Amino acid dipepetide frequency for Eubacterium sp. CAG:156

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.78AlaAla: 4.78 ± 0.118
0.862AlaCys: 0.862 ± 0.039
3.862AlaAsp: 3.862 ± 0.076
3.735AlaGlu: 3.735 ± 0.075
2.544AlaPhe: 2.544 ± 0.074
4.857AlaGly: 4.857 ± 0.096
0.872AlaHis: 0.872 ± 0.037
5.642AlaIle: 5.642 ± 0.106
5.584AlaLys: 5.584 ± 0.097
5.378AlaLeu: 5.378 ± 0.094
2.017AlaMet: 2.017 ± 0.052
3.331AlaAsn: 3.331 ± 0.068
1.56AlaPro: 1.56 ± 0.058
1.794AlaGln: 1.794 ± 0.056
2.071AlaArg: 2.071 ± 0.062
3.512AlaSer: 3.512 ± 0.085
3.71AlaThr: 3.71 ± 0.095
5.095AlaVal: 5.095 ± 0.091
0.469AlaTrp: 0.469 ± 0.026
2.666AlaTyr: 2.666 ± 0.067
0.0AlaXaa: 0.0 ± 0.0
Cys
0.834CysAla: 0.834 ± 0.034
0.232CysCys: 0.232 ± 0.022
0.857CysAsp: 0.857 ± 0.039
0.814CysGlu: 0.814 ± 0.036
0.595CysPhe: 0.595 ± 0.029
1.247CysGly: 1.247 ± 0.049
0.249CysHis: 0.249 ± 0.021
1.206CysIle: 1.206 ± 0.041
1.047CysLys: 1.047 ± 0.038
0.888CysLeu: 0.888 ± 0.035
0.385CysMet: 0.385 ± 0.025
0.686CysAsn: 0.686 ± 0.032
0.465CysPro: 0.465 ± 0.029
0.265CysGln: 0.265 ± 0.019
0.433CysArg: 0.433 ± 0.025
0.847CysSer: 0.847 ± 0.038
0.685CysThr: 0.685 ± 0.035
0.982CysVal: 0.982 ± 0.039
0.088CysTrp: 0.088 ± 0.012
0.531CysTyr: 0.531 ± 0.027
0.0CysXaa: 0.0 ± 0.0
Asp
3.674AspAla: 3.674 ± 0.075
0.728AspCys: 0.728 ± 0.034
3.768AspAsp: 3.768 ± 0.098
5.378AspGlu: 5.378 ± 0.109
2.624AspPhe: 2.624 ± 0.059
4.349AspGly: 4.349 ± 0.094
0.568AspHis: 0.568 ± 0.027
5.347AspIle: 5.347 ± 0.095
5.475AspLys: 5.475 ± 0.088
4.203AspLeu: 4.203 ± 0.087
1.861AspMet: 1.861 ± 0.048
3.684AspAsn: 3.684 ± 0.079
1.253AspPro: 1.253 ± 0.037
0.859AspGln: 0.859 ± 0.037
1.868AspArg: 1.868 ± 0.057
3.575AspSer: 3.575 ± 0.082
3.15AspThr: 3.15 ± 0.075
4.156AspVal: 4.156 ± 0.087
0.505AspTrp: 0.505 ± 0.035
3.063AspTyr: 3.063 ± 0.072
0.0AspXaa: 0.0 ± 0.0
Glu
4.478GluAla: 4.478 ± 0.087
0.895GluCys: 0.895 ± 0.036
4.161GluAsp: 4.161 ± 0.098
6.327GluGlu: 6.327 ± 0.13
2.986GluPhe: 2.986 ± 0.072
3.806GluGly: 3.806 ± 0.081
1.138GluHis: 1.138 ± 0.044
6.608GluIle: 6.608 ± 0.117
7.263GluLys: 7.263 ± 0.126
5.949GluLeu: 5.949 ± 0.122
2.363GluMet: 2.363 ± 0.064
5.526GluAsn: 5.526 ± 0.1
1.551GluPro: 1.551 ± 0.05
2.326GluGln: 2.326 ± 0.064
2.56GluArg: 2.56 ± 0.067
3.739GluSer: 3.739 ± 0.083
3.785GluThr: 3.785 ± 0.1
4.562GluVal: 4.562 ± 0.092
0.587GluTrp: 0.587 ± 0.03
3.535GluTyr: 3.535 ± 0.081
0.0GluXaa: 0.0 ± 0.0
Phe
2.741PheAla: 2.741 ± 0.076
0.607PheCys: 0.607 ± 0.027
2.73PheAsp: 2.73 ± 0.06
2.886PheGlu: 2.886 ± 0.074
1.568PhePhe: 1.568 ± 0.051
2.996PheGly: 2.996 ± 0.081
0.54PheHis: 0.54 ± 0.029
3.348PheIle: 3.348 ± 0.081
2.982PheLys: 2.982 ± 0.068
2.885PheLeu: 2.885 ± 0.081
1.218PheMet: 1.218 ± 0.045
2.204PheAsn: 2.204 ± 0.052
1.025PhePro: 1.025 ± 0.041
0.922PheGln: 0.922 ± 0.035
1.24PheArg: 1.24 ± 0.043
2.912PheSer: 2.912 ± 0.074
2.277PheThr: 2.277 ± 0.069
2.904PheVal: 2.904 ± 0.064
0.339PheTrp: 0.339 ± 0.022
1.852PheTyr: 1.852 ± 0.058
0.0PheXaa: 0.0 ± 0.0
Gly
4.344GlyAla: 4.344 ± 0.087
1.056GlyCys: 1.056 ± 0.044
3.394GlyAsp: 3.394 ± 0.07
4.294GlyGlu: 4.294 ± 0.088
2.754GlyPhe: 2.754 ± 0.064
4.061GlyGly: 4.061 ± 0.1
1.067GlyHis: 1.067 ± 0.041
6.512GlyIle: 6.512 ± 0.103
6.184GlyLys: 6.184 ± 0.1
4.999GlyLeu: 4.999 ± 0.093
2.146GlyMet: 2.146 ± 0.066
3.878GlyAsn: 3.878 ± 0.098
1.066GlyPro: 1.066 ± 0.045
1.781GlyGln: 1.781 ± 0.052
2.307GlyArg: 2.307 ± 0.059
3.51GlySer: 3.51 ± 0.082
4.152GlyThr: 4.152 ± 0.093
4.625GlyVal: 4.625 ± 0.087
0.602GlyTrp: 0.602 ± 0.033
3.46GlyTyr: 3.46 ± 0.09
0.0GlyXaa: 0.0 ± 0.0
His
0.72HisAla: 0.72 ± 0.034
0.251HisCys: 0.251 ± 0.017
0.741HisAsp: 0.741 ± 0.034
0.828HisGlu: 0.828 ± 0.037
0.689HisPhe: 0.689 ± 0.033
1.057HisGly: 1.057 ± 0.037
0.293HisHis: 0.293 ± 0.026
1.305HisIle: 1.305 ± 0.04
1.027HisLys: 1.027 ± 0.04
1.054HisLeu: 1.054 ± 0.041
0.433HisMet: 0.433 ± 0.024
0.81HisAsn: 0.81 ± 0.035
0.607HisPro: 0.607 ± 0.031
0.365HisGln: 0.365 ± 0.022
0.54HisArg: 0.54 ± 0.033
0.802HisSer: 0.802 ± 0.037
0.757HisThr: 0.757 ± 0.034
0.825HisVal: 0.825 ± 0.034
0.116HisTrp: 0.116 ± 0.012
0.594HisTyr: 0.594 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
6.037IleAla: 6.037 ± 0.109
1.397IleCys: 1.397 ± 0.046
5.247IleAsp: 5.247 ± 0.094
6.286IleGlu: 6.286 ± 0.104
3.435IlePhe: 3.435 ± 0.097
5.425IleGly: 5.425 ± 0.104
1.114IleHis: 1.114 ± 0.043
7.639IleIle: 7.639 ± 0.117
7.176IleLys: 7.176 ± 0.111
6.766IleLeu: 6.766 ± 0.125
2.284IleMet: 2.284 ± 0.065
5.053IleAsn: 5.053 ± 0.085
3.048IlePro: 3.048 ± 0.062
2.062IleGln: 2.062 ± 0.066
2.875IleArg: 2.875 ± 0.068
5.793IleSer: 5.793 ± 0.1
4.932IleThr: 4.932 ± 0.087
6.272IleVal: 6.272 ± 0.102
0.578IleTrp: 0.578 ± 0.031
3.436IleTyr: 3.436 ± 0.07
0.0IleXaa: 0.0 ± 0.0
Lys
5.429LysAla: 5.429 ± 0.095
0.97LysCys: 0.97 ± 0.041
5.29LysAsp: 5.29 ± 0.108
7.942LysGlu: 7.942 ± 0.127
3.037LysPhe: 3.037 ± 0.072
4.66LysGly: 4.66 ± 0.096
1.131LysHis: 1.131 ± 0.045
7.345LysIle: 7.345 ± 0.113
8.912LysLys: 8.912 ± 0.153
6.601LysLeu: 6.601 ± 0.103
2.886LysMet: 2.886 ± 0.075
5.739LysAsn: 5.739 ± 0.114
2.067LysPro: 2.067 ± 0.05
2.484LysGln: 2.484 ± 0.063
2.911LysArg: 2.911 ± 0.064
4.411LysSer: 4.411 ± 0.086
4.481LysThr: 4.481 ± 0.084
5.945LysVal: 5.945 ± 0.094
0.757LysTrp: 0.757 ± 0.039
4.62LysTyr: 4.62 ± 0.094
0.0LysXaa: 0.0 ± 0.0
Leu
4.996LeuAla: 4.996 ± 0.087
1.027LeuCys: 1.027 ± 0.04
4.727LeuAsp: 4.727 ± 0.094
5.548LeuGlu: 5.548 ± 0.115
3.163LeuPhe: 3.163 ± 0.087
4.972LeuGly: 4.972 ± 0.089
1.106LeuHis: 1.106 ± 0.042
6.223LeuIle: 6.223 ± 0.114
6.892LeuLys: 6.892 ± 0.099
6.21LeuLeu: 6.21 ± 0.116
2.261LeuMet: 2.261 ± 0.066
4.502LeuAsn: 4.502 ± 0.083
2.669LeuPro: 2.669 ± 0.066
2.088LeuGln: 2.088 ± 0.055
2.507LeuArg: 2.507 ± 0.066
5.322LeuSer: 5.322 ± 0.09
4.381LeuThr: 4.381 ± 0.073
4.902LeuVal: 4.902 ± 0.097
0.529LeuTrp: 0.529 ± 0.027
3.061LeuTyr: 3.061 ± 0.077
0.0LeuXaa: 0.0 ± 0.0
Met
2.187MetAla: 2.187 ± 0.06
0.388MetCys: 0.388 ± 0.024
1.828MetAsp: 1.828 ± 0.049
2.268MetGlu: 2.268 ± 0.061
1.15MetPhe: 1.15 ± 0.039
1.923MetGly: 1.923 ± 0.06
0.392MetHis: 0.392 ± 0.026
2.346MetIle: 2.346 ± 0.061
2.601MetLys: 2.601 ± 0.07
2.395MetLeu: 2.395 ± 0.063
0.841MetMet: 0.841 ± 0.038
1.807MetAsn: 1.807 ± 0.05
1.053MetPro: 1.053 ± 0.035
0.786MetGln: 0.786 ± 0.036
1.028MetArg: 1.028 ± 0.034
1.981MetSer: 1.981 ± 0.06
1.736MetThr: 1.736 ± 0.046
1.833MetVal: 1.833 ± 0.051
0.201MetTrp: 0.201 ± 0.019
1.108MetTyr: 1.108 ± 0.041
0.0MetXaa: 0.0 ± 0.0
Asn
3.571AsnAla: 3.571 ± 0.076
0.772AsnCys: 0.772 ± 0.037
3.403AsnAsp: 3.403 ± 0.07
4.565AsnGlu: 4.565 ± 0.099
2.027AsnPhe: 2.027 ± 0.049
4.499AsnGly: 4.499 ± 0.102
0.772AsnHis: 0.772 ± 0.034
5.538AsnIle: 5.538 ± 0.104
5.418AsnLys: 5.418 ± 0.104
4.282AsnLeu: 4.282 ± 0.08
1.803AsnMet: 1.803 ± 0.053
3.968AsnAsn: 3.968 ± 0.114
2.033AsnPro: 2.033 ± 0.051
1.673AsnGln: 1.673 ± 0.051
1.903AsnArg: 1.903 ± 0.059
3.571AsnSer: 3.571 ± 0.096
3.035AsnThr: 3.035 ± 0.084
4.213AsnVal: 4.213 ± 0.085
0.455AsnTrp: 0.455 ± 0.027
2.67AsnTyr: 2.67 ± 0.068
0.0AsnXaa: 0.0 ± 0.0
Pro
1.697ProAla: 1.697 ± 0.052
0.388ProCys: 0.388 ± 0.023
1.855ProAsp: 1.855 ± 0.051
2.543ProGlu: 2.543 ± 0.071
1.282ProPhe: 1.282 ± 0.045
1.854ProGly: 1.854 ± 0.06
0.465ProHis: 0.465 ± 0.025
2.243ProIle: 2.243 ± 0.054
1.974ProLys: 1.974 ± 0.052
2.038ProLeu: 2.038 ± 0.052
0.773ProMet: 0.773 ± 0.035
1.369ProAsn: 1.369 ± 0.05
0.488ProPro: 0.488 ± 0.029
0.796ProGln: 0.796 ± 0.04
0.678ProArg: 0.678 ± 0.03
1.534ProSer: 1.534 ± 0.047
1.599ProThr: 1.599 ± 0.05
2.178ProVal: 2.178 ± 0.053
0.258ProTrp: 0.258 ± 0.019
1.282ProTyr: 1.282 ± 0.048
0.001ProXaa: 0.001 ± 0.002
Gln
1.71GlnAla: 1.71 ± 0.056
0.301GlnCys: 0.301 ± 0.021
1.276GlnAsp: 1.276 ± 0.044
1.718GlnGlu: 1.718 ± 0.052
1.038GlnPhe: 1.038 ± 0.039
1.573GlnGly: 1.573 ± 0.051
0.337GlnHis: 0.337 ± 0.022
2.556GlnIle: 2.556 ± 0.063
2.345GlnLys: 2.345 ± 0.059
2.187GlnLeu: 2.187 ± 0.059
0.972GlnMet: 0.972 ± 0.038
1.612GlnAsn: 1.612 ± 0.052
0.698GlnPro: 0.698 ± 0.031
0.886GlnGln: 0.886 ± 0.04
0.97GlnArg: 0.97 ± 0.04
1.424GlnSer: 1.424 ± 0.046
1.366GlnThr: 1.366 ± 0.044
1.7GlnVal: 1.7 ± 0.05
0.256GlnTrp: 0.256 ± 0.025
1.258GlnTyr: 1.258 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
1.954ArgAla: 1.954 ± 0.057
0.413ArgCys: 0.413 ± 0.023
1.735ArgAsp: 1.735 ± 0.057
2.628ArgGlu: 2.628 ± 0.07
1.334ArgPhe: 1.334 ± 0.047
1.923ArgGly: 1.923 ± 0.063
0.527ArgHis: 0.527 ± 0.026
2.967ArgIle: 2.967 ± 0.066
3.153ArgLys: 3.153 ± 0.073
2.644ArgLeu: 2.644 ± 0.065
1.182ArgMet: 1.182 ± 0.041
2.001ArgAsn: 2.001 ± 0.059
0.921ArgPro: 0.921 ± 0.038
1.017ArgGln: 1.017 ± 0.039
1.397ArgArg: 1.397 ± 0.056
1.487ArgSer: 1.487 ± 0.045
1.76ArgThr: 1.76 ± 0.051
2.214ArgVal: 2.214 ± 0.063
0.265ArgTrp: 0.265 ± 0.022
1.542ArgTyr: 1.542 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
3.575SerAla: 3.575 ± 0.073
0.675SerCys: 0.675 ± 0.034
3.864SerAsp: 3.864 ± 0.079
4.048SerGlu: 4.048 ± 0.082
2.488SerPhe: 2.488 ± 0.056
4.552SerGly: 4.552 ± 0.093
0.838SerHis: 0.838 ± 0.038
4.915SerIle: 4.915 ± 0.083
4.924SerLys: 4.924 ± 0.091
4.644SerLeu: 4.644 ± 0.091
1.694SerMet: 1.694 ± 0.053
3.332SerAsn: 3.332 ± 0.079
1.348SerPro: 1.348 ± 0.043
1.644SerGln: 1.644 ± 0.052
2.051SerArg: 2.051 ± 0.055
3.822SerSer: 3.822 ± 0.124
3.357SerThr: 3.357 ± 0.073
4.478SerVal: 4.478 ± 0.08
0.468SerTrp: 0.468 ± 0.03
2.734SerTyr: 2.734 ± 0.076
0.0SerXaa: 0.0 ± 0.0
Thr
3.652ThrAla: 3.652 ± 0.093
0.594ThrCys: 0.594 ± 0.032
3.577ThrAsp: 3.577 ± 0.083
3.574ThrGlu: 3.574 ± 0.08
2.365ThrPhe: 2.365 ± 0.067
4.247ThrGly: 4.247 ± 0.083
0.756ThrHis: 0.756 ± 0.035
4.947ThrIle: 4.947 ± 0.082
4.381ThrLys: 4.381 ± 0.097
4.291ThrLeu: 4.291 ± 0.087
1.384ThrMet: 1.384 ± 0.039
3.041ThrAsn: 3.041 ± 0.074
1.841ThrPro: 1.841 ± 0.052
1.476ThrGln: 1.476 ± 0.054
1.596ThrArg: 1.596 ± 0.045
3.305ThrSer: 3.305 ± 0.084
4.01ThrThr: 4.01 ± 0.164
4.586ThrVal: 4.586 ± 0.091
0.461ThrTrp: 0.461 ± 0.024
2.566ThrTyr: 2.566 ± 0.082
0.0ThrXaa: 0.0 ± 0.0
Val
4.791ValAla: 4.791 ± 0.085
1.061ValCys: 1.061 ± 0.041
4.194ValAsp: 4.194 ± 0.084
4.945ValGlu: 4.945 ± 0.094
2.822ValPhe: 2.822 ± 0.067
4.434ValGly: 4.434 ± 0.094
0.875ValHis: 0.875 ± 0.037
5.906ValIle: 5.906 ± 0.113
5.955ValLys: 5.955 ± 0.108
5.665ValLeu: 5.665 ± 0.091
1.868ValMet: 1.868 ± 0.052
4.111ValAsn: 4.111 ± 0.09
2.201ValPro: 2.201 ± 0.056
1.502ValGln: 1.502 ± 0.043
2.303ValArg: 2.303 ± 0.063
4.562ValSer: 4.562 ± 0.09
4.408ValThr: 4.408 ± 0.09
5.326ValVal: 5.326 ± 0.095
0.534ValTrp: 0.534 ± 0.031
2.899ValTyr: 2.899 ± 0.07
0.001ValXaa: 0.001 ± 0.001
Trp
0.456TrpAla: 0.456 ± 0.028
0.113TrpCys: 0.113 ± 0.014
0.51TrpAsp: 0.51 ± 0.029
0.466TrpGlu: 0.466 ± 0.028
0.352TrpPhe: 0.352 ± 0.027
0.602TrpGly: 0.602 ± 0.033
0.136TrpHis: 0.136 ± 0.014
0.623TrpIle: 0.623 ± 0.029
0.647TrpLys: 0.647 ± 0.032
0.621TrpLeu: 0.621 ± 0.032
0.255TrpMet: 0.255 ± 0.02
0.571TrpAsn: 0.571 ± 0.033
0.194TrpPro: 0.194 ± 0.016
0.31TrpGln: 0.31 ± 0.023
0.239TrpArg: 0.239 ± 0.019
0.52TrpSer: 0.52 ± 0.03
0.429TrpThr: 0.429 ± 0.027
0.439TrpVal: 0.439 ± 0.026
0.103TrpTrp: 0.103 ± 0.012
0.307TrpTyr: 0.307 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.712TyrAla: 2.712 ± 0.066
0.608TyrCys: 0.608 ± 0.031
3.07TyrAsp: 3.07 ± 0.077
3.35TyrGlu: 3.35 ± 0.079
1.922TyrPhe: 1.922 ± 0.055
3.157TyrGly: 3.157 ± 0.078
0.637TyrHis: 0.637 ± 0.032
3.639TyrIle: 3.639 ± 0.073
3.68TyrLys: 3.68 ± 0.077
3.386TyrLeu: 3.386 ± 0.074
1.225TyrMet: 1.225 ± 0.043
2.946TyrAsn: 2.946 ± 0.071
1.206TyrPro: 1.206 ± 0.043
1.147TyrGln: 1.147 ± 0.045
1.589TyrArg: 1.589 ± 0.049
2.821TyrSer: 2.821 ± 0.071
2.64TyrThr: 2.64 ± 0.082
3.129TyrVal: 3.129 ± 0.07
0.321TyrTrp: 0.321 ± 0.025
2.236TyrTyr: 2.236 ± 0.067
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.001XaaAla: 0.001 ± 0.002
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.001XaaGlu: 0.001 ± 0.001
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.004XaaXaa: 0.004 ± 0.003
Statistics based on 2092 proteins (690534 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski