Amino acid dipepetide frequency for Walkabout Creek virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.512AlaAla: 3.512 ± 2.759
1.08AlaCys: 1.08 ± 0.728
3.782AlaAsp: 3.782 ± 1.079
2.161AlaGlu: 2.161 ± 1.007
2.431AlaPhe: 2.431 ± 1.156
2.161AlaGly: 2.161 ± 0.731
0.54AlaHis: 0.54 ± 0.307
2.431AlaIle: 2.431 ± 0.977
4.862AlaLys: 4.862 ± 1.258
4.862AlaLeu: 4.862 ± 0.981
0.81AlaMet: 0.81 ± 0.722
2.701AlaAsn: 2.701 ± 0.939
0.54AlaPro: 0.54 ± 0.466
1.08AlaGln: 1.08 ± 0.613
2.701AlaArg: 2.701 ± 0.964
2.161AlaSer: 2.161 ± 0.337
2.161AlaThr: 2.161 ± 0.67
1.351AlaVal: 1.351 ± 0.56
0.0AlaTrp: 0.0 ± 0.0
1.08AlaTyr: 1.08 ± 0.414
0.0AlaXaa: 0.0 ± 0.0
Cys
0.54CysAla: 0.54 ± 0.307
0.27CysCys: 0.27 ± 0.153
1.351CysAsp: 1.351 ± 0.838
2.161CysGlu: 2.161 ± 1.051
0.81CysPhe: 0.81 ± 0.361
2.431CysGly: 2.431 ± 1.083
0.27CysHis: 0.27 ± 0.609
1.08CysIle: 1.08 ± 0.433
1.891CysLys: 1.891 ± 0.856
1.891CysLeu: 1.891 ± 0.832
0.54CysMet: 0.54 ± 0.508
0.54CysAsn: 0.54 ± 0.307
1.351CysPro: 1.351 ± 1.024
0.81CysGln: 0.81 ± 0.529
1.08CysArg: 1.08 ± 0.694
1.351CysSer: 1.351 ± 0.322
1.08CysThr: 1.08 ± 0.414
0.81CysVal: 0.81 ± 0.399
0.27CysTrp: 0.27 ± 0.153
0.54CysTyr: 0.54 ± 0.271
0.0CysXaa: 0.0 ± 0.0
Asp
1.891AspAla: 1.891 ± 1.071
2.161AspCys: 2.161 ± 0.695
3.512AspAsp: 3.512 ± 1.314
4.052AspGlu: 4.052 ± 1.149
2.971AspPhe: 2.971 ± 0.73
3.241AspGly: 3.241 ± 1.361
0.81AspHis: 0.81 ± 0.271
2.701AspIle: 2.701 ± 0.738
3.512AspLys: 3.512 ± 0.984
7.293AspLeu: 7.293 ± 0.883
2.161AspMet: 2.161 ± 0.658
3.241AspAsn: 3.241 ± 0.939
2.971AspPro: 2.971 ± 1.29
2.161AspGln: 2.161 ± 0.405
2.701AspArg: 2.701 ± 0.756
4.322AspSer: 4.322 ± 0.823
1.891AspThr: 1.891 ± 0.512
2.971AspVal: 2.971 ± 0.716
1.08AspTrp: 1.08 ± 0.846
4.322AspTyr: 4.322 ± 0.545
0.0AspXaa: 0.0 ± 0.0
Glu
2.971GluAla: 2.971 ± 0.865
1.08GluCys: 1.08 ± 0.461
4.322GluAsp: 4.322 ± 0.865
4.052GluGlu: 4.052 ± 1.32
4.862GluPhe: 4.862 ± 1.498
4.322GluGly: 4.322 ± 1.09
1.08GluHis: 1.08 ± 0.373
5.943GluIle: 5.943 ± 2.218
6.753GluLys: 6.753 ± 0.824
5.132GluLeu: 5.132 ± 1.68
1.351GluMet: 1.351 ± 0.6
5.673GluAsn: 5.673 ± 1.187
0.81GluPro: 0.81 ± 0.529
1.621GluGln: 1.621 ± 0.557
4.052GluArg: 4.052 ± 1.091
5.943GluSer: 5.943 ± 1.563
2.701GluThr: 2.701 ± 0.814
1.891GluVal: 1.891 ± 0.715
1.621GluTrp: 1.621 ± 0.382
2.431GluTyr: 2.431 ± 0.75
0.0GluXaa: 0.0 ± 0.0
Phe
1.351PheAla: 1.351 ± 0.463
1.08PheCys: 1.08 ± 0.879
3.782PheAsp: 3.782 ± 1.502
4.592PheGlu: 4.592 ± 2.048
2.701PhePhe: 2.701 ± 0.67
2.701PheGly: 2.701 ± 1.107
0.27PheHis: 0.27 ± 0.395
3.512PheIle: 3.512 ± 0.79
4.322PheLys: 4.322 ± 0.794
3.782PheLeu: 3.782 ± 0.862
1.351PheMet: 1.351 ± 0.584
1.351PheAsn: 1.351 ± 0.463
1.891PhePro: 1.891 ± 0.456
1.351PheGln: 1.351 ± 0.52
1.891PheArg: 1.891 ± 0.311
4.322PheSer: 4.322 ± 1.158
1.891PheThr: 1.891 ± 1.074
3.241PheVal: 3.241 ± 0.568
0.54PheTrp: 0.54 ± 0.307
0.27PheTyr: 0.27 ± 0.153
0.0PheXaa: 0.0 ± 0.0
Gly
3.241GlyAla: 3.241 ± 1.423
0.27GlyCys: 0.27 ± 0.153
4.322GlyAsp: 4.322 ± 1.33
2.431GlyGlu: 2.431 ± 1.348
2.971GlyPhe: 2.971 ± 1.629
2.701GlyGly: 2.701 ± 0.974
0.54GlyHis: 0.54 ± 0.307
4.592GlyIle: 4.592 ± 1.711
3.782GlyLys: 3.782 ± 1.447
7.023GlyLeu: 7.023 ± 1.246
1.08GlyMet: 1.08 ± 0.433
2.431GlyAsn: 2.431 ± 0.581
1.891GlyPro: 1.891 ± 0.491
3.241GlyGln: 3.241 ± 1.033
1.351GlyArg: 1.351 ± 0.82
3.512GlySer: 3.512 ± 0.794
2.161GlyThr: 2.161 ± 0.952
4.052GlyVal: 4.052 ± 1.017
1.08GlyTrp: 1.08 ± 0.621
1.891GlyTyr: 1.891 ± 0.598
0.0GlyXaa: 0.0 ± 0.0
His
0.54HisAla: 0.54 ± 0.266
0.81HisCys: 0.81 ± 0.727
0.27HisAsp: 0.27 ± 0.347
1.351HisGlu: 1.351 ± 0.355
1.621HisPhe: 1.621 ± 0.553
1.621HisGly: 1.621 ± 1.198
0.0HisHis: 0.0 ± 0.0
1.351HisIle: 1.351 ± 0.558
1.351HisLys: 1.351 ± 0.767
1.351HisLeu: 1.351 ± 0.787
1.351HisMet: 1.351 ± 0.541
0.81HisAsn: 0.81 ± 0.846
1.351HisPro: 1.351 ± 0.869
1.08HisGln: 1.08 ± 0.461
1.351HisArg: 1.351 ± 0.869
1.351HisSer: 1.351 ± 0.355
0.54HisThr: 0.54 ± 0.695
0.0HisVal: 0.0 ± 0.0
0.27HisTrp: 0.27 ± 0.592
0.81HisTyr: 0.81 ± 0.46
0.0HisXaa: 0.0 ± 0.0
Ile
2.701IleAla: 2.701 ± 0.898
1.891IleCys: 1.891 ± 0.466
4.052IleAsp: 4.052 ± 0.94
7.293IleGlu: 7.293 ± 0.586
2.161IlePhe: 2.161 ± 0.466
5.132IleGly: 5.132 ± 1.447
2.431IleHis: 2.431 ± 0.633
6.753IleIle: 6.753 ± 1.961
9.184IleLys: 9.184 ± 2.533
6.753IleLeu: 6.753 ± 1.665
1.08IleMet: 1.08 ± 0.538
5.673IleAsn: 5.673 ± 0.833
3.782IlePro: 3.782 ± 1.869
1.621IleGln: 1.621 ± 0.547
5.132IleArg: 5.132 ± 0.785
5.943IleSer: 5.943 ± 1.784
5.402IleThr: 5.402 ± 1.79
3.241IleVal: 3.241 ± 1.589
0.0IleTrp: 0.0 ± 0.0
2.161IleTyr: 2.161 ± 0.592
0.0IleXaa: 0.0 ± 0.0
Lys
4.322LysAla: 4.322 ± 0.702
2.161LysCys: 2.161 ± 0.888
5.943LysAsp: 5.943 ± 0.71
5.402LysGlu: 5.402 ± 0.983
3.241LysPhe: 3.241 ± 0.6
5.132LysGly: 5.132 ± 0.944
1.351LysHis: 1.351 ± 0.606
9.724LysIle: 9.724 ± 1.913
5.943LysLys: 5.943 ± 1.387
6.483LysLeu: 6.483 ± 0.817
1.621LysMet: 1.621 ± 1.423
4.052LysAsn: 4.052 ± 0.989
1.891LysPro: 1.891 ± 0.26
2.161LysGln: 2.161 ± 1.19
3.782LysArg: 3.782 ± 0.773
6.213LysSer: 6.213 ± 1.391
5.673LysThr: 5.673 ± 1.404
3.782LysVal: 3.782 ± 0.862
1.621LysTrp: 1.621 ± 0.406
2.431LysTyr: 2.431 ± 0.499
0.0LysXaa: 0.0 ± 0.0
Leu
6.213LeuAla: 6.213 ± 0.632
0.81LeuCys: 0.81 ± 0.271
5.402LeuAsp: 5.402 ± 1.566
7.023LeuGlu: 7.023 ± 1.259
3.512LeuPhe: 3.512 ± 0.736
5.402LeuGly: 5.402 ± 1.201
1.351LeuHis: 1.351 ± 0.672
9.995LeuIle: 9.995 ± 1.091
7.834LeuLys: 7.834 ± 1.258
10.265LeuLeu: 10.265 ± 1.157
1.351LeuMet: 1.351 ± 0.613
6.753LeuAsn: 6.753 ± 1.562
2.971LeuPro: 2.971 ± 0.82
1.891LeuGln: 1.891 ± 0.959
7.023LeuArg: 7.023 ± 2.368
9.184LeuSer: 9.184 ± 1.372
5.402LeuThr: 5.402 ± 3.068
2.161LeuVal: 2.161 ± 0.898
0.81LeuTrp: 0.81 ± 0.312
2.431LeuTyr: 2.431 ± 0.663
0.0LeuXaa: 0.0 ± 0.0
Met
0.81MetAla: 0.81 ± 0.312
0.0MetCys: 0.0 ± 0.0
1.891MetAsp: 1.891 ± 0.26
1.351MetGlu: 1.351 ± 0.898
1.891MetPhe: 1.891 ± 0.528
1.08MetGly: 1.08 ± 0.523
0.0MetHis: 0.0 ± 0.0
3.512MetIle: 3.512 ± 1.214
1.891MetLys: 1.891 ± 0.655
1.351MetLeu: 1.351 ± 0.999
0.54MetMet: 0.54 ± 0.296
1.621MetAsn: 1.621 ± 1.118
0.54MetPro: 0.54 ± 0.356
1.08MetGln: 1.08 ± 0.712
1.891MetArg: 1.891 ± 0.456
1.891MetSer: 1.891 ± 0.946
1.351MetThr: 1.351 ± 0.463
1.351MetVal: 1.351 ± 0.767
0.27MetTrp: 0.27 ± 0.153
0.54MetTyr: 0.54 ± 0.652
0.0MetXaa: 0.0 ± 0.0
Asn
2.431AsnAla: 2.431 ± 0.937
1.621AsnCys: 1.621 ± 0.703
3.241AsnAsp: 3.241 ± 0.658
1.351AsnGlu: 1.351 ± 0.54
3.512AsnPhe: 3.512 ± 0.736
2.161AsnGly: 2.161 ± 1.32
2.701AsnHis: 2.701 ± 1.618
3.512AsnIle: 3.512 ± 1.63
3.512AsnLys: 3.512 ± 1.033
8.104AsnLeu: 8.104 ± 1.549
0.81AsnMet: 0.81 ± 0.312
2.161AsnAsn: 2.161 ± 1.18
2.971AsnPro: 2.971 ± 1.317
2.701AsnGln: 2.701 ± 0.428
2.431AsnArg: 2.431 ± 1.117
4.322AsnSer: 4.322 ± 1.261
2.161AsnThr: 2.161 ± 0.942
1.891AsnVal: 1.891 ± 0.737
1.891AsnTrp: 1.891 ± 1.119
2.431AsnTyr: 2.431 ± 0.68
0.0AsnXaa: 0.0 ± 0.0
Pro
0.81ProAla: 0.81 ± 0.652
1.08ProCys: 1.08 ± 0.433
2.161ProAsp: 2.161 ± 0.637
2.701ProGlu: 2.701 ± 1.457
1.351ProPhe: 1.351 ± 0.343
0.54ProGly: 0.54 ± 0.266
0.54ProHis: 0.54 ± 0.307
2.161ProIle: 2.161 ± 0.882
2.701ProLys: 2.701 ± 0.77
2.701ProLeu: 2.701 ± 0.638
0.81ProMet: 0.81 ± 0.46
1.891ProAsn: 1.891 ± 0.577
1.621ProPro: 1.621 ± 0.486
1.351ProGln: 1.351 ± 0.672
1.08ProArg: 1.08 ± 0.414
4.592ProSer: 4.592 ± 0.711
1.621ProThr: 1.621 ± 0.651
1.351ProVal: 1.351 ± 0.52
0.81ProTrp: 0.81 ± 0.382
3.512ProTyr: 3.512 ± 0.888
0.0ProXaa: 0.0 ± 0.0
Gln
1.891GlnAla: 1.891 ± 0.531
0.27GlnCys: 0.27 ± 0.609
0.27GlnAsp: 0.27 ± 0.302
2.971GlnGlu: 2.971 ± 0.977
1.891GlnPhe: 1.891 ± 0.604
2.161GlnGly: 2.161 ± 0.701
1.08GlnHis: 1.08 ± 0.687
1.891GlnIle: 1.891 ± 0.573
3.241GlnLys: 3.241 ± 1.447
2.161GlnLeu: 2.161 ± 1.035
1.891GlnMet: 1.891 ± 0.938
0.81GlnAsn: 0.81 ± 0.549
0.27GlnPro: 0.27 ± 0.393
0.81GlnGln: 0.81 ± 0.361
1.621GlnArg: 1.621 ± 0.532
3.782GlnSer: 3.782 ± 1.268
2.161GlnThr: 2.161 ± 0.623
1.351GlnVal: 1.351 ± 0.493
1.08GlnTrp: 1.08 ± 0.347
1.08GlnTyr: 1.08 ± 0.373
0.0GlnXaa: 0.0 ± 0.0
Arg
1.891ArgAla: 1.891 ± 0.466
1.08ArgCys: 1.08 ± 0.433
3.241ArgAsp: 3.241 ± 0.869
4.592ArgGlu: 4.592 ± 1.287
1.351ArgPhe: 1.351 ± 0.886
3.241ArgGly: 3.241 ± 0.966
0.27ArgHis: 0.27 ± 0.153
3.241ArgIle: 3.241 ± 0.987
4.322ArgLys: 4.322 ± 0.987
4.052ArgLeu: 4.052 ± 1.017
0.81ArgMet: 0.81 ± 0.312
3.241ArgAsn: 3.241 ± 0.943
0.54ArgPro: 0.54 ± 0.307
2.431ArgGln: 2.431 ± 0.71
2.431ArgArg: 2.431 ± 0.551
3.782ArgSer: 3.782 ± 1.023
2.701ArgThr: 2.701 ± 1.315
3.782ArgVal: 3.782 ± 0.721
2.161ArgTrp: 2.161 ± 1.472
1.891ArgTyr: 1.891 ± 0.418
0.0ArgXaa: 0.0 ± 0.0
Ser
2.161SerAla: 2.161 ± 0.732
2.971SerCys: 2.971 ± 0.543
6.213SerAsp: 6.213 ± 0.919
5.673SerGlu: 5.673 ± 1.312
3.241SerPhe: 3.241 ± 0.59
3.241SerGly: 3.241 ± 0.586
2.971SerHis: 2.971 ± 0.589
7.293SerIle: 7.293 ± 1.208
7.563SerLys: 7.563 ± 0.515
7.293SerLeu: 7.293 ± 1.531
1.08SerMet: 1.08 ± 0.712
4.862SerAsn: 4.862 ± 1.733
3.241SerPro: 3.241 ± 0.841
2.701SerGln: 2.701 ± 1.47
3.782SerArg: 3.782 ± 0.76
6.753SerSer: 6.753 ± 1.565
4.052SerThr: 4.052 ± 1.0
1.891SerVal: 1.891 ± 0.825
2.161SerTrp: 2.161 ± 0.491
1.891SerTyr: 1.891 ± 0.852
0.0SerXaa: 0.0 ± 0.0
Thr
1.08ThrAla: 1.08 ± 0.663
0.0ThrCys: 0.0 ± 0.0
0.81ThrAsp: 0.81 ± 0.399
3.782ThrGlu: 3.782 ± 1.83
1.891ThrPhe: 1.891 ± 1.354
2.431ThrGly: 2.431 ± 0.672
0.81ThrHis: 0.81 ± 0.46
5.132ThrIle: 5.132 ± 1.083
2.971ThrLys: 2.971 ± 0.852
6.213ThrLeu: 6.213 ± 1.244
2.431ThrMet: 2.431 ± 0.373
1.621ThrAsn: 1.621 ± 0.406
1.891ThrPro: 1.891 ± 1.102
2.701ThrGln: 2.701 ± 1.204
2.701ThrArg: 2.701 ± 1.038
4.592ThrSer: 4.592 ± 1.377
1.351ThrThr: 1.351 ± 0.54
2.431ThrVal: 2.431 ± 0.571
1.621ThrTrp: 1.621 ± 0.791
1.08ThrTyr: 1.08 ± 0.334
0.0ThrXaa: 0.0 ± 0.0
Val
2.701ValAla: 2.701 ± 1.347
1.08ValCys: 1.08 ± 0.329
2.161ValAsp: 2.161 ± 1.046
2.431ValGlu: 2.431 ± 0.597
1.351ValPhe: 1.351 ± 0.54
2.161ValGly: 2.161 ± 0.733
0.27ValHis: 0.27 ± 0.302
2.701ValIle: 2.701 ± 0.721
2.971ValLys: 2.971 ± 1.604
4.322ValLeu: 4.322 ± 1.336
1.621ValMet: 1.621 ± 0.703
2.161ValAsn: 2.161 ± 0.967
2.701ValPro: 2.701 ± 0.567
1.08ValGln: 1.08 ± 0.433
1.621ValArg: 1.621 ± 0.532
2.971ValSer: 2.971 ± 0.73
1.891ValThr: 1.891 ± 0.737
2.161ValVal: 2.161 ± 0.518
0.81ValTrp: 0.81 ± 0.271
2.971ValTyr: 2.971 ± 0.802
0.0ValXaa: 0.0 ± 0.0
Trp
0.81TrpAla: 0.81 ± 0.399
0.27TrpCys: 0.27 ± 0.347
1.08TrpAsp: 1.08 ± 0.613
1.08TrpGlu: 1.08 ± 0.347
1.08TrpPhe: 1.08 ± 0.613
1.08TrpGly: 1.08 ± 0.347
0.27TrpHis: 0.27 ± 0.347
1.891TrpIle: 1.891 ± 0.808
2.161TrpLys: 2.161 ± 0.528
1.621TrpLeu: 1.621 ± 0.263
1.351TrpMet: 1.351 ± 0.976
1.351TrpAsn: 1.351 ± 1.067
0.27TrpPro: 0.27 ± 0.153
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
1.351TrpSer: 1.351 ± 0.511
0.27TrpThr: 0.27 ± 0.153
1.621TrpVal: 1.621 ± 1.257
0.27TrpTrp: 0.27 ± 0.609
0.54TrpTyr: 0.54 ± 0.652
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.54TyrAla: 0.54 ± 0.271
1.08TyrCys: 1.08 ± 0.334
2.161TyrAsp: 2.161 ± 0.528
2.161TyrGlu: 2.161 ± 0.881
1.621TyrPhe: 1.621 ± 0.67
1.621TyrGly: 1.621 ± 0.406
1.621TyrHis: 1.621 ± 0.938
2.971TyrIle: 2.971 ± 0.817
2.161TyrLys: 2.161 ± 0.589
5.132TyrLeu: 5.132 ± 1.124
0.54TyrMet: 0.54 ± 0.316
2.971TyrAsn: 2.971 ± 0.62
1.891TyrPro: 1.891 ± 0.573
0.81TyrGln: 0.81 ± 0.382
2.431TyrArg: 2.431 ± 0.81
2.701TyrSer: 2.701 ± 0.472
1.08TyrThr: 1.08 ± 0.769
0.81TyrVal: 0.81 ± 0.74
0.0TyrTrp: 0.0 ± 0.0
1.621TyrTyr: 1.621 ± 0.707
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8 proteins (3703 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski