Amino acid dipepetide frequency for Capsella rubella

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.779AlaAla: 5.779 ± 0.04	1.16AlaCys: 1.16 ± 0.012	2.893AlaAsp: 2.893 ± 0.018	4.071AlaGlu: 4.071 ± 0.025	2.616AlaPhe: 2.616 ± 0.017	3.769AlaGly: 3.769 ± 0.021	1.155AlaHis: 1.155 ± 0.009	3.502AlaIle: 3.502 ± 0.02	3.95AlaLys: 3.95 ± 0.019	6.107AlaLeu: 6.107 ± 0.028	1.77AlaMet: 1.77 ± 0.015	2.404AlaAsn: 2.404 ± 0.017	2.552AlaPro: 2.552 ± 0.02	1.867AlaGln: 1.867 ± 0.016	3.188AlaArg: 3.188 ± 0.02	5.747AlaSer: 5.747 ± 0.027	3.57AlaThr: 3.57 ± 0.021	4.68AlaVal: 4.68 ± 0.022	0.702AlaTrp: 0.702 ± 0.009	1.746AlaTyr: 1.746 ± 0.013	0.0AlaXaa: 0.0 ± 0.0
Cys	0.927CysAla: 0.927 ± 0.01	0.545CysCys: 0.545 ± 0.008	0.958CysAsp: 0.958 ± 0.01	0.925CysGlu: 0.925 ± 0.009	0.989CysPhe: 0.989 ± 0.01	1.409CysGly: 1.409 ± 0.013	0.456CysHis: 0.456 ± 0.007	0.999CysIle: 0.999 ± 0.01	1.168CysLys: 1.168 ± 0.012	1.939CysLeu: 1.939 ± 0.015	0.412CysMet: 0.412 ± 0.006	0.849CysAsn: 0.849 ± 0.01	0.914CysPro: 0.914 ± 0.011	0.544CysGln: 0.544 ± 0.008	1.068CysArg: 1.068 ± 0.012	1.834CysSer: 1.834 ± 0.015	0.842CysThr: 0.842 ± 0.009	1.207CysVal: 1.207 ± 0.011	0.224CysTrp: 0.224 ± 0.005	0.583CysTyr: 0.583 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	3.229AspAla: 3.229 ± 0.018	0.965AspCys: 0.965 ± 0.011	3.927AspAsp: 3.927 ± 0.023	4.254AspGlu: 4.254 ± 0.026	2.418AspPhe: 2.418 ± 0.016	3.754AspGly: 3.754 ± 0.021	1.309AspHis: 1.309 ± 0.011	3.002AspIle: 3.002 ± 0.018	2.875AspLys: 2.875 ± 0.018	5.255AspLeu: 5.255 ± 0.023	1.362AspMet: 1.362 ± 0.012	2.082AspAsn: 2.082 ± 0.015	2.614AspPro: 2.614 ± 0.016	1.809AspGln: 1.809 ± 0.013	2.375AspArg: 2.375 ± 0.016	4.462AspSer: 4.462 ± 0.021	2.315AspThr: 2.315 ± 0.014	3.755AspVal: 3.755 ± 0.02	0.709AspTrp: 0.709 ± 0.008	1.612AspTyr: 1.612 ± 0.015	0.0AspXaa: 0.0 ± 0.0
Glu	4.794GluAla: 4.794 ± 0.027	0.891GluCys: 0.891 ± 0.01	4.239GluAsp: 4.239 ± 0.026	6.922GluGlu: 6.922 ± 0.043	2.445GluPhe: 2.445 ± 0.015	3.481GluGly: 3.481 ± 0.018	1.196GluHis: 1.196 ± 0.01	3.948GluIle: 3.948 ± 0.022	5.162GluLys: 5.162 ± 0.036	5.841GluLeu: 5.841 ± 0.027	1.857GluMet: 1.857 ± 0.012	3.116GluAsn: 3.116 ± 0.019	2.205GluPro: 2.205 ± 0.017	2.07GluGln: 2.07 ± 0.015	3.493GluArg: 3.493 ± 0.021	4.912GluSer: 4.912 ± 0.026	3.722GluThr: 3.722 ± 0.021	4.132GluVal: 4.132 ± 0.019	0.74GluTrp: 0.74 ± 0.008	1.69GluTyr: 1.69 ± 0.014	0.0GluXaa: 0.0 ± 0.0
Phe	2.472PheAla: 2.472 ± 0.014	0.92PheCys: 0.92 ± 0.01	2.472PheAsp: 2.472 ± 0.015	2.366PheGlu: 2.366 ± 0.013	2.079PhePhe: 2.079 ± 0.016	3.055PheGly: 3.055 ± 0.022	1.089PheHis: 1.089 ± 0.01	2.071PheIle: 2.071 ± 0.016	2.283PheLys: 2.283 ± 0.015	4.379PheLeu: 4.379 ± 0.021	0.994PheMet: 0.994 ± 0.009	1.713PheAsn: 1.713 ± 0.013	2.094PhePro: 2.094 ± 0.015	1.48PheGln: 1.48 ± 0.011	2.117PheArg: 2.117 ± 0.014	4.204PheSer: 4.204 ± 0.02	2.188PheThr: 2.188 ± 0.015	2.942PheVal: 2.942 ± 0.017	0.552PheTrp: 0.552 ± 0.007	1.274PheTyr: 1.274 ± 0.011	0.0PheXaa: 0.0 ± 0.0
Gly	3.484GlyAla: 3.484 ± 0.022	1.278GlyCys: 1.278 ± 0.012	3.514GlyAsp: 3.514 ± 0.018	3.809GlyGlu: 3.809 ± 0.019	3.261GlyPhe: 3.261 ± 0.019	5.342GlyGly: 5.342 ± 0.047	1.408GlyHis: 1.408 ± 0.013	3.407GlyIle: 3.407 ± 0.02	4.18GlyLys: 4.18 ± 0.024	5.704GlyLeu: 5.704 ± 0.026	1.431GlyMet: 1.431 ± 0.012	3.054GlyAsn: 3.054 ± 0.016	2.206GlyPro: 2.206 ± 0.016	1.915GlyGln: 1.915 ± 0.016	3.464GlyArg: 3.464 ± 0.02	5.797GlySer: 5.797 ± 0.028	3.167GlyThr: 3.167 ± 0.016	4.138GlyVal: 4.138 ± 0.024	0.831GlyTrp: 0.831 ± 0.009	2.134GlyTyr: 2.134 ± 0.017	0.0GlyXaa: 0.0 ± 0.0
His	1.182HisAla: 1.182 ± 0.011	0.527HisCys: 0.527 ± 0.007	1.139HisAsp: 1.139 ± 0.011	1.296HisGlu: 1.296 ± 0.012	0.99HisPhe: 0.99 ± 0.009	1.625HisGly: 1.625 ± 0.013	1.014HisHis: 1.014 ± 0.015	1.197HisIle: 1.197 ± 0.01	1.223HisLys: 1.223 ± 0.012	2.275HisLeu: 2.275 ± 0.015	0.565HisMet: 0.565 ± 0.007	0.962HisAsn: 0.962 ± 0.01	1.26HisPro: 1.26 ± 0.014	1.016HisGln: 1.016 ± 0.011	1.382HisArg: 1.382 ± 0.012	1.796HisSer: 1.796 ± 0.014	0.961HisThr: 0.961 ± 0.009	1.521HisVal: 1.521 ± 0.013	0.282HisTrp: 0.282 ± 0.005	0.695HisTyr: 0.695 ± 0.008	0.0HisXaa: 0.0 ± 0.0
Ile	3.402IleAla: 3.402 ± 0.02	1.137IleCys: 1.137 ± 0.01	3.001IleAsp: 3.001 ± 0.015	3.23IleGlu: 3.23 ± 0.02	2.238IlePhe: 2.238 ± 0.016	3.342IleGly: 3.342 ± 0.021	1.287IleHis: 1.287 ± 0.01	2.708IleIle: 2.708 ± 0.017	3.039IleLys: 3.039 ± 0.019	5.08IleLeu: 5.08 ± 0.022	1.133IleMet: 1.133 ± 0.009	2.191IleAsn: 2.191 ± 0.014	2.879IlePro: 2.879 ± 0.019	1.898IleGln: 1.898 ± 0.013	2.693IleArg: 2.693 ± 0.017	4.957IleSer: 4.957 ± 0.023	2.721IleThr: 2.721 ± 0.016	3.536IleVal: 3.536 ± 0.019	0.689IleTrp: 0.689 ± 0.009	1.557IleTyr: 1.557 ± 0.012	0.0IleXaa: 0.0 ± 0.0
Lys	4.002LysAla: 4.002 ± 0.02	1.015LysCys: 1.015 ± 0.01	3.374LysAsp: 3.374 ± 0.018	4.865LysGlu: 4.865 ± 0.033	2.203LysPhe: 2.203 ± 0.014	3.515LysGly: 3.515 ± 0.02	1.377LysHis: 1.377 ± 0.011	3.499LysIle: 3.499 ± 0.018	5.456LysLys: 5.456 ± 0.033	6.2LysLeu: 6.2 ± 0.026	1.609LysMet: 1.609 ± 0.013	2.803LysAsn: 2.803 ± 0.018	2.978LysPro: 2.978 ± 0.018	2.316LysGln: 2.316 ± 0.016	3.85LysArg: 3.85 ± 0.021	4.962LysSer: 4.962 ± 0.023	3.431LysThr: 3.431 ± 0.02	3.839LysVal: 3.839 ± 0.021	0.813LysTrp: 0.813 ± 0.009	1.619LysTyr: 1.619 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	6.094LeuAla: 6.094 ± 0.028	1.939LeuCys: 1.939 ± 0.016	5.065LeuAsp: 5.065 ± 0.025	6.274LeuGlu: 6.274 ± 0.033	3.92LeuPhe: 3.92 ± 0.02	5.583LeuGly: 5.583 ± 0.025	2.414LeuHis: 2.414 ± 0.015	4.635LeuIle: 4.635 ± 0.024	6.23LeuLys: 6.23 ± 0.03	9.645LeuLeu: 9.645 ± 0.04	2.223LeuMet: 2.223 ± 0.015	3.84LeuAsn: 3.84 ± 0.021	4.985LeuPro: 4.985 ± 0.027	3.888LeuGln: 3.888 ± 0.023	5.448LeuArg: 5.448 ± 0.024	8.7LeuSer: 8.7 ± 0.04	4.633LeuThr: 4.633 ± 0.023	6.592LeuVal: 6.592 ± 0.028	1.149LeuTrp: 1.149 ± 0.01	2.523LeuTyr: 2.523 ± 0.015	0.0LeuXaa: 0.0 ± 0.0
Met	2.042MetAla: 2.042 ± 0.014	0.344MetCys: 0.344 ± 0.005	1.416MetAsp: 1.416 ± 0.011	2.007MetGlu: 2.007 ± 0.016	0.918MetPhe: 0.918 ± 0.01	1.512MetGly: 1.512 ± 0.011	0.476MetHis: 0.476 ± 0.007	1.329MetIle: 1.329 ± 0.01	1.756MetLys: 1.756 ± 0.013	2.08MetLeu: 2.08 ± 0.013	0.784MetMet: 0.784 ± 0.011	1.109MetAsn: 1.109 ± 0.01	0.937MetPro: 0.937 ± 0.009	0.817MetGln: 0.817 ± 0.008	1.265MetArg: 1.265 ± 0.011	1.949MetSer: 1.949 ± 0.015	1.128MetThr: 1.128 ± 0.011	1.743MetVal: 1.743 ± 0.012	0.262MetTrp: 0.262 ± 0.005	0.631MetTyr: 0.631 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	2.519AsnAla: 2.519 ± 0.016	0.81AsnCys: 0.81 ± 0.01	2.054AsnAsp: 2.054 ± 0.015	2.486AsnGlu: 2.486 ± 0.016	1.784AsnPhe: 1.784 ± 0.013	3.213AsnGly: 3.213 ± 0.021	1.161AsnHis: 1.161 ± 0.012	2.44AsnIle: 2.44 ± 0.016	2.521AsnLys: 2.521 ± 0.017	4.535AsnLeu: 4.535 ± 0.026	1.096AsnMet: 1.096 ± 0.009	2.428AsnAsn: 2.428 ± 0.022	2.391AsnPro: 2.391 ± 0.015	1.734AsnGln: 1.734 ± 0.014	2.162AsnArg: 2.162 ± 0.015	3.74AsnSer: 3.74 ± 0.024	2.096AsnThr: 2.096 ± 0.014	2.907AsnVal: 2.907 ± 0.016	0.536AsnTrp: 0.536 ± 0.007	1.255AsnTyr: 1.255 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	2.726ProAla: 2.726 ± 0.02	0.765ProCys: 0.765 ± 0.008	2.436ProAsp: 2.436 ± 0.018	3.312ProGlu: 3.312 ± 0.017	1.937ProPhe: 1.937 ± 0.014	2.617ProGly: 2.617 ± 0.019	1.029ProHis: 1.029 ± 0.009	2.226ProIle: 2.226 ± 0.016	2.848ProLys: 2.848 ± 0.017	4.187ProLeu: 4.187 ± 0.021	1.012ProMet: 1.012 ± 0.01	2.219ProAsn: 2.219 ± 0.015	3.802ProPro: 3.802 ± 0.054	1.711ProGln: 1.711 ± 0.016	2.509ProArg: 2.509 ± 0.019	5.014ProSer: 5.014 ± 0.028	2.527ProThr: 2.527 ± 0.017	3.207ProVal: 3.207 ± 0.021	0.596ProTrp: 0.596 ± 0.007	1.34ProTyr: 1.34 ± 0.014	0.0ProXaa: 0.0 ± 0.0
Gln	2.143GlnAla: 2.143 ± 0.014	0.573GlnCys: 0.573 ± 0.007	1.659GlnAsp: 1.659 ± 0.01	2.458GlnGlu: 2.458 ± 0.018	1.315GlnPhe: 1.315 ± 0.01	1.994GlnGly: 1.994 ± 0.014	0.836GlnHis: 0.836 ± 0.01	1.937GlnIle: 1.937 ± 0.012	2.206GlnLys: 2.206 ± 0.016	3.239GlnLeu: 3.239 ± 0.021	0.918GlnMet: 0.918 ± 0.01	1.691GlnAsn: 1.691 ± 0.013	1.647GlnPro: 1.647 ± 0.019	1.936GlnGln: 1.936 ± 0.034	2.125GlnArg: 2.125 ± 0.013	2.78GlnSer: 2.78 ± 0.02	1.792GlnThr: 1.792 ± 0.014	2.24GlnVal: 2.24 ± 0.013	0.441GlnTrp: 0.441 ± 0.006	0.89GlnTyr: 0.89 ± 0.009	0.0GlnXaa: 0.0 ± 0.0
Arg	3.035ArgAla: 3.035 ± 0.017	1.044ArgCys: 1.044 ± 0.011	2.811ArgAsp: 2.811 ± 0.017	3.517ArgGlu: 3.517 ± 0.022	2.503ArgPhe: 2.503 ± 0.017	3.224ArgGly: 3.224 ± 0.021	1.208ArgHis: 1.208 ± 0.01	2.902ArgIle: 2.902 ± 0.017	3.818ArgLys: 3.818 ± 0.02	5.081ArgLeu: 5.081 ± 0.021	1.267ArgMet: 1.267 ± 0.01	2.523ArgAsn: 2.523 ± 0.013	2.28ArgPro: 2.28 ± 0.017	1.785ArgGln: 1.785 ± 0.013	4.152ArgArg: 4.152 ± 0.027	4.635ArgSer: 4.635 ± 0.026	2.488ArgThr: 2.488 ± 0.016	3.523ArgVal: 3.523 ± 0.018	0.732ArgTrp: 0.732 ± 0.008	1.507ArgTyr: 1.507 ± 0.012	0.0ArgXaa: 0.0 ± 0.0
Ser	5.022SerAla: 5.022 ± 0.026	1.758SerCys: 1.758 ± 0.015	4.687SerAsp: 4.687 ± 0.021	5.001SerGlu: 5.001 ± 0.026	4.197SerPhe: 4.197 ± 0.019	6.017SerGly: 6.017 ± 0.031	2.056SerHis: 2.056 ± 0.014	4.39SerIle: 4.39 ± 0.021	5.114SerLys: 5.114 ± 0.023	9.117SerLeu: 9.117 ± 0.038	2.065SerMet: 2.065 ± 0.013	3.957SerAsn: 3.957 ± 0.021	4.776SerPro: 4.776 ± 0.032	3.009SerGln: 3.009 ± 0.019	4.644SerArg: 4.644 ± 0.025	11.979SerSer: 11.979 ± 0.063	4.572SerThr: 4.572 ± 0.022	5.615SerVal: 5.615 ± 0.024	1.147SerTrp: 1.147 ± 0.011	2.464SerTyr: 2.464 ± 0.018	0.0SerXaa: 0.0 ± 0.0
Thr	3.341ThrAla: 3.341 ± 0.021	1.013ThrCys: 1.013 ± 0.01	2.381ThrAsp: 2.381 ± 0.014	3.109ThrGlu: 3.109 ± 0.022	2.104ThrPhe: 2.104 ± 0.015	3.391ThrGly: 3.391 ± 0.021	1.041ThrHis: 1.041 ± 0.012	2.76ThrIle: 2.76 ± 0.018	3.093ThrLys: 3.093 ± 0.019	4.838ThrLeu: 4.838 ± 0.019	1.233ThrMet: 1.233 ± 0.01	2.208ThrAsn: 2.208 ± 0.014	2.569ThrPro: 2.569 ± 0.017	1.601ThrGln: 1.601 ± 0.015	2.6ThrArg: 2.6 ± 0.015	4.801ThrSer: 4.801 ± 0.024	3.304ThrThr: 3.304 ± 0.022	3.575ThrVal: 3.575 ± 0.021	0.662ThrTrp: 0.662 ± 0.008	1.433ThrTyr: 1.433 ± 0.012	0.0ThrXaa: 0.0 ± 0.0
Val	4.648ValAla: 4.648 ± 0.023	1.239ValCys: 1.239 ± 0.012	3.759ValAsp: 3.759 ± 0.018	4.518ValGlu: 4.518 ± 0.025	2.946ValPhe: 2.946 ± 0.021	3.872ValGly: 3.872 ± 0.021	1.436ValHis: 1.436 ± 0.012	3.512ValIle: 3.512 ± 0.02	4.23ValLys: 4.23 ± 0.02	6.372ValLeu: 6.372 ± 0.025	1.674ValMet: 1.674 ± 0.013	2.678ValAsn: 2.678 ± 0.017	3.205ValPro: 3.205 ± 0.019	2.098ValGln: 2.098 ± 0.014	3.159ValArg: 3.159 ± 0.017	5.99ValSer: 5.99 ± 0.024	3.584ValThr: 3.584 ± 0.021	5.132ValVal: 5.132 ± 0.027	0.796ValTrp: 0.796 ± 0.007	2.043ValTyr: 2.043 ± 0.015	0.0ValXaa: 0.0 ± 0.0
Trp	0.68TrpAla: 0.68 ± 0.008	0.24TrpCys: 0.24 ± 0.004	0.711TrpAsp: 0.711 ± 0.008	0.769TrpGlu: 0.769 ± 0.009	0.571TrpPhe: 0.571 ± 0.007	0.692TrpGly: 0.692 ± 0.009	0.252TrpHis: 0.252 ± 0.005	0.736TrpIle: 0.736 ± 0.008	0.924TrpLys: 0.924 ± 0.009	1.185TrpLeu: 1.185 ± 0.012	0.325TrpMet: 0.325 ± 0.005	0.694TrpAsn: 0.694 ± 0.01	0.462TrpPro: 0.462 ± 0.007	0.394TrpGln: 0.394 ± 0.006	0.866TrpArg: 0.866 ± 0.01	1.006TrpSer: 1.006 ± 0.01	0.638TrpThr: 0.638 ± 0.009	0.782TrpVal: 0.782 ± 0.008	0.232TrpTrp: 0.232 ± 0.005	0.343TrpTyr: 0.343 ± 0.006	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.707TyrAla: 1.707 ± 0.015	0.627TyrCys: 0.627 ± 0.009	1.589TyrAsp: 1.589 ± 0.011	1.665TyrGlu: 1.665 ± 0.014	1.31TyrPhe: 1.31 ± 0.011	2.116TyrGly: 2.116 ± 0.017	0.707TyrHis: 0.707 ± 0.008	1.518TyrIle: 1.518 ± 0.012	1.652TyrLys: 1.652 ± 0.014	2.724TyrLeu: 2.724 ± 0.017	0.774TyrMet: 0.774 ± 0.008	1.344TyrAsn: 1.344 ± 0.012	1.261TyrPro: 1.261 ± 0.012	0.931TyrGln: 0.931 ± 0.01	1.475TyrArg: 1.475 ± 0.012	2.322TyrSer: 2.322 ± 0.016	1.381TyrThr: 1.381 ± 0.012	1.826TyrVal: 1.826 ± 0.016	0.407TyrTrp: 0.407 ± 0.007	1.01TyrTyr: 1.01 ± 0.011	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 28039 proteins (11560300 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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