Amino acid dipepetide frequency for Microviridae Fen51_42

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.449AlaAla: 9.449 ± 6.005
1.575AlaCys: 1.575 ± 0.952
4.724AlaAsp: 4.724 ± 1.411
3.937AlaGlu: 3.937 ± 1.819
3.15AlaPhe: 3.15 ± 1.113
2.362AlaGly: 2.362 ± 1.379
0.787AlaHis: 0.787 ± 1.043
4.724AlaIle: 4.724 ± 0.697
3.937AlaLys: 3.937 ± 2.421
7.087AlaLeu: 7.087 ± 2.456
3.15AlaMet: 3.15 ± 1.156
3.15AlaAsn: 3.15 ± 1.469
2.362AlaPro: 2.362 ± 0.604
5.512AlaGln: 5.512 ± 2.196
6.299AlaArg: 6.299 ± 2.689
3.15AlaSer: 3.15 ± 0.766
6.299AlaThr: 6.299 ± 3.349
2.362AlaVal: 2.362 ± 1.589
0.787AlaTrp: 0.787 ± 0.53
3.937AlaTyr: 3.937 ± 1.041
0.0AlaXaa: 0.0 ± 0.0
Cys
0.787CysAla: 0.787 ± 1.043
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
1.575CysGly: 1.575 ± 1.442
0.787CysHis: 0.787 ± 1.043
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.787CysLeu: 0.787 ± 0.721
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
1.575CysPro: 1.575 ± 1.271
0.787CysGln: 0.787 ± 0.53
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.787CysTyr: 0.787 ± 0.721
0.0CysXaa: 0.0 ± 0.0
Asp
2.362AspAla: 2.362 ± 1.031
0.0AspCys: 0.0 ± 0.0
2.362AspAsp: 2.362 ± 1.931
3.15AspGlu: 3.15 ± 2.317
1.575AspPhe: 1.575 ± 1.816
1.575AspGly: 1.575 ± 0.603
0.787AspHis: 0.787 ± 0.53
1.575AspIle: 1.575 ± 1.14
3.15AspLys: 3.15 ± 2.279
5.512AspLeu: 5.512 ± 2.505
1.575AspMet: 1.575 ± 1.356
2.362AspAsn: 2.362 ± 0.877
2.362AspPro: 2.362 ± 1.031
4.724AspGln: 4.724 ± 1.209
2.362AspArg: 2.362 ± 1.176
1.575AspSer: 1.575 ± 1.816
3.937AspThr: 3.937 ± 1.057
3.15AspVal: 3.15 ± 1.219
1.575AspTrp: 1.575 ± 1.442
2.362AspTyr: 2.362 ± 1.219
0.0AspXaa: 0.0 ± 0.0
Glu
5.512GluAla: 5.512 ± 2.505
0.0GluCys: 0.0 ± 0.0
0.0GluAsp: 0.0 ± 0.0
3.15GluGlu: 3.15 ± 1.648
2.362GluPhe: 2.362 ± 1.155
1.575GluGly: 1.575 ± 1.053
0.787GluHis: 0.787 ± 0.53
2.362GluIle: 2.362 ± 0.604
2.362GluLys: 2.362 ± 1.736
3.937GluLeu: 3.937 ± 2.7
0.0GluMet: 0.0 ± 0.0
0.787GluAsn: 0.787 ± 0.748
0.0GluPro: 0.0 ± 0.0
3.15GluGln: 3.15 ± 1.91
2.362GluArg: 2.362 ± 1.524
3.15GluSer: 3.15 ± 1.156
3.15GluThr: 3.15 ± 0.992
2.362GluVal: 2.362 ± 0.877
2.362GluTrp: 2.362 ± 1.135
3.15GluTyr: 3.15 ± 1.024
0.0GluXaa: 0.0 ± 0.0
Phe
3.15PheAla: 3.15 ± 1.206
0.0PheCys: 0.0 ± 0.0
2.362PheAsp: 2.362 ± 0.893
2.362PheGlu: 2.362 ± 0.928
5.512PhePhe: 5.512 ± 0.907
3.15PheGly: 3.15 ± 1.206
0.787PheHis: 0.787 ± 0.721
0.787PheIle: 0.787 ± 0.908
1.575PheLys: 1.575 ± 1.271
5.512PheLeu: 5.512 ± 1.773
0.0PheMet: 0.0 ± 0.0
0.787PheAsn: 0.787 ± 0.53
2.362PhePro: 2.362 ± 1.176
0.0PheGln: 0.0 ± 0.0
2.362PheArg: 2.362 ± 0.877
1.575PheSer: 1.575 ± 0.603
4.724PheThr: 4.724 ± 1.368
3.937PheVal: 3.937 ± 1.806
0.0PheTrp: 0.0 ± 0.0
0.787PheTyr: 0.787 ± 0.721
0.0PheXaa: 0.0 ± 0.0
Gly
3.15GlyAla: 3.15 ± 1.102
0.0GlyCys: 0.0 ± 0.0
3.15GlyAsp: 3.15 ± 1.392
1.575GlyGlu: 1.575 ± 1.06
3.937GlyPhe: 3.937 ± 1.409
8.661GlyGly: 8.661 ± 3.552
0.787GlyHis: 0.787 ± 0.53
5.512GlyIle: 5.512 ± 1.391
3.937GlyLys: 3.937 ± 0.948
9.449GlyLeu: 9.449 ± 4.351
0.787GlyMet: 0.787 ± 0.53
6.299GlyAsn: 6.299 ± 2.722
2.362GlyPro: 2.362 ± 1.135
1.575GlyGln: 1.575 ± 0.952
5.512GlyArg: 5.512 ± 2.717
6.299GlySer: 6.299 ± 1.644
3.15GlyThr: 3.15 ± 2.119
4.724GlyVal: 4.724 ± 1.057
2.362GlyTrp: 2.362 ± 1.585
2.362GlyTyr: 2.362 ± 1.589
0.0GlyXaa: 0.0 ± 0.0
His
2.362HisAla: 2.362 ± 1.926
0.0HisCys: 0.0 ± 0.0
0.787HisAsp: 0.787 ± 0.721
0.0HisGlu: 0.0 ± 0.0
0.787HisPhe: 0.787 ± 0.53
2.362HisGly: 2.362 ± 1.589
0.0HisHis: 0.0 ± 0.0
1.575HisIle: 1.575 ± 2.086
0.787HisLys: 0.787 ± 0.721
3.15HisLeu: 3.15 ± 0.992
0.0HisMet: 0.0 ± 0.0
1.575HisAsn: 1.575 ± 1.14
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
2.362HisArg: 2.362 ± 0.893
0.0HisSer: 0.0 ± 0.0
0.0HisThr: 0.0 ± 0.0
1.575HisVal: 1.575 ± 1.14
0.0HisTrp: 0.0 ± 0.0
3.15HisTyr: 3.15 ± 2.884
0.0HisXaa: 0.0 ± 0.0
Ile
0.787IleAla: 0.787 ± 1.043
0.0IleCys: 0.0 ± 0.0
2.362IleAsp: 2.362 ± 0.604
2.362IleGlu: 2.362 ± 1.736
2.362IlePhe: 2.362 ± 0.877
4.724IleGly: 4.724 ± 0.881
2.362IleHis: 2.362 ± 1.677
0.0IleIle: 0.0 ± 0.0
0.787IleLys: 0.787 ± 1.043
5.512IleLeu: 5.512 ± 1.845
1.575IleMet: 1.575 ± 0.723
3.937IleAsn: 3.937 ± 1.706
2.362IlePro: 2.362 ± 1.589
1.575IleGln: 1.575 ± 1.356
1.575IleArg: 1.575 ± 0.603
4.724IleSer: 4.724 ± 0.968
0.787IleThr: 0.787 ± 0.721
1.575IleVal: 1.575 ± 0.911
0.787IleTrp: 0.787 ± 0.53
3.15IleTyr: 3.15 ± 0.992
0.0IleXaa: 0.0 ± 0.0
Lys
3.15LysAla: 3.15 ± 2.106
0.787LysCys: 0.787 ± 0.721
2.362LysAsp: 2.362 ± 0.604
3.15LysGlu: 3.15 ± 1.113
1.575LysPhe: 1.575 ± 0.603
3.937LysGly: 3.937 ± 0.787
0.0LysHis: 0.0 ± 0.0
3.937LysIle: 3.937 ± 2.014
4.724LysLys: 4.724 ± 2.998
3.937LysLeu: 3.937 ± 1.453
1.575LysMet: 1.575 ± 0.99
1.575LysAsn: 1.575 ± 1.271
3.15LysPro: 3.15 ± 2.406
3.15LysGln: 3.15 ± 1.823
5.512LysArg: 5.512 ± 3.502
3.15LysSer: 3.15 ± 1.648
4.724LysThr: 4.724 ± 2.377
1.575LysVal: 1.575 ± 1.14
0.0LysTrp: 0.0 ± 0.0
3.937LysTyr: 3.937 ± 1.776
0.0LysXaa: 0.0 ± 0.0
Leu
5.512LeuAla: 5.512 ± 0.855
0.0LeuCys: 0.0 ± 0.0
5.512LeuAsp: 5.512 ± 2.25
2.362LeuGlu: 2.362 ± 0.893
0.787LeuPhe: 0.787 ± 0.721
8.661LeuGly: 8.661 ± 3.465
0.787LeuHis: 0.787 ± 1.043
5.512LeuIle: 5.512 ± 1.391
11.024LeuLys: 11.024 ± 5.526
7.874LeuLeu: 7.874 ± 2.104
3.937LeuMet: 3.937 ± 0.948
8.661LeuAsn: 8.661 ± 3.8
4.724LeuPro: 4.724 ± 2.313
6.299LeuGln: 6.299 ± 0.842
8.661LeuArg: 8.661 ± 1.495
9.449LeuSer: 9.449 ± 3.595
9.449LeuThr: 9.449 ± 1.307
1.575LeuVal: 1.575 ± 0.907
0.0LeuTrp: 0.0 ± 0.0
2.362LeuTyr: 2.362 ± 1.176
0.0LeuXaa: 0.0 ± 0.0
Met
3.937MetAla: 3.937 ± 2.45
0.787MetCys: 0.787 ± 0.721
0.787MetAsp: 0.787 ± 0.908
0.0MetGlu: 0.0 ± 0.0
0.0MetPhe: 0.0 ± 0.0
2.362MetGly: 2.362 ± 0.877
1.575MetHis: 1.575 ± 0.729
0.0MetIle: 0.0 ± 0.0
3.15MetLys: 3.15 ± 1.156
1.575MetLeu: 1.575 ± 0.729
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
1.575MetPro: 1.575 ± 1.06
0.0MetGln: 0.0 ± 0.0
0.787MetArg: 0.787 ± 0.53
3.937MetSer: 3.937 ± 1.409
0.787MetThr: 0.787 ± 1.043
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
0.787MetTyr: 0.787 ± 0.908
0.0MetXaa: 0.0 ± 0.0
Asn
7.874AsnAla: 7.874 ± 3.506
0.0AsnCys: 0.0 ± 0.0
2.362AsnAsp: 2.362 ± 1.815
3.15AsnGlu: 3.15 ± 1.578
3.937AsnPhe: 3.937 ± 1.041
2.362AsnGly: 2.362 ± 1.031
0.0AsnHis: 0.0 ± 0.0
1.575AsnIle: 1.575 ± 0.603
0.787AsnLys: 0.787 ± 0.721
9.449AsnLeu: 9.449 ± 3.535
0.787AsnMet: 0.787 ± 0.681
2.362AsnAsn: 2.362 ± 1.031
1.575AsnPro: 1.575 ± 1.496
5.512AsnGln: 5.512 ± 1.801
1.575AsnArg: 1.575 ± 0.729
3.15AsnSer: 3.15 ± 1.102
3.15AsnThr: 3.15 ± 1.493
7.087AsnVal: 7.087 ± 2.631
0.787AsnTrp: 0.787 ± 0.53
0.787AsnTyr: 0.787 ± 0.721
0.0AsnXaa: 0.0 ± 0.0
Pro
2.362ProAla: 2.362 ± 1.069
0.787ProCys: 0.787 ± 0.721
1.575ProAsp: 1.575 ± 1.14
0.0ProGlu: 0.0 ± 0.0
4.724ProPhe: 4.724 ± 1.057
1.575ProGly: 1.575 ± 0.729
0.787ProHis: 0.787 ± 0.721
2.362ProIle: 2.362 ± 1.135
0.0ProLys: 0.0 ± 0.0
2.362ProLeu: 2.362 ± 0.999
1.575ProMet: 1.575 ± 0.913
3.937ProAsn: 3.937 ± 1.364
0.787ProPro: 0.787 ± 0.721
1.575ProGln: 1.575 ± 0.729
2.362ProArg: 2.362 ± 0.877
4.724ProSer: 4.724 ± 1.832
2.362ProThr: 2.362 ± 1.379
4.724ProVal: 4.724 ± 2.456
0.0ProTrp: 0.0 ± 0.0
1.575ProTyr: 1.575 ± 0.603
0.0ProXaa: 0.0 ± 0.0
Gln
1.575GlnAla: 1.575 ± 0.603
0.0GlnCys: 0.0 ± 0.0
0.787GlnAsp: 0.787 ± 0.721
5.512GlnGlu: 5.512 ± 0.907
1.575GlnPhe: 1.575 ± 1.06
3.15GlnGly: 3.15 ± 0.971
0.0GlnHis: 0.0 ± 0.0
3.937GlnIle: 3.937 ± 0.948
5.512GlnLys: 5.512 ± 2.711
6.299GlnLeu: 6.299 ± 1.776
2.362GlnMet: 2.362 ± 0.893
5.512GlnAsn: 5.512 ± 3.401
2.362GlnPro: 2.362 ± 1.379
3.937GlnGln: 3.937 ± 2.828
5.512GlnArg: 5.512 ± 1.983
3.937GlnSer: 3.937 ± 1.366
1.575GlnThr: 1.575 ± 0.729
0.0GlnVal: 0.0 ± 0.0
0.0GlnTrp: 0.0 ± 0.0
3.15GlnTyr: 3.15 ± 0.679
0.0GlnXaa: 0.0 ± 0.0
Arg
4.724ArgAla: 4.724 ± 1.921
0.787ArgCys: 0.787 ± 1.043
3.15ArgAsp: 3.15 ± 1.206
2.362ArgGlu: 2.362 ± 2.059
2.362ArgPhe: 2.362 ± 1.176
5.512ArgGly: 5.512 ± 1.414
1.575ArgHis: 1.575 ± 1.356
1.575ArgIle: 1.575 ± 0.911
3.15ArgLys: 3.15 ± 2.884
5.512ArgLeu: 5.512 ± 0.907
0.787ArgMet: 0.787 ± 0.748
3.15ArgAsn: 3.15 ± 1.58
1.575ArgPro: 1.575 ± 0.603
3.937ArgGln: 3.937 ± 1.128
1.575ArgArg: 1.575 ± 1.271
3.15ArgSer: 3.15 ± 1.797
4.724ArgThr: 4.724 ± 0.903
3.15ArgVal: 3.15 ± 0.971
0.787ArgTrp: 0.787 ± 1.043
4.724ArgTyr: 4.724 ± 1.306
0.0ArgXaa: 0.0 ± 0.0
Ser
6.299SerAla: 6.299 ± 0.781
2.362SerCys: 2.362 ± 1.784
3.937SerAsp: 3.937 ± 1.057
3.937SerGlu: 3.937 ± 2.027
2.362SerPhe: 2.362 ± 0.877
7.087SerGly: 7.087 ± 1.773
0.787SerHis: 0.787 ± 0.908
2.362SerIle: 2.362 ± 0.604
3.15SerLys: 3.15 ± 1.53
5.512SerLeu: 5.512 ± 2.903
0.0SerMet: 0.0 ± 0.0
2.362SerAsn: 2.362 ± 1.589
3.15SerPro: 3.15 ± 1.024
4.724SerGln: 4.724 ± 2.609
0.0SerArg: 0.0 ± 0.0
3.15SerSer: 3.15 ± 1.024
4.724SerThr: 4.724 ± 2.536
5.512SerVal: 5.512 ± 1.545
1.575SerTrp: 1.575 ± 0.603
3.15SerTyr: 3.15 ± 1.206
0.0SerXaa: 0.0 ± 0.0
Thr
7.874ThrAla: 7.874 ± 2.208
0.0ThrCys: 0.0 ± 0.0
5.512ThrAsp: 5.512 ± 1.443
1.575ThrGlu: 1.575 ± 1.053
3.15ThrPhe: 3.15 ± 0.679
8.661ThrGly: 8.661 ± 4.175
3.15ThrHis: 3.15 ± 1.459
3.15ThrIle: 3.15 ± 0.679
1.575ThrLys: 1.575 ± 1.356
6.299ThrLeu: 6.299 ± 0.781
0.787ThrMet: 0.787 ± 0.53
3.15ThrAsn: 3.15 ± 1.582
2.362ThrPro: 2.362 ± 1.031
2.362ThrGln: 2.362 ± 1.135
2.362ThrArg: 2.362 ± 0.999
6.299ThrSer: 6.299 ± 2.634
4.724ThrThr: 4.724 ± 2.536
3.15ThrVal: 3.15 ± 1.582
0.0ThrTrp: 0.0 ± 0.0
2.362ThrTyr: 2.362 ± 0.928
0.0ThrXaa: 0.0 ± 0.0
Val
4.724ValAla: 4.724 ± 1.798
0.0ValCys: 0.0 ± 0.0
2.362ValAsp: 2.362 ± 0.928
0.787ValGlu: 0.787 ± 0.53
0.0ValPhe: 0.0 ± 0.0
1.575ValGly: 1.575 ± 1.496
2.362ValHis: 2.362 ± 1.031
0.787ValIle: 0.787 ± 0.53
2.362ValLys: 2.362 ± 1.219
7.874ValLeu: 7.874 ± 1.483
2.362ValMet: 2.362 ± 1.589
4.724ValAsn: 4.724 ± 1.586
3.937ValPro: 3.937 ± 1.041
3.15ValGln: 3.15 ± 2.095
1.575ValArg: 1.575 ± 0.907
0.787ValSer: 0.787 ± 0.53
5.512ValThr: 5.512 ± 2.273
1.575ValVal: 1.575 ± 0.603
1.575ValTrp: 1.575 ± 0.603
2.362ValTyr: 2.362 ± 0.877
0.0ValXaa: 0.0 ± 0.0
Trp
0.787TrpAla: 0.787 ± 0.53
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.575TrpGlu: 1.575 ± 0.907
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.787TrpHis: 0.787 ± 0.721
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
1.575TrpLeu: 1.575 ± 0.729
0.0TrpMet: 0.0 ± 0.0
1.575TrpAsn: 1.575 ± 0.603
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
1.575TrpArg: 1.575 ± 1.271
2.362TrpSer: 2.362 ± 1.135
1.575TrpThr: 1.575 ± 0.603
0.787TrpVal: 0.787 ± 0.748
0.0TrpTrp: 0.0 ± 0.0
0.787TrpTyr: 0.787 ± 0.53
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.362TyrAla: 2.362 ± 1.135
0.0TyrCys: 0.0 ± 0.0
3.937TyrAsp: 3.937 ± 1.687
1.575TyrGlu: 1.575 ± 1.14
1.575TyrPhe: 1.575 ± 1.442
4.724TyrGly: 4.724 ± 1.209
1.575TyrHis: 1.575 ± 1.442
1.575TyrIle: 1.575 ± 1.06
3.937TyrLys: 3.937 ± 1.409
3.937TyrLeu: 3.937 ± 2.617
0.0TyrMet: 0.0 ± 0.0
2.362TyrAsn: 2.362 ± 0.604
2.362TyrPro: 2.362 ± 0.999
4.724TyrGln: 4.724 ± 1.809
3.937TyrArg: 3.937 ± 1.583
1.575TyrSer: 1.575 ± 0.729
3.15TyrThr: 3.15 ± 1.582
1.575TyrVal: 1.575 ± 0.603
0.787TyrTrp: 0.787 ± 0.53
3.937TyrTyr: 3.937 ± 1.806
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1271 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski