Amino acid dipepetide frequency for Mycoplasma sp. CAG:956

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.247AlaAla: 2.247 ± 0.101
0.653AlaCys: 0.653 ± 0.046
2.36AlaAsp: 2.36 ± 0.082
2.126AlaGlu: 2.126 ± 0.085
1.998AlaPhe: 1.998 ± 0.079
2.649AlaGly: 2.649 ± 0.106
0.668AlaHis: 0.668 ± 0.041
4.486AlaIle: 4.486 ± 0.118
4.662AlaLys: 4.662 ± 0.109
4.816AlaLeu: 4.816 ± 0.109
1.16AlaMet: 1.16 ± 0.049
3.22AlaAsn: 3.22 ± 0.096
0.992AlaPro: 0.992 ± 0.049
0.852AlaGln: 0.852 ± 0.044
1.683AlaArg: 1.683 ± 0.067
3.613AlaSer: 3.613 ± 0.104
2.843AlaThr: 2.843 ± 0.103
2.659AlaVal: 2.659 ± 0.097
0.249AlaTrp: 0.249 ± 0.024
2.441AlaTyr: 2.441 ± 0.078
0.0AlaXaa: 0.0 ± 0.0
Cys
0.474CysAla: 0.474 ± 0.032
0.199CysCys: 0.199 ± 0.021
0.85CysAsp: 0.85 ± 0.074
0.592CysGlu: 0.592 ± 0.041
0.563CysPhe: 0.563 ± 0.04
0.914CysGly: 0.914 ± 0.047
0.204CysHis: 0.204 ± 0.025
0.781CysIle: 0.781 ± 0.041
0.938CysLys: 0.938 ± 0.052
1.196CysLeu: 1.196 ± 0.057
0.211CysMet: 0.211 ± 0.022
0.921CysAsn: 0.921 ± 0.049
0.469CysPro: 0.469 ± 0.042
0.284CysGln: 0.284 ± 0.027
0.272CysArg: 0.272 ± 0.023
0.689CysSer: 0.689 ± 0.047
0.58CysThr: 0.58 ± 0.041
0.665CysVal: 0.665 ± 0.042
0.038CysTrp: 0.038 ± 0.011
0.623CysTyr: 0.623 ± 0.037
0.0CysXaa: 0.0 ± 0.0
Asp
3.064AspAla: 3.064 ± 0.097
0.679AspCys: 0.679 ± 0.046
4.183AspAsp: 4.183 ± 0.118
4.363AspGlu: 4.363 ± 0.119
3.021AspPhe: 3.021 ± 0.095
3.274AspGly: 3.274 ± 0.174
0.511AspHis: 0.511 ± 0.036
6.743AspIle: 6.743 ± 0.16
6.423AspLys: 6.423 ± 0.118
5.469AspLeu: 5.469 ± 0.131
1.451AspMet: 1.451 ± 0.059
5.362AspAsn: 5.362 ± 0.129
1.013AspPro: 1.013 ± 0.057
0.696AspGln: 0.696 ± 0.039
1.548AspArg: 1.548 ± 0.073
3.471AspSer: 3.471 ± 0.108
3.992AspThr: 3.992 ± 0.126
3.48AspVal: 3.48 ± 0.097
0.362AspTrp: 0.362 ± 0.033
4.397AspTyr: 4.397 ± 0.098
0.0AspXaa: 0.0 ± 0.0
Glu
3.509GluAla: 3.509 ± 0.106
0.58GluCys: 0.58 ± 0.034
4.004GluAsp: 4.004 ± 0.101
6.208GluGlu: 6.208 ± 0.185
2.713GluPhe: 2.713 ± 0.091
2.495GluGly: 2.495 ± 0.097
0.784GluHis: 0.784 ± 0.043
6.487GluIle: 6.487 ± 0.134
6.658GluLys: 6.658 ± 0.154
6.397GluLeu: 6.397 ± 0.143
1.65GluMet: 1.65 ± 0.063
5.076GluAsn: 5.076 ± 0.112
1.198GluPro: 1.198 ± 0.068
1.698GluGln: 1.698 ± 0.065
1.96GluArg: 1.96 ± 0.076
3.073GluSer: 3.073 ± 0.085
3.341GluThr: 3.341 ± 0.086
4.259GluVal: 4.259 ± 0.103
0.429GluTrp: 0.429 ± 0.028
3.582GluTyr: 3.582 ± 0.091
0.0GluXaa: 0.0 ± 0.0
Phe
2.169PheAla: 2.169 ± 0.076
0.509PheCys: 0.509 ± 0.036
2.827PheAsp: 2.827 ± 0.08
1.972PheGlu: 1.972 ± 0.075
1.804PhePhe: 1.804 ± 0.075
2.275PheGly: 2.275 ± 0.082
0.476PheHis: 0.476 ± 0.036
4.283PheIle: 4.283 ± 0.121
3.996PheLys: 3.996 ± 0.105
4.378PheLeu: 4.378 ± 0.144
0.923PheMet: 0.923 ± 0.047
3.539PheAsn: 3.539 ± 0.095
0.902PhePro: 0.902 ± 0.047
0.997PheGln: 0.997 ± 0.045
1.231PheArg: 1.231 ± 0.056
2.682PheSer: 2.682 ± 0.075
2.571PheThr: 2.571 ± 0.074
2.344PheVal: 2.344 ± 0.084
0.239PheTrp: 0.239 ± 0.022
2.261PheTyr: 2.261 ± 0.082
0.0PheXaa: 0.0 ± 0.0
Gly
2.64GlyAla: 2.64 ± 0.105
0.694GlyCys: 0.694 ± 0.044
2.692GlyAsp: 2.692 ± 0.109
2.699GlyGlu: 2.699 ± 0.106
2.391GlyPhe: 2.391 ± 0.066
2.971GlyGly: 2.971 ± 0.154
0.805GlyHis: 0.805 ± 0.05
5.412GlyIle: 5.412 ± 0.128
4.681GlyLys: 4.681 ± 0.153
5.017GlyLeu: 5.017 ± 0.129
1.134GlyMet: 1.134 ± 0.052
3.549GlyAsn: 3.549 ± 0.118
0.928GlyPro: 0.928 ± 0.067
1.013GlyGln: 1.013 ± 0.054
1.688GlyArg: 1.688 ± 0.076
3.362GlySer: 3.362 ± 0.1
3.307GlyThr: 3.307 ± 0.12
2.881GlyVal: 2.881 ± 0.088
0.289GlyTrp: 0.289 ± 0.032
3.284GlyTyr: 3.284 ± 0.116
0.0GlyXaa: 0.0 ± 0.0
His
0.632HisAla: 0.632 ± 0.042
0.133HisCys: 0.133 ± 0.019
0.632HisAsp: 0.632 ± 0.039
0.765HisGlu: 0.765 ± 0.045
0.623HisPhe: 0.623 ± 0.042
0.663HisGly: 0.663 ± 0.045
0.327HisHis: 0.327 ± 0.025
1.198HisIle: 1.198 ± 0.051
0.992HisLys: 0.992 ± 0.048
1.423HisLeu: 1.423 ± 0.063
0.218HisMet: 0.218 ± 0.022
0.907HisAsn: 0.907 ± 0.046
0.502HisPro: 0.502 ± 0.036
0.372HisGln: 0.372 ± 0.031
0.469HisArg: 0.469 ± 0.029
0.649HisSer: 0.649 ± 0.038
0.677HisThr: 0.677 ± 0.045
0.549HisVal: 0.549 ± 0.036
0.052HisTrp: 0.052 ± 0.011
0.727HisTyr: 0.727 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
4.503IleAla: 4.503 ± 0.124
1.122IleCys: 1.122 ± 0.049
6.238IleAsp: 6.238 ± 0.126
5.746IleGlu: 5.746 ± 0.128
4.063IlePhe: 4.063 ± 0.116
4.884IleGly: 4.884 ± 0.151
1.028IleHis: 1.028 ± 0.056
9.731IleIle: 9.731 ± 0.209
9.151IleLys: 9.151 ± 0.169
9.233IleLeu: 9.233 ± 0.205
2.124IleMet: 2.124 ± 0.076
7.993IleAsn: 7.993 ± 0.17
2.867IlePro: 2.867 ± 0.083
1.394IleGln: 1.394 ± 0.055
2.756IleArg: 2.756 ± 0.072
6.679IleSer: 6.679 ± 0.146
5.606IleThr: 5.606 ± 0.116
5.568IleVal: 5.568 ± 0.112
0.533IleTrp: 0.533 ± 0.038
4.65IleTyr: 4.65 ± 0.104
0.0IleXaa: 0.0 ± 0.0
Lys
3.899LysAla: 3.899 ± 0.104
1.013LysCys: 1.013 ± 0.064
6.998LysAsp: 6.998 ± 0.147
9.304LysGlu: 9.304 ± 0.177
3.241LysPhe: 3.241 ± 0.089
3.935LysGly: 3.935 ± 0.11
1.032LysHis: 1.032 ± 0.051
9.125LysIle: 9.125 ± 0.154
10.583LysLys: 10.583 ± 0.204
8.159LysLeu: 8.159 ± 0.162
2.848LysMet: 2.848 ± 0.092
8.322LysAsn: 8.322 ± 0.149
1.842LysPro: 1.842 ± 0.083
2.072LysGln: 2.072 ± 0.079
3.101LysArg: 3.101 ± 0.094
4.993LysSer: 4.993 ± 0.096
5.185LysThr: 5.185 ± 0.123
5.656LysVal: 5.656 ± 0.125
0.644LysTrp: 0.644 ± 0.043
5.895LysTyr: 5.895 ± 0.127
0.0LysXaa: 0.0 ± 0.0
Leu
4.64LeuAla: 4.64 ± 0.109
1.032LeuCys: 1.032 ± 0.053
6.482LeuAsp: 6.482 ± 0.135
7.394LeuGlu: 7.394 ± 0.186
3.93LeuPhe: 3.93 ± 0.145
5.045LeuGly: 5.045 ± 0.125
1.179LeuHis: 1.179 ± 0.043
8.445LeuIle: 8.445 ± 0.189
9.996LeuLys: 9.996 ± 0.167
8.275LeuLeu: 8.275 ± 0.178
1.965LeuMet: 1.965 ± 0.067
7.552LeuAsn: 7.552 ± 0.168
2.424LeuPro: 2.424 ± 0.072
2.095LeuGln: 2.095 ± 0.081
2.737LeuArg: 2.737 ± 0.087
6.307LeuSer: 6.307 ± 0.142
5.265LeuThr: 5.265 ± 0.124
5.687LeuVal: 5.687 ± 0.13
0.481LeuTrp: 0.481 ± 0.034
4.141LeuTyr: 4.141 ± 0.101
0.0LeuXaa: 0.0 ± 0.0
Met
1.477MetAla: 1.477 ± 0.062
0.265MetCys: 0.265 ± 0.025
1.413MetAsp: 1.413 ± 0.064
1.371MetGlu: 1.371 ± 0.059
0.94MetPhe: 0.94 ± 0.05
1.236MetGly: 1.236 ± 0.06
0.334MetHis: 0.334 ± 0.027
1.915MetIle: 1.915 ± 0.075
2.228MetLys: 2.228 ± 0.073
2.147MetLeu: 2.147 ± 0.073
0.625MetMet: 0.625 ± 0.048
1.574MetAsn: 1.574 ± 0.064
0.826MetPro: 0.826 ± 0.049
0.883MetGln: 0.883 ± 0.043
0.661MetArg: 0.661 ± 0.036
1.319MetSer: 1.319 ± 0.051
1.196MetThr: 1.196 ± 0.051
1.326MetVal: 1.326 ± 0.06
0.118MetTrp: 0.118 ± 0.017
0.971MetTyr: 0.971 ± 0.048
0.0MetXaa: 0.0 ± 0.0
Asn
3.367AsnAla: 3.367 ± 0.083
0.85AsnCys: 0.85 ± 0.046
5.258AsnAsp: 5.258 ± 0.132
4.737AsnGlu: 4.737 ± 0.08
3.319AsnPhe: 3.319 ± 0.09
4.266AsnGly: 4.266 ± 0.12
0.999AsnHis: 0.999 ± 0.048
8.149AsnIle: 8.149 ± 0.151
7.903AsnLys: 7.903 ± 0.161
7.711AsnLeu: 7.711 ± 0.157
1.889AsnMet: 1.889 ± 0.075
7.896AsnAsn: 7.896 ± 0.214
2.235AsnPro: 2.235 ± 0.088
1.745AsnGln: 1.745 ± 0.078
1.97AsnArg: 1.97 ± 0.075
4.647AsnSer: 4.647 ± 0.136
4.347AsnThr: 4.347 ± 0.105
4.153AsnVal: 4.153 ± 0.109
0.469AsnTrp: 0.469 ± 0.036
5.01AsnTyr: 5.01 ± 0.126
0.0AsnXaa: 0.0 ± 0.0
Pro
1.011ProAla: 1.011 ± 0.047
0.227ProCys: 0.227 ± 0.025
1.598ProAsp: 1.598 ± 0.085
1.787ProGlu: 1.787 ± 0.07
1.151ProPhe: 1.151 ± 0.055
0.964ProGly: 0.964 ± 0.052
0.348ProHis: 0.348 ± 0.03
2.242ProIle: 2.242 ± 0.071
2.221ProLys: 2.221 ± 0.064
2.169ProLeu: 2.169 ± 0.086
0.504ProMet: 0.504 ± 0.037
1.851ProAsn: 1.851 ± 0.068
0.348ProPro: 0.348 ± 0.033
0.488ProGln: 0.488 ± 0.035
0.606ProArg: 0.606 ± 0.035
1.655ProSer: 1.655 ± 0.064
1.532ProThr: 1.532 ± 0.073
1.676ProVal: 1.676 ± 0.069
0.206ProTrp: 0.206 ± 0.024
1.371ProTyr: 1.371 ± 0.058
0.0ProXaa: 0.0 ± 0.0
Gln
1.103GlnAla: 1.103 ± 0.064
0.14GlnCys: 0.14 ± 0.018
1.444GlnAsp: 1.444 ± 0.051
2.064GlnGlu: 2.064 ± 0.083
0.67GlnPhe: 0.67 ± 0.04
0.971GlnGly: 0.971 ± 0.06
0.234GlnHis: 0.234 ± 0.024
2.119GlnIle: 2.119 ± 0.077
2.114GlnLys: 2.114 ± 0.086
1.627GlnLeu: 1.627 ± 0.077
0.523GlnMet: 0.523 ± 0.039
1.849GlnAsn: 1.849 ± 0.081
0.391GlnPro: 0.391 ± 0.037
0.526GlnGln: 0.526 ± 0.038
0.762GlnArg: 0.762 ± 0.051
1.3GlnSer: 1.3 ± 0.053
1.241GlnThr: 1.241 ± 0.05
1.376GlnVal: 1.376 ± 0.05
0.109GlnTrp: 0.109 ± 0.017
0.867GlnTyr: 0.867 ± 0.053
0.0GlnXaa: 0.0 ± 0.0
Arg
1.198ArgAla: 1.198 ± 0.055
0.369ArgCys: 0.369 ± 0.033
1.634ArgAsp: 1.634 ± 0.075
2.067ArgGlu: 2.067 ± 0.08
1.167ArgPhe: 1.167 ± 0.057
1.527ArgGly: 1.527 ± 0.068
0.464ArgHis: 0.464 ± 0.033
2.673ArgIle: 2.673 ± 0.083
3.111ArgLys: 3.111 ± 0.092
2.765ArgLeu: 2.765 ± 0.074
0.824ArgMet: 0.824 ± 0.047
2.079ArgAsn: 2.079 ± 0.069
0.762ArgPro: 0.762 ± 0.044
0.845ArgGln: 0.845 ± 0.049
1.231ArgArg: 1.231 ± 0.058
1.721ArgSer: 1.721 ± 0.059
1.527ArgThr: 1.527 ± 0.055
1.7ArgVal: 1.7 ± 0.079
0.204ArgTrp: 0.204 ± 0.023
1.676ArgTyr: 1.676 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
2.415SerAla: 2.415 ± 0.083
0.67SerCys: 0.67 ± 0.045
3.951SerAsp: 3.951 ± 0.117
3.135SerGlu: 3.135 ± 0.092
2.929SerPhe: 2.929 ± 0.084
3.608SerGly: 3.608 ± 0.12
0.765SerHis: 0.765 ± 0.042
6.191SerIle: 6.191 ± 0.134
6.601SerLys: 6.601 ± 0.12
6.345SerLeu: 6.345 ± 0.136
1.305SerMet: 1.305 ± 0.065
5.448SerAsn: 5.448 ± 0.137
1.338SerPro: 1.338 ± 0.053
1.404SerGln: 1.404 ± 0.064
1.828SerArg: 1.828 ± 0.069
4.91SerSer: 4.91 ± 0.16
3.376SerThr: 3.376 ± 0.096
3.083SerVal: 3.083 ± 0.095
0.369SerTrp: 0.369 ± 0.027
3.518SerTyr: 3.518 ± 0.102
0.0SerXaa: 0.0 ± 0.0
Thr
2.417ThrAla: 2.417 ± 0.092
0.793ThrCys: 0.793 ± 0.055
3.601ThrAsp: 3.601 ± 0.087
2.789ThrGlu: 2.789 ± 0.076
2.446ThrPhe: 2.446 ± 0.086
3.414ThrGly: 3.414 ± 0.118
0.691ThrHis: 0.691 ± 0.041
5.545ThrIle: 5.545 ± 0.116
5.552ThrLys: 5.552 ± 0.113
5.467ThrLeu: 5.467 ± 0.123
1.02ThrMet: 1.02 ± 0.059
4.406ThrAsn: 4.406 ± 0.136
1.7ThrPro: 1.7 ± 0.065
1.025ThrGln: 1.025 ± 0.057
1.565ThrArg: 1.565 ± 0.066
4.077ThrSer: 4.077 ± 0.115
3.653ThrThr: 3.653 ± 0.147
3.229ThrVal: 3.229 ± 0.097
0.372ThrTrp: 0.372 ± 0.034
3.241ThrTyr: 3.241 ± 0.097
0.0ThrXaa: 0.0 ± 0.0
Val
2.903ValAla: 2.903 ± 0.085
0.855ValCys: 0.855 ± 0.052
3.454ValAsp: 3.454 ± 0.095
3.374ValGlu: 3.374 ± 0.101
2.394ValPhe: 2.394 ± 0.08
3.239ValGly: 3.239 ± 0.096
0.658ValHis: 0.658 ± 0.042
5.381ValIle: 5.381 ± 0.118
5.296ValLys: 5.296 ± 0.128
5.547ValLeu: 5.547 ± 0.121
1.276ValMet: 1.276 ± 0.064
4.302ValAsn: 4.302 ± 0.093
1.579ValPro: 1.579 ± 0.063
0.807ValGln: 0.807 ± 0.045
1.738ValArg: 1.738 ± 0.064
4.389ValSer: 4.389 ± 0.119
3.381ValThr: 3.381 ± 0.109
3.819ValVal: 3.819 ± 0.116
0.294ValTrp: 0.294 ± 0.027
2.68ValTyr: 2.68 ± 0.08
0.0ValXaa: 0.0 ± 0.0
Trp
0.227TrpAla: 0.227 ± 0.02
0.083TrpCys: 0.083 ± 0.013
0.341TrpAsp: 0.341 ± 0.03
0.31TrpGlu: 0.31 ± 0.032
0.32TrpPhe: 0.32 ± 0.03
0.282TrpGly: 0.282 ± 0.028
0.14TrpHis: 0.14 ± 0.021
0.388TrpIle: 0.388 ± 0.03
0.32TrpLys: 0.32 ± 0.03
0.679TrpLeu: 0.679 ± 0.051
0.14TrpMet: 0.14 ± 0.018
0.44TrpAsn: 0.44 ± 0.034
0.163TrpPro: 0.163 ± 0.027
0.291TrpGln: 0.291 ± 0.026
0.168TrpArg: 0.168 ± 0.021
0.4TrpSer: 0.4 ± 0.033
0.313TrpThr: 0.313 ± 0.03
0.289TrpVal: 0.289 ± 0.027
0.092TrpTrp: 0.092 ± 0.02
0.469TrpTyr: 0.469 ± 0.039
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.484TyrAla: 2.484 ± 0.075
0.594TyrCys: 0.594 ± 0.04
3.542TyrAsp: 3.542 ± 0.114
3.296TyrGlu: 3.296 ± 0.095
2.697TyrPhe: 2.697 ± 0.088
2.824TyrGly: 2.824 ± 0.107
0.862TyrHis: 0.862 ± 0.046
4.574TyrIle: 4.574 ± 0.113
4.427TyrLys: 4.427 ± 0.111
6.255TyrLeu: 6.255 ± 0.141
1.032TyrMet: 1.032 ± 0.047
4.633TyrAsn: 4.633 ± 0.122
1.475TyrPro: 1.475 ± 0.053
1.941TyrGln: 1.941 ± 0.07
1.57TyrArg: 1.57 ± 0.057
3.251TyrSer: 3.251 ± 0.105
3.071TyrThr: 3.071 ± 0.092
2.967TyrVal: 2.967 ± 0.1
0.308TyrTrp: 0.308 ± 0.029
3.556TyrTyr: 3.556 ± 0.114
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1369 proteins (422380 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski