Amino acid dipepetide frequency for Chitinophagaceae bacterium BSSC1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.731AlaAla: 6.731 ± 0.091	0.758AlaCys: 0.758 ± 0.025	4.003AlaAsp: 4.003 ± 0.067	3.882AlaGlu: 3.882 ± 0.062	3.737AlaPhe: 3.737 ± 0.06	5.552AlaGly: 5.552 ± 0.074	1.285AlaHis: 1.285 ± 0.036	5.818AlaIle: 5.818 ± 0.077	5.059AlaLys: 5.059 ± 0.065	7.05AlaLeu: 7.05 ± 0.086	1.943AlaMet: 1.943 ± 0.044	4.142AlaAsn: 4.142 ± 0.058	2.712AlaPro: 2.712 ± 0.065	3.099AlaGln: 3.099 ± 0.046	2.232AlaArg: 2.232 ± 0.04	5.092AlaSer: 5.092 ± 0.074	4.411AlaThr: 4.411 ± 0.094	4.734AlaVal: 4.734 ± 0.067	0.907AlaTrp: 0.907 ± 0.026	2.879AlaTyr: 2.879 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.55CysAla: 0.55 ± 0.021	0.15CysCys: 0.15 ± 0.011	0.4CysAsp: 0.4 ± 0.02	0.385CysGlu: 0.385 ± 0.018	0.486CysPhe: 0.486 ± 0.018	0.658CysGly: 0.658 ± 0.024	0.209CysHis: 0.209 ± 0.015	0.708CysIle: 0.708 ± 0.022	0.555CysLys: 0.555 ± 0.021	0.906CysLeu: 0.906 ± 0.025	0.22CysMet: 0.22 ± 0.012	0.459CysAsn: 0.459 ± 0.021	0.374CysPro: 0.374 ± 0.022	0.303CysGln: 0.303 ± 0.017	0.284CysArg: 0.284 ± 0.014	0.655CysSer: 0.655 ± 0.032	0.432CysThr: 0.432 ± 0.022	0.498CysVal: 0.498 ± 0.021	0.106CysTrp: 0.106 ± 0.008	0.372CysTyr: 0.372 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.075AspAla: 4.075 ± 0.055	0.433AspCys: 0.433 ± 0.02	2.014AspAsp: 2.014 ± 0.05	2.642AspGlu: 2.642 ± 0.046	2.91AspPhe: 2.91 ± 0.049	3.772AspGly: 3.772 ± 0.069	0.978AspHis: 0.978 ± 0.026	3.412AspIle: 3.412 ± 0.055	3.554AspLys: 3.554 ± 0.056	5.169AspLeu: 5.169 ± 0.074	1.136AspMet: 1.136 ± 0.031	2.527AspAsn: 2.527 ± 0.042	2.111AspPro: 2.111 ± 0.044	2.193AspGln: 2.193 ± 0.041	1.727AspArg: 1.727 ± 0.037	3.253AspSer: 3.253 ± 0.067	2.477AspThr: 2.477 ± 0.057	2.758AspVal: 2.758 ± 0.053	0.889AspTrp: 0.889 ± 0.027	2.331AspTyr: 2.331 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	4.24GluAla: 4.24 ± 0.072	0.332GluCys: 0.332 ± 0.014	2.373GluAsp: 2.373 ± 0.048	3.206GluGlu: 3.206 ± 0.068	2.353GluPhe: 2.353 ± 0.043	3.3GluGly: 3.3 ± 0.061	1.067GluHis: 1.067 ± 0.031	3.935GluIle: 3.935 ± 0.058	4.802GluLys: 4.802 ± 0.077	5.476GluLeu: 5.476 ± 0.072	1.557GluMet: 1.557 ± 0.034	3.163GluAsn: 3.163 ± 0.055	1.679GluPro: 1.679 ± 0.039	2.669GluGln: 2.669 ± 0.054	2.106GluArg: 2.106 ± 0.046	2.85GluSer: 2.85 ± 0.047	3.039GluThr: 3.039 ± 0.047	3.072GluVal: 3.072 ± 0.062	0.797GluTrp: 0.797 ± 0.024	1.905GluTyr: 1.905 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.44PheAla: 3.44 ± 0.051	0.523PheCys: 0.523 ± 0.021	2.732PheAsp: 2.732 ± 0.045	2.829PheGlu: 2.829 ± 0.056	2.598PhePhe: 2.598 ± 0.057	3.507PheGly: 3.507 ± 0.058	0.913PheHis: 0.913 ± 0.026	3.14PheIle: 3.14 ± 0.052	3.326PheLys: 3.326 ± 0.053	4.722PheLeu: 4.722 ± 0.076	1.083PheMet: 1.083 ± 0.028	3.018PheAsn: 3.018 ± 0.057	1.847PhePro: 1.847 ± 0.042	2.031PheGln: 2.031 ± 0.043	1.692PheArg: 1.692 ± 0.035	3.817PheSer: 3.817 ± 0.063	2.787PheThr: 2.787 ± 0.049	2.962PheVal: 2.962 ± 0.049	0.696PheTrp: 0.696 ± 0.023	2.031PheTyr: 2.031 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	4.947GlyAla: 4.947 ± 0.075	0.73GlyCys: 0.73 ± 0.032	3.06GlyAsp: 3.06 ± 0.05	3.116GlyGlu: 3.116 ± 0.054	3.905GlyPhe: 3.905 ± 0.05	5.254GlyGly: 5.254 ± 0.088	1.258GlyHis: 1.258 ± 0.032	5.533GlyIle: 5.533 ± 0.065	5.789GlyLys: 5.789 ± 0.077	6.605GlyLeu: 6.605 ± 0.072	1.978GlyMet: 1.978 ± 0.039	3.812GlyAsn: 3.812 ± 0.063	1.782GlyPro: 1.782 ± 0.043	2.465GlyGln: 2.465 ± 0.049	2.462GlyArg: 2.462 ± 0.047	4.443GlySer: 4.443 ± 0.074	4.217GlyThr: 4.217 ± 0.091	4.438GlyVal: 4.438 ± 0.061	1.156GlyTrp: 1.156 ± 0.033	3.098GlyTyr: 3.098 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.301HisAla: 1.301 ± 0.029	0.223HisCys: 0.223 ± 0.014	0.856HisAsp: 0.856 ± 0.028	0.972HisGlu: 0.972 ± 0.029	1.328HisPhe: 1.328 ± 0.029	1.214HisGly: 1.214 ± 0.033	0.577HisHis: 0.577 ± 0.022	1.29HisIle: 1.29 ± 0.03	0.957HisLys: 0.957 ± 0.026	2.108HisLeu: 2.108 ± 0.048	0.389HisMet: 0.389 ± 0.017	0.809HisAsn: 0.809 ± 0.022	1.239HisPro: 1.239 ± 0.031	0.969HisGln: 0.969 ± 0.031	0.708HisArg: 0.708 ± 0.025	1.146HisSer: 1.146 ± 0.027	0.923HisThr: 0.923 ± 0.026	0.978HisVal: 0.978 ± 0.024	0.339HisTrp: 0.339 ± 0.017	0.88HisTyr: 0.88 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.867IleAla: 5.867 ± 0.076	0.797IleCys: 0.797 ± 0.03	3.992IleAsp: 3.992 ± 0.059	4.049IleGlu: 4.049 ± 0.066	2.994IlePhe: 2.994 ± 0.052	5.104IleGly: 5.104 ± 0.073	1.474IleHis: 1.474 ± 0.034	4.506IleIle: 4.506 ± 0.075	4.765IleLys: 4.765 ± 0.066	6.47IleLeu: 6.47 ± 0.078	1.381IleMet: 1.381 ± 0.031	4.027IleAsn: 4.027 ± 0.061	3.41IlePro: 3.41 ± 0.055	3.146IleGln: 3.146 ± 0.049	2.851IleArg: 2.851 ± 0.051	5.036IleSer: 5.036 ± 0.073	4.077IleThr: 4.077 ± 0.062	4.246IleVal: 4.246 ± 0.059	0.877IleTrp: 0.877 ± 0.029	2.466IleTyr: 2.466 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	5.382LysAla: 5.382 ± 0.073	0.365LysCys: 0.365 ± 0.016	4.249LysAsp: 4.249 ± 0.067	4.806LysGlu: 4.806 ± 0.07	2.595LysPhe: 2.595 ± 0.051	4.907LysGly: 4.907 ± 0.068	1.318LysHis: 1.318 ± 0.034	4.826LysIle: 4.826 ± 0.071	5.521LysLys: 5.521 ± 0.077	6.083LysLeu: 6.083 ± 0.068	2.116LysMet: 2.116 ± 0.044	3.972LysAsn: 3.972 ± 0.057	2.808LysPro: 2.808 ± 0.044	3.428LysGln: 3.428 ± 0.052	2.568LysArg: 2.568 ± 0.043	4.117LysSer: 4.117 ± 0.062	4.413LysThr: 4.413 ± 0.059	3.847LysVal: 3.847 ± 0.052	0.96LysTrp: 0.96 ± 0.028	2.681LysTyr: 2.681 ± 0.053	0.0LysXaa: 0.0 ± 0.0
Leu	7.122LeuAla: 7.122 ± 0.078	0.834LeuCys: 0.834 ± 0.027	4.891LeuAsp: 4.891 ± 0.059	5.343LeuGlu: 5.343 ± 0.07	4.974LeuPhe: 4.974 ± 0.071	6.186LeuGly: 6.186 ± 0.071	1.847LeuHis: 1.847 ± 0.04	6.506LeuIle: 6.506 ± 0.081	6.81LeuLys: 6.81 ± 0.085	9.741LeuLeu: 9.741 ± 0.126	2.435LeuMet: 2.435 ± 0.043	5.273LeuAsn: 5.273 ± 0.077	4.174LeuPro: 4.174 ± 0.064	4.251LeuGln: 4.251 ± 0.063	3.277LeuArg: 3.277 ± 0.045	6.635LeuSer: 6.635 ± 0.071	5.028LeuThr: 5.028 ± 0.072	6.479LeuVal: 6.479 ± 0.08	0.933LeuTrp: 0.933 ± 0.03	3.267LeuTyr: 3.267 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.052MetAla: 2.052 ± 0.039	0.128MetCys: 0.128 ± 0.008	1.365MetAsp: 1.365 ± 0.036	1.569MetGlu: 1.569 ± 0.033	0.833MetPhe: 0.833 ± 0.025	1.974MetGly: 1.974 ± 0.039	0.575MetHis: 0.575 ± 0.022	1.596MetIle: 1.596 ± 0.039	1.988MetLys: 1.988 ± 0.04	2.128MetLeu: 2.128 ± 0.041	0.735MetMet: 0.735 ± 0.025	1.343MetAsn: 1.343 ± 0.032	1.178MetPro: 1.178 ± 0.029	1.297MetGln: 1.297 ± 0.033	1.023MetArg: 1.023 ± 0.028	1.492MetSer: 1.492 ± 0.036	1.112MetThr: 1.112 ± 0.03	1.698MetVal: 1.698 ± 0.036	0.182MetTrp: 0.182 ± 0.012	0.697MetTyr: 0.697 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	4.194AsnAla: 4.194 ± 0.072	0.515AsnCys: 0.515 ± 0.021	2.548AsnAsp: 2.548 ± 0.053	2.758AsnGlu: 2.758 ± 0.041	2.582AsnPhe: 2.582 ± 0.047	4.264AsnGly: 4.264 ± 0.075	1.102AsnHis: 1.102 ± 0.028	3.971AsnIle: 3.971 ± 0.074	3.839AsnLys: 3.839 ± 0.058	5.19AsnLeu: 5.19 ± 0.067	1.309AsnMet: 1.309 ± 0.028	3.43AsnAsn: 3.43 ± 0.08	2.923AsnPro: 2.923 ± 0.061	2.681AsnGln: 2.681 ± 0.047	2.238AsnArg: 2.238 ± 0.043	3.406AsnSer: 3.406 ± 0.058	3.265AsnThr: 3.265 ± 0.067	2.689AsnVal: 2.689 ± 0.052	0.91AsnTrp: 0.91 ± 0.029	2.471AsnTyr: 2.471 ± 0.052	0.0AsnXaa: 0.0 ± 0.0
Pro	3.211ProAla: 3.211 ± 0.057	0.245ProCys: 0.245 ± 0.014	2.289ProAsp: 2.289 ± 0.044	2.507ProGlu: 2.507 ± 0.047	2.092ProPhe: 2.092 ± 0.046	2.69ProGly: 2.69 ± 0.056	0.687ProHis: 0.687 ± 0.022	2.986ProIle: 2.986 ± 0.052	2.5ProLys: 2.5 ± 0.045	3.432ProLeu: 3.432 ± 0.048	0.954ProMet: 0.954 ± 0.028	2.427ProAsn: 2.427 ± 0.049	0.979ProPro: 0.979 ± 0.034	1.395ProGln: 1.395 ± 0.034	1.107ProArg: 1.107 ± 0.03	2.533ProSer: 2.533 ± 0.05	2.358ProThr: 2.358 ± 0.06	3.006ProVal: 3.006 ± 0.058	0.51ProTrp: 0.51 ± 0.022	1.565ProTyr: 1.565 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.031GlnAla: 3.031 ± 0.056	0.26GlnCys: 0.26 ± 0.014	1.844GlnAsp: 1.844 ± 0.045	2.313GlnGlu: 2.313 ± 0.048	2.285GlnPhe: 2.285 ± 0.043	2.289GlnGly: 2.289 ± 0.042	0.861GlnHis: 0.861 ± 0.026	3.048GlnIle: 3.048 ± 0.045	2.993GlnLys: 2.993 ± 0.047	4.834GlnLeu: 4.834 ± 0.07	1.173GlnMet: 1.173 ± 0.031	2.076GlnAsn: 2.076 ± 0.046	1.714GlnPro: 1.714 ± 0.035	2.465GlnGln: 2.465 ± 0.055	1.485GlnArg: 1.485 ± 0.035	2.599GlnSer: 2.599 ± 0.042	2.519GlnThr: 2.519 ± 0.045	2.8GlnVal: 2.8 ± 0.048	0.657GlnTrp: 0.657 ± 0.018	1.743GlnTyr: 1.743 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	2.246ArgAla: 2.246 ± 0.043	0.236ArgCys: 0.236 ± 0.013	1.745ArgAsp: 1.745 ± 0.036	1.941ArgGlu: 1.941 ± 0.045	2.036ArgPhe: 2.036 ± 0.037	2.151ArgGly: 2.151 ± 0.041	0.557ArgHis: 0.557 ± 0.021	2.944ArgIle: 2.944 ± 0.046	2.756ArgLys: 2.756 ± 0.046	3.319ArgLeu: 3.319 ± 0.058	1.044ArgMet: 1.044 ± 0.025	2.204ArgAsn: 2.204 ± 0.048	1.253ArgPro: 1.253 ± 0.035	1.263ArgGln: 1.263 ± 0.03	1.258ArgArg: 1.258 ± 0.034	1.997ArgSer: 1.997 ± 0.039	1.818ArgThr: 1.818 ± 0.035	2.18ArgVal: 2.18 ± 0.046	0.529ArgTrp: 0.529 ± 0.018	1.568ArgTyr: 1.568 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	4.567SerAla: 4.567 ± 0.069	0.581SerCys: 0.581 ± 0.022	2.922SerAsp: 2.922 ± 0.05	2.805SerGlu: 2.805 ± 0.054	3.923SerPhe: 3.923 ± 0.062	4.701SerGly: 4.701 ± 0.067	1.108SerHis: 1.108 ± 0.032	5.531SerIle: 5.531 ± 0.073	4.423SerLys: 4.423 ± 0.07	6.533SerLeu: 6.533 ± 0.069	1.578SerMet: 1.578 ± 0.031	3.932SerAsn: 3.932 ± 0.072	2.281SerPro: 2.281 ± 0.049	2.153SerGln: 2.153 ± 0.039	2.028SerArg: 2.028 ± 0.039	4.359SerSer: 4.359 ± 0.081	3.528SerThr: 3.528 ± 0.061	3.915SerVal: 3.915 ± 0.053	0.898SerTrp: 0.898 ± 0.029	2.63SerTyr: 2.63 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	4.63ThrAla: 4.63 ± 0.09	0.426ThrCys: 0.426 ± 0.021	3.053ThrAsp: 3.053 ± 0.051	2.886ThrGlu: 2.886 ± 0.054	2.018ThrPhe: 2.018 ± 0.042	4.931ThrGly: 4.931 ± 0.091	1.012ThrHis: 1.012 ± 0.025	4.483ThrIle: 4.483 ± 0.078	3.607ThrLys: 3.607 ± 0.05	4.777ThrLeu: 4.777 ± 0.059	1.147ThrMet: 1.147 ± 0.027	3.228ThrAsn: 3.228 ± 0.055	2.409ThrPro: 2.409 ± 0.065	2.021ThrGln: 2.021 ± 0.041	1.752ThrArg: 1.752 ± 0.036	3.435ThrSer: 3.435 ± 0.062	3.296ThrThr: 3.296 ± 0.087	4.035ThrVal: 4.035 ± 0.102	0.706ThrTrp: 0.706 ± 0.028	2.107ThrTyr: 2.107 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	4.801ValAla: 4.801 ± 0.07	0.664ValCys: 0.664 ± 0.022	3.228ValAsp: 3.228 ± 0.056	3.251ValGlu: 3.251 ± 0.052	3.187ValPhe: 3.187 ± 0.055	3.908ValGly: 3.908 ± 0.061	1.121ValHis: 1.121 ± 0.033	4.187ValIle: 4.187 ± 0.057	4.216ValLys: 4.216 ± 0.059	6.148ValLeu: 6.148 ± 0.066	1.557ValMet: 1.557 ± 0.036	3.418ValAsn: 3.418 ± 0.072	2.455ValPro: 2.455 ± 0.048	2.286ValGln: 2.286 ± 0.044	2.043ValArg: 2.043 ± 0.039	4.237ValSer: 4.237 ± 0.066	3.327ValThr: 3.327 ± 0.076	4.118ValVal: 4.118 ± 0.067	0.764ValTrp: 0.764 ± 0.025	2.417ValTyr: 2.417 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.833TrpAla: 0.833 ± 0.025	0.118TrpCys: 0.118 ± 0.01	0.75TrpAsp: 0.75 ± 0.027	0.741TrpGlu: 0.741 ± 0.025	0.671TrpPhe: 0.671 ± 0.023	0.908TrpGly: 0.908 ± 0.027	0.336TrpHis: 0.336 ± 0.017	0.891TrpIle: 0.891 ± 0.025	1.095TrpLys: 1.095 ± 0.03	1.309TrpLeu: 1.309 ± 0.033	0.486TrpMet: 0.486 ± 0.019	0.896TrpAsn: 0.896 ± 0.028	0.373TrpPro: 0.373 ± 0.016	0.577TrpGln: 0.577 ± 0.022	0.532TrpArg: 0.532 ± 0.022	0.778TrpSer: 0.778 ± 0.023	0.683TrpThr: 0.683 ± 0.026	0.922TrpVal: 0.922 ± 0.03	0.244TrpTrp: 0.244 ± 0.017	0.537TrpTyr: 0.537 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.805TyrAla: 2.805 ± 0.045	0.389TyrCys: 0.389 ± 0.015	2.045TyrAsp: 2.045 ± 0.039	1.918TyrGlu: 1.918 ± 0.035	2.186TyrPhe: 2.186 ± 0.042	2.781TyrGly: 2.781 ± 0.054	0.924TyrHis: 0.924 ± 0.025	2.225TyrIle: 2.225 ± 0.042	2.411TyrLys: 2.411 ± 0.05	4.007TyrLeu: 4.007 ± 0.057	0.744TyrMet: 0.744 ± 0.028	2.13TyrAsn: 2.13 ± 0.049	1.77TyrPro: 1.77 ± 0.038	2.301TyrGln: 2.301 ± 0.043	1.67TyrArg: 1.67 ± 0.036	2.516TyrSer: 2.516 ± 0.04	2.249TyrThr: 2.249 ± 0.06	1.959TyrVal: 1.959 ± 0.041	0.618TyrTrp: 0.618 ± 0.025	1.764TyrTyr: 1.764 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3607 proteins (1338094 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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