Human papillomavirus 42

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Alphapapillomavirus; Alphapapillomavirus 1

Average proteome isoelectric point is 6.41

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 9 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>sp|P27233|VL1_HPV42 Major capsid protein L1 OS=Human papillomavirus 42 OX=10590 GN=L1 PE=3 SV=1
MM1 pKa = 7.69RR2 pKa = 11.84GEE4 pKa = 4.28TPTLKK9 pKa = 10.71DD10 pKa = 2.98IVLFDD15 pKa = 3.94IPTCEE20 pKa = 4.08TPIDD24 pKa = 4.43LYY26 pKa = 11.06CYY28 pKa = 9.05EE29 pKa = 4.52QLDD32 pKa = 4.27SSDD35 pKa = 4.52EE36 pKa = 4.13DD37 pKa = 3.85DD38 pKa = 4.49QAKK41 pKa = 10.13QDD43 pKa = 3.37IQRR46 pKa = 11.84YY47 pKa = 9.46RR48 pKa = 11.84ILCVCTQCYY57 pKa = 10.17KK58 pKa = 10.33SVKK61 pKa = 10.25LVVQCTEE68 pKa = 3.32ADD70 pKa = 3.29IRR72 pKa = 11.84NLQQMLLGTLDD83 pKa = 3.63IVCPLCARR91 pKa = 11.84VEE93 pKa = 4.14

Molecular weight: 10.68 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>sp|P27221|VE1_HPV42 Replication protein E1 OS=Human papillomavirus 42 OX=10590 GN=E1 PE=3 SV=1
MM1 pKa = 7.43KK2 pKa = 9.81ALSVIHH8 pKa = 6.12STTSTDD14 pKa = 3.46AEE16 pKa = 4.35IPSTGSTKK24 pKa = 10.47LVQQVCTTNPLHH36 pKa = 5.72TTTSIDD42 pKa = 3.32NHH44 pKa = 6.62HH45 pKa = 7.27ADD47 pKa = 4.21CTDD50 pKa = 2.85GTAYY54 pKa = 10.33NVPIQTSPPRR64 pKa = 11.84KK65 pKa = 9.22RR66 pKa = 11.84YY67 pKa = 8.26RR68 pKa = 11.84QCGQSPSQHH77 pKa = 5.97LQHH80 pKa = 6.93SNPSIPSIPSASVDD94 pKa = 3.28PGLCGVRR101 pKa = 11.84TNSEE105 pKa = 3.85NCNKK109 pKa = 9.6RR110 pKa = 11.84RR111 pKa = 11.84NHH113 pKa = 6.71CGSQATPVIHH123 pKa = 6.79LQGDD127 pKa = 4.19PNCLKK132 pKa = 10.62CLRR135 pKa = 11.84FRR137 pKa = 11.84LKK139 pKa = 10.55RR140 pKa = 11.84NCSHH144 pKa = 7.46LFTQVSSTWHH154 pKa = 5.25LTEE157 pKa = 4.51NDD159 pKa = 3.57CTRR162 pKa = 11.84DD163 pKa = 3.39TKK165 pKa = 10.87TGIITIHH172 pKa = 6.65YY173 pKa = 9.01YY174 pKa = 10.94DD175 pKa = 3.7EE176 pKa = 4.36AQRR179 pKa = 11.84NLFLNTVKK187 pKa = 10.26IPSGIKK193 pKa = 9.57SCIGYY198 pKa = 8.63MSMLQFII205 pKa = 4.8

Molecular weight: 22.72 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

9

0

9

2680

93

643

297.8

33.25

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.522 ± 0.322

3.246 ± 0.861

5.224 ± 0.551

4.366 ± 0.607

3.694 ± 0.457

5.97 ± 0.525

3.172 ± 0.459

5.0 ± 0.614

4.701 ± 0.837

8.731 ± 1.15

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.754 ± 0.215

4.216 ± 0.681

6.157 ± 1.154

4.925 ± 0.584

4.888 ± 0.364

8.172 ± 0.702

8.955 ± 1.085

6.418 ± 0.443

1.604 ± 0.274

3.284 ± 0.413
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski