Amino acid dipepetide frequency for Corynebacterium phage IME1320_01

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.08AlaAla: 14.08 ± 2.061
0.402AlaCys: 0.402 ± 0.172
6.839AlaAsp: 6.839 ± 0.751
9.011AlaGlu: 9.011 ± 1.11
3.057AlaPhe: 3.057 ± 0.423
9.574AlaGly: 9.574 ± 0.849
2.494AlaHis: 2.494 ± 0.523
4.506AlaIle: 4.506 ± 0.578
5.31AlaLys: 5.31 ± 1.471
7.402AlaLeu: 7.402 ± 0.722
1.529AlaMet: 1.529 ± 0.376
3.057AlaAsn: 3.057 ± 0.51
4.425AlaPro: 4.425 ± 0.575
4.264AlaGln: 4.264 ± 0.579
6.437AlaArg: 6.437 ± 0.492
5.552AlaSer: 5.552 ± 1.179
5.149AlaThr: 5.149 ± 0.83
8.046AlaVal: 8.046 ± 0.978
1.851AlaTrp: 1.851 ± 0.421
2.414AlaTyr: 2.414 ± 0.434
0.0AlaXaa: 0.0 ± 0.0
Cys
0.322CysAla: 0.322 ± 0.136
0.0CysCys: 0.0 ± 0.0
0.402CysAsp: 0.402 ± 0.181
0.563CysGlu: 0.563 ± 0.188
0.08CysPhe: 0.08 ± 0.062
0.483CysGly: 0.483 ± 0.203
0.161CysHis: 0.161 ± 0.12
0.161CysIle: 0.161 ± 0.104
0.161CysLys: 0.161 ± 0.104
0.483CysLeu: 0.483 ± 0.176
0.241CysMet: 0.241 ± 0.136
0.241CysAsn: 0.241 ± 0.144
0.241CysPro: 0.241 ± 0.12
0.563CysGln: 0.563 ± 0.243
0.402CysArg: 0.402 ± 0.173
0.483CysSer: 0.483 ± 0.157
0.322CysThr: 0.322 ± 0.19
0.483CysVal: 0.483 ± 0.194
0.0CysTrp: 0.0 ± 0.0
0.322CysTyr: 0.322 ± 0.134
0.0CysXaa: 0.0 ± 0.0
Asp
7.483AspAla: 7.483 ± 0.714
0.724AspCys: 0.724 ± 0.231
4.023AspAsp: 4.023 ± 0.823
5.23AspGlu: 5.23 ± 0.923
2.494AspPhe: 2.494 ± 0.435
5.552AspGly: 5.552 ± 0.555
1.368AspHis: 1.368 ± 0.336
4.345AspIle: 4.345 ± 0.676
3.299AspLys: 3.299 ± 0.586
6.276AspLeu: 6.276 ± 0.576
1.368AspMet: 1.368 ± 0.406
1.448AspAsn: 1.448 ± 0.332
3.379AspPro: 3.379 ± 0.475
2.414AspGln: 2.414 ± 0.397
3.218AspArg: 3.218 ± 0.607
3.057AspSer: 3.057 ± 0.563
3.701AspThr: 3.701 ± 0.559
3.46AspVal: 3.46 ± 0.504
1.529AspTrp: 1.529 ± 0.355
1.931AspTyr: 1.931 ± 0.332
0.0AspXaa: 0.0 ± 0.0
Glu
6.678GluAla: 6.678 ± 0.721
0.483GluCys: 0.483 ± 0.195
4.908GluAsp: 4.908 ± 1.121
4.345GluGlu: 4.345 ± 0.903
2.977GluPhe: 2.977 ± 0.422
4.425GluGly: 4.425 ± 0.561
1.69GluHis: 1.69 ± 0.298
3.46GluIle: 3.46 ± 0.447
4.506GluLys: 4.506 ± 0.476
7.08GluLeu: 7.08 ± 0.715
1.368GluMet: 1.368 ± 0.326
1.931GluAsn: 1.931 ± 0.416
2.655GluPro: 2.655 ± 0.37
2.575GluGln: 2.575 ± 0.357
3.379GluArg: 3.379 ± 0.389
4.586GluSer: 4.586 ± 0.653
3.781GluThr: 3.781 ± 0.613
5.31GluVal: 5.31 ± 0.737
1.931GluTrp: 1.931 ± 0.418
1.448GluTyr: 1.448 ± 0.328
0.0GluXaa: 0.0 ± 0.0
Phe
3.218PheAla: 3.218 ± 0.599
0.402PheCys: 0.402 ± 0.179
2.575PheAsp: 2.575 ± 0.401
2.172PheGlu: 2.172 ± 0.361
1.126PhePhe: 1.126 ± 0.438
3.54PheGly: 3.54 ± 0.619
0.563PheHis: 0.563 ± 0.218
1.287PheIle: 1.287 ± 0.286
2.172PheLys: 2.172 ± 0.351
2.011PheLeu: 2.011 ± 0.393
0.563PheMet: 0.563 ± 0.22
1.529PheAsn: 1.529 ± 0.235
1.126PhePro: 1.126 ± 0.282
0.885PheGln: 0.885 ± 0.245
1.851PheArg: 1.851 ± 0.407
1.77PheSer: 1.77 ± 0.386
2.011PheThr: 2.011 ± 0.31
1.368PheVal: 1.368 ± 0.355
0.563PheTrp: 0.563 ± 0.233
0.724PheTyr: 0.724 ± 0.236
0.0PheXaa: 0.0 ± 0.0
Gly
7.965GlyAla: 7.965 ± 0.67
0.563GlyCys: 0.563 ± 0.216
5.391GlyAsp: 5.391 ± 0.604
5.471GlyGlu: 5.471 ± 0.477
2.816GlyPhe: 2.816 ± 0.614
8.046GlyGly: 8.046 ± 1.336
1.851GlyHis: 1.851 ± 0.341
3.46GlyIle: 3.46 ± 0.683
4.747GlyLys: 4.747 ± 0.537
7.885GlyLeu: 7.885 ± 0.882
2.494GlyMet: 2.494 ± 0.321
2.414GlyAsn: 2.414 ± 0.369
3.46GlyPro: 3.46 ± 0.482
2.333GlyGln: 2.333 ± 0.5
5.471GlyArg: 5.471 ± 0.676
5.069GlySer: 5.069 ± 0.727
5.471GlyThr: 5.471 ± 0.818
4.586GlyVal: 4.586 ± 0.664
1.851GlyTrp: 1.851 ± 0.397
1.529GlyTyr: 1.529 ± 0.338
0.0GlyXaa: 0.0 ± 0.0
His
1.851HisAla: 1.851 ± 0.333
0.08HisCys: 0.08 ± 0.078
0.241HisAsp: 0.241 ± 0.098
1.046HisGlu: 1.046 ± 0.344
0.805HisPhe: 0.805 ± 0.225
2.414HisGly: 2.414 ± 0.457
0.563HisHis: 0.563 ± 0.218
1.126HisIle: 1.126 ± 0.301
1.126HisLys: 1.126 ± 0.332
1.931HisLeu: 1.931 ± 0.426
0.402HisMet: 0.402 ± 0.182
0.805HisAsn: 0.805 ± 0.283
1.609HisPro: 1.609 ± 0.416
0.644HisGln: 0.644 ± 0.238
2.172HisArg: 2.172 ± 0.461
1.69HisSer: 1.69 ± 0.465
0.965HisThr: 0.965 ± 0.268
1.448HisVal: 1.448 ± 0.449
0.241HisTrp: 0.241 ± 0.125
0.724HisTyr: 0.724 ± 0.261
0.0HisXaa: 0.0 ± 0.0
Ile
3.46IleAla: 3.46 ± 0.42
0.241IleCys: 0.241 ± 0.137
3.781IleAsp: 3.781 ± 0.661
3.218IleGlu: 3.218 ± 0.394
1.448IlePhe: 1.448 ± 0.291
3.379IleGly: 3.379 ± 0.763
1.207IleHis: 1.207 ± 0.277
2.011IleIle: 2.011 ± 0.525
1.851IleLys: 1.851 ± 0.387
3.781IleLeu: 3.781 ± 0.635
0.563IleMet: 0.563 ± 0.197
1.448IleAsn: 1.448 ± 0.401
2.011IlePro: 2.011 ± 0.325
1.77IleGln: 1.77 ± 0.369
2.896IleArg: 2.896 ± 0.477
3.218IleSer: 3.218 ± 0.577
3.54IleThr: 3.54 ± 0.571
3.379IleVal: 3.379 ± 0.42
1.126IleTrp: 1.126 ± 0.373
1.69IleTyr: 1.69 ± 0.495
0.0IleXaa: 0.0 ± 0.0
Lys
4.988LysAla: 4.988 ± 0.802
0.241LysCys: 0.241 ± 0.132
3.218LysAsp: 3.218 ± 0.423
2.977LysGlu: 2.977 ± 0.564
1.529LysPhe: 1.529 ± 0.301
4.023LysGly: 4.023 ± 0.763
1.368LysHis: 1.368 ± 0.257
2.575LysIle: 2.575 ± 0.576
2.575LysLys: 2.575 ± 0.453
4.667LysLeu: 4.667 ± 0.618
0.805LysMet: 0.805 ± 0.228
1.609LysAsn: 1.609 ± 0.372
3.057LysPro: 3.057 ± 0.536
3.218LysGln: 3.218 ± 0.505
2.896LysArg: 2.896 ± 0.525
3.862LysSer: 3.862 ± 0.607
3.54LysThr: 3.54 ± 0.494
2.977LysVal: 2.977 ± 0.403
0.644LysTrp: 0.644 ± 0.234
1.448LysTyr: 1.448 ± 0.288
0.0LysXaa: 0.0 ± 0.0
Leu
9.172LeuAla: 9.172 ± 0.824
0.965LeuCys: 0.965 ± 0.301
6.115LeuAsp: 6.115 ± 0.739
5.954LeuGlu: 5.954 ± 0.779
2.011LeuPhe: 2.011 ± 0.351
6.758LeuGly: 6.758 ± 0.736
1.448LeuHis: 1.448 ± 0.358
4.023LeuIle: 4.023 ± 0.596
4.425LeuLys: 4.425 ± 0.681
5.552LeuLeu: 5.552 ± 0.599
2.011LeuMet: 2.011 ± 0.344
2.655LeuAsn: 2.655 ± 0.56
5.391LeuPro: 5.391 ± 0.72
2.011LeuGln: 2.011 ± 0.401
6.115LeuArg: 6.115 ± 0.96
4.264LeuSer: 4.264 ± 0.444
5.552LeuThr: 5.552 ± 0.542
4.667LeuVal: 4.667 ± 0.677
1.287LeuTrp: 1.287 ± 0.356
2.011LeuTyr: 2.011 ± 0.383
0.0LeuXaa: 0.0 ± 0.0
Met
1.287MetAla: 1.287 ± 0.262
0.0MetCys: 0.0 ± 0.0
1.287MetAsp: 1.287 ± 0.3
1.287MetGlu: 1.287 ± 0.298
0.885MetPhe: 0.885 ± 0.244
1.931MetGly: 1.931 ± 0.358
0.483MetHis: 0.483 ± 0.169
0.563MetIle: 0.563 ± 0.185
1.126MetLys: 1.126 ± 0.254
1.851MetLeu: 1.851 ± 0.381
0.402MetMet: 0.402 ± 0.175
0.965MetAsn: 0.965 ± 0.246
1.207MetPro: 1.207 ± 0.284
1.126MetGln: 1.126 ± 0.369
1.69MetArg: 1.69 ± 0.341
1.609MetSer: 1.609 ± 0.329
1.851MetThr: 1.851 ± 0.326
1.609MetVal: 1.609 ± 0.33
0.402MetTrp: 0.402 ± 0.142
0.161MetTyr: 0.161 ± 0.092
0.0MetXaa: 0.0 ± 0.0
Asn
4.506AsnAla: 4.506 ± 0.657
0.241AsnCys: 0.241 ± 0.141
1.448AsnAsp: 1.448 ± 0.291
1.851AsnGlu: 1.851 ± 0.393
0.965AsnPhe: 0.965 ± 0.289
2.494AsnGly: 2.494 ± 0.345
0.644AsnHis: 0.644 ± 0.249
1.77AsnIle: 1.77 ± 0.336
1.287AsnLys: 1.287 ± 0.352
2.575AsnLeu: 2.575 ± 0.445
0.805AsnMet: 0.805 ± 0.243
0.724AsnAsn: 0.724 ± 0.186
1.931AsnPro: 1.931 ± 0.347
1.126AsnGln: 1.126 ± 0.371
1.69AsnArg: 1.69 ± 0.314
1.368AsnSer: 1.368 ± 0.27
2.092AsnThr: 2.092 ± 0.506
1.851AsnVal: 1.851 ± 0.343
0.724AsnTrp: 0.724 ± 0.29
0.483AsnTyr: 0.483 ± 0.188
0.0AsnXaa: 0.0 ± 0.0
Pro
4.264ProAla: 4.264 ± 0.673
0.241ProCys: 0.241 ± 0.139
4.586ProAsp: 4.586 ± 0.637
4.747ProGlu: 4.747 ± 0.61
1.609ProPhe: 1.609 ± 0.307
4.103ProGly: 4.103 ± 0.666
0.885ProHis: 0.885 ± 0.25
2.172ProIle: 2.172 ± 0.417
2.333ProLys: 2.333 ± 0.461
3.54ProLeu: 3.54 ± 0.517
1.529ProMet: 1.529 ± 0.426
1.529ProAsn: 1.529 ± 0.299
2.333ProPro: 2.333 ± 0.452
1.609ProGln: 1.609 ± 0.405
2.575ProArg: 2.575 ± 0.503
2.896ProSer: 2.896 ± 0.534
2.896ProThr: 2.896 ± 0.557
3.781ProVal: 3.781 ± 0.37
1.126ProTrp: 1.126 ± 0.342
1.287ProTyr: 1.287 ± 0.235
0.0ProXaa: 0.0 ± 0.0
Gln
4.747GlnAla: 4.747 ± 0.663
0.161GlnCys: 0.161 ± 0.1
1.851GlnAsp: 1.851 ± 0.421
2.172GlnGlu: 2.172 ± 0.535
0.885GlnPhe: 0.885 ± 0.264
2.414GlnGly: 2.414 ± 0.332
0.241GlnHis: 0.241 ± 0.11
1.448GlnIle: 1.448 ± 0.349
1.609GlnLys: 1.609 ± 0.375
4.103GlnLeu: 4.103 ± 0.55
0.805GlnMet: 0.805 ± 0.222
0.805GlnAsn: 0.805 ± 0.272
2.011GlnPro: 2.011 ± 0.384
2.575GlnGln: 2.575 ± 0.55
2.655GlnArg: 2.655 ± 0.452
1.77GlnSer: 1.77 ± 0.317
2.011GlnThr: 2.011 ± 0.585
2.896GlnVal: 2.896 ± 0.411
0.965GlnTrp: 0.965 ± 0.24
0.402GlnTyr: 0.402 ± 0.175
0.0GlnXaa: 0.0 ± 0.0
Arg
6.195ArgAla: 6.195 ± 0.593
0.483ArgCys: 0.483 ± 0.227
4.103ArgAsp: 4.103 ± 0.695
4.506ArgGlu: 4.506 ± 0.524
1.851ArgPhe: 1.851 ± 0.362
4.425ArgGly: 4.425 ± 0.559
1.207ArgHis: 1.207 ± 0.345
3.701ArgIle: 3.701 ± 0.62
3.862ArgLys: 3.862 ± 0.479
5.149ArgLeu: 5.149 ± 0.746
1.448ArgMet: 1.448 ± 0.287
2.011ArgAsn: 2.011 ± 0.425
2.172ArgPro: 2.172 ± 0.347
1.77ArgGln: 1.77 ± 0.341
4.264ArgArg: 4.264 ± 0.791
3.621ArgSer: 3.621 ± 0.457
2.896ArgThr: 2.896 ± 0.456
4.184ArgVal: 4.184 ± 0.506
1.448ArgTrp: 1.448 ± 0.451
1.77ArgTyr: 1.77 ± 0.348
0.0ArgXaa: 0.0 ± 0.0
Ser
7.322SerAla: 7.322 ± 1.293
0.241SerCys: 0.241 ± 0.135
2.736SerAsp: 2.736 ± 0.49
3.46SerGlu: 3.46 ± 0.526
2.011SerPhe: 2.011 ± 0.3
5.23SerGly: 5.23 ± 0.843
1.207SerHis: 1.207 ± 0.279
2.575SerIle: 2.575 ± 0.401
2.655SerLys: 2.655 ± 0.474
3.942SerLeu: 3.942 ± 0.597
1.609SerMet: 1.609 ± 0.36
2.092SerAsn: 2.092 ± 0.422
3.621SerPro: 3.621 ± 0.515
2.172SerGln: 2.172 ± 0.525
2.896SerArg: 2.896 ± 0.479
4.264SerSer: 4.264 ± 0.855
4.988SerThr: 4.988 ± 0.719
4.184SerVal: 4.184 ± 0.554
1.207SerTrp: 1.207 ± 0.317
2.092SerTyr: 2.092 ± 0.361
0.0SerXaa: 0.0 ± 0.0
Thr
6.437ThrAla: 6.437 ± 1.277
0.161ThrCys: 0.161 ± 0.105
4.345ThrAsp: 4.345 ± 0.956
3.299ThrGlu: 3.299 ± 0.509
1.529ThrPhe: 1.529 ± 0.373
4.988ThrGly: 4.988 ± 0.657
1.609ThrHis: 1.609 ± 0.284
2.655ThrIle: 2.655 ± 0.445
3.138ThrLys: 3.138 ± 0.43
4.908ThrLeu: 4.908 ± 0.574
1.207ThrMet: 1.207 ± 0.313
2.172ThrAsn: 2.172 ± 0.364
3.781ThrPro: 3.781 ± 0.594
1.287ThrGln: 1.287 ± 0.258
3.218ThrArg: 3.218 ± 0.494
3.621ThrSer: 3.621 ± 0.592
3.218ThrThr: 3.218 ± 0.517
5.712ThrVal: 5.712 ± 0.836
1.609ThrTrp: 1.609 ± 0.341
2.011ThrTyr: 2.011 ± 0.44
0.0ThrXaa: 0.0 ± 0.0
Val
6.839ValAla: 6.839 ± 0.798
0.161ValCys: 0.161 ± 0.101
5.149ValAsp: 5.149 ± 0.656
4.908ValGlu: 4.908 ± 0.583
2.092ValPhe: 2.092 ± 0.4
4.827ValGly: 4.827 ± 0.625
1.931ValHis: 1.931 ± 0.412
2.253ValIle: 2.253 ± 0.488
4.103ValLys: 4.103 ± 0.589
4.747ValLeu: 4.747 ± 0.603
1.609ValMet: 1.609 ± 0.281
1.77ValAsn: 1.77 ± 0.325
2.816ValPro: 2.816 ± 0.427
2.333ValGln: 2.333 ± 0.48
4.023ValArg: 4.023 ± 0.621
5.31ValSer: 5.31 ± 0.777
4.667ValThr: 4.667 ± 0.682
4.506ValVal: 4.506 ± 0.537
1.851ValTrp: 1.851 ± 0.408
2.011ValTyr: 2.011 ± 0.379
0.0ValXaa: 0.0 ± 0.0
Trp
2.494TrpAla: 2.494 ± 0.519
0.08TrpCys: 0.08 ± 0.077
1.931TrpAsp: 1.931 ± 0.38
1.931TrpGlu: 1.931 ± 0.426
0.644TrpPhe: 0.644 ± 0.249
1.448TrpGly: 1.448 ± 0.295
0.644TrpHis: 0.644 ± 0.204
0.965TrpIle: 0.965 ± 0.25
0.805TrpLys: 0.805 ± 0.221
2.011TrpLeu: 2.011 ± 0.386
0.322TrpMet: 0.322 ± 0.183
0.483TrpAsn: 0.483 ± 0.172
1.207TrpPro: 1.207 ± 0.413
0.805TrpGln: 0.805 ± 0.323
1.368TrpArg: 1.368 ± 0.356
0.965TrpSer: 0.965 ± 0.268
0.965TrpThr: 0.965 ± 0.255
1.448TrpVal: 1.448 ± 0.377
0.402TrpTrp: 0.402 ± 0.239
0.402TrpTyr: 0.402 ± 0.179
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.092TyrAla: 2.092 ± 0.336
0.241TyrCys: 0.241 ± 0.149
1.368TyrAsp: 1.368 ± 0.33
1.368TyrGlu: 1.368 ± 0.297
0.644TyrPhe: 0.644 ± 0.192
2.816TyrGly: 2.816 ± 0.482
0.322TyrHis: 0.322 ± 0.127
0.965TyrIle: 0.965 ± 0.278
1.126TyrLys: 1.126 ± 0.335
2.494TyrLeu: 2.494 ± 0.613
0.563TyrMet: 0.563 ± 0.263
0.885TyrAsn: 0.885 ± 0.358
1.609TyrPro: 1.609 ± 0.378
1.046TyrGln: 1.046 ± 0.273
1.931TyrArg: 1.931 ± 0.384
1.529TyrSer: 1.529 ± 0.364
1.287TyrThr: 1.287 ± 0.36
2.011TyrVal: 2.011 ± 0.411
0.563TyrTrp: 0.563 ± 0.211
0.402TyrTyr: 0.402 ± 0.172
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 53 proteins (12430 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski