Amino acid dipepetide frequency for Paenibacillus tyrfis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.784AlaAla: 9.784 ± 0.115
0.829AlaCys: 0.829 ± 0.021
4.582AlaAsp: 4.582 ± 0.056
6.057AlaGlu: 6.057 ± 0.082
3.565AlaPhe: 3.565 ± 0.044
7.166AlaGly: 7.166 ± 0.072
1.508AlaHis: 1.508 ± 0.027
4.965AlaIle: 4.965 ± 0.048
4.626AlaLys: 4.626 ± 0.051
9.016AlaLeu: 9.016 ± 0.075
2.4AlaMet: 2.4 ± 0.038
2.587AlaAsn: 2.587 ± 0.04
3.057AlaPro: 3.057 ± 0.043
2.947AlaGln: 2.947 ± 0.048
4.02AlaArg: 4.02 ± 0.042
5.314AlaSer: 5.314 ± 0.06
3.562AlaThr: 3.562 ± 0.053
7.13AlaVal: 7.13 ± 0.077
1.052AlaTrp: 1.052 ± 0.023
2.981AlaTyr: 2.981 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.603CysAla: 0.603 ± 0.018
0.119CysCys: 0.119 ± 0.01
0.41CysAsp: 0.41 ± 0.017
0.469CysGlu: 0.469 ± 0.015
0.355CysPhe: 0.355 ± 0.013
0.825CysGly: 0.825 ± 0.023
0.208CysHis: 0.208 ± 0.011
0.529CysIle: 0.529 ± 0.017
0.339CysLys: 0.339 ± 0.013
0.807CysLeu: 0.807 ± 0.019
0.215CysMet: 0.215 ± 0.011
0.252CysAsn: 0.252 ± 0.01
0.377CysPro: 0.377 ± 0.015
0.238CysGln: 0.238 ± 0.011
0.514CysArg: 0.514 ± 0.017
0.576CysSer: 0.576 ± 0.017
0.415CysThr: 0.415 ± 0.015
0.496CysVal: 0.496 ± 0.016
0.111CysTrp: 0.111 ± 0.008
0.286CysTyr: 0.286 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
4.074AspAla: 4.074 ± 0.049
0.401AspCys: 0.401 ± 0.017
2.365AspAsp: 2.365 ± 0.042
3.714AspGlu: 3.714 ± 0.046
2.116AspPhe: 2.116 ± 0.035
3.942AspGly: 3.942 ± 0.047
1.044AspHis: 1.044 ± 0.025
3.275AspIle: 3.275 ± 0.041
2.752AspLys: 2.752 ± 0.046
4.718AspLeu: 4.718 ± 0.049
1.304AspMet: 1.304 ± 0.026
1.638AspAsn: 1.638 ± 0.03
2.468AspPro: 2.468 ± 0.041
1.717AspGln: 1.717 ± 0.031
3.173AspArg: 3.173 ± 0.043
2.64AspSer: 2.64 ± 0.038
2.427AspThr: 2.427 ± 0.033
3.524AspVal: 3.524 ± 0.04
0.804AspTrp: 0.804 ± 0.021
1.991AspTyr: 1.991 ± 0.03
0.0AspXaa: 0.0 ± 0.0
Glu
6.769GluAla: 6.769 ± 0.082
0.423GluCys: 0.423 ± 0.015
2.927GluAsp: 2.927 ± 0.043
5.144GluGlu: 5.144 ± 0.065
2.102GluPhe: 2.102 ± 0.035
4.278GluGly: 4.278 ± 0.048
1.559GluHis: 1.559 ± 0.03
4.016GluIle: 4.016 ± 0.048
3.938GluLys: 3.938 ± 0.051
7.609GluLeu: 7.609 ± 0.088
1.853GluMet: 1.853 ± 0.031
2.184GluAsn: 2.184 ± 0.036
2.53GluPro: 2.53 ± 0.04
3.718GluGln: 3.718 ± 0.058
4.591GluArg: 4.591 ± 0.061
3.354GluSer: 3.354 ± 0.044
3.541GluThr: 3.541 ± 0.037
4.223GluVal: 4.223 ± 0.044
0.946GluTrp: 0.946 ± 0.026
1.94GluTyr: 1.94 ± 0.032
0.0GluXaa: 0.0 ± 0.0
Phe
3.476PheAla: 3.476 ± 0.046
0.384PheCys: 0.384 ± 0.015
2.298PheAsp: 2.298 ± 0.036
2.565PheGlu: 2.565 ± 0.039
1.821PhePhe: 1.821 ± 0.038
3.313PheGly: 3.313 ± 0.042
0.953PheHis: 0.953 ± 0.022
2.59PheIle: 2.59 ± 0.042
1.868PheLys: 1.868 ± 0.026
3.946PheLeu: 3.946 ± 0.056
1.117PheMet: 1.117 ± 0.022
1.41PheAsn: 1.41 ± 0.031
1.694PhePro: 1.694 ± 0.028
1.471PheGln: 1.471 ± 0.024
2.169PheArg: 2.169 ± 0.037
2.683PheSer: 2.683 ± 0.04
2.366PheThr: 2.366 ± 0.037
3.235PheVal: 3.235 ± 0.039
0.529PheTrp: 0.529 ± 0.016
1.501PheTyr: 1.501 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
5.926GlyAla: 5.926 ± 0.067
0.799GlyCys: 0.799 ± 0.02
3.387GlyAsp: 3.387 ± 0.042
4.625GlyGlu: 4.625 ± 0.06
3.19GlyPhe: 3.19 ± 0.037
5.672GlyGly: 5.672 ± 0.079
1.537GlyHis: 1.537 ± 0.03
5.358GlyIle: 5.358 ± 0.065
4.651GlyLys: 4.651 ± 0.057
7.59GlyLeu: 7.59 ± 0.081
2.345GlyMet: 2.345 ± 0.037
2.473GlyAsn: 2.473 ± 0.039
2.149GlyPro: 2.149 ± 0.035
2.86GlyGln: 2.86 ± 0.044
3.818GlyArg: 3.818 ± 0.051
4.684GlySer: 4.684 ± 0.053
4.614GlyThr: 4.614 ± 0.065
5.276GlyVal: 5.276 ± 0.054
1.093GlyTrp: 1.093 ± 0.024
2.864GlyTyr: 2.864 ± 0.039
0.0GlyXaa: 0.0 ± 0.0
His
1.677HisAla: 1.677 ± 0.031
0.206HisCys: 0.206 ± 0.01
0.999HisAsp: 0.999 ± 0.025
1.338HisGlu: 1.338 ± 0.027
0.998HisPhe: 0.998 ± 0.025
1.55HisGly: 1.55 ± 0.03
0.627HisHis: 0.627 ± 0.024
1.316HisIle: 1.316 ± 0.023
0.883HisLys: 0.883 ± 0.023
2.218HisLeu: 2.218 ± 0.036
0.572HisMet: 0.572 ± 0.016
0.619HisAsn: 0.619 ± 0.019
1.274HisPro: 1.274 ± 0.026
0.784HisGln: 0.784 ± 0.02
1.244HisArg: 1.244 ± 0.026
1.132HisSer: 1.132 ± 0.025
1.085HisThr: 1.085 ± 0.025
1.42HisVal: 1.42 ± 0.029
0.322HisTrp: 0.322 ± 0.012
0.85HisTyr: 0.85 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
5.841IleAla: 5.841 ± 0.057
0.566IleCys: 0.566 ± 0.017
3.567IleAsp: 3.567 ± 0.049
4.111IleGlu: 4.111 ± 0.049
2.16IlePhe: 2.16 ± 0.035
5.364IleGly: 5.364 ± 0.053
1.347IleHis: 1.347 ± 0.027
3.382IleIle: 3.382 ± 0.055
2.743IleLys: 2.743 ± 0.04
5.355IleLeu: 5.355 ± 0.068
1.427IleMet: 1.427 ± 0.031
2.018IleAsn: 2.018 ± 0.034
2.959IlePro: 2.959 ± 0.039
2.239IleGln: 2.239 ± 0.031
4.015IleArg: 4.015 ± 0.047
3.85IleSer: 3.85 ± 0.047
3.278IleThr: 3.278 ± 0.045
5.283IleVal: 5.283 ± 0.054
0.635IleTrp: 0.635 ± 0.019
1.882IleTyr: 1.882 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
4.582LysAla: 4.582 ± 0.057
0.254LysCys: 0.254 ± 0.01
2.828LysAsp: 2.828 ± 0.045
4.24LysGlu: 4.24 ± 0.051
1.591LysPhe: 1.591 ± 0.028
3.484LysGly: 3.484 ± 0.05
1.179LysHis: 1.179 ± 0.025
3.073LysIle: 3.073 ± 0.045
3.421LysLys: 3.421 ± 0.057
5.61LysLeu: 5.61 ± 0.055
1.522LysMet: 1.522 ± 0.031
1.968LysAsn: 1.968 ± 0.037
2.54LysPro: 2.54 ± 0.037
2.623LysGln: 2.623 ± 0.039
3.07LysArg: 3.07 ± 0.041
2.842LysSer: 2.842 ± 0.04
2.942LysThr: 2.942 ± 0.043
3.542LysVal: 3.542 ± 0.052
0.648LysTrp: 0.648 ± 0.017
1.726LysTyr: 1.726 ± 0.031
0.0LysXaa: 0.0 ± 0.0
Leu
9.049LeuAla: 9.049 ± 0.093
0.914LeuCys: 0.914 ± 0.025
5.116LeuAsp: 5.116 ± 0.053
6.453LeuGlu: 6.453 ± 0.063
4.658LeuPhe: 4.658 ± 0.061
7.189LeuGly: 7.189 ± 0.083
2.244LeuHis: 2.244 ± 0.036
6.128LeuIle: 6.128 ± 0.069
5.392LeuLys: 5.392 ± 0.059
11.734LeuLeu: 11.734 ± 0.105
2.609LeuMet: 2.609 ± 0.035
3.639LeuAsn: 3.639 ± 0.048
4.723LeuPro: 4.723 ± 0.049
4.27LeuGln: 4.27 ± 0.047
5.541LeuArg: 5.541 ± 0.061
6.947LeuSer: 6.947 ± 0.062
5.938LeuThr: 5.938 ± 0.056
6.522LeuVal: 6.522 ± 0.063
1.094LeuTrp: 1.094 ± 0.023
3.196LeuTyr: 3.196 ± 0.044
0.0LeuXaa: 0.0 ± 0.0
Met
2.275MetAla: 2.275 ± 0.04
0.154MetCys: 0.154 ± 0.009
1.368MetAsp: 1.368 ± 0.025
1.911MetGlu: 1.911 ± 0.03
1.027MetPhe: 1.027 ± 0.021
1.653MetGly: 1.653 ± 0.029
0.474MetHis: 0.474 ± 0.016
1.859MetIle: 1.859 ± 0.035
1.956MetLys: 1.956 ± 0.033
2.932MetLeu: 2.932 ± 0.038
0.827MetMet: 0.827 ± 0.024
1.409MetAsn: 1.409 ± 0.025
1.148MetPro: 1.148 ± 0.029
1.021MetGln: 1.021 ± 0.02
1.399MetArg: 1.399 ± 0.028
1.675MetSer: 1.675 ± 0.028
1.689MetThr: 1.689 ± 0.029
1.672MetVal: 1.672 ± 0.031
0.221MetTrp: 0.221 ± 0.01
0.754MetTyr: 0.754 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.706AsnAla: 2.706 ± 0.038
0.249AsnCys: 0.249 ± 0.012
1.728AsnAsp: 1.728 ± 0.035
2.278AsnGlu: 2.278 ± 0.039
1.261AsnPhe: 1.261 ± 0.026
3.052AsnGly: 3.052 ± 0.056
0.757AsnHis: 0.757 ± 0.024
2.091AsnIle: 2.091 ± 0.038
1.879AsnLys: 1.879 ± 0.039
3.114AsnLeu: 3.114 ± 0.042
0.92AsnMet: 0.92 ± 0.021
1.324AsnAsn: 1.324 ± 0.034
2.013AsnPro: 2.013 ± 0.037
1.359AsnGln: 1.359 ± 0.028
2.112AsnArg: 2.112 ± 0.035
1.719AsnSer: 1.719 ± 0.032
1.712AsnThr: 1.712 ± 0.03
2.502AsnVal: 2.502 ± 0.038
0.449AsnTrp: 0.449 ± 0.014
1.279AsnTyr: 1.279 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
3.782ProAla: 3.782 ± 0.056
0.26ProCys: 0.26 ± 0.012
2.731ProAsp: 2.731 ± 0.043
3.626ProGlu: 3.626 ± 0.048
1.949ProPhe: 1.949 ± 0.03
3.186ProGly: 3.186 ± 0.046
0.961ProHis: 0.961 ± 0.023
2.358ProIle: 2.358 ± 0.037
2.004ProLys: 2.004 ± 0.032
4.261ProLeu: 4.261 ± 0.053
1.068ProMet: 1.068 ± 0.023
1.57ProAsn: 1.57 ± 0.029
1.456ProPro: 1.456 ± 0.028
1.606ProGln: 1.606 ± 0.032
1.594ProArg: 1.594 ± 0.029
2.57ProSer: 2.57 ± 0.042
1.973ProThr: 1.973 ± 0.036
3.516ProVal: 3.516 ± 0.041
0.541ProTrp: 0.541 ± 0.016
1.604ProTyr: 1.604 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
3.852GlnAla: 3.852 ± 0.055
0.219GlnCys: 0.219 ± 0.011
1.688GlnAsp: 1.688 ± 0.028
2.712GlnGlu: 2.712 ± 0.043
1.522GlnPhe: 1.522 ± 0.027
2.686GlnGly: 2.686 ± 0.039
0.769GlnHis: 0.769 ± 0.021
2.328GlnIle: 2.328 ± 0.037
2.045GlnLys: 2.045 ± 0.03
4.311GlnLeu: 4.311 ± 0.049
1.08GlnMet: 1.08 ± 0.025
1.218GlnAsn: 1.218 ± 0.024
1.707GlnPro: 1.707 ± 0.032
1.917GlnGln: 1.917 ± 0.037
1.995GlnArg: 1.995 ± 0.036
2.129GlnSer: 2.129 ± 0.033
2.134GlnThr: 2.134 ± 0.033
2.682GlnVal: 2.682 ± 0.038
0.571GlnTrp: 0.571 ± 0.017
1.263GlnTyr: 1.263 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
3.728ArgAla: 3.728 ± 0.043
0.436ArgCys: 0.436 ± 0.015
2.494ArgAsp: 2.494 ± 0.04
4.062ArgGlu: 4.062 ± 0.059
2.511ArgPhe: 2.511 ± 0.037
3.226ArgGly: 3.226 ± 0.043
1.263ArgHis: 1.263 ± 0.024
3.875ArgIle: 3.875 ± 0.049
3.212ArgLys: 3.212 ± 0.04
6.143ArgLeu: 6.143 ± 0.069
1.816ArgMet: 1.816 ± 0.03
1.877ArgAsn: 1.877 ± 0.028
2.029ArgPro: 2.029 ± 0.034
2.331ArgGln: 2.331 ± 0.035
3.109ArgArg: 3.109 ± 0.047
3.351ArgSer: 3.351 ± 0.042
2.993ArgThr: 2.993 ± 0.042
3.401ArgVal: 3.401 ± 0.041
0.813ArgTrp: 0.813 ± 0.021
2.025ArgTyr: 2.025 ± 0.031
0.0ArgXaa: 0.0 ± 0.0
Ser
4.824SerAla: 4.824 ± 0.056
0.442SerCys: 0.442 ± 0.016
2.876SerAsp: 2.876 ± 0.042
3.6SerGlu: 3.6 ± 0.044
3.002SerPhe: 3.002 ± 0.035
5.44SerGly: 5.44 ± 0.059
1.157SerHis: 1.157 ± 0.024
3.797SerIle: 3.797 ± 0.048
3.052SerLys: 3.052 ± 0.047
6.297SerLeu: 6.297 ± 0.063
1.741SerMet: 1.741 ± 0.024
1.928SerAsn: 1.928 ± 0.035
2.515SerPro: 2.515 ± 0.038
1.902SerGln: 1.902 ± 0.028
3.136SerArg: 3.136 ± 0.039
3.765SerSer: 3.765 ± 0.05
2.907SerThr: 2.907 ± 0.037
4.572SerVal: 4.572 ± 0.05
0.765SerTrp: 0.765 ± 0.021
2.149SerTyr: 2.149 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
4.942ThrAla: 4.942 ± 0.055
0.35ThrCys: 0.35 ± 0.014
2.761ThrAsp: 2.761 ± 0.038
3.27ThrGlu: 3.27 ± 0.043
2.355ThrPhe: 2.355 ± 0.039
4.611ThrGly: 4.611 ± 0.054
0.964ThrHis: 0.964 ± 0.021
3.585ThrIle: 3.585 ± 0.062
2.487ThrLys: 2.487 ± 0.034
5.39ThrLeu: 5.39 ± 0.057
1.374ThrMet: 1.374 ± 0.029
1.843ThrAsn: 1.843 ± 0.033
2.596ThrPro: 2.596 ± 0.033
1.531ThrGln: 1.531 ± 0.028
2.239ThrArg: 2.239 ± 0.034
3.002ThrSer: 3.002 ± 0.039
2.701ThrThr: 2.701 ± 0.048
4.674ThrVal: 4.674 ± 0.052
0.641ThrTrp: 0.641 ± 0.019
1.881ThrTyr: 1.881 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
5.554ValAla: 5.554 ± 0.053
0.699ValCys: 0.699 ± 0.018
3.443ValAsp: 3.443 ± 0.041
4.425ValGlu: 4.425 ± 0.054
2.975ValPhe: 2.975 ± 0.046
4.728ValGly: 4.728 ± 0.048
1.53ValHis: 1.53 ± 0.027
4.659ValIle: 4.659 ± 0.051
3.999ValLys: 3.999 ± 0.05
7.559ValLeu: 7.559 ± 0.073
1.947ValMet: 1.947 ± 0.031
2.637ValAsn: 2.637 ± 0.042
3.406ValPro: 3.406 ± 0.04
2.734ValGln: 2.734 ± 0.034
4.065ValArg: 4.065 ± 0.046
4.819ValSer: 4.819 ± 0.051
4.455ValThr: 4.455 ± 0.053
5.311ValVal: 5.311 ± 0.072
0.893ValTrp: 0.893 ± 0.021
2.409ValTyr: 2.409 ± 0.032
0.0ValXaa: 0.0 ± 0.0
Trp
0.858TrpAla: 0.858 ± 0.021
0.107TrpCys: 0.107 ± 0.008
0.644TrpAsp: 0.644 ± 0.018
0.748TrpGlu: 0.748 ± 0.022
0.61TrpPhe: 0.61 ± 0.017
0.841TrpGly: 0.841 ± 0.021
0.264TrpHis: 0.264 ± 0.012
0.893TrpIle: 0.893 ± 0.025
0.787TrpLys: 0.787 ± 0.021
1.529TrpLeu: 1.529 ± 0.029
0.409TrpMet: 0.409 ± 0.015
0.675TrpAsn: 0.675 ± 0.02
0.38TrpPro: 0.38 ± 0.013
0.496TrpGln: 0.496 ± 0.014
0.639TrpArg: 0.639 ± 0.018
0.815TrpSer: 0.815 ± 0.021
0.663TrpThr: 0.663 ± 0.018
0.849TrpVal: 0.849 ± 0.023
0.157TrpTrp: 0.157 ± 0.009
0.421TrpTyr: 0.421 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.847TyrAla: 2.847 ± 0.037
0.329TyrCys: 0.329 ± 0.013
1.876TyrAsp: 1.876 ± 0.036
2.296TyrGlu: 2.296 ± 0.034
1.622TyrPhe: 1.622 ± 0.026
2.705TyrGly: 2.705 ± 0.04
0.767TyrHis: 0.767 ± 0.022
1.945TyrIle: 1.945 ± 0.032
1.65TyrLys: 1.65 ± 0.027
3.218TyrLeu: 3.218 ± 0.039
0.88TyrMet: 0.88 ± 0.023
1.237TyrAsn: 1.237 ± 0.024
1.593TyrPro: 1.593 ± 0.033
1.064TyrGln: 1.064 ± 0.02
2.252TyrArg: 2.252 ± 0.039
2.0TyrSer: 2.0 ± 0.033
1.801TyrThr: 1.801 ± 0.038
2.418TyrVal: 2.418 ± 0.04
0.5TyrTrp: 0.5 ± 0.015
1.332TyrTyr: 1.332 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6455 proteins (2041611 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski