Amino acid dipepetide frequency for Vibrio phage JSF36

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.082AlaAla: 10.082 ± 1.294
0.74AlaCys: 0.74 ± 0.25
4.902AlaAsp: 4.902 ± 0.691
6.29AlaGlu: 6.29 ± 0.841
2.867AlaPhe: 2.867 ± 0.424
5.735AlaGly: 5.735 ± 0.774
1.202AlaHis: 1.202 ± 0.319
5.735AlaIle: 5.735 ± 0.739
7.122AlaLys: 7.122 ± 0.782
7.677AlaLeu: 7.677 ± 0.818
3.422AlaMet: 3.422 ± 0.622
4.532AlaAsn: 4.532 ± 0.559
2.127AlaPro: 2.127 ± 0.401
3.977AlaGln: 3.977 ± 0.681
3.885AlaArg: 3.885 ± 0.504
5.457AlaSer: 5.457 ± 0.743
3.977AlaThr: 3.977 ± 0.706
5.18AlaVal: 5.18 ± 0.68
1.202AlaTrp: 1.202 ± 0.514
3.885AlaTyr: 3.885 ± 0.67
0.0AlaXaa: 0.0 ± 0.0
Cys
1.017CysAla: 1.017 ± 0.276
0.092CysCys: 0.092 ± 0.1
0.462CysAsp: 0.462 ± 0.243
0.925CysGlu: 0.925 ± 0.326
0.925CysPhe: 0.925 ± 0.283
0.74CysGly: 0.74 ± 0.229
0.462CysHis: 0.462 ± 0.172
0.647CysIle: 0.647 ± 0.275
0.37CysLys: 0.37 ± 0.208
0.74CysLeu: 0.74 ± 0.265
0.37CysMet: 0.37 ± 0.246
0.092CysAsn: 0.092 ± 0.096
0.555CysPro: 0.555 ± 0.209
0.37CysGln: 0.37 ± 0.15
0.74CysArg: 0.74 ± 0.349
0.277CysSer: 0.277 ± 0.154
0.277CysThr: 0.277 ± 0.167
0.74CysVal: 0.74 ± 0.277
0.185CysTrp: 0.185 ± 0.144
0.185CysTyr: 0.185 ± 0.182
0.0CysXaa: 0.0 ± 0.0
Asp
5.642AspAla: 5.642 ± 0.833
1.017AspCys: 1.017 ± 0.325
3.422AspAsp: 3.422 ± 0.771
3.792AspGlu: 3.792 ± 0.592
2.775AspPhe: 2.775 ± 0.565
4.255AspGly: 4.255 ± 0.603
0.832AspHis: 0.832 ± 0.241
3.422AspIle: 3.422 ± 0.578
3.977AspLys: 3.977 ± 0.618
3.885AspLeu: 3.885 ± 0.542
1.665AspMet: 1.665 ± 0.334
2.405AspAsn: 2.405 ± 0.427
2.497AspPro: 2.497 ± 0.618
1.11AspGln: 1.11 ± 0.305
2.312AspArg: 2.312 ± 0.507
3.33AspSer: 3.33 ± 0.555
3.885AspThr: 3.885 ± 0.67
4.532AspVal: 4.532 ± 0.593
1.11AspTrp: 1.11 ± 0.39
2.405AspTyr: 2.405 ± 0.553
0.0AspXaa: 0.0 ± 0.0
Glu
8.602GluAla: 8.602 ± 0.896
0.74GluCys: 0.74 ± 0.254
5.735GluAsp: 5.735 ± 0.753
7.03GluGlu: 7.03 ± 0.88
2.127GluPhe: 2.127 ± 0.361
5.365GluGly: 5.365 ± 0.828
1.572GluHis: 1.572 ± 0.488
4.347GluIle: 4.347 ± 0.594
3.607GluLys: 3.607 ± 0.467
6.567GluLeu: 6.567 ± 0.762
3.145GluMet: 3.145 ± 0.528
2.497GluAsn: 2.497 ± 0.392
1.665GluPro: 1.665 ± 0.444
3.792GluGln: 3.792 ± 0.554
4.07GluArg: 4.07 ± 0.502
4.902GluSer: 4.902 ± 0.775
3.145GluThr: 3.145 ± 0.451
4.625GluVal: 4.625 ± 0.68
1.295GluTrp: 1.295 ± 0.272
3.145GluTyr: 3.145 ± 0.448
0.0GluXaa: 0.0 ± 0.0
Phe
2.59PheAla: 2.59 ± 0.477
0.74PheCys: 0.74 ± 0.255
2.59PheAsp: 2.59 ± 0.497
3.145PheGlu: 3.145 ± 0.435
0.925PhePhe: 0.925 ± 0.295
2.867PheGly: 2.867 ± 0.511
0.74PheHis: 0.74 ± 0.297
2.22PheIle: 2.22 ± 0.5
3.052PheLys: 3.052 ± 0.663
3.145PheLeu: 3.145 ± 0.587
1.572PheMet: 1.572 ± 0.372
2.96PheAsn: 2.96 ± 0.585
0.925PhePro: 0.925 ± 0.293
1.48PheGln: 1.48 ± 0.299
1.572PheArg: 1.572 ± 0.329
2.497PheSer: 2.497 ± 0.345
2.312PheThr: 2.312 ± 0.447
2.405PheVal: 2.405 ± 0.57
0.37PheTrp: 0.37 ± 0.202
1.295PheTyr: 1.295 ± 0.323
0.0PheXaa: 0.0 ± 0.0
Gly
6.567GlyAla: 6.567 ± 0.853
0.462GlyCys: 0.462 ± 0.222
3.792GlyAsp: 3.792 ± 0.631
5.272GlyGlu: 5.272 ± 0.642
2.59GlyPhe: 2.59 ± 0.357
4.717GlyGly: 4.717 ± 0.675
1.48GlyHis: 1.48 ± 0.406
3.33GlyIle: 3.33 ± 0.506
5.642GlyLys: 5.642 ± 0.821
6.29GlyLeu: 6.29 ± 0.97
2.59GlyMet: 2.59 ± 0.439
2.867GlyAsn: 2.867 ± 0.379
0.092GlyPro: 0.092 ± 0.09
2.497GlyGln: 2.497 ± 0.395
3.792GlyArg: 3.792 ± 0.419
3.33GlySer: 3.33 ± 0.511
3.792GlyThr: 3.792 ± 0.606
4.255GlyVal: 4.255 ± 0.69
0.555GlyTrp: 0.555 ± 0.234
3.237GlyTyr: 3.237 ± 0.418
0.0GlyXaa: 0.0 ± 0.0
His
1.202HisAla: 1.202 ± 0.293
0.277HisCys: 0.277 ± 0.166
1.202HisAsp: 1.202 ± 0.323
1.665HisGlu: 1.665 ± 0.327
1.387HisPhe: 1.387 ± 0.337
1.017HisGly: 1.017 ± 0.294
0.185HisHis: 0.185 ± 0.118
1.202HisIle: 1.202 ± 0.274
0.832HisLys: 0.832 ± 0.301
1.48HisLeu: 1.48 ± 0.424
0.462HisMet: 0.462 ± 0.235
0.74HisAsn: 0.74 ± 0.295
0.832HisPro: 0.832 ± 0.264
0.37HisGln: 0.37 ± 0.155
1.017HisArg: 1.017 ± 0.365
1.202HisSer: 1.202 ± 0.381
0.74HisThr: 0.74 ± 0.338
1.387HisVal: 1.387 ± 0.291
0.555HisTrp: 0.555 ± 0.266
0.462HisTyr: 0.462 ± 0.206
0.0HisXaa: 0.0 ± 0.0
Ile
4.44IleAla: 4.44 ± 0.548
0.925IleCys: 0.925 ± 0.32
2.682IleAsp: 2.682 ± 0.567
4.07IleGlu: 4.07 ± 0.667
1.11IlePhe: 1.11 ± 0.324
3.145IleGly: 3.145 ± 0.433
0.925IleHis: 0.925 ± 0.326
2.497IleIle: 2.497 ± 0.56
5.087IleLys: 5.087 ± 0.768
4.347IleLeu: 4.347 ± 0.539
1.387IleMet: 1.387 ± 0.332
2.682IleAsn: 2.682 ± 0.505
2.775IlePro: 2.775 ± 0.452
2.59IleGln: 2.59 ± 0.506
3.145IleArg: 3.145 ± 0.525
2.682IleSer: 2.682 ± 0.467
3.422IleThr: 3.422 ± 0.514
4.347IleVal: 4.347 ± 0.559
0.555IleTrp: 0.555 ± 0.175
1.48IleTyr: 1.48 ± 0.336
0.0IleXaa: 0.0 ± 0.0
Lys
6.845LysAla: 6.845 ± 0.742
0.74LysCys: 0.74 ± 0.28
4.162LysAsp: 4.162 ± 0.741
4.995LysGlu: 4.995 ± 0.616
2.775LysPhe: 2.775 ± 0.526
4.81LysGly: 4.81 ± 0.699
1.48LysHis: 1.48 ± 0.464
3.052LysIle: 3.052 ± 0.428
5.735LysLys: 5.735 ± 0.93
6.012LysLeu: 6.012 ± 0.816
2.497LysMet: 2.497 ± 0.394
2.405LysAsn: 2.405 ± 0.525
3.237LysPro: 3.237 ± 0.77
3.422LysGln: 3.422 ± 0.678
4.07LysArg: 4.07 ± 0.547
4.162LysSer: 4.162 ± 0.724
3.977LysThr: 3.977 ± 0.591
4.625LysVal: 4.625 ± 0.776
1.017LysTrp: 1.017 ± 0.381
2.867LysTyr: 2.867 ± 0.603
0.0LysXaa: 0.0 ± 0.0
Leu
7.03LeuAla: 7.03 ± 0.66
0.647LeuCys: 0.647 ± 0.29
3.977LeuAsp: 3.977 ± 0.369
7.307LeuGlu: 7.307 ± 0.82
2.682LeuPhe: 2.682 ± 0.5
5.18LeuGly: 5.18 ± 0.836
1.48LeuHis: 1.48 ± 0.31
4.902LeuIle: 4.902 ± 0.616
7.955LeuLys: 7.955 ± 0.827
6.012LeuLeu: 6.012 ± 0.784
2.405LeuMet: 2.405 ± 0.389
4.532LeuAsn: 4.532 ± 0.64
2.497LeuPro: 2.497 ± 0.411
3.885LeuGln: 3.885 ± 0.637
5.087LeuArg: 5.087 ± 0.691
4.07LeuSer: 4.07 ± 0.455
4.625LeuThr: 4.625 ± 0.644
4.532LeuVal: 4.532 ± 0.538
1.11LeuTrp: 1.11 ± 0.322
2.682LeuTyr: 2.682 ± 0.501
0.0LeuXaa: 0.0 ± 0.0
Met
3.237MetAla: 3.237 ± 0.504
0.462MetCys: 0.462 ± 0.221
1.387MetAsp: 1.387 ± 0.306
2.497MetGlu: 2.497 ± 0.429
1.202MetPhe: 1.202 ± 0.344
2.035MetGly: 2.035 ± 0.58
0.277MetHis: 0.277 ± 0.17
1.295MetIle: 1.295 ± 0.314
2.035MetLys: 2.035 ± 0.438
2.035MetLeu: 2.035 ± 0.444
0.462MetMet: 0.462 ± 0.153
1.665MetAsn: 1.665 ± 0.392
1.665MetPro: 1.665 ± 0.351
1.757MetGln: 1.757 ± 0.395
1.387MetArg: 1.387 ± 0.375
1.942MetSer: 1.942 ± 0.354
2.775MetThr: 2.775 ± 0.606
2.22MetVal: 2.22 ± 0.375
0.185MetTrp: 0.185 ± 0.104
0.37MetTyr: 0.37 ± 0.175
0.0MetXaa: 0.0 ± 0.0
Asn
3.422AsnAla: 3.422 ± 0.741
0.37AsnCys: 0.37 ± 0.168
2.405AsnAsp: 2.405 ± 0.513
2.682AsnGlu: 2.682 ± 0.492
1.757AsnPhe: 1.757 ± 0.335
3.33AsnGly: 3.33 ± 0.645
1.11AsnHis: 1.11 ± 0.336
2.312AsnIle: 2.312 ± 0.552
2.775AsnLys: 2.775 ± 0.611
4.625AsnLeu: 4.625 ± 0.626
1.85AsnMet: 1.85 ± 0.513
2.22AsnAsn: 2.22 ± 0.399
2.867AsnPro: 2.867 ± 0.41
1.48AsnGln: 1.48 ± 0.385
1.942AsnArg: 1.942 ± 0.48
2.59AsnSer: 2.59 ± 0.614
2.312AsnThr: 2.312 ± 0.389
3.515AsnVal: 3.515 ± 0.473
0.555AsnTrp: 0.555 ± 0.258
1.387AsnTyr: 1.387 ± 0.393
0.0AsnXaa: 0.0 ± 0.0
Pro
2.867ProAla: 2.867 ± 0.596
0.277ProCys: 0.277 ± 0.177
2.682ProAsp: 2.682 ± 0.48
4.532ProGlu: 4.532 ± 0.414
1.387ProPhe: 1.387 ± 0.39
0.0ProGly: 0.0 ± 0.0
0.832ProHis: 0.832 ± 0.229
1.202ProIle: 1.202 ± 0.281
1.942ProLys: 1.942 ± 0.467
2.405ProLeu: 2.405 ± 0.416
0.925ProMet: 0.925 ± 0.271
2.405ProAsn: 2.405 ± 0.507
0.555ProPro: 0.555 ± 0.19
1.665ProGln: 1.665 ± 0.447
1.017ProArg: 1.017 ± 0.284
2.867ProSer: 2.867 ± 0.424
1.757ProThr: 1.757 ± 0.374
3.885ProVal: 3.885 ± 0.46
0.647ProTrp: 0.647 ± 0.255
0.925ProTyr: 0.925 ± 0.349
0.0ProXaa: 0.0 ± 0.0
Gln
5.457GlnAla: 5.457 ± 0.987
0.277GlnCys: 0.277 ± 0.149
2.497GlnAsp: 2.497 ± 0.546
3.607GlnGlu: 3.607 ± 0.598
1.665GlnPhe: 1.665 ± 0.352
2.497GlnGly: 2.497 ± 0.493
0.555GlnHis: 0.555 ± 0.183
2.127GlnIle: 2.127 ± 0.411
2.127GlnLys: 2.127 ± 0.465
3.977GlnLeu: 3.977 ± 0.693
0.832GlnMet: 0.832 ± 0.238
0.925GlnAsn: 0.925 ± 0.298
0.925GlnPro: 0.925 ± 0.271
2.035GlnGln: 2.035 ± 0.615
2.127GlnArg: 2.127 ± 0.395
2.775GlnSer: 2.775 ± 0.485
2.497GlnThr: 2.497 ± 0.474
3.607GlnVal: 3.607 ± 0.562
0.647GlnTrp: 0.647 ± 0.234
1.202GlnTyr: 1.202 ± 0.296
0.0GlnXaa: 0.0 ± 0.0
Arg
4.07ArgAla: 4.07 ± 0.527
0.647ArgCys: 0.647 ± 0.293
3.237ArgAsp: 3.237 ± 0.525
3.7ArgGlu: 3.7 ± 0.579
2.497ArgPhe: 2.497 ± 0.387
3.422ArgGly: 3.422 ± 0.65
0.462ArgHis: 0.462 ± 0.173
3.145ArgIle: 3.145 ± 0.523
3.792ArgLys: 3.792 ± 0.763
3.607ArgLeu: 3.607 ± 0.542
0.925ArgMet: 0.925 ± 0.293
2.312ArgAsn: 2.312 ± 0.423
2.127ArgPro: 2.127 ± 0.37
2.59ArgGln: 2.59 ± 0.471
2.22ArgArg: 2.22 ± 0.344
3.052ArgSer: 3.052 ± 0.566
2.59ArgThr: 2.59 ± 0.468
2.775ArgVal: 2.775 ± 0.419
0.832ArgTrp: 0.832 ± 0.271
1.387ArgTyr: 1.387 ± 0.317
0.0ArgXaa: 0.0 ± 0.0
Ser
4.717SerAla: 4.717 ± 0.557
0.647SerCys: 0.647 ± 0.231
3.792SerAsp: 3.792 ± 0.565
3.145SerGlu: 3.145 ± 0.624
3.052SerPhe: 3.052 ± 0.468
5.272SerGly: 5.272 ± 0.546
0.832SerHis: 0.832 ± 0.301
3.607SerIle: 3.607 ± 0.537
4.44SerLys: 4.44 ± 0.805
4.902SerLeu: 4.902 ± 0.537
1.85SerMet: 1.85 ± 0.399
2.682SerAsn: 2.682 ± 0.492
1.942SerPro: 1.942 ± 0.391
1.757SerGln: 1.757 ± 0.349
2.22SerArg: 2.22 ± 0.377
3.33SerSer: 3.33 ± 0.793
2.682SerThr: 2.682 ± 0.442
2.682SerVal: 2.682 ± 0.375
0.37SerTrp: 0.37 ± 0.159
2.59SerTyr: 2.59 ± 0.489
0.0SerXaa: 0.0 ± 0.0
Thr
3.33ThrAla: 3.33 ± 0.645
0.37ThrCys: 0.37 ± 0.16
2.405ThrAsp: 2.405 ± 0.484
3.7ThrGlu: 3.7 ± 0.497
3.33ThrPhe: 3.33 ± 0.614
5.735ThrGly: 5.735 ± 0.708
1.017ThrHis: 1.017 ± 0.254
3.7ThrIle: 3.7 ± 0.671
3.33ThrLys: 3.33 ± 0.683
5.55ThrLeu: 5.55 ± 0.71
1.295ThrMet: 1.295 ± 0.345
2.22ThrAsn: 2.22 ± 0.479
2.497ThrPro: 2.497 ± 0.334
2.405ThrGln: 2.405 ± 0.533
2.682ThrArg: 2.682 ± 0.367
2.497ThrSer: 2.497 ± 0.411
3.515ThrThr: 3.515 ± 0.567
3.145ThrVal: 3.145 ± 0.445
0.647ThrTrp: 0.647 ± 0.308
2.035ThrTyr: 2.035 ± 0.275
0.0ThrXaa: 0.0 ± 0.0
Val
5.365ValAla: 5.365 ± 0.577
0.185ValCys: 0.185 ± 0.123
3.7ValAsp: 3.7 ± 0.465
6.105ValGlu: 6.105 ± 0.851
2.312ValPhe: 2.312 ± 0.358
3.607ValGly: 3.607 ± 0.529
1.572ValHis: 1.572 ± 0.408
2.96ValIle: 2.96 ± 0.518
5.735ValLys: 5.735 ± 0.785
5.365ValLeu: 5.365 ± 0.556
1.757ValMet: 1.757 ± 0.502
3.237ValAsn: 3.237 ± 0.548
2.775ValPro: 2.775 ± 0.442
2.405ValGln: 2.405 ± 0.395
3.33ValArg: 3.33 ± 0.598
3.33ValSer: 3.33 ± 0.532
4.162ValThr: 4.162 ± 0.629
4.625ValVal: 4.625 ± 0.756
0.555ValTrp: 0.555 ± 0.186
2.682ValTyr: 2.682 ± 0.464
0.0ValXaa: 0.0 ± 0.0
Trp
0.925TrpAla: 0.925 ± 0.326
0.092TrpCys: 0.092 ± 0.109
0.74TrpAsp: 0.74 ± 0.294
0.74TrpGlu: 0.74 ± 0.253
0.462TrpPhe: 0.462 ± 0.211
0.37TrpGly: 0.37 ± 0.139
0.462TrpHis: 0.462 ± 0.229
0.647TrpIle: 0.647 ± 0.274
1.295TrpLys: 1.295 ± 0.361
1.295TrpLeu: 1.295 ± 0.384
0.092TrpMet: 0.092 ± 0.079
0.74TrpAsn: 0.74 ± 0.248
0.37TrpPro: 0.37 ± 0.182
0.37TrpGln: 0.37 ± 0.183
0.832TrpArg: 0.832 ± 0.265
0.74TrpSer: 0.74 ± 0.328
1.202TrpThr: 1.202 ± 0.324
0.832TrpVal: 0.832 ± 0.35
0.185TrpTrp: 0.185 ± 0.107
0.74TrpTyr: 0.74 ± 0.332
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.59TyrAla: 2.59 ± 0.498
0.462TyrCys: 0.462 ± 0.225
2.497TyrAsp: 2.497 ± 0.39
2.775TyrGlu: 2.775 ± 0.464
1.572TyrPhe: 1.572 ± 0.342
3.052TyrGly: 3.052 ± 0.43
0.74TyrHis: 0.74 ± 0.256
1.942TyrIle: 1.942 ± 0.437
2.035TyrLys: 2.035 ± 0.453
2.682TyrLeu: 2.682 ± 0.47
1.295TyrMet: 1.295 ± 0.3
1.387TyrAsn: 1.387 ± 0.295
1.85TyrPro: 1.85 ± 0.407
2.405TyrGln: 2.405 ± 0.489
2.035TyrArg: 2.035 ± 0.353
1.48TyrSer: 1.48 ± 0.349
1.757TyrThr: 1.757 ± 0.437
1.85TyrVal: 1.85 ± 0.425
0.555TyrTrp: 0.555 ± 0.223
0.277TyrTyr: 0.277 ± 0.143
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 47 proteins (10812 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski