Amino acid dipepetide frequency for Streptococcus phage 73

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.412AlaAla: 3.412 ± 0.858
0.175AlaCys: 0.175 ± 0.112
3.937AlaAsp: 3.937 ± 0.751
4.811AlaGlu: 4.811 ± 0.659
2.624AlaPhe: 2.624 ± 0.705
4.287AlaGly: 4.287 ± 0.624
0.612AlaHis: 0.612 ± 0.206
4.374AlaIle: 4.374 ± 0.828
5.949AlaLys: 5.949 ± 0.95
6.386AlaLeu: 6.386 ± 0.463
1.137AlaMet: 1.137 ± 0.277
4.899AlaAsn: 4.899 ± 0.693
1.575AlaPro: 1.575 ± 0.288
2.887AlaGln: 2.887 ± 0.448
2.362AlaArg: 2.362 ± 0.437
4.374AlaSer: 4.374 ± 0.755
4.024AlaThr: 4.024 ± 0.798
4.112AlaVal: 4.112 ± 0.659
1.137AlaTrp: 1.137 ± 0.245
2.712AlaTyr: 2.712 ± 0.502
0.0AlaXaa: 0.0 ± 0.0
Cys
0.087CysAla: 0.087 ± 0.074
0.0CysCys: 0.0 ± 0.0
0.612CysAsp: 0.612 ± 0.289
0.35CysGlu: 0.35 ± 0.197
0.35CysPhe: 0.35 ± 0.231
0.087CysGly: 0.087 ± 0.08
0.087CysHis: 0.087 ± 0.102
0.175CysIle: 0.175 ± 0.106
0.262CysLys: 0.262 ± 0.148
0.7CysLeu: 0.7 ± 0.276
0.087CysMet: 0.087 ± 0.089
0.175CysAsn: 0.175 ± 0.103
0.087CysPro: 0.087 ± 0.089
0.087CysGln: 0.087 ± 0.078
0.175CysArg: 0.175 ± 0.156
0.525CysSer: 0.525 ± 0.246
0.262CysThr: 0.262 ± 0.157
0.35CysVal: 0.35 ± 0.137
0.175CysTrp: 0.175 ± 0.139
0.087CysTyr: 0.087 ± 0.094
0.0CysXaa: 0.0 ± 0.0
Asp
3.587AspAla: 3.587 ± 0.637
0.35AspCys: 0.35 ± 0.168
3.849AspAsp: 3.849 ± 0.67
4.112AspGlu: 4.112 ± 0.743
4.462AspPhe: 4.462 ± 0.536
6.824AspGly: 6.824 ± 1.694
0.875AspHis: 0.875 ± 0.272
5.336AspIle: 5.336 ± 0.688
5.686AspLys: 5.686 ± 0.763
3.849AspLeu: 3.849 ± 0.681
2.187AspMet: 2.187 ± 0.481
3.937AspAsn: 3.937 ± 0.61
2.012AspPro: 2.012 ± 0.372
1.312AspGln: 1.312 ± 0.247
2.449AspArg: 2.449 ± 0.318
3.937AspSer: 3.937 ± 0.774
3.412AspThr: 3.412 ± 0.531
2.974AspVal: 2.974 ± 0.455
0.787AspTrp: 0.787 ± 0.223
2.449AspTyr: 2.449 ± 0.52
0.0AspXaa: 0.0 ± 0.0
Glu
4.287GluAla: 4.287 ± 0.552
0.175GluCys: 0.175 ± 0.095
3.937GluAsp: 3.937 ± 0.501
5.074GluGlu: 5.074 ± 0.855
2.187GluPhe: 2.187 ± 0.398
2.712GluGly: 2.712 ± 0.409
1.225GluHis: 1.225 ± 0.4
5.861GluIle: 5.861 ± 0.685
4.199GluLys: 4.199 ± 0.961
7.173GluLeu: 7.173 ± 1.124
2.362GluMet: 2.362 ± 0.502
4.024GluAsn: 4.024 ± 0.724
1.925GluPro: 1.925 ± 0.416
3.499GluGln: 3.499 ± 0.555
3.062GluArg: 3.062 ± 0.483
2.537GluSer: 2.537 ± 0.559
3.587GluThr: 3.587 ± 0.548
5.161GluVal: 5.161 ± 0.749
1.225GluTrp: 1.225 ± 0.269
3.587GluTyr: 3.587 ± 0.632
0.0GluXaa: 0.0 ± 0.0
Phe
2.887PheAla: 2.887 ± 0.516
0.0PheCys: 0.0 ± 0.0
3.762PheAsp: 3.762 ± 0.511
2.887PheGlu: 2.887 ± 0.711
1.4PhePhe: 1.4 ± 0.287
3.324PheGly: 3.324 ± 0.753
0.35PheHis: 0.35 ± 0.138
2.974PheIle: 2.974 ± 0.529
4.374PheLys: 4.374 ± 0.635
2.449PheLeu: 2.449 ± 0.561
0.7PheMet: 0.7 ± 0.249
3.324PheAsn: 3.324 ± 0.54
0.7PhePro: 0.7 ± 0.233
0.962PheGln: 0.962 ± 0.237
1.575PheArg: 1.575 ± 0.299
2.974PheSer: 2.974 ± 0.452
2.799PheThr: 2.799 ± 0.598
2.537PheVal: 2.537 ± 0.404
0.525PheTrp: 0.525 ± 0.245
1.662PheTyr: 1.662 ± 0.38
0.0PheXaa: 0.0 ± 0.0
Gly
2.974GlyAla: 2.974 ± 0.708
0.437GlyCys: 0.437 ± 0.202
4.199GlyAsp: 4.199 ± 0.643
4.199GlyGlu: 4.199 ± 0.628
2.624GlyPhe: 2.624 ± 0.423
3.937GlyGly: 3.937 ± 0.845
0.787GlyHis: 0.787 ± 0.235
6.036GlyIle: 6.036 ± 0.683
6.036GlyLys: 6.036 ± 0.819
6.211GlyLeu: 6.211 ± 0.79
1.662GlyMet: 1.662 ± 0.369
3.762GlyAsn: 3.762 ± 0.561
1.75GlyPro: 1.75 ± 0.49
3.062GlyGln: 3.062 ± 0.497
3.062GlyArg: 3.062 ± 0.588
4.549GlySer: 4.549 ± 0.643
4.986GlyThr: 4.986 ± 0.656
2.974GlyVal: 2.974 ± 0.627
1.225GlyTrp: 1.225 ± 0.361
2.887GlyTyr: 2.887 ± 0.453
0.0GlyXaa: 0.0 ± 0.0
His
0.35HisAla: 0.35 ± 0.169
0.0HisCys: 0.0 ± 0.0
0.787HisAsp: 0.787 ± 0.216
0.525HisGlu: 0.525 ± 0.194
0.525HisPhe: 0.525 ± 0.194
0.787HisGly: 0.787 ± 0.254
0.262HisHis: 0.262 ± 0.133
0.962HisIle: 0.962 ± 0.299
1.137HisLys: 1.137 ± 0.264
1.05HisLeu: 1.05 ± 0.243
0.525HisMet: 0.525 ± 0.225
0.962HisAsn: 0.962 ± 0.392
0.525HisPro: 0.525 ± 0.195
1.137HisGln: 1.137 ± 0.34
0.612HisArg: 0.612 ± 0.238
0.787HisSer: 0.787 ± 0.242
0.7HisThr: 0.7 ± 0.228
1.312HisVal: 1.312 ± 0.234
0.0HisTrp: 0.0 ± 0.0
0.7HisTyr: 0.7 ± 0.328
0.0HisXaa: 0.0 ± 0.0
Ile
4.811IleAla: 4.811 ± 0.948
0.437IleCys: 0.437 ± 0.176
4.724IleAsp: 4.724 ± 0.628
5.074IleGlu: 5.074 ± 0.884
1.662IlePhe: 1.662 ± 0.333
4.199IleGly: 4.199 ± 0.452
0.875IleHis: 0.875 ± 0.241
3.149IleIle: 3.149 ± 0.51
7.173IleLys: 7.173 ± 0.726
4.374IleLeu: 4.374 ± 0.756
1.487IleMet: 1.487 ± 0.496
4.637IleAsn: 4.637 ± 0.552
3.062IlePro: 3.062 ± 0.49
2.887IleGln: 2.887 ± 0.36
2.537IleArg: 2.537 ± 0.474
4.811IleSer: 4.811 ± 0.618
3.674IleThr: 3.674 ± 0.479
3.062IleVal: 3.062 ± 0.685
0.7IleTrp: 0.7 ± 0.221
1.837IleTyr: 1.837 ± 0.341
0.0IleXaa: 0.0 ± 0.0
Lys
6.299LysAla: 6.299 ± 0.659
0.262LysCys: 0.262 ± 0.158
5.599LysAsp: 5.599 ± 0.785
6.911LysGlu: 6.911 ± 0.871
3.587LysPhe: 3.587 ± 0.802
6.036LysGly: 6.036 ± 0.609
1.487LysHis: 1.487 ± 0.477
5.074LysIle: 5.074 ± 0.769
6.649LysLys: 6.649 ± 1.375
6.736LysLeu: 6.736 ± 0.972
2.1LysMet: 2.1 ± 0.408
5.074LysAsn: 5.074 ± 0.623
2.799LysPro: 2.799 ± 0.401
4.024LysGln: 4.024 ± 0.61
3.324LysArg: 3.324 ± 0.597
4.374LysSer: 4.374 ± 0.429
5.424LysThr: 5.424 ± 0.727
4.549LysVal: 4.549 ± 0.638
1.05LysTrp: 1.05 ± 0.25
3.499LysTyr: 3.499 ± 0.681
0.0LysXaa: 0.0 ± 0.0
Leu
7.086LeuAla: 7.086 ± 0.638
0.525LeuCys: 0.525 ± 0.239
4.287LeuAsp: 4.287 ± 0.709
7.086LeuGlu: 7.086 ± 0.998
2.712LeuPhe: 2.712 ± 0.449
5.686LeuGly: 5.686 ± 0.756
0.787LeuHis: 0.787 ± 0.233
4.199LeuIle: 4.199 ± 0.536
6.999LeuLys: 6.999 ± 0.813
5.511LeuLeu: 5.511 ± 0.624
2.275LeuMet: 2.275 ± 0.519
5.074LeuAsn: 5.074 ± 0.615
2.449LeuPro: 2.449 ± 0.41
2.275LeuGln: 2.275 ± 0.382
3.587LeuArg: 3.587 ± 0.681
5.336LeuSer: 5.336 ± 0.651
5.511LeuThr: 5.511 ± 0.657
4.462LeuVal: 4.462 ± 0.583
0.7LeuTrp: 0.7 ± 0.233
2.624LeuTyr: 2.624 ± 0.539
0.0LeuXaa: 0.0 ± 0.0
Met
1.575MetAla: 1.575 ± 0.406
0.087MetCys: 0.087 ± 0.102
0.7MetAsp: 0.7 ± 0.228
1.487MetGlu: 1.487 ± 0.355
1.05MetPhe: 1.05 ± 0.244
1.225MetGly: 1.225 ± 0.34
0.35MetHis: 0.35 ± 0.191
1.837MetIle: 1.837 ± 0.344
3.149MetLys: 3.149 ± 0.564
2.1MetLeu: 2.1 ± 0.357
0.787MetMet: 0.787 ± 0.322
1.4MetAsn: 1.4 ± 0.294
0.962MetPro: 0.962 ± 0.244
0.962MetGln: 0.962 ± 0.379
0.612MetArg: 0.612 ± 0.183
1.575MetSer: 1.575 ± 0.49
1.575MetThr: 1.575 ± 0.294
1.312MetVal: 1.312 ± 0.374
0.087MetTrp: 0.087 ± 0.07
1.4MetTyr: 1.4 ± 0.398
0.0MetXaa: 0.0 ± 0.0
Asn
4.899AsnAla: 4.899 ± 1.027
0.262AsnCys: 0.262 ± 0.145
4.024AsnAsp: 4.024 ± 0.44
3.849AsnGlu: 3.849 ± 0.597
3.062AsnPhe: 3.062 ± 0.526
6.561AsnGly: 6.561 ± 0.99
0.875AsnHis: 0.875 ± 0.255
4.199AsnIle: 4.199 ± 0.476
4.724AsnLys: 4.724 ± 0.611
5.249AsnLeu: 5.249 ± 0.492
0.787AsnMet: 0.787 ± 0.242
4.024AsnAsn: 4.024 ± 0.59
2.974AsnPro: 2.974 ± 0.536
3.149AsnGln: 3.149 ± 0.667
2.537AsnArg: 2.537 ± 0.549
3.412AsnSer: 3.412 ± 0.644
3.324AsnThr: 3.324 ± 0.578
3.499AsnVal: 3.499 ± 0.464
1.575AsnTrp: 1.575 ± 0.351
2.624AsnTyr: 2.624 ± 0.445
0.0AsnXaa: 0.0 ± 0.0
Pro
1.662ProAla: 1.662 ± 0.368
0.0ProCys: 0.0 ± 0.0
1.137ProAsp: 1.137 ± 0.309
1.662ProGlu: 1.662 ± 0.456
1.312ProPhe: 1.312 ± 0.36
1.487ProGly: 1.487 ± 0.613
0.35ProHis: 0.35 ± 0.165
1.575ProIle: 1.575 ± 0.389
3.762ProLys: 3.762 ± 0.642
2.449ProLeu: 2.449 ± 0.38
0.262ProMet: 0.262 ± 0.16
3.062ProAsn: 3.062 ± 0.341
0.525ProPro: 0.525 ± 0.265
1.75ProGln: 1.75 ± 0.4
1.4ProArg: 1.4 ± 0.437
2.887ProSer: 2.887 ± 0.45
2.1ProThr: 2.1 ± 0.48
1.225ProVal: 1.225 ± 0.37
0.437ProTrp: 0.437 ± 0.141
1.4ProTyr: 1.4 ± 0.465
0.0ProXaa: 0.0 ± 0.0
Gln
3.499GlnAla: 3.499 ± 0.746
0.262GlnCys: 0.262 ± 0.147
2.275GlnAsp: 2.275 ± 0.396
2.712GlnGlu: 2.712 ± 0.583
1.837GlnPhe: 1.837 ± 0.425
3.149GlnGly: 3.149 ± 0.775
0.35GlnHis: 0.35 ± 0.155
2.275GlnIle: 2.275 ± 0.547
3.412GlnLys: 3.412 ± 0.497
3.587GlnLeu: 3.587 ± 0.392
1.75GlnMet: 1.75 ± 0.392
2.624GlnAsn: 2.624 ± 0.509
0.612GlnPro: 0.612 ± 0.293
3.237GlnGln: 3.237 ± 0.777
1.662GlnArg: 1.662 ± 0.317
2.362GlnSer: 2.362 ± 0.598
3.149GlnThr: 3.149 ± 0.402
2.275GlnVal: 2.275 ± 0.509
0.875GlnTrp: 0.875 ± 0.304
2.187GlnTyr: 2.187 ± 0.439
0.0GlnXaa: 0.0 ± 0.0
Arg
2.362ArgAla: 2.362 ± 0.437
0.087ArgCys: 0.087 ± 0.078
3.062ArgAsp: 3.062 ± 0.482
2.362ArgGlu: 2.362 ± 0.616
1.575ArgPhe: 1.575 ± 0.368
1.925ArgGly: 1.925 ± 0.422
0.7ArgHis: 0.7 ± 0.24
2.799ArgIle: 2.799 ± 0.487
2.624ArgLys: 2.624 ± 0.568
3.237ArgLeu: 3.237 ± 0.585
1.137ArgMet: 1.137 ± 0.335
2.187ArgAsn: 2.187 ± 0.345
0.962ArgPro: 0.962 ± 0.289
2.624ArgGln: 2.624 ± 0.459
1.137ArgArg: 1.137 ± 0.279
1.575ArgSer: 1.575 ± 0.401
2.799ArgThr: 2.799 ± 0.641
2.362ArgVal: 2.362 ± 0.378
1.225ArgTrp: 1.225 ± 0.337
2.624ArgTyr: 2.624 ± 0.548
0.0ArgXaa: 0.0 ± 0.0
Ser
3.499SerAla: 3.499 ± 0.405
0.437SerCys: 0.437 ± 0.247
4.637SerAsp: 4.637 ± 0.498
3.587SerGlu: 3.587 ± 0.44
2.887SerPhe: 2.887 ± 0.506
4.374SerGly: 4.374 ± 0.561
0.875SerHis: 0.875 ± 0.259
3.499SerIle: 3.499 ± 0.503
5.249SerLys: 5.249 ± 0.814
4.112SerLeu: 4.112 ± 0.539
1.75SerMet: 1.75 ± 0.406
4.724SerAsn: 4.724 ± 0.783
1.925SerPro: 1.925 ± 0.379
2.974SerGln: 2.974 ± 0.533
2.624SerArg: 2.624 ± 0.663
4.024SerSer: 4.024 ± 0.724
3.849SerThr: 3.849 ± 0.544
5.161SerVal: 5.161 ± 0.643
0.525SerTrp: 0.525 ± 0.222
2.362SerTyr: 2.362 ± 0.526
0.0SerXaa: 0.0 ± 0.0
Thr
5.161ThrAla: 5.161 ± 0.601
0.262ThrCys: 0.262 ± 0.132
3.849ThrAsp: 3.849 ± 0.633
3.499ThrGlu: 3.499 ± 0.613
2.799ThrPhe: 2.799 ± 0.538
4.112ThrGly: 4.112 ± 0.625
0.875ThrHis: 0.875 ± 0.234
4.549ThrIle: 4.549 ± 0.866
4.811ThrLys: 4.811 ± 0.803
6.299ThrLeu: 6.299 ± 0.668
0.7ThrMet: 0.7 ± 0.264
4.899ThrAsn: 4.899 ± 0.803
1.925ThrPro: 1.925 ± 0.402
2.449ThrGln: 2.449 ± 0.475
2.1ThrArg: 2.1 ± 0.357
3.937ThrSer: 3.937 ± 0.54
3.499ThrThr: 3.499 ± 0.702
3.587ThrVal: 3.587 ± 0.505
0.962ThrTrp: 0.962 ± 0.249
3.149ThrTyr: 3.149 ± 0.648
0.0ThrXaa: 0.0 ± 0.0
Val
3.849ValAla: 3.849 ± 0.601
0.35ValCys: 0.35 ± 0.163
4.811ValAsp: 4.811 ± 0.505
4.462ValGlu: 4.462 ± 0.666
2.275ValPhe: 2.275 ± 0.417
4.199ValGly: 4.199 ± 0.491
0.875ValHis: 0.875 ± 0.288
3.149ValIle: 3.149 ± 0.384
4.724ValLys: 4.724 ± 0.547
2.887ValLeu: 2.887 ± 0.471
0.962ValMet: 0.962 ± 0.294
3.324ValAsn: 3.324 ± 0.605
2.362ValPro: 2.362 ± 0.403
1.837ValGln: 1.837 ± 0.401
2.1ValArg: 2.1 ± 0.606
4.811ValSer: 4.811 ± 0.68
4.899ValThr: 4.899 ± 0.789
3.324ValVal: 3.324 ± 0.598
0.962ValTrp: 0.962 ± 0.323
2.012ValTyr: 2.012 ± 0.411
0.0ValXaa: 0.0 ± 0.0
Trp
0.525TrpAla: 0.525 ± 0.224
0.0TrpCys: 0.0 ± 0.0
0.962TrpAsp: 0.962 ± 0.395
0.7TrpGlu: 0.7 ± 0.175
0.7TrpPhe: 0.7 ± 0.194
0.525TrpGly: 0.525 ± 0.199
0.262TrpHis: 0.262 ± 0.133
0.787TrpIle: 0.787 ± 0.211
0.787TrpLys: 0.787 ± 0.264
1.4TrpLeu: 1.4 ± 0.332
0.175TrpMet: 0.175 ± 0.115
1.225TrpAsn: 1.225 ± 0.474
0.087TrpPro: 0.087 ± 0.087
0.787TrpGln: 0.787 ± 0.215
0.787TrpArg: 0.787 ± 0.253
1.575TrpSer: 1.575 ± 0.446
1.225TrpThr: 1.225 ± 0.584
1.4TrpVal: 1.4 ± 0.288
0.35TrpTrp: 0.35 ± 0.178
0.35TrpTyr: 0.35 ± 0.144
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.974TyrAla: 2.974 ± 0.55
0.612TyrCys: 0.612 ± 0.296
3.237TyrAsp: 3.237 ± 0.482
2.537TyrGlu: 2.537 ± 0.613
2.537TyrPhe: 2.537 ± 0.393
1.925TyrGly: 1.925 ± 0.393
0.787TyrHis: 0.787 ± 0.233
2.362TyrIle: 2.362 ± 0.378
3.149TyrLys: 3.149 ± 0.594
3.412TyrLeu: 3.412 ± 0.438
1.312TyrMet: 1.312 ± 0.39
2.275TyrAsn: 2.275 ± 0.437
1.225TyrPro: 1.225 ± 0.335
2.187TyrGln: 2.187 ± 0.409
1.662TyrArg: 1.662 ± 0.303
2.712TyrSer: 2.712 ± 0.632
2.624TyrThr: 2.624 ± 0.711
2.537TyrVal: 2.537 ± 0.465
0.087TyrTrp: 0.087 ± 0.092
1.75TyrTyr: 1.75 ± 0.605
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 46 proteins (11432 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski