Amino acid dipepetide frequency for Bacteroides sp. CAG:633

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.296AlaAla: 6.296 ± 0.1	1.231AlaCys: 1.231 ± 0.04	4.992AlaAsp: 4.992 ± 0.073	5.253AlaGlu: 5.253 ± 0.086	3.341AlaPhe: 3.341 ± 0.051	5.371AlaGly: 5.371 ± 0.079	1.29AlaHis: 1.29 ± 0.036	4.511AlaIle: 4.511 ± 0.067	3.691AlaLys: 3.691 ± 0.071	7.192AlaLeu: 7.192 ± 0.108	1.992AlaMet: 1.992 ± 0.044	3.104AlaAsn: 3.104 ± 0.064	2.439AlaPro: 2.439 ± 0.051	3.067AlaGln: 3.067 ± 0.055	3.623AlaArg: 3.623 ± 0.06	4.555AlaSer: 4.555 ± 0.07	4.107AlaThr: 4.107 ± 0.072	5.143AlaVal: 5.143 ± 0.082	0.905AlaTrp: 0.905 ± 0.03	3.036AlaTyr: 3.036 ± 0.059	0.004AlaXaa: 0.004 ± 0.002
Cys	0.889CysAla: 0.889 ± 0.027	0.258CysCys: 0.258 ± 0.017	0.659CysAsp: 0.659 ± 0.024	0.693CysGlu: 0.693 ± 0.024	0.709CysPhe: 0.709 ± 0.029	1.12CysGly: 1.12 ± 0.036	0.319CysHis: 0.319 ± 0.02	0.983CysIle: 0.983 ± 0.032	0.646CysLys: 0.646 ± 0.027	1.269CysLeu: 1.269 ± 0.036	0.368CysMet: 0.368 ± 0.02	0.546CysAsn: 0.546 ± 0.023	0.647CysPro: 0.647 ± 0.028	0.446CysGln: 0.446 ± 0.02	0.798CysArg: 0.798 ± 0.03	0.825CysSer: 0.825 ± 0.032	0.71CysThr: 0.71 ± 0.03	0.786CysVal: 0.786 ± 0.031	0.174CysTrp: 0.174 ± 0.013	0.57CysTyr: 0.57 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	4.285AspAla: 4.285 ± 0.07	0.698AspCys: 0.698 ± 0.028	2.96AspAsp: 2.96 ± 0.064	4.196AspGlu: 4.196 ± 0.067	2.92AspPhe: 2.92 ± 0.056	4.36AspGly: 4.36 ± 0.073	0.83AspHis: 0.83 ± 0.031	3.889AspIle: 3.889 ± 0.056	3.599AspLys: 3.599 ± 0.067	4.742AspLeu: 4.742 ± 0.074	1.619AspMet: 1.619 ± 0.04	2.624AspAsn: 2.624 ± 0.06	1.876AspPro: 1.876 ± 0.045	1.333AspGln: 1.333 ± 0.035	2.782AspArg: 2.782 ± 0.054	3.112AspSer: 3.112 ± 0.067	2.864AspThr: 2.864 ± 0.054	3.739AspVal: 3.739 ± 0.064	0.914AspTrp: 0.914 ± 0.026	2.876AspTyr: 2.876 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	5.281GluAla: 5.281 ± 0.092	0.633GluCys: 0.633 ± 0.023	3.158GluAsp: 3.158 ± 0.062	5.076GluGlu: 5.076 ± 0.09	2.282GluPhe: 2.282 ± 0.043	4.56GluGly: 4.56 ± 0.076	1.298GluHis: 1.298 ± 0.036	4.127GluIle: 4.127 ± 0.073	4.75GluLys: 4.75 ± 0.082	6.181GluLeu: 6.181 ± 0.08	1.967GluMet: 1.967 ± 0.052	3.376GluAsn: 3.376 ± 0.059	1.768GluPro: 1.768 ± 0.046	2.962GluGln: 2.962 ± 0.057	3.371GluArg: 3.371 ± 0.065	3.005GluSer: 3.005 ± 0.059	3.35GluThr: 3.35 ± 0.058	4.442GluVal: 4.442 ± 0.068	0.855GluTrp: 0.855 ± 0.031	2.714GluTyr: 2.714 ± 0.053	0.003GluXaa: 0.003 ± 0.002
Phe	3.13PheAla: 3.13 ± 0.056	0.722PheCys: 0.722 ± 0.028	2.721PheAsp: 2.721 ± 0.05	2.358PheGlu: 2.358 ± 0.046	2.141PhePhe: 2.141 ± 0.052	3.138PheGly: 3.138 ± 0.055	0.921PheHis: 0.921 ± 0.034	2.88PheIle: 2.88 ± 0.053	2.135PheLys: 2.135 ± 0.049	4.104PheLeu: 4.104 ± 0.072	1.203PheMet: 1.203 ± 0.039	2.094PheAsn: 2.094 ± 0.045	1.734PhePro: 1.734 ± 0.038	1.319PheGln: 1.319 ± 0.033	2.392PheArg: 2.392 ± 0.053	3.192PheSer: 3.192 ± 0.056	2.678PheThr: 2.678 ± 0.052	3.019PheVal: 3.019 ± 0.06	0.576PheTrp: 0.576 ± 0.026	2.007PheTyr: 2.007 ± 0.048	0.001PheXaa: 0.001 ± 0.001
Gly	4.519GlyAla: 4.519 ± 0.075	0.968GlyCys: 0.968 ± 0.039	3.493GlyAsp: 3.493 ± 0.064	4.316GlyGlu: 4.316 ± 0.073	3.113GlyPhe: 3.113 ± 0.054	4.88GlyGly: 4.88 ± 0.102	1.438GlyHis: 1.438 ± 0.042	5.161GlyIle: 5.161 ± 0.087	4.943GlyLys: 4.943 ± 0.077	5.896GlyLeu: 5.896 ± 0.089	2.311GlyMet: 2.311 ± 0.051	3.453GlyAsn: 3.453 ± 0.059	1.356GlyPro: 1.356 ± 0.037	2.371GlyGln: 2.371 ± 0.045	3.28GlyArg: 3.28 ± 0.056	3.933GlySer: 3.933 ± 0.073	4.28GlyThr: 4.28 ± 0.057	4.86GlyVal: 4.86 ± 0.076	1.058GlyTrp: 1.058 ± 0.036	3.346GlyTyr: 3.346 ± 0.058	0.003GlyXaa: 0.003 ± 0.002
His	1.356HisAla: 1.356 ± 0.037	0.326HisCys: 0.326 ± 0.022	1.009HisAsp: 1.009 ± 0.036	1.092HisGlu: 1.092 ± 0.028	1.072HisPhe: 1.072 ± 0.034	1.313HisGly: 1.313 ± 0.042	0.538HisHis: 0.538 ± 0.029	1.386HisIle: 1.386 ± 0.04	0.939HisLys: 0.939 ± 0.029	1.927HisLeu: 1.927 ± 0.044	0.382HisMet: 0.382 ± 0.02	0.946HisAsn: 0.946 ± 0.03	1.174HisPro: 1.174 ± 0.036	0.669HisGln: 0.669 ± 0.024	1.053HisArg: 1.053 ± 0.039	1.091HisSer: 1.091 ± 0.033	1.171HisThr: 1.171 ± 0.036	1.225HisVal: 1.225 ± 0.036	0.259HisTrp: 0.259 ± 0.017	0.964HisTyr: 0.964 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	5.17IleAla: 5.17 ± 0.085	0.945IleCys: 0.945 ± 0.028	4.085IleAsp: 4.085 ± 0.065	4.126IleGlu: 4.126 ± 0.069	2.544IlePhe: 2.544 ± 0.045	4.51IleGly: 4.51 ± 0.076	1.31IleHis: 1.31 ± 0.033	3.848IleIle: 3.848 ± 0.076	3.419IleLys: 3.419 ± 0.069	5.352IleLeu: 5.352 ± 0.089	1.406IleMet: 1.406 ± 0.041	2.94IleAsn: 2.94 ± 0.061	2.912IlePro: 2.912 ± 0.058	2.014IleGln: 2.014 ± 0.049	3.55IleArg: 3.55 ± 0.056	4.128IleSer: 4.128 ± 0.065	3.618IleThr: 3.618 ± 0.069	4.364IleVal: 4.364 ± 0.068	0.672IleTrp: 0.672 ± 0.026	2.55IleTyr: 2.55 ± 0.051	0.002IleXaa: 0.002 ± 0.001
Lys	4.775LysAla: 4.775 ± 0.065	0.506LysCys: 0.506 ± 0.023	3.712LysAsp: 3.712 ± 0.071	4.981LysGlu: 4.981 ± 0.089	1.915LysPhe: 1.915 ± 0.042	4.078LysGly: 4.078 ± 0.078	1.168LysHis: 1.168 ± 0.032	3.57LysIle: 3.57 ± 0.069	4.396LysLys: 4.396 ± 0.088	5.017LysLeu: 5.017 ± 0.077	1.9LysMet: 1.9 ± 0.045	3.07LysAsn: 3.07 ± 0.059	2.012LysPro: 2.012 ± 0.046	2.608LysGln: 2.608 ± 0.055	3.041LysArg: 3.041 ± 0.048	2.847LysSer: 2.847 ± 0.055	3.128LysThr: 3.128 ± 0.059	4.017LysVal: 4.017 ± 0.074	0.696LysTrp: 0.696 ± 0.026	2.774LysTyr: 2.774 ± 0.057	0.001LysXaa: 0.001 ± 0.001
Leu	6.899LeuAla: 6.899 ± 0.091	1.515LeuCys: 1.515 ± 0.039	4.753LeuAsp: 4.753 ± 0.069	5.059LeuGlu: 5.059 ± 0.072	4.479LeuPhe: 4.479 ± 0.076	5.611LeuGly: 5.611 ± 0.092	2.042LeuHis: 2.042 ± 0.05	5.262LeuIle: 5.262 ± 0.085	6.098LeuLys: 6.098 ± 0.079	9.702LeuLeu: 9.702 ± 0.145	2.59LeuMet: 2.59 ± 0.055	4.585LeuAsn: 4.585 ± 0.07	4.35LeuPro: 4.35 ± 0.07	3.785LeuGln: 3.785 ± 0.068	4.47LeuArg: 4.47 ± 0.075	6.364LeuSer: 6.364 ± 0.083	5.655LeuThr: 5.655 ± 0.089	5.533LeuVal: 5.533 ± 0.078	1.196LeuTrp: 1.196 ± 0.035	3.814LeuTyr: 3.814 ± 0.064	0.002LeuXaa: 0.002 ± 0.001
Met	2.22MetAla: 2.22 ± 0.048	0.26MetCys: 0.26 ± 0.015	1.518MetAsp: 1.518 ± 0.037	1.822MetGlu: 1.822 ± 0.046	1.035MetPhe: 1.035 ± 0.034	1.878MetGly: 1.878 ± 0.046	0.5MetHis: 0.5 ± 0.024	1.491MetIle: 1.491 ± 0.04	2.511MetLys: 2.511 ± 0.046	2.604MetLeu: 2.604 ± 0.057	0.81MetMet: 0.81 ± 0.029	1.5MetAsn: 1.5 ± 0.042	1.245MetPro: 1.245 ± 0.036	1.187MetGln: 1.187 ± 0.031	1.361MetArg: 1.361 ± 0.034	1.505MetSer: 1.505 ± 0.033	1.503MetThr: 1.503 ± 0.038	1.526MetVal: 1.526 ± 0.038	0.25MetTrp: 0.25 ± 0.014	0.878MetTyr: 0.878 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.47AsnAla: 3.47 ± 0.058	0.506AsnCys: 0.506 ± 0.024	2.475AsnAsp: 2.475 ± 0.052	2.985AsnGlu: 2.985 ± 0.062	2.053AsnPhe: 2.053 ± 0.048	3.818AsnGly: 3.818 ± 0.071	0.924AsnHis: 0.924 ± 0.031	3.304AsnIle: 3.304 ± 0.066	2.698AsnLys: 2.698 ± 0.053	4.229AsnLeu: 4.229 ± 0.071	1.241AsnMet: 1.241 ± 0.031	2.484AsnAsn: 2.484 ± 0.062	2.383AsnPro: 2.383 ± 0.054	1.495AsnGln: 1.495 ± 0.043	2.54AsnArg: 2.54 ± 0.053	2.577AsnSer: 2.577 ± 0.049	2.527AsnThr: 2.527 ± 0.057	3.155AsnVal: 3.155 ± 0.052	0.652AsnTrp: 0.652 ± 0.026	2.191AsnTyr: 2.191 ± 0.051	0.001AsnXaa: 0.001 ± 0.001
Pro	3.152ProAla: 3.152 ± 0.061	0.459ProCys: 0.459 ± 0.025	2.745ProAsp: 2.745 ± 0.054	3.274ProGlu: 3.274 ± 0.062	1.83ProPhe: 1.83 ± 0.043	2.409ProGly: 2.409 ± 0.05	0.812ProHis: 0.812 ± 0.029	2.08ProIle: 2.08 ± 0.042	1.788ProLys: 1.788 ± 0.04	3.508ProLeu: 3.508 ± 0.07	1.003ProMet: 1.003 ± 0.028	1.582ProAsn: 1.582 ± 0.039	0.825ProPro: 0.825 ± 0.032	1.693ProGln: 1.693 ± 0.046	1.479ProArg: 1.479 ± 0.045	2.182ProSer: 2.182 ± 0.048	1.958ProThr: 1.958 ± 0.044	3.054ProVal: 3.054 ± 0.054	0.475ProTrp: 0.475 ± 0.026	1.799ProTyr: 1.799 ± 0.042	0.002ProXaa: 0.002 ± 0.001
Gln	2.979GlnAla: 2.979 ± 0.052	0.343GlnCys: 0.343 ± 0.018	1.693GlnAsp: 1.693 ± 0.038	2.449GlnGlu: 2.449 ± 0.052	1.336GlnPhe: 1.336 ± 0.034	2.331GlnGly: 2.331 ± 0.054	0.813GlnHis: 0.813 ± 0.029	2.311GlnIle: 2.311 ± 0.041	2.398GlnLys: 2.398 ± 0.048	3.697GlnLeu: 3.697 ± 0.066	1.157GlnMet: 1.157 ± 0.035	1.75GlnAsn: 1.75 ± 0.04	1.477GlnPro: 1.477 ± 0.042	1.851GlnGln: 1.851 ± 0.05	1.893GlnArg: 1.893 ± 0.046	2.037GlnSer: 2.037 ± 0.044	2.211GlnThr: 2.211 ± 0.045	2.37GlnVal: 2.37 ± 0.054	0.515GlnTrp: 0.515 ± 0.024	1.572GlnTyr: 1.572 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	3.091ArgAla: 3.091 ± 0.06	0.588ArgCys: 0.588 ± 0.025	2.239ArgAsp: 2.239 ± 0.045	3.083ArgGlu: 3.083 ± 0.065	2.419ArgPhe: 2.419 ± 0.052	2.612ArgGly: 2.612 ± 0.058	1.075ArgHis: 1.075 ± 0.035	3.721ArgIle: 3.721 ± 0.057	3.505ArgLys: 3.505 ± 0.064	5.162ArgLeu: 5.162 ± 0.076	1.755ArgMet: 1.755 ± 0.039	2.571ArgAsn: 2.571 ± 0.055	1.894ArgPro: 1.894 ± 0.05	2.273ArgGln: 2.273 ± 0.058	2.818ArgArg: 2.818 ± 0.06	2.568ArgSer: 2.568 ± 0.05	2.734ArgThr: 2.734 ± 0.054	2.9ArgVal: 2.9 ± 0.051	0.69ArgTrp: 0.69 ± 0.027	2.381ArgTyr: 2.381 ± 0.053	0.002ArgXaa: 0.002 ± 0.001
Ser	4.308SerAla: 4.308 ± 0.067	0.904SerCys: 0.904 ± 0.032	3.325SerAsp: 3.325 ± 0.062	3.326SerGlu: 3.326 ± 0.055	3.009SerPhe: 3.009 ± 0.061	4.364SerGly: 4.364 ± 0.068	1.191SerHis: 1.191 ± 0.036	3.888SerIle: 3.888 ± 0.072	2.931SerLys: 2.931 ± 0.047	6.028SerLeu: 6.028 ± 0.09	1.471SerMet: 1.471 ± 0.039	2.485SerAsn: 2.485 ± 0.055	2.253SerPro: 2.253 ± 0.053	1.955SerGln: 1.955 ± 0.042	2.728SerArg: 2.728 ± 0.052	3.706SerSer: 3.706 ± 0.069	3.121SerThr: 3.121 ± 0.058	4.226SerVal: 4.226 ± 0.079	0.781SerTrp: 0.781 ± 0.03	2.749SerTyr: 2.749 ± 0.058	0.0SerXaa: 0.0 ± 0.0
Thr	4.319ThrAla: 4.319 ± 0.074	0.654ThrCys: 0.654 ± 0.025	3.658ThrAsp: 3.658 ± 0.064	3.497ThrGlu: 3.497 ± 0.068	2.588ThrPhe: 2.588 ± 0.048	4.365ThrGly: 4.365 ± 0.068	1.045ThrHis: 1.045 ± 0.032	3.45ThrIle: 3.45 ± 0.058	2.421ThrLys: 2.421 ± 0.051	5.776ThrLeu: 5.776 ± 0.086	1.19ThrMet: 1.19 ± 0.03	2.205ThrAsn: 2.205 ± 0.057	2.767ThrPro: 2.767 ± 0.048	1.825ThrGln: 1.825 ± 0.04	2.41ThrArg: 2.41 ± 0.048	3.265ThrSer: 3.265 ± 0.063	3.126ThrThr: 3.126 ± 0.071	4.249ThrVal: 4.249 ± 0.072	0.656ThrTrp: 0.656 ± 0.029	2.5ThrTyr: 2.5 ± 0.055	0.004ThrXaa: 0.004 ± 0.002
Val	4.971ValAla: 4.971 ± 0.077	1.134ValCys: 1.134 ± 0.037	3.752ValAsp: 3.752 ± 0.069	4.267ValGlu: 4.267 ± 0.065	2.987ValPhe: 2.987 ± 0.057	4.379ValGly: 4.379 ± 0.088	1.18ValHis: 1.18 ± 0.035	4.044ValIle: 4.044 ± 0.064	4.026ValLys: 4.026 ± 0.064	6.046ValLeu: 6.046 ± 0.089	1.714ValMet: 1.714 ± 0.043	3.265ValAsn: 3.265 ± 0.063	2.731ValPro: 2.731 ± 0.05	2.131ValGln: 2.131 ± 0.049	3.38ValArg: 3.38 ± 0.074	4.588ValSer: 4.588 ± 0.066	3.836ValThr: 3.836 ± 0.063	4.779ValVal: 4.779 ± 0.084	0.787ValTrp: 0.787 ± 0.032	2.738ValTyr: 2.738 ± 0.049	0.001ValXaa: 0.001 ± 0.001
Trp	0.894TrpAla: 0.894 ± 0.031	0.178TrpCys: 0.178 ± 0.012	0.742TrpAsp: 0.742 ± 0.029	0.828TrpGlu: 0.828 ± 0.025	0.533TrpPhe: 0.533 ± 0.028	0.979TrpGly: 0.979 ± 0.038	0.292TrpHis: 0.292 ± 0.017	0.794TrpIle: 0.794 ± 0.028	0.937TrpLys: 0.937 ± 0.035	1.215TrpLeu: 1.215 ± 0.037	0.445TrpMet: 0.445 ± 0.02	0.771TrpAsn: 0.771 ± 0.03	0.316TrpPro: 0.316 ± 0.019	0.538TrpGln: 0.538 ± 0.024	0.579TrpArg: 0.579 ± 0.027	0.666TrpSer: 0.666 ± 0.028	0.728TrpThr: 0.728 ± 0.03	0.721TrpVal: 0.721 ± 0.029	0.226TrpTrp: 0.226 ± 0.017	0.555TrpTyr: 0.555 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.133TyrAla: 3.133 ± 0.049	0.59TyrCys: 0.59 ± 0.026	2.531TyrAsp: 2.531 ± 0.054	2.475TyrGlu: 2.475 ± 0.053	2.161TyrPhe: 2.161 ± 0.046	2.898TyrGly: 2.898 ± 0.057	0.903TyrHis: 0.903 ± 0.028	2.763TyrIle: 2.763 ± 0.057	2.378TyrLys: 2.378 ± 0.052	4.113TyrLeu: 4.113 ± 0.066	1.079TyrMet: 1.079 ± 0.03	2.357TyrAsn: 2.357 ± 0.056	1.942TyrPro: 1.942 ± 0.046	1.661TyrGln: 1.661 ± 0.039	2.529TyrArg: 2.529 ± 0.055	2.603TyrSer: 2.603 ± 0.056	2.664TyrThr: 2.664 ± 0.056	2.63TyrVal: 2.63 ± 0.058	0.6TyrTrp: 0.6 ± 0.027	2.138TyrTyr: 2.138 ± 0.052	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.004XaaAla: 0.004 ± 0.002	0.001XaaCys: 0.001 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.003XaaGly: 0.003 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.005XaaLeu: 0.005 ± 0.002	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.007XaaPro: 0.007 ± 0.003	0.001XaaGln: 0.001 ± 0.001	0.003XaaArg: 0.003 ± 0.002	0.002XaaSer: 0.002 ± 0.002	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.039XaaXaa: 0.039 ± 0.009

Statistics based on 3004 proteins (1032115 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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