Amino acid dipepetide frequency for Porphyromonas circumdentaria

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.44AlaAla: 4.44 ± 0.111
0.819AlaCys: 0.819 ± 0.039
3.381AlaAsp: 3.381 ± 0.084
4.965AlaGlu: 4.965 ± 0.1
3.182AlaPhe: 3.182 ± 0.074
4.299AlaGly: 4.299 ± 0.094
1.584AlaHis: 1.584 ± 0.051
5.198AlaIle: 5.198 ± 0.102
3.967AlaLys: 3.967 ± 0.081
8.445AlaLeu: 8.445 ± 0.156
1.837AlaMet: 1.837 ± 0.065
2.84AlaAsn: 2.84 ± 0.087
2.956AlaPro: 2.956 ± 0.073
3.287AlaGln: 3.287 ± 0.078
3.447AlaArg: 3.447 ± 0.096
4.842AlaSer: 4.842 ± 0.074
4.467AlaThr: 4.467 ± 0.099
4.388AlaVal: 4.388 ± 0.099
0.669AlaTrp: 0.669 ± 0.032
2.71AlaTyr: 2.71 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
0.7CysAla: 0.7 ± 0.038
0.127CysCys: 0.127 ± 0.014
0.573CysAsp: 0.573 ± 0.032
0.59CysGlu: 0.59 ± 0.043
0.493CysPhe: 0.493 ± 0.028
0.871CysGly: 0.871 ± 0.049
0.313CysHis: 0.313 ± 0.027
0.725CysIle: 0.725 ± 0.036
0.599CysLys: 0.599 ± 0.037
0.927CysLeu: 0.927 ± 0.039
0.219CysMet: 0.219 ± 0.023
0.52CysAsn: 0.52 ± 0.032
0.546CysPro: 0.546 ± 0.034
0.311CysGln: 0.311 ± 0.027
0.671CysArg: 0.671 ± 0.034
0.979CysSer: 0.979 ± 0.054
0.606CysThr: 0.606 ± 0.03
0.58CysVal: 0.58 ± 0.035
0.111CysTrp: 0.111 ± 0.011
0.544CysTyr: 0.544 ± 0.027
0.0CysXaa: 0.0 ± 0.0
Asp
3.523AspAla: 3.523 ± 0.084
0.575AspCys: 0.575 ± 0.038
1.932AspAsp: 1.932 ± 0.061
3.211AspGlu: 3.211 ± 0.08
2.761AspPhe: 2.761 ± 0.069
3.079AspGly: 3.079 ± 0.085
0.777AspHis: 0.777 ± 0.036
3.697AspIle: 3.697 ± 0.084
3.374AspLys: 3.374 ± 0.069
5.079AspLeu: 5.079 ± 0.097
1.157AspMet: 1.157 ± 0.044
2.133AspAsn: 2.133 ± 0.057
1.884AspPro: 1.884 ± 0.061
1.249AspGln: 1.249 ± 0.044
2.546AspArg: 2.546 ± 0.062
2.674AspSer: 2.674 ± 0.09
2.667AspThr: 2.667 ± 0.074
2.985AspVal: 2.985 ± 0.077
0.636AspTrp: 0.636 ± 0.037
2.358AspTyr: 2.358 ± 0.07
0.0AspXaa: 0.0 ± 0.0
Glu
5.776GluAla: 5.776 ± 0.128
0.609GluCys: 0.609 ± 0.032
3.199GluAsp: 3.199 ± 0.079
7.404GluGlu: 7.404 ± 0.152
2.192GluPhe: 2.192 ± 0.069
5.458GluGly: 5.458 ± 0.106
1.579GluHis: 1.579 ± 0.057
4.809GluIle: 4.809 ± 0.092
5.091GluLys: 5.091 ± 0.105
6.852GluLeu: 6.852 ± 0.107
1.873GluMet: 1.873 ± 0.057
2.924GluAsn: 2.924 ± 0.076
1.99GluPro: 1.99 ± 0.062
3.329GluGln: 3.329 ± 0.08
4.588GluArg: 4.588 ± 0.105
3.352GluSer: 3.352 ± 0.075
3.334GluThr: 3.334 ± 0.082
5.035GluVal: 5.035 ± 0.096
0.818GluTrp: 0.818 ± 0.041
2.571GluTyr: 2.571 ± 0.076
0.0GluXaa: 0.0 ± 0.0
Phe
3.179PheAla: 3.179 ± 0.077
0.571PheCys: 0.571 ± 0.032
2.585PheAsp: 2.585 ± 0.066
2.657PheGlu: 2.657 ± 0.062
2.457PhePhe: 2.457 ± 0.075
2.96PheGly: 2.96 ± 0.079
0.768PheHis: 0.768 ± 0.034
3.078PheIle: 3.078 ± 0.076
2.075PheLys: 2.075 ± 0.06
4.523PheLeu: 4.523 ± 0.103
1.006PheMet: 1.006 ± 0.048
1.863PheAsn: 1.863 ± 0.059
1.711PhePro: 1.711 ± 0.05
1.163PheGln: 1.163 ± 0.048
2.08PheArg: 2.08 ± 0.057
3.896PheSer: 3.896 ± 0.103
2.553PheThr: 2.553 ± 0.068
3.033PheVal: 3.033 ± 0.073
0.459PheTrp: 0.459 ± 0.031
1.642PheTyr: 1.642 ± 0.057
0.0PheXaa: 0.0 ± 0.0
Gly
4.895GlyAla: 4.895 ± 0.091
0.936GlyCys: 0.936 ± 0.042
3.119GlyAsp: 3.119 ± 0.076
4.679GlyGlu: 4.679 ± 0.085
2.871GlyPhe: 2.871 ± 0.069
4.783GlyGly: 4.783 ± 0.117
1.28GlyHis: 1.28 ± 0.047
5.213GlyIle: 5.213 ± 0.105
4.681GlyLys: 4.681 ± 0.097
5.796GlyLeu: 5.796 ± 0.107
1.648GlyMet: 1.648 ± 0.062
2.852GlyAsn: 2.852 ± 0.075
1.204GlyPro: 1.204 ± 0.054
1.832GlyGln: 1.832 ± 0.058
3.341GlyArg: 3.341 ± 0.073
3.887GlySer: 3.887 ± 0.088
3.837GlyThr: 3.837 ± 0.093
5.071GlyVal: 5.071 ± 0.111
0.778GlyTrp: 0.778 ± 0.041
3.028GlyTyr: 3.028 ± 0.08
0.0GlyXaa: 0.0 ± 0.0
His
1.119HisAla: 1.119 ± 0.04
0.347HisCys: 0.347 ± 0.024
0.809HisAsp: 0.809 ± 0.036
1.003HisGlu: 1.003 ± 0.045
1.119HisPhe: 1.119 ± 0.045
1.1HisGly: 1.1 ± 0.048
0.525HisHis: 0.525 ± 0.043
1.529HisIle: 1.529 ± 0.064
1.222HisLys: 1.222 ± 0.045
2.484HisLeu: 2.484 ± 0.07
0.311HisMet: 0.311 ± 0.023
0.926HisAsn: 0.926 ± 0.043
1.199HisPro: 1.199 ± 0.044
0.684HisGln: 0.684 ± 0.03
1.141HisArg: 1.141 ± 0.047
1.362HisSer: 1.362 ± 0.05
1.198HisThr: 1.198 ± 0.054
0.939HisVal: 0.939 ± 0.035
0.253HisTrp: 0.253 ± 0.023
0.91HisTyr: 0.91 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
6.101IleAla: 6.101 ± 0.109
0.722IleCys: 0.722 ± 0.035
4.299IleAsp: 4.299 ± 0.096
5.596IleGlu: 5.596 ± 0.108
2.686IlePhe: 2.686 ± 0.078
4.628IleGly: 4.628 ± 0.096
1.336IleHis: 1.336 ± 0.05
4.402IleIle: 4.402 ± 0.1
4.077IleLys: 4.077 ± 0.086
6.024IleLeu: 6.024 ± 0.121
1.256IleMet: 1.256 ± 0.05
2.903IleAsn: 2.903 ± 0.069
3.363IlePro: 3.363 ± 0.084
2.137IleGln: 2.137 ± 0.057
3.485IleArg: 3.485 ± 0.083
4.611IleSer: 4.611 ± 0.097
4.185IleThr: 4.185 ± 0.088
4.859IleVal: 4.859 ± 0.106
0.46IleTrp: 0.46 ± 0.029
2.503IleTyr: 2.503 ± 0.07
0.0IleXaa: 0.0 ± 0.0
Lys
4.787LysAla: 4.787 ± 0.088
0.407LysCys: 0.407 ± 0.029
3.095LysAsp: 3.095 ± 0.067
6.229LysGlu: 6.229 ± 0.114
1.634LysPhe: 1.634 ± 0.061
4.878LysGly: 4.878 ± 0.085
1.175LysHis: 1.175 ± 0.044
3.969LysIle: 3.969 ± 0.091
5.049LysLys: 5.049 ± 0.118
5.057LysLeu: 5.057 ± 0.106
1.884LysMet: 1.884 ± 0.065
2.866LysAsn: 2.866 ± 0.076
2.022LysPro: 2.022 ± 0.059
2.279LysGln: 2.279 ± 0.069
3.523LysArg: 3.523 ± 0.078
3.524LysSer: 3.524 ± 0.072
3.216LysThr: 3.216 ± 0.075
4.108LysVal: 4.108 ± 0.083
0.571LysTrp: 0.571 ± 0.035
2.113LysTyr: 2.113 ± 0.07
0.0LysXaa: 0.0 ± 0.0
Leu
6.799LeuAla: 6.799 ± 0.126
1.182LeuCys: 1.182 ± 0.044
4.633LeuAsp: 4.633 ± 0.098
6.219LeuGlu: 6.219 ± 0.112
5.576LeuPhe: 5.576 ± 0.116
6.099LeuGly: 6.099 ± 0.125
2.183LeuHis: 2.183 ± 0.062
6.065LeuIle: 6.065 ± 0.102
6.084LeuLys: 6.084 ± 0.119
11.894LeuLeu: 11.894 ± 0.197
2.262LeuMet: 2.262 ± 0.07
3.937LeuAsn: 3.937 ± 0.08
5.033LeuPro: 5.033 ± 0.097
3.991LeuGln: 3.991 ± 0.089
5.627LeuArg: 5.627 ± 0.1
8.932LeuSer: 8.932 ± 0.154
5.632LeuThr: 5.632 ± 0.112
5.382LeuVal: 5.382 ± 0.086
1.009LeuTrp: 1.009 ± 0.042
3.928LeuTyr: 3.928 ± 0.097
0.0LeuXaa: 0.0 ± 0.0
Met
1.979MetAla: 1.979 ± 0.067
0.214MetCys: 0.214 ± 0.019
1.126MetAsp: 1.126 ± 0.047
1.648MetGlu: 1.648 ± 0.059
0.701MetPhe: 0.701 ± 0.038
1.853MetGly: 1.853 ± 0.057
0.491MetHis: 0.491 ± 0.033
1.365MetIle: 1.365 ± 0.053
1.762MetLys: 1.762 ± 0.052
2.233MetLeu: 2.233 ± 0.066
0.633MetMet: 0.633 ± 0.038
1.254MetAsn: 1.254 ± 0.044
1.102MetPro: 1.102 ± 0.051
1.021MetGln: 1.021 ± 0.047
1.326MetArg: 1.326 ± 0.047
1.415MetSer: 1.415 ± 0.047
1.216MetThr: 1.216 ± 0.047
1.403MetVal: 1.403 ± 0.047
0.161MetTrp: 0.161 ± 0.016
0.655MetTyr: 0.655 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
3.023AsnAla: 3.023 ± 0.076
0.474AsnCys: 0.474 ± 0.033
1.872AsnAsp: 1.872 ± 0.066
2.571AsnGlu: 2.571 ± 0.074
1.808AsnPhe: 1.808 ± 0.063
2.777AsnGly: 2.777 ± 0.086
0.785AsnHis: 0.785 ± 0.036
3.133AsnIle: 3.133 ± 0.076
2.852AsnLys: 2.852 ± 0.078
4.205AsnLeu: 4.205 ± 0.097
1.047AsnMet: 1.047 ± 0.043
2.253AsnAsn: 2.253 ± 0.079
2.402AsnPro: 2.402 ± 0.068
1.391AsnGln: 1.391 ± 0.046
2.404AsnArg: 2.404 ± 0.072
2.464AsnSer: 2.464 ± 0.07
2.441AsnThr: 2.441 ± 0.074
2.498AsnVal: 2.498 ± 0.077
0.512AsnTrp: 0.512 ± 0.03
1.848AsnTyr: 1.848 ± 0.062
0.0AsnXaa: 0.0 ± 0.0
Pro
2.455ProAla: 2.455 ± 0.068
0.344ProCys: 0.344 ± 0.026
2.214ProAsp: 2.214 ± 0.058
3.5ProGlu: 3.5 ± 0.076
2.007ProPhe: 2.007 ± 0.061
1.873ProGly: 1.873 ± 0.059
0.864ProHis: 0.864 ± 0.038
3.013ProIle: 3.013 ± 0.072
2.397ProLys: 2.397 ± 0.068
4.246ProLeu: 4.246 ± 0.088
0.927ProMet: 0.927 ± 0.035
1.928ProAsn: 1.928 ± 0.057
1.216ProPro: 1.216 ± 0.049
1.728ProGln: 1.728 ± 0.055
1.612ProArg: 1.612 ± 0.052
3.068ProSer: 3.068 ± 0.075
2.38ProThr: 2.38 ± 0.073
2.476ProVal: 2.476 ± 0.066
0.373ProTrp: 0.373 ± 0.027
1.764ProTyr: 1.764 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
2.488GlnAla: 2.488 ± 0.07
0.327GlnCys: 0.327 ± 0.024
1.488GlnAsp: 1.488 ± 0.052
3.228GlnGlu: 3.228 ± 0.077
1.179GlnPhe: 1.179 ± 0.039
2.294GlnGly: 2.294 ± 0.062
0.671GlnHis: 0.671 ± 0.036
2.53GlnIle: 2.53 ± 0.079
2.876GlnLys: 2.876 ± 0.081
3.649GlnLeu: 3.649 ± 0.08
0.941GlnMet: 0.941 ± 0.046
1.547GlnAsn: 1.547 ± 0.058
1.189GlnPro: 1.189 ± 0.045
1.738GlnGln: 1.738 ± 0.07
2.151GlnArg: 2.151 ± 0.071
2.127GlnSer: 2.127 ± 0.064
2.02GlnThr: 2.02 ± 0.061
2.039GlnVal: 2.039 ± 0.061
0.428GlnTrp: 0.428 ± 0.026
1.269GlnTyr: 1.269 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
3.482ArgAla: 3.482 ± 0.08
0.583ArgCys: 0.583 ± 0.033
2.188ArgAsp: 2.188 ± 0.058
4.092ArgGlu: 4.092 ± 0.091
2.429ArgPhe: 2.429 ± 0.063
3.093ArgGly: 3.093 ± 0.091
1.11ArgHis: 1.11 ± 0.048
4.012ArgIle: 4.012 ± 0.096
3.523ArgLys: 3.523 ± 0.09
5.586ArgLeu: 5.586 ± 0.106
1.509ArgMet: 1.509 ± 0.045
2.299ArgAsn: 2.299 ± 0.071
1.831ArgPro: 1.831 ± 0.066
1.831ArgGln: 1.831 ± 0.053
3.025ArgArg: 3.025 ± 0.088
3.249ArgSer: 3.249 ± 0.087
2.633ArgThr: 2.633 ± 0.084
3.146ArgVal: 3.146 ± 0.078
0.599ArgTrp: 0.599 ± 0.033
2.393ArgTyr: 2.393 ± 0.066
0.0ArgXaa: 0.0 ± 0.0
Ser
4.176SerAla: 4.176 ± 0.089
0.84SerCys: 0.84 ± 0.041
2.982SerAsp: 2.982 ± 0.064
4.048SerGlu: 4.048 ± 0.084
3.805SerPhe: 3.805 ± 0.084
4.323SerGly: 4.323 ± 0.107
1.269SerHis: 1.269 ± 0.051
5.182SerIle: 5.182 ± 0.09
3.666SerLys: 3.666 ± 0.079
7.877SerLeu: 7.877 ± 0.133
1.533SerMet: 1.533 ± 0.053
2.799SerAsn: 2.799 ± 0.075
2.689SerPro: 2.689 ± 0.072
2.207SerGln: 2.207 ± 0.059
2.992SerArg: 2.992 ± 0.071
5.247SerSer: 5.247 ± 0.113
3.483SerThr: 3.483 ± 0.077
4.267SerVal: 4.267 ± 0.081
0.698SerTrp: 0.698 ± 0.039
2.939SerTyr: 2.939 ± 0.083
0.0SerXaa: 0.0 ± 0.0
Thr
3.908ThrAla: 3.908 ± 0.08
0.47ThrCys: 0.47 ± 0.03
2.676ThrAsp: 2.676 ± 0.065
3.629ThrGlu: 3.629 ± 0.08
2.577ThrPhe: 2.577 ± 0.082
3.577ThrGly: 3.577 ± 0.082
1.204ThrHis: 1.204 ± 0.049
4.275ThrIle: 4.275 ± 0.105
2.739ThrLys: 2.739 ± 0.056
6.809ThrLeu: 6.809 ± 0.121
1.16ThrMet: 1.16 ± 0.047
2.046ThrAsn: 2.046 ± 0.058
3.547ThrPro: 3.547 ± 0.084
2.017ThrGln: 2.017 ± 0.056
2.193ThrArg: 2.193 ± 0.064
3.67ThrSer: 3.67 ± 0.084
3.529ThrThr: 3.529 ± 0.083
3.387ThrVal: 3.387 ± 0.083
0.496ThrTrp: 0.496 ± 0.035
2.118ThrTyr: 2.118 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
5.276ValAla: 5.276 ± 0.111
0.801ValCys: 0.801 ± 0.037
3.427ValAsp: 3.427 ± 0.091
4.578ValGlu: 4.578 ± 0.102
2.594ValPhe: 2.594 ± 0.071
4.346ValGly: 4.346 ± 0.093
1.191ValHis: 1.191 ± 0.048
4.032ValIle: 4.032 ± 0.084
3.312ValLys: 3.312 ± 0.072
5.996ValLeu: 5.996 ± 0.089
1.304ValMet: 1.304 ± 0.055
2.438ValAsn: 2.438 ± 0.071
2.446ValPro: 2.446 ± 0.068
2.089ValGln: 2.089 ± 0.056
3.577ValArg: 3.577 ± 0.085
4.344ValSer: 4.344 ± 0.099
3.641ValThr: 3.641 ± 0.093
4.683ValVal: 4.683 ± 0.12
0.626ValTrp: 0.626 ± 0.031
2.308ValTyr: 2.308 ± 0.063
0.0ValXaa: 0.0 ± 0.0
Trp
0.703TrpAla: 0.703 ± 0.032
0.135TrpCys: 0.135 ± 0.016
0.494TrpAsp: 0.494 ± 0.032
0.715TrpGlu: 0.715 ± 0.03
0.344TrpPhe: 0.344 ± 0.024
0.867TrpGly: 0.867 ± 0.039
0.258TrpHis: 0.258 ± 0.02
0.679TrpIle: 0.679 ± 0.032
0.648TrpLys: 0.648 ± 0.032
0.979TrpLeu: 0.979 ± 0.038
0.317TrpMet: 0.317 ± 0.021
0.472TrpAsn: 0.472 ± 0.028
0.181TrpPro: 0.181 ± 0.016
0.5TrpGln: 0.5 ± 0.032
0.592TrpArg: 0.592 ± 0.031
0.691TrpSer: 0.691 ± 0.038
0.477TrpThr: 0.477 ± 0.029
0.691TrpVal: 0.691 ± 0.037
0.127TrpTrp: 0.127 ± 0.017
0.352TrpTyr: 0.352 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.917TyrAla: 2.917 ± 0.071
0.52TyrCys: 0.52 ± 0.034
2.205TyrAsp: 2.205 ± 0.071
2.221TyrGlu: 2.221 ± 0.063
1.846TyrPhe: 1.846 ± 0.055
2.573TyrGly: 2.573 ± 0.079
0.816TyrHis: 0.816 ± 0.04
2.725TyrIle: 2.725 ± 0.069
2.393TyrLys: 2.393 ± 0.063
3.805TyrLeu: 3.805 ± 0.088
0.734TyrMet: 0.734 ± 0.036
1.959TyrAsn: 1.959 ± 0.059
1.872TyrPro: 1.872 ± 0.056
1.394TyrGln: 1.394 ± 0.048
2.293TyrArg: 2.293 ± 0.07
2.693TyrSer: 2.693 ± 0.074
2.512TyrThr: 2.512 ± 0.067
2.038TyrVal: 2.038 ± 0.058
0.44TyrTrp: 0.44 ± 0.026
1.803TyrTyr: 1.803 ± 0.066
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1689 proteins (584512 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski