Amino acid dipepetide frequency for Lachnospiraceae bacterium A4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.454AlaAla: 7.454 ± 0.084	1.144AlaCys: 1.144 ± 0.027	4.71AlaAsp: 4.71 ± 0.056	5.617AlaGlu: 5.617 ± 0.065	3.08AlaPhe: 3.08 ± 0.044	5.541AlaGly: 5.541 ± 0.066	1.116AlaHis: 1.116 ± 0.026	4.028AlaIle: 4.028 ± 0.045	4.566AlaLys: 4.566 ± 0.061	6.881AlaLeu: 6.881 ± 0.075	2.161AlaMet: 2.161 ± 0.039	2.533AlaAsn: 2.533 ± 0.042	1.949AlaPro: 1.949 ± 0.045	2.711AlaGln: 2.711 ± 0.046	2.979AlaArg: 2.979 ± 0.04	3.999AlaSer: 3.999 ± 0.055	2.682AlaThr: 2.682 ± 0.048	6.49AlaVal: 6.49 ± 0.073	0.67AlaTrp: 0.67 ± 0.021	3.201AlaTyr: 3.201 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.094CysAla: 1.094 ± 0.028	0.322CysCys: 0.322 ± 0.014	0.954CysAsp: 0.954 ± 0.024	0.959CysGlu: 0.959 ± 0.026	0.757CysPhe: 0.757 ± 0.021	1.374CysGly: 1.374 ± 0.033	0.318CysHis: 0.318 ± 0.013	1.274CysIle: 1.274 ± 0.027	0.88CysLys: 0.88 ± 0.021	1.228CysLeu: 1.228 ± 0.027	0.533CysMet: 0.533 ± 0.019	0.648CysAsn: 0.648 ± 0.017	0.584CysPro: 0.584 ± 0.02	0.453CysGln: 0.453 ± 0.016	0.844CysArg: 0.844 ± 0.022	0.983CysSer: 0.983 ± 0.025	0.771CysThr: 0.771 ± 0.023	1.055CysVal: 1.055 ± 0.022	0.162CysTrp: 0.162 ± 0.009	0.715CysTyr: 0.715 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.309AspAla: 4.309 ± 0.061	0.975AspCys: 0.975 ± 0.022	2.928AspAsp: 2.928 ± 0.042	4.727AspGlu: 4.727 ± 0.056	2.892AspPhe: 2.892 ± 0.035	4.379AspGly: 4.379 ± 0.061	0.786AspHis: 0.786 ± 0.023	4.677AspIle: 4.677 ± 0.049	3.961AspLys: 3.961 ± 0.052	4.412AspLeu: 4.412 ± 0.049	1.874AspMet: 1.874 ± 0.033	2.578AspAsn: 2.578 ± 0.038	1.358AspPro: 1.358 ± 0.028	1.307AspGln: 1.307 ± 0.03	2.763AspArg: 2.763 ± 0.044	3.366AspSer: 3.366 ± 0.047	3.492AspThr: 3.492 ± 0.055	3.336AspVal: 3.336 ± 0.043	0.695AspTrp: 0.695 ± 0.021	2.93AspTyr: 2.93 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	5.569GluAla: 5.569 ± 0.066	0.953GluCys: 0.953 ± 0.025	4.07GluAsp: 4.07 ± 0.056	7.067GluGlu: 7.067 ± 0.088	2.531GluPhe: 2.531 ± 0.037	4.227GluGly: 4.227 ± 0.054	1.399GluHis: 1.399 ± 0.027	5.748GluIle: 5.748 ± 0.053	6.579GluLys: 6.579 ± 0.076	7.2GluLeu: 7.2 ± 0.072	2.438GluMet: 2.438 ± 0.038	4.53GluAsn: 4.53 ± 0.058	1.815GluPro: 1.815 ± 0.035	3.512GluGln: 3.512 ± 0.049	3.77GluArg: 3.77 ± 0.051	3.58GluSer: 3.58 ± 0.052	4.203GluThr: 4.203 ± 0.055	4.228GluVal: 4.228 ± 0.057	0.832GluTrp: 0.832 ± 0.024	3.679GluTyr: 3.679 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	2.931PheAla: 2.931 ± 0.041	0.834PheCys: 0.834 ± 0.023	2.711PheAsp: 2.711 ± 0.039	2.886PheGlu: 2.886 ± 0.04	1.828PhePhe: 1.828 ± 0.034	2.755PheGly: 2.755 ± 0.041	0.925PheHis: 0.925 ± 0.026	2.681PheIle: 2.681 ± 0.039	1.896PheLys: 1.896 ± 0.033	3.828PheLeu: 3.828 ± 0.061	1.196PheMet: 1.196 ± 0.024	1.466PheAsn: 1.466 ± 0.027	1.291PhePro: 1.291 ± 0.026	1.484PheGln: 1.484 ± 0.026	1.899PheArg: 1.899 ± 0.035	2.89PheSer: 2.89 ± 0.047	2.231PheThr: 2.231 ± 0.043	2.811PheVal: 2.811 ± 0.038	0.508PheTrp: 0.508 ± 0.017	1.935PheTyr: 1.935 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	4.25GlyAla: 4.25 ± 0.06	1.102GlyCys: 1.102 ± 0.03	3.211GlyAsp: 3.211 ± 0.046	4.534GlyGlu: 4.534 ± 0.057	2.802GlyPhe: 2.802 ± 0.037	4.098GlyGly: 4.098 ± 0.054	1.049GlyHis: 1.049 ± 0.028	5.7GlyIle: 5.7 ± 0.063	5.09GlyLys: 5.09 ± 0.051	5.103GlyLeu: 5.103 ± 0.05	2.303GlyMet: 2.303 ± 0.039	3.319GlyAsn: 3.319 ± 0.051	0.78GlyPro: 0.78 ± 0.021	2.18GlyGln: 2.18 ± 0.038	3.287GlyArg: 3.287 ± 0.049	3.808GlySer: 3.808 ± 0.049	3.922GlyThr: 3.922 ± 0.057	4.092GlyVal: 4.092 ± 0.058	0.717GlyTrp: 0.717 ± 0.02	3.29GlyTyr: 3.29 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.091HisAla: 1.091 ± 0.024	0.303HisCys: 0.303 ± 0.013	1.052HisAsp: 1.052 ± 0.026	1.205HisGlu: 1.205 ± 0.027	0.908HisPhe: 0.908 ± 0.026	1.18HisGly: 1.18 ± 0.028	0.399HisHis: 0.399 ± 0.016	1.442HisIle: 1.442 ± 0.029	1.033HisLys: 1.033 ± 0.025	1.476HisLeu: 1.476 ± 0.031	0.559HisMet: 0.559 ± 0.019	0.802HisAsn: 0.802 ± 0.019	0.698HisPro: 0.698 ± 0.022	0.604HisGln: 0.604 ± 0.019	0.834HisArg: 0.834 ± 0.021	1.012HisSer: 1.012 ± 0.022	1.023HisThr: 1.023 ± 0.024	1.053HisVal: 1.053 ± 0.025	0.19HisTrp: 0.19 ± 0.01	0.836HisTyr: 0.836 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.093IleAla: 5.093 ± 0.051	1.315IleCys: 1.315 ± 0.029	4.258IleAsp: 4.258 ± 0.049	5.202IleGlu: 5.202 ± 0.06	2.759IlePhe: 2.759 ± 0.044	4.322IleGly: 4.322 ± 0.053	1.341IleHis: 1.341 ± 0.028	4.747IleIle: 4.747 ± 0.064	4.299IleLys: 4.299 ± 0.051	6.544IleLeu: 6.544 ± 0.068	1.92IleMet: 1.92 ± 0.034	2.985IleAsn: 2.985 ± 0.044	2.815IlePro: 2.815 ± 0.037	2.598IleGln: 2.598 ± 0.034	3.735IleArg: 3.735 ± 0.049	4.762IleSer: 4.762 ± 0.054	4.114IleThr: 4.114 ± 0.061	4.566IleVal: 4.566 ± 0.052	0.656IleTrp: 0.656 ± 0.019	3.038IleTyr: 3.038 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	4.782LysAla: 4.782 ± 0.061	0.803LysCys: 0.803 ± 0.024	3.774LysAsp: 3.774 ± 0.052	6.305LysGlu: 6.305 ± 0.067	1.87LysPhe: 1.87 ± 0.032	3.988LysGly: 3.988 ± 0.052	1.068LysHis: 1.068 ± 0.026	4.719LysIle: 4.719 ± 0.048	5.969LysLys: 5.969 ± 0.069	5.661LysLeu: 5.661 ± 0.059	2.015LysMet: 2.015 ± 0.032	3.943LysAsn: 3.943 ± 0.053	2.106LysPro: 2.106 ± 0.035	2.597LysGln: 2.597 ± 0.038	3.3LysArg: 3.3 ± 0.047	3.549LysSer: 3.549 ± 0.046	3.717LysThr: 3.717 ± 0.044	3.911LysVal: 3.911 ± 0.053	0.688LysTrp: 0.688 ± 0.019	3.189LysTyr: 3.189 ± 0.047	0.0LysXaa: 0.0 ± 0.0
Leu	6.456LeuAla: 6.456 ± 0.07	1.712LeuCys: 1.712 ± 0.035	5.037LeuAsp: 5.037 ± 0.049	6.384LeuGlu: 6.384 ± 0.065	3.819LeuPhe: 3.819 ± 0.055	5.155LeuGly: 5.155 ± 0.061	1.641LeuHis: 1.641 ± 0.032	5.383LeuIle: 5.383 ± 0.068	5.793LeuLys: 5.793 ± 0.056	8.511LeuLeu: 8.511 ± 0.108	2.585LeuMet: 2.585 ± 0.041	3.942LeuAsn: 3.942 ± 0.046	3.267LeuPro: 3.267 ± 0.048	3.083LeuGln: 3.083 ± 0.046	4.216LeuArg: 4.216 ± 0.051	6.284LeuSer: 6.284 ± 0.06	4.896LeuThr: 4.896 ± 0.062	5.199LeuVal: 5.199 ± 0.053	0.861LeuTrp: 0.861 ± 0.024	3.959LeuTyr: 3.959 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.26MetAla: 2.26 ± 0.037	0.35MetCys: 0.35 ± 0.015	1.806MetAsp: 1.806 ± 0.027	2.711MetGlu: 2.711 ± 0.039	0.981MetPhe: 0.981 ± 0.025	1.887MetGly: 1.887 ± 0.036	0.472MetHis: 0.472 ± 0.017	2.059MetIle: 2.059 ± 0.034	2.366MetLys: 2.366 ± 0.033	2.793MetLeu: 2.793 ± 0.044	0.921MetMet: 0.921 ± 0.025	1.596MetAsn: 1.596 ± 0.027	1.148MetPro: 1.148 ± 0.026	1.252MetGln: 1.252 ± 0.027	1.403MetArg: 1.403 ± 0.03	1.723MetSer: 1.723 ± 0.03	1.781MetThr: 1.781 ± 0.028	1.71MetVal: 1.71 ± 0.032	0.225MetTrp: 0.225 ± 0.01	1.019MetTyr: 1.019 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.471AsnAla: 3.471 ± 0.05	0.709AsnCys: 0.709 ± 0.019	2.369AsnAsp: 2.369 ± 0.041	3.209AsnGlu: 3.209 ± 0.048	1.662AsnPhe: 1.662 ± 0.028	3.646AsnGly: 3.646 ± 0.055	0.87AsnHis: 0.87 ± 0.021	3.608AsnIle: 3.608 ± 0.049	2.85AsnLys: 2.85 ± 0.042	3.734AsnLeu: 3.734 ± 0.047	1.389AsnMet: 1.389 ± 0.027	2.182AsnAsn: 2.182 ± 0.036	1.961AsnPro: 1.961 ± 0.039	1.656AsnGln: 1.656 ± 0.031	2.277AsnArg: 2.277 ± 0.042	2.498AsnSer: 2.498 ± 0.039	2.684AsnThr: 2.684 ± 0.047	2.864AsnVal: 2.864 ± 0.041	0.454AsnTrp: 0.454 ± 0.016	2.04AsnTyr: 2.04 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	2.346ProAla: 2.346 ± 0.047	0.436ProCys: 0.436 ± 0.016	2.302ProAsp: 2.302 ± 0.036	2.974ProGlu: 2.974 ± 0.039	1.379ProPhe: 1.379 ± 0.03	1.616ProGly: 1.616 ± 0.03	0.54ProHis: 0.54 ± 0.019	1.81ProIle: 1.81 ± 0.035	1.855ProLys: 1.855 ± 0.03	2.459ProLeu: 2.459 ± 0.034	0.802ProMet: 0.802 ± 0.019	1.2ProAsn: 1.2 ± 0.025	0.757ProPro: 0.757 ± 0.024	1.203ProGln: 1.203 ± 0.027	1.023ProArg: 1.023 ± 0.026	1.694ProSer: 1.694 ± 0.036	1.276ProThr: 1.276 ± 0.028	2.751ProVal: 2.751 ± 0.043	0.298ProTrp: 0.298 ± 0.013	1.527ProTyr: 1.527 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	2.528GlnAla: 2.528 ± 0.038	0.486GlnCys: 0.486 ± 0.016	1.761GlnAsp: 1.761 ± 0.029	3.151GlnGlu: 3.151 ± 0.056	1.368GlnPhe: 1.368 ± 0.027	2.056GlnGly: 2.056 ± 0.037	0.599GlnHis: 0.599 ± 0.019	2.833GlnIle: 2.833 ± 0.035	3.029GlnLys: 3.029 ± 0.043	3.151GlnLeu: 3.151 ± 0.042	1.275GlnMet: 1.275 ± 0.028	2.041GlnAsn: 2.041 ± 0.03	1.025GlnPro: 1.025 ± 0.025	1.612GlnGln: 1.612 ± 0.04	1.691GlnArg: 1.691 ± 0.03	1.909GlnSer: 1.909 ± 0.034	2.095GlnThr: 2.095 ± 0.037	1.907GlnVal: 1.907 ± 0.033	0.377GlnTrp: 0.377 ± 0.014	1.835GlnTyr: 1.835 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	3.055ArgAla: 3.055 ± 0.035	0.669ArgCys: 0.669 ± 0.02	2.392ArgAsp: 2.392 ± 0.036	4.052ArgGlu: 4.052 ± 0.052	2.059ArgPhe: 2.059 ± 0.035	2.451ArgGly: 2.451 ± 0.04	0.883ArgHis: 0.883 ± 0.022	3.728ArgIle: 3.728 ± 0.053	3.745ArgLys: 3.745 ± 0.043	4.353ArgLeu: 4.353 ± 0.059	1.639ArgMet: 1.639 ± 0.035	2.338ArgAsn: 2.338 ± 0.035	1.232ArgPro: 1.232 ± 0.029	2.178ArgGln: 2.178 ± 0.036	2.675ArgArg: 2.675 ± 0.052	2.25ArgSer: 2.25 ± 0.038	2.487ArgThr: 2.487 ± 0.039	2.59ArgVal: 2.59 ± 0.042	0.483ArgTrp: 0.483 ± 0.019	2.28ArgTyr: 2.28 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	4.35SerAla: 4.35 ± 0.056	0.878SerCys: 0.878 ± 0.024	3.596SerAsp: 3.596 ± 0.049	4.222SerGlu: 4.222 ± 0.058	2.683SerPhe: 2.683 ± 0.038	4.617SerGly: 4.617 ± 0.062	1.011SerHis: 1.011 ± 0.025	4.224SerIle: 4.224 ± 0.045	3.381SerLys: 3.381 ± 0.047	5.023SerLeu: 5.023 ± 0.055	1.924SerMet: 1.924 ± 0.031	2.328SerAsn: 2.328 ± 0.042	1.661SerPro: 1.661 ± 0.03	1.919SerGln: 1.919 ± 0.035	2.759SerArg: 2.759 ± 0.041	3.487SerSer: 3.487 ± 0.059	2.729SerThr: 2.729 ± 0.046	4.307SerVal: 4.307 ± 0.057	0.547SerTrp: 0.547 ± 0.02	2.709SerTyr: 2.709 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	4.746ThrAla: 4.746 ± 0.079	0.633ThrCys: 0.633 ± 0.017	3.582ThrAsp: 3.582 ± 0.05	4.072ThrGlu: 4.072 ± 0.058	2.095ThrPhe: 2.095 ± 0.035	4.232ThrGly: 4.232 ± 0.06	0.839ThrHis: 0.839 ± 0.02	3.861ThrIle: 3.861 ± 0.052	3.121ThrLys: 3.121 ± 0.044	4.584ThrLeu: 4.584 ± 0.061	1.373ThrMet: 1.373 ± 0.029	2.064ThrAsn: 2.064 ± 0.039	1.965ThrPro: 1.965 ± 0.038	1.787ThrGln: 1.787 ± 0.031	2.008ThrArg: 2.008 ± 0.034	2.825ThrSer: 2.825 ± 0.047	2.696ThrThr: 2.696 ± 0.05	4.418ThrVal: 4.418 ± 0.078	0.506ThrTrp: 0.506 ± 0.016	2.387ThrTyr: 2.387 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	4.04ValAla: 4.04 ± 0.052	1.282ValCys: 1.282 ± 0.03	3.408ValAsp: 3.408 ± 0.043	4.305ValGlu: 4.305 ± 0.049	2.938ValPhe: 2.938 ± 0.043	3.467ValGly: 3.467 ± 0.054	1.129ValHis: 1.129 ± 0.026	4.62ValIle: 4.62 ± 0.06	4.14ValLys: 4.14 ± 0.057	6.3ValLeu: 6.3 ± 0.068	2.003ValMet: 2.003 ± 0.033	2.834ValAsn: 2.834 ± 0.035	2.246ValPro: 2.246 ± 0.036	2.216ValGln: 2.216 ± 0.031	3.213ValArg: 3.213 ± 0.045	4.649ValSer: 4.649 ± 0.053	3.949ValThr: 3.949 ± 0.077	4.238ValVal: 4.238 ± 0.059	0.7ValTrp: 0.7 ± 0.019	2.947ValTyr: 2.947 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.586TrpAla: 0.586 ± 0.019	0.194TrpCys: 0.194 ± 0.012	0.618TrpAsp: 0.618 ± 0.019	0.77TrpGlu: 0.77 ± 0.019	0.509TrpPhe: 0.509 ± 0.017	0.678TrpGly: 0.678 ± 0.017	0.238TrpHis: 0.238 ± 0.012	0.719TrpIle: 0.719 ± 0.019	0.768TrpLys: 0.768 ± 0.021	0.953TrpLeu: 0.953 ± 0.026	0.294TrpMet: 0.294 ± 0.012	0.629TrpAsn: 0.629 ± 0.019	0.133TrpPro: 0.133 ± 0.009	0.472TrpGln: 0.472 ± 0.016	0.471TrpArg: 0.471 ± 0.014	0.53TrpSer: 0.53 ± 0.016	0.5TrpThr: 0.5 ± 0.018	0.521TrpVal: 0.521 ± 0.016	0.14TrpTrp: 0.14 ± 0.007	0.49TrpTyr: 0.49 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.103TyrAla: 3.103 ± 0.043	0.808TyrCys: 0.808 ± 0.023	3.205TyrAsp: 3.205 ± 0.058	3.578TyrGlu: 3.578 ± 0.048	2.067TyrPhe: 2.067 ± 0.032	2.967TyrGly: 2.967 ± 0.038	1.075TyrHis: 1.075 ± 0.023	3.209TyrIle: 3.209 ± 0.045	2.633TyrLys: 2.633 ± 0.047	3.992TyrLeu: 3.992 ± 0.053	1.258TyrMet: 1.258 ± 0.027	2.175TyrAsn: 2.175 ± 0.04	1.455TyrPro: 1.455 ± 0.025	1.902TyrGln: 1.902 ± 0.031	2.394TyrArg: 2.394 ± 0.037	2.557TyrSer: 2.557 ± 0.038	2.547TyrThr: 2.547 ± 0.053	2.577TyrVal: 2.577 ± 0.041	0.505TyrTrp: 0.505 ± 0.016	2.263TyrTyr: 2.263 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6440 proteins (1943585 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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