Amino acid dipepetide frequency for Edwardsiella phage eiAU-183

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.784AlaAla: 14.784 ± 1.654
1.167AlaCys: 1.167 ± 0.297
9.337AlaAsp: 9.337 ± 0.914
9.96AlaGlu: 9.96 ± 1.008
4.046AlaPhe: 4.046 ± 0.59
10.893AlaGly: 10.893 ± 0.92
1.245AlaHis: 1.245 ± 0.283
5.991AlaIle: 5.991 ± 0.839
6.458AlaLys: 6.458 ± 0.744
11.282AlaLeu: 11.282 ± 1.099
3.579AlaMet: 3.579 ± 0.492
2.723AlaAsn: 2.723 ± 0.602
4.435AlaPro: 4.435 ± 0.583
4.279AlaGln: 4.279 ± 0.551
5.602AlaArg: 5.602 ± 0.679
6.769AlaSer: 6.769 ± 0.818
6.925AlaThr: 6.925 ± 0.756
7.392AlaVal: 7.392 ± 1.144
1.79AlaTrp: 1.79 ± 0.373
2.723AlaTyr: 2.723 ± 0.388
0.0AlaXaa: 0.0 ± 0.0
Cys
1.478CysAla: 1.478 ± 0.441
0.311CysCys: 0.311 ± 0.188
1.323CysAsp: 1.323 ± 0.397
0.934CysGlu: 0.934 ± 0.274
0.389CysPhe: 0.389 ± 0.191
0.934CysGly: 0.934 ± 0.323
0.233CysHis: 0.233 ± 0.113
0.622CysIle: 0.622 ± 0.258
0.545CysLys: 0.545 ± 0.215
0.934CysLeu: 0.934 ± 0.279
0.233CysMet: 0.233 ± 0.13
0.545CysAsn: 0.545 ± 0.192
0.467CysPro: 0.467 ± 0.194
0.389CysGln: 0.389 ± 0.158
0.7CysArg: 0.7 ± 0.215
0.545CysSer: 0.545 ± 0.191
0.311CysThr: 0.311 ± 0.166
0.856CysVal: 0.856 ± 0.255
0.233CysTrp: 0.233 ± 0.128
0.467CysTyr: 0.467 ± 0.201
0.0CysXaa: 0.0 ± 0.0
Asp
6.925AspAla: 6.925 ± 0.708
1.012AspCys: 1.012 ± 0.33
5.524AspAsp: 5.524 ± 1.036
5.058AspGlu: 5.058 ± 0.92
2.646AspPhe: 2.646 ± 0.332
5.447AspGly: 5.447 ± 0.724
0.622AspHis: 0.622 ± 0.272
3.501AspIle: 3.501 ± 0.522
3.579AspLys: 3.579 ± 0.588
5.213AspLeu: 5.213 ± 0.983
1.556AspMet: 1.556 ± 0.333
1.712AspAsn: 1.712 ± 0.327
2.646AspPro: 2.646 ± 0.483
1.867AspGln: 1.867 ± 0.397
3.657AspArg: 3.657 ± 0.365
2.801AspSer: 2.801 ± 0.504
4.279AspThr: 4.279 ± 0.549
3.346AspVal: 3.346 ± 0.531
0.934AspTrp: 0.934 ± 0.219
1.712AspTyr: 1.712 ± 0.346
0.0AspXaa: 0.0 ± 0.0
Glu
6.536GluAla: 6.536 ± 0.84
0.7GluCys: 0.7 ± 0.288
3.657GluAsp: 3.657 ± 0.679
3.813GluGlu: 3.813 ± 0.638
2.49GluPhe: 2.49 ± 0.46
3.579GluGly: 3.579 ± 0.561
1.012GluHis: 1.012 ± 0.36
4.513GluIle: 4.513 ± 0.354
4.357GluLys: 4.357 ± 0.658
6.303GluLeu: 6.303 ± 0.718
1.79GluMet: 1.79 ± 0.384
2.801GluAsn: 2.801 ± 0.439
1.79GluPro: 1.79 ± 0.448
2.412GluGln: 2.412 ± 0.529
4.202GluArg: 4.202 ± 0.661
2.646GluSer: 2.646 ± 0.457
1.945GluThr: 1.945 ± 0.288
3.579GluVal: 3.579 ± 0.593
0.856GluTrp: 0.856 ± 0.259
1.945GluTyr: 1.945 ± 0.316
0.0GluXaa: 0.0 ± 0.0
Phe
3.424PheAla: 3.424 ± 0.421
0.545PheCys: 0.545 ± 0.194
2.023PheAsp: 2.023 ± 0.411
1.945PheGlu: 1.945 ± 0.458
0.545PhePhe: 0.545 ± 0.204
3.035PheGly: 3.035 ± 0.48
0.467PheHis: 0.467 ± 0.212
1.634PheIle: 1.634 ± 0.336
1.712PheLys: 1.712 ± 0.341
1.945PheLeu: 1.945 ± 0.419
0.389PheMet: 0.389 ± 0.194
1.712PheAsn: 1.712 ± 0.428
1.556PhePro: 1.556 ± 0.375
1.323PheGln: 1.323 ± 0.289
2.256PheArg: 2.256 ± 0.358
1.945PheSer: 1.945 ± 0.342
1.945PheThr: 1.945 ± 0.422
1.478PheVal: 1.478 ± 0.339
0.545PheTrp: 0.545 ± 0.206
1.012PheTyr: 1.012 ± 0.294
0.0PheXaa: 0.0 ± 0.0
Gly
9.804GlyAla: 9.804 ± 0.846
1.089GlyCys: 1.089 ± 0.28
3.89GlyAsp: 3.89 ± 0.729
4.513GlyGlu: 4.513 ± 0.451
2.723GlyPhe: 2.723 ± 0.469
9.493GlyGly: 9.493 ± 1.663
0.934GlyHis: 0.934 ± 0.334
3.89GlyIle: 3.89 ± 0.412
4.902GlyLys: 4.902 ± 0.75
6.925GlyLeu: 6.925 ± 0.747
2.412GlyMet: 2.412 ± 0.512
3.035GlyAsn: 3.035 ± 0.506
1.867GlyPro: 1.867 ± 0.361
2.49GlyGln: 2.49 ± 0.664
4.279GlyArg: 4.279 ± 0.575
4.513GlySer: 4.513 ± 0.875
4.202GlyThr: 4.202 ± 0.572
6.847GlyVal: 6.847 ± 0.823
1.089GlyTrp: 1.089 ± 0.344
3.035GlyTyr: 3.035 ± 0.498
0.0GlyXaa: 0.0 ± 0.0
His
2.101HisAla: 2.101 ± 0.405
0.311HisCys: 0.311 ± 0.165
1.012HisAsp: 1.012 ± 0.318
0.622HisGlu: 0.622 ± 0.346
0.622HisPhe: 0.622 ± 0.193
0.934HisGly: 0.934 ± 0.318
0.7HisHis: 0.7 ± 0.409
1.245HisIle: 1.245 ± 0.319
0.467HisLys: 0.467 ± 0.215
1.012HisLeu: 1.012 ± 0.301
0.233HisMet: 0.233 ± 0.127
0.622HisAsn: 0.622 ± 0.329
1.634HisPro: 1.634 ± 0.451
0.856HisGln: 0.856 ± 0.292
0.545HisArg: 0.545 ± 0.173
0.856HisSer: 0.856 ± 0.202
0.778HisThr: 0.778 ± 0.267
0.778HisVal: 0.778 ± 0.3
0.156HisTrp: 0.156 ± 0.105
1.089HisTyr: 1.089 ± 0.28
0.0HisXaa: 0.0 ± 0.0
Ile
5.913IleAla: 5.913 ± 0.762
0.545IleCys: 0.545 ± 0.227
3.89IleAsp: 3.89 ± 0.477
3.424IleGlu: 3.424 ± 0.412
1.245IlePhe: 1.245 ± 0.391
4.435IleGly: 4.435 ± 0.603
0.7IleHis: 0.7 ± 0.236
2.646IleIle: 2.646 ± 0.412
2.568IleLys: 2.568 ± 0.459
2.646IleLeu: 2.646 ± 0.513
1.478IleMet: 1.478 ± 0.314
2.023IleAsn: 2.023 ± 0.331
1.712IlePro: 1.712 ± 0.428
1.167IleGln: 1.167 ± 0.373
3.735IleArg: 3.735 ± 0.635
2.879IleSer: 2.879 ± 0.509
4.902IleThr: 4.902 ± 0.457
2.49IleVal: 2.49 ± 0.391
0.311IleTrp: 0.311 ± 0.157
1.634IleTyr: 1.634 ± 0.42
0.0IleXaa: 0.0 ± 0.0
Lys
6.847LysAla: 6.847 ± 0.884
0.545LysCys: 0.545 ± 0.213
2.256LysAsp: 2.256 ± 0.449
2.334LysGlu: 2.334 ± 0.413
1.712LysPhe: 1.712 ± 0.391
2.957LysGly: 2.957 ± 0.43
0.856LysHis: 0.856 ± 0.276
2.179LysIle: 2.179 ± 0.438
4.279LysLys: 4.279 ± 0.879
4.435LysLeu: 4.435 ± 0.6
1.634LysMet: 1.634 ± 0.347
2.179LysAsn: 2.179 ± 0.4
2.646LysPro: 2.646 ± 0.408
2.334LysGln: 2.334 ± 0.482
3.657LysArg: 3.657 ± 0.657
2.879LysSer: 2.879 ± 0.478
3.346LysThr: 3.346 ± 0.584
3.657LysVal: 3.657 ± 0.618
1.012LysTrp: 1.012 ± 0.237
1.323LysTyr: 1.323 ± 0.303
0.0LysXaa: 0.0 ± 0.0
Leu
9.57LeuAla: 9.57 ± 0.994
1.79LeuCys: 1.79 ± 0.428
5.602LeuAsp: 5.602 ± 0.661
3.89LeuGlu: 3.89 ± 0.442
1.712LeuPhe: 1.712 ± 0.339
4.98LeuGly: 4.98 ± 0.488
1.089LeuHis: 1.089 ± 0.331
4.046LeuIle: 4.046 ± 0.507
3.657LeuLys: 3.657 ± 0.598
5.836LeuLeu: 5.836 ± 0.636
2.49LeuMet: 2.49 ± 0.334
3.19LeuAsn: 3.19 ± 0.561
3.424LeuPro: 3.424 ± 0.714
3.579LeuGln: 3.579 ± 0.567
6.069LeuArg: 6.069 ± 0.793
4.591LeuSer: 4.591 ± 0.521
4.98LeuThr: 4.98 ± 0.655
4.669LeuVal: 4.669 ± 0.589
0.7LeuTrp: 0.7 ± 0.191
2.101LeuTyr: 2.101 ± 0.47
0.0LeuXaa: 0.0 ± 0.0
Met
4.202MetAla: 4.202 ± 0.552
0.233MetCys: 0.233 ± 0.124
0.622MetAsp: 0.622 ± 0.216
1.245MetGlu: 1.245 ± 0.389
1.401MetPhe: 1.401 ± 0.346
1.478MetGly: 1.478 ± 0.283
1.089MetHis: 1.089 ± 0.252
1.012MetIle: 1.012 ± 0.309
1.167MetLys: 1.167 ± 0.309
1.867MetLeu: 1.867 ± 0.338
0.778MetMet: 0.778 ± 0.259
0.934MetAsn: 0.934 ± 0.317
1.401MetPro: 1.401 ± 0.321
0.7MetGln: 0.7 ± 0.28
2.179MetArg: 2.179 ± 0.39
1.556MetSer: 1.556 ± 0.328
2.256MetThr: 2.256 ± 0.414
1.167MetVal: 1.167 ± 0.233
0.389MetTrp: 0.389 ± 0.177
0.7MetTyr: 0.7 ± 0.234
0.0MetXaa: 0.0 ± 0.0
Asn
5.913AsnAla: 5.913 ± 0.633
0.233AsnCys: 0.233 ± 0.1
2.101AsnAsp: 2.101 ± 0.361
1.712AsnGlu: 1.712 ± 0.302
0.934AsnPhe: 0.934 ± 0.253
4.046AsnGly: 4.046 ± 0.605
0.7AsnHis: 0.7 ± 0.199
1.323AsnIle: 1.323 ± 0.384
1.478AsnLys: 1.478 ± 0.306
2.879AsnLeu: 2.879 ± 0.389
0.934AsnMet: 0.934 ± 0.302
1.401AsnAsn: 1.401 ± 0.302
1.79AsnPro: 1.79 ± 0.435
1.245AsnGln: 1.245 ± 0.25
1.945AsnArg: 1.945 ± 0.451
1.478AsnSer: 1.478 ± 0.303
1.867AsnThr: 1.867 ± 0.28
2.646AsnVal: 2.646 ± 0.463
0.545AsnTrp: 0.545 ± 0.163
1.089AsnTyr: 1.089 ± 0.292
0.0AsnXaa: 0.0 ± 0.0
Pro
5.602ProAla: 5.602 ± 0.615
0.389ProCys: 0.389 ± 0.223
3.657ProAsp: 3.657 ± 0.6
2.723ProGlu: 2.723 ± 0.526
1.245ProPhe: 1.245 ± 0.29
3.424ProGly: 3.424 ± 0.585
1.089ProHis: 1.089 ± 0.251
2.023ProIle: 2.023 ± 0.404
2.101ProLys: 2.101 ± 0.371
2.646ProLeu: 2.646 ± 0.49
0.545ProMet: 0.545 ± 0.21
1.245ProAsn: 1.245 ± 0.332
1.478ProPro: 1.478 ± 0.413
1.323ProGln: 1.323 ± 0.375
2.256ProArg: 2.256 ± 0.407
3.424ProSer: 3.424 ± 0.566
2.101ProThr: 2.101 ± 0.398
3.424ProVal: 3.424 ± 0.488
0.622ProTrp: 0.622 ± 0.202
0.856ProTyr: 0.856 ± 0.225
0.0ProXaa: 0.0 ± 0.0
Gln
3.89GlnAla: 3.89 ± 0.549
0.311GlnCys: 0.311 ± 0.163
1.712GlnAsp: 1.712 ± 0.365
1.712GlnGlu: 1.712 ± 0.304
1.012GlnPhe: 1.012 ± 0.322
2.256GlnGly: 2.256 ± 0.419
0.934GlnHis: 0.934 ± 0.29
1.79GlnIle: 1.79 ± 0.527
2.179GlnLys: 2.179 ± 0.519
3.19GlnLeu: 3.19 ± 0.615
1.478GlnMet: 1.478 ± 0.407
1.556GlnAsn: 1.556 ± 0.383
2.023GlnPro: 2.023 ± 0.326
1.478GlnGln: 1.478 ± 0.458
3.735GlnArg: 3.735 ± 0.5
1.79GlnSer: 1.79 ± 0.466
2.101GlnThr: 2.101 ± 0.405
2.412GlnVal: 2.412 ± 0.349
0.622GlnTrp: 0.622 ± 0.215
1.634GlnTyr: 1.634 ± 0.31
0.0GlnXaa: 0.0 ± 0.0
Arg
8.092ArgAla: 8.092 ± 0.853
0.934ArgCys: 0.934 ± 0.265
3.813ArgAsp: 3.813 ± 0.718
3.89ArgGlu: 3.89 ± 0.529
2.179ArgPhe: 2.179 ± 0.385
5.291ArgGly: 5.291 ± 0.842
1.79ArgHis: 1.79 ± 0.477
3.268ArgIle: 3.268 ± 0.634
3.035ArgLys: 3.035 ± 0.454
5.058ArgLeu: 5.058 ± 0.534
1.712ArgMet: 1.712 ± 0.373
2.179ArgAsn: 2.179 ± 0.433
2.568ArgPro: 2.568 ± 0.466
3.19ArgGln: 3.19 ± 0.369
5.447ArgArg: 5.447 ± 0.922
2.49ArgSer: 2.49 ± 0.522
3.579ArgThr: 3.579 ± 0.527
4.202ArgVal: 4.202 ± 0.855
1.323ArgTrp: 1.323 ± 0.245
1.401ArgTyr: 1.401 ± 0.282
0.0ArgXaa: 0.0 ± 0.0
Ser
7.081SerAla: 7.081 ± 0.719
0.545SerCys: 0.545 ± 0.23
3.424SerAsp: 3.424 ± 0.366
2.334SerGlu: 2.334 ± 0.401
1.634SerPhe: 1.634 ± 0.355
6.536SerGly: 6.536 ± 0.809
0.7SerHis: 0.7 ± 0.265
2.412SerIle: 2.412 ± 0.569
2.49SerLys: 2.49 ± 0.426
3.424SerLeu: 3.424 ± 0.533
1.012SerMet: 1.012 ± 0.31
1.556SerAsn: 1.556 ± 0.336
2.023SerPro: 2.023 ± 0.322
1.79SerGln: 1.79 ± 0.31
4.046SerArg: 4.046 ± 0.708
3.19SerSer: 3.19 ± 0.889
2.879SerThr: 2.879 ± 0.52
4.98SerVal: 4.98 ± 0.701
0.622SerTrp: 0.622 ± 0.212
1.478SerTyr: 1.478 ± 0.342
0.0SerXaa: 0.0 ± 0.0
Thr
7.158ThrAla: 7.158 ± 0.801
0.311ThrCys: 0.311 ± 0.174
3.19ThrAsp: 3.19 ± 0.567
4.124ThrGlu: 4.124 ± 0.495
1.712ThrPhe: 1.712 ± 0.411
5.213ThrGly: 5.213 ± 0.814
0.467ThrHis: 0.467 ± 0.178
2.957ThrIle: 2.957 ± 0.555
2.256ThrLys: 2.256 ± 0.387
4.824ThrLeu: 4.824 ± 0.53
1.245ThrMet: 1.245 ± 0.274
2.256ThrAsn: 2.256 ± 0.381
3.346ThrPro: 3.346 ± 0.567
2.023ThrGln: 2.023 ± 0.486
3.346ThrArg: 3.346 ± 0.608
2.801ThrSer: 2.801 ± 0.412
3.657ThrThr: 3.657 ± 0.588
4.124ThrVal: 4.124 ± 0.579
1.401ThrTrp: 1.401 ± 0.343
2.412ThrTyr: 2.412 ± 0.495
0.0ThrXaa: 0.0 ± 0.0
Val
6.692ValAla: 6.692 ± 0.726
0.545ValCys: 0.545 ± 0.205
4.513ValAsp: 4.513 ± 0.542
3.968ValGlu: 3.968 ± 0.66
1.79ValPhe: 1.79 ± 0.407
3.89ValGly: 3.89 ± 0.786
1.167ValHis: 1.167 ± 0.258
3.19ValIle: 3.19 ± 0.435
3.813ValLys: 3.813 ± 0.703
4.435ValLeu: 4.435 ± 0.611
2.179ValMet: 2.179 ± 0.458
2.879ValAsn: 2.879 ± 0.663
2.879ValPro: 2.879 ± 0.462
2.723ValGln: 2.723 ± 0.447
4.046ValArg: 4.046 ± 0.591
4.591ValSer: 4.591 ± 0.629
4.513ValThr: 4.513 ± 0.732
4.435ValVal: 4.435 ± 0.935
1.167ValTrp: 1.167 ± 0.388
1.401ValTyr: 1.401 ± 0.273
0.0ValXaa: 0.0 ± 0.0
Trp
1.945TrpAla: 1.945 ± 0.379
0.467TrpCys: 0.467 ± 0.18
0.7TrpAsp: 0.7 ± 0.188
1.089TrpGlu: 1.089 ± 0.283
0.467TrpPhe: 0.467 ± 0.2
1.245TrpGly: 1.245 ± 0.267
0.233TrpHis: 0.233 ± 0.137
0.233TrpIle: 0.233 ± 0.122
0.467TrpLys: 0.467 ± 0.19
1.245TrpLeu: 1.245 ± 0.391
0.156TrpMet: 0.156 ± 0.118
0.467TrpAsn: 0.467 ± 0.216
0.934TrpPro: 0.934 ± 0.364
0.7TrpGln: 0.7 ± 0.185
1.478TrpArg: 1.478 ± 0.319
0.622TrpSer: 0.622 ± 0.19
0.7TrpThr: 0.7 ± 0.202
1.012TrpVal: 1.012 ± 0.346
0.156TrpTrp: 0.156 ± 0.123
0.545TrpTyr: 0.545 ± 0.176
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.424TyrAla: 3.424 ± 0.571
0.467TyrCys: 0.467 ± 0.204
1.79TyrAsp: 1.79 ± 0.476
1.634TyrGlu: 1.634 ± 0.344
0.934TyrPhe: 0.934 ± 0.277
1.867TyrGly: 1.867 ± 0.47
0.545TyrHis: 0.545 ± 0.251
1.867TyrIle: 1.867 ± 0.331
1.556TyrLys: 1.556 ± 0.326
1.867TyrLeu: 1.867 ± 0.379
0.467TyrMet: 0.467 ± 0.193
1.245TyrAsn: 1.245 ± 0.293
1.556TyrPro: 1.556 ± 0.41
1.945TyrGln: 1.945 ± 0.322
2.256TyrArg: 2.256 ± 0.483
1.79TyrSer: 1.79 ± 0.391
1.634TyrThr: 1.634 ± 0.257
1.323TyrVal: 1.323 ± 0.321
0.389TyrTrp: 0.389 ± 0.166
0.622TyrTyr: 0.622 ± 0.218
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 54 proteins (12853 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski