 0.088
4.699GlyLys: 4.699 ± 0.087
5.714GlyLeu: 5.714 ± 0.088
2.256GlyMet: 2.256 ± 0.054
3.407GlyAsn: 3.407 ± 0.074
1.427GlyPro: 1.427 ± 0.042
2.224GlyGln: 2.224 ± 0.065
3.731GlyArg: 3.731 ± 0.079
3.992GlySer: 3.992 ± 0.087
4.009GlyThr: 4.009 ± 0.085
5.285GlyVal: 5.285 ± 0.091
0.998GlyTrp: 0.998 ± 0.037
3.259GlyTyr: 3.259 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
1.655HisAla: 1.655 ± 0.043
0.372HisCys: 0.372 ± 0.024
1.343HisAsp: 1.343 ± 0.049
1.139HisGlu: 1.139 ± 0.044
1.001HisPhe: 1.001 ± 0.036
1.59HisGly: 1.59 ± 0.045
0.722HisHis: 0.722 ± 0.032
1.647HisIle: 1.647 ± 0.047
1.057HisLys: 1.057 ± 0.034
2.047HisLeu: 2.047 ± 0.062
0.478HisMet: 0.478 ± 0.024
1.038HisAsn: 1.038 ± 0.033
1.186HisPro: 1.186 ± 0.042
0.743HisGln: 0.743 ± 0.029
1.335HisArg: 1.335 ± 0.043
1.255HisSer: 1.255 ± 0.042
1.27HisThr: 1.27 ± 0.04
1.373HisVal: 1.373 ± 0.043
0.293HisTrp: 0.293 ± 0.017
1.117HisTyr: 1.117 ± 0.048
0.0HisXaa: 0.0 ± 0.0
Ile
5.537IleAla: 5.537 ± 0.1
0.967IleCys: 0.967 ± 0.041
5.057IleAsp: 5.057 ± 0.088
3.938IleGlu: 3.938 ± 0.077
2.415IlePhe: 2.415 ± 0.062
4.492IleGly: 4.492 ± 0.085
1.347IleHis: 1.347 ± 0.048
4.356IleIle: 4.356 ± 0.087
3.538IleLys: 3.538 ± 0.075
4.935IleLeu: 4.935 ± 0.096
1.661IleMet: 1.661 ± 0.051
3.111IleAsn: 3.111 ± 0.073
2.829IlePro: 2.829 ± 0.066
1.835IleGln: 1.835 ± 0.052
3.162IleArg: 3.162 ± 0.065
4.02IleSer: 4.02 ± 0.072
3.99IleThr: 3.99 ± 0.076
4.502IleVal: 4.502 ± 0.092
0.618IleTrp: 0.618 ± 0.034
2.647IleTyr: 2.647 ± 0.06
0.0IleXaa: 0.0 ± 0.0
Lys
4.898LysAla: 4.898 ± 0.088
0.541LysCys: 0.541 ± 0.027
3.55LysAsp: 3.55 ± 0.072
3.833LysGlu: 3.833 ± 0.093
1.846LysPhe: 1.846 ± 0.044
3.976LysGly: 3.976 ± 0.072
1.111LysHis: 1.111 ± 0.04
3.412LysIle: 3.412 ± 0.069
3.973LysLys: 3.973 ± 0.086
4.355LysLeu: 4.355 ± 0.085
2.096LysMet: 2.096 ± 0.053
2.625LysAsn: 2.625 ± 0.065
2.114LysPro: 2.114 ± 0.062
2.161LysGln: 2.161 ± 0.06
3.044LysArg: 3.044 ± 0.07
3.059LysSer: 3.059 ± 0.069
3.385LysThr: 3.385 ± 0.074
3.904LysVal: 3.904 ± 0.085
0.728LysTrp: 0.728 ± 0.029
2.544LysTyr: 2.544 ± 0.062
0.001LysXaa: 0.001 ± 0.001
Leu
7.463LeuAla: 7.463 ± 0.138
1.493LeuCys: 1.493 ± 0.043
4.806LeuAsp: 4.806 ± 0.097
4.088LeuGlu: 4.088 ± 0.074
3.809LeuPhe: 3.809 ± 0.087
5.766LeuGly: 5.766 ± 0.094
1.962LeuHis: 1.962 ± 0.061
4.783LeuIle: 4.783 ± 0.097
4.964LeuLys: 4.964 ± 0.086
8.343LeuLeu: 8.343 ± 0.153
2.772LeuMet: 2.772 ± 0.062
3.966LeuAsn: 3.966 ± 0.079
3.837LeuPro: 3.837 ± 0.076
3.113LeuGln: 3.113 ± 0.065
4.925LeuArg: 4.925 ± 0.091
6.132LeuSer: 6.132 ± 0.114
5.454LeuThr: 5.454 ± 0.095
5.459LeuVal: 5.459 ± 0.089
1.089LeuTrp: 1.089 ± 0.044
3.473LeuTyr: 3.473 ± 0.078
0.001LeuXaa: 0.001 ± 0.001
Met
3.026MetAla: 3.026 ± 0.059
0.353MetCys: 0.353 ± 0.022
1.688MetAsp: 1.688 ± 0.047
1.738MetGlu: 1.738 ± 0.049
1.035MetPhe: 1.035 ± 0.038
2.239MetGly: 2.239 ± 0.063
0.559MetHis: 0.559 ± 0.025
1.598MetIle: 1.598 ± 0.053
2.098MetLys: 2.098 ± 0.061
2.875MetLeu: 2.875 ± 0.069
1.108MetMet: 1.108 ± 0.045
1.399MetAsn: 1.399 ± 0.044
1.377MetPro: 1.377 ± 0.038
1.159MetGln: 1.159 ± 0.039
1.714MetArg: 1.714 ± 0.049
1.641MetSer: 1.641 ± 0.055
1.978MetThr: 1.978 ± 0.052
2.063MetVal: 2.063 ± 0.051
0.249MetTrp: 0.249 ± 0.018
0.872MetTyr: 0.872 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
3.556AsnAla: 3.556 ± 0.065
0.53AsnCys: 0.53 ± 0.023
2.678AsnAsp: 2.678 ± 0.06
2.492AsnGlu: 2.492 ± 0.065
1.888AsnPhe: 1.888 ± 0.055
3.598AsnGly: 3.598 ± 0.081
1.034AsnHis: 1.034 ± 0.036
3.38AsnIle: 3.38 ± 0.066
2.517AsnLys: 2.517 ± 0.07
3.806AsnLeu: 3.806 ± 0.076
1.248AsnMet: 1.248 ± 0.042
2.271AsnAsn: 2.271 ± 0.062
2.235AsnPro: 2.235 ± 0.055
1.415AsnGln: 1.415 ± 0.041
2.503AsnArg: 2.503 ± 0.056
2.486AsnSer: 2.486 ± 0.058
2.502AsnThr: 2.502 ± 0.057
3.215AsnVal: 3.215 ± 0.076
0.576AsnTrp: 0.576 ± 0.029
2.001AsnTyr: 2.001 ± 0.057
0.0AsnXaa: 0.0 ± 0.0
Pro
3.027ProAla: 3.027 ± 0.071
0.426ProCys: 0.426 ± 0.023
2.59ProAsp: 2.59 ± 0.068
2.79ProGlu: 2.79 ± 0.064
1.686ProPhe: 1.686 ± 0.046
2.37ProGly: 2.37 ± 0.062
0.861ProHis: 0.861 ± 0.036
2.325ProIle: 2.325 ± 0.056
1.956ProLys: 1.956 ± 0.052
3.123ProLeu: 3.123 ± 0.065
1.113ProMet: 1.113 ± 0.034
1.593ProAsn: 1.593 ± 0.044
0.812ProPro: 0.812 ± 0.035
1.537ProGln: 1.537 ± 0.052
1.558ProArg: 1.558 ± 0.054
2.182ProSer: 2.182 ± 0.054
2.322ProThr: 2.322 ± 0.059
2.795ProVal: 2.795 ± 0.061
0.465ProTrp: 0.465 ± 0.026
1.715ProTyr: 1.715 ± 0.05
0.001ProXaa: 0.001 ± 0.001
Gln
2.776GlnAla: 2.776 ± 0.057
0.377GlnCys: 0.377 ± 0.022
1.508GlnAsp: 1.508 ± 0.044
1.865GlnGlu: 1.865 ± 0.051
1.218GlnPhe: 1.218 ± 0.043
2.234GlnGly: 2.234 ± 0.059
0.817GlnHis: 0.817 ± 0.032
2.303GlnIle: 2.303 ± 0.065
2.025GlnLys: 2.025 ± 0.054
3.782GlnLeu: 3.782 ± 0.086
1.315GlnMet: 1.315 ± 0.041
1.435GlnAsn: 1.435 ± 0.046
1.488GlnPro: 1.488 ± 0.052
1.911GlnGln: 1.911 ± 0.058
2.247GlnArg: 2.247 ± 0.063
1.96GlnSer: 1.96 ± 0.057
2.303GlnThr: 2.303 ± 0.054
2.192GlnVal: 2.192 ± 0.052
0.509GlnTrp: 0.509 ± 0.028
1.432GlnTyr: 1.432 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
3.517ArgAla: 3.517 ± 0.074
0.653ArgCys: 0.653 ± 0.033
2.787ArgAsp: 2.787 ± 0.057
3.097ArgGlu: 3.097 ± 0.076
2.339ArgPhe: 2.339 ± 0.053
3.155ArgGly: 3.155 ± 0.072
1.591ArgHis: 1.591 ± 0.055
3.728ArgIle: 3.728 ± 0.067
2.967ArgLys: 2.967 ± 0.068
5.472ArgLeu: 5.472 ± 0.093
1.858ArgMet: 1.858 ± 0.046
2.49ArgAsn: 2.49 ± 0.06
1.886ArgPro: 1.886 ± 0.052
2.712ArgGln: 2.712 ± 0.072
3.552ArgArg: 3.552 ± 0.094
2.588ArgSer: 2.588 ± 0.059
2.576ArgThr: 2.576 ± 0.056
3.385ArgVal: 3.385 ± 0.071
0.756ArgTrp: 0.756 ± 0.034
2.548ArgTyr: 2.548 ± 0.062
0.0ArgXaa: 0.0 ± 0.0
Ser
4.759SerAla: 4.759 ± 0.084
0.806SerCys: 0.806 ± 0.037
3.355SerAsp: 3.355 ± 0.059
2.991SerGlu: 2.991 ± 0.064
2.572SerPhe: 2.572 ± 0.062
4.06SerGly: 4.06 ± 0.07
1.497SerHis: 1.497 ± 0.045
3.72SerIle: 3.72 ± 0.079
2.938SerLys: 2.938 ± 0.068
5.545SerLeu: 5.545 ± 0.103
1.653SerMet: 1.653 ± 0.044
2.364SerAsn: 2.364 ± 0.059
2.265SerPro: 2.265 ± 0.059
2.106SerGln: 2.106 ± 0.049
3.102SerArg: 3.102 ± 0.07
3.356SerSer: 3.356 ± 0.076
3.181SerThr: 3.181 ± 0.065
4.083SerVal: 4.083 ± 0.078
0.793SerTrp: 0.793 ± 0.032
2.54SerTyr: 2.54 ± 0.065
0.001SerXaa: 0.001 ± 0.001
Thr
4.942ThrAla: 4.942 ± 0.082
0.671ThrCys: 0.671 ± 0.032
3.646ThrAsp: 3.646 ± 0.078
2.893ThrGlu: 2.893 ± 0.06
2.558ThrPhe: 2.558 ± 0.06
4.205ThrGly: 4.205 ± 0.073
1.252ThrHis: 1.252 ± 0.043
4.149ThrIle: 4.149 ± 0.076
2.586ThrLys: 2.586 ± 0.064
5.872ThrLeu: 5.872 ± 0.086
1.571ThrMet: 1.571 ± 0.045
2.253ThrAsn: 2.253 ± 0.06
2.916ThrPro: 2.916 ± 0.071
1.887ThrGln: 1.887 ± 0.05
2.786ThrArg: 2.786 ± 0.061
3.225ThrSer: 3.225 ± 0.07
3.661ThrThr: 3.661 ± 0.079
4.136ThrVal: 4.136 ± 0.065
0.657ThrTrp: 0.657 ± 0.034
2.355ThrTyr: 2.355 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
6.063ValAla: 6.063 ± 0.093
1.15ValCys: 1.15 ± 0.041
4.014ValAsp: 4.014 ± 0.073
4.212ValGlu: 4.212 ± 0.085
2.719ValPhe: 2.719 ± 0.071
4.746ValGly: 4.746 ± 0.093
1.168ValHis: 1.168 ± 0.039
4.341ValIle: 4.341 ± 0.088
4.216ValLys: 4.216 ± 0.079
5.45ValLeu: 5.45 ± 0.091
2.09ValMet: 2.09 ± 0.063
3.318ValAsn: 3.318 ± 0.077
2.444ValPro: 2.444 ± 0.058
1.872ValGln: 1.872 ± 0.048
3.222ValArg: 3.222 ± 0.061
4.388ValSer: 4.388 ± 0.079
4.224ValThr: 4.224 ± 0.09
5.529ValVal: 5.529 ± 0.107
0.805ValTrp: 0.805 ± 0.033
2.749ValTyr: 2.749 ± 0.052
0.0ValXaa: 0.0 ± 0.0
Trp
0.896TrpAla: 0.896 ± 0.035
0.176TrpCys: 0.176 ± 0.015
0.691TrpAsp: 0.691 ± 0.029
0.608TrpGlu: 0.608 ± 0.027
0.501TrpPhe: 0.501 ± 0.028
0.928TrpGly: 0.928 ± 0.044
0.353TrpHis: 0.353 ± 0.023
0.714TrpIle: 0.714 ± 0.028
0.68TrpLys: 0.68 ± 0.029
1.313TrpLeu: 1.313 ± 0.048
0.45TrpMet: 0.45 ± 0.025
0.659TrpAsn: 0.659 ± 0.031
0.293TrpPro: 0.293 ± 0.02
0.539TrpGln: 0.539 ± 0.029
0.748TrpArg: 0.748 ± 0.033
0.724TrpSer: 0.724 ± 0.034
0.722TrpThr: 0.722 ± 0.033
0.771TrpVal: 0.771 ± 0.036
0.194TrpTrp: 0.194 ± 0.017
0.504TrpTyr: 0.504 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.341TyrAla: 3.341 ± 0.067
0.62TyrCys: 0.62 ± 0.03
2.784TyrAsp: 2.784 ± 0.061
2.205TyrGlu: 2.205 ± 0.056
1.817TyrPhe: 1.817 ± 0.049
3.055TyrGly: 3.055 ± 0.074
1.021TyrHis: 1.021 ± 0.039
2.852TyrIle: 2.852 ± 0.061
2.231TyrLys: 2.231 ± 0.056
3.697TyrLeu: 3.697 ± 0.073
1.111TyrMet: 1.111 ± 0.033
2.226TyrAsn: 2.226 ± 0.061
1.692TyrPro: 1.692 ± 0.042
1.531TyrGln: 1.531 ± 0.042
2.554TyrArg: 2.554 ± 0.065
2.498TyrSer: 2.498 ± 0.069
2.552TyrThr: 2.552 ± 0.072
2.609TyrVal: 2.609 ± 0.062
0.502TyrTrp: 0.502 ± 0.025
2.187TyrTyr: 2.187 ± 0.07
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.001XaaGly: 0.001 ± 0.001
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.001XaaMet: 0.001 ± 0.001
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.003XaaArg: 0.003 ± 0.002
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.008XaaXaa: 0.008 ± 0.004
Statistics based on 2297 proteins (784242 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski