Amino acid dipepetide frequency for Emiliania huxleyi virus 202

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.666AlaAla: 5.666 ± 0.315
0.981AlaCys: 0.981 ± 0.083
3.311AlaAsp: 3.311 ± 0.157
3.132AlaGlu: 3.132 ± 0.197
2.842AlaPhe: 2.842 ± 0.171
3.396AlaGly: 3.396 ± 0.194
1.357AlaHis: 1.357 ± 0.11
4.958AlaIle: 4.958 ± 0.201
3.61AlaLys: 3.61 ± 0.219
5.018AlaLeu: 5.018 ± 0.218
2.21AlaMet: 2.21 ± 0.15
3.362AlaAsn: 3.362 ± 0.203
3.789AlaPro: 3.789 ± 0.238
1.886AlaGln: 1.886 ± 0.144
3.166AlaArg: 3.166 ± 0.204
4.975AlaSer: 4.975 ± 0.217
3.806AlaThr: 3.806 ± 0.213
4.608AlaVal: 4.608 ± 0.229
0.674AlaTrp: 0.674 ± 0.082
2.321AlaTyr: 2.321 ± 0.151
0.0AlaXaa: 0.0 ± 0.0
Cys
1.118CysAla: 1.118 ± 0.116
0.546CysCys: 0.546 ± 0.076
0.99CysAsp: 0.99 ± 0.101
0.939CysGlu: 0.939 ± 0.128
0.631CysPhe: 0.631 ± 0.066
1.28CysGly: 1.28 ± 0.135
0.393CysHis: 0.393 ± 0.054
1.485CysIle: 1.485 ± 0.112
1.34CysLys: 1.34 ± 0.101
0.862CysLeu: 0.862 ± 0.098
0.717CysMet: 0.717 ± 0.084
1.186CysAsn: 1.186 ± 0.115
0.922CysPro: 0.922 ± 0.105
0.41CysGln: 0.41 ± 0.067
0.768CysArg: 0.768 ± 0.083
1.306CysSer: 1.306 ± 0.126
1.178CysThr: 1.178 ± 0.097
1.314CysVal: 1.314 ± 0.112
0.162CysTrp: 0.162 ± 0.042
0.717CysTyr: 0.717 ± 0.083
0.0CysXaa: 0.0 ± 0.0
Asp
4.233AspAla: 4.233 ± 0.237
0.93AspCys: 0.93 ± 0.101
4.096AspAsp: 4.096 ± 0.24
4.565AspGlu: 4.565 ± 0.228
2.057AspPhe: 2.057 ± 0.155
3.174AspGly: 3.174 ± 0.184
1.34AspHis: 1.34 ± 0.115
4.693AspIle: 4.693 ± 0.221
3.226AspLys: 3.226 ± 0.188
3.985AspLeu: 3.985 ± 0.19
1.801AspMet: 1.801 ± 0.124
2.893AspAsn: 2.893 ± 0.157
2.449AspPro: 2.449 ± 0.16
1.638AspGln: 1.638 ± 0.118
2.202AspArg: 2.202 ± 0.167
3.422AspSer: 3.422 ± 0.17
3.635AspThr: 3.635 ± 0.165
3.874AspVal: 3.874 ± 0.172
0.572AspTrp: 0.572 ± 0.058
2.082AspTyr: 2.082 ± 0.124
0.0AspXaa: 0.0 ± 0.0
Glu
2.662GluAla: 2.662 ± 0.199
1.05GluCys: 1.05 ± 0.114
2.833GluAsp: 2.833 ± 0.174
3.302GluGlu: 3.302 ± 0.235
2.355GluPhe: 2.355 ± 0.135
1.971GluGly: 1.971 ± 0.126
1.374GluHis: 1.374 ± 0.124
3.849GluIle: 3.849 ± 0.209
3.243GluLys: 3.243 ± 0.177
4.873GluLeu: 4.873 ± 0.217
1.749GluMet: 1.749 ± 0.136
3.106GluAsn: 3.106 ± 0.176
1.929GluPro: 1.929 ± 0.146
2.065GluGln: 2.065 ± 0.126
2.705GluArg: 2.705 ± 0.141
3.183GluSer: 3.183 ± 0.171
3.558GluThr: 3.558 ± 0.195
3.029GluVal: 3.029 ± 0.198
0.666GluTrp: 0.666 ± 0.081
2.859GluTyr: 2.859 ± 0.155
0.0GluXaa: 0.0 ± 0.0
Phe
2.628PheAla: 2.628 ± 0.166
0.7PheCys: 0.7 ± 0.089
2.705PheAsp: 2.705 ± 0.165
2.108PheGlu: 2.108 ± 0.134
1.587PhePhe: 1.587 ± 0.131
2.389PheGly: 2.389 ± 0.143
0.913PheHis: 0.913 ± 0.083
3.516PheIle: 3.516 ± 0.191
1.954PheLys: 1.954 ± 0.136
2.867PheLeu: 2.867 ± 0.17
1.545PheMet: 1.545 ± 0.13
2.355PheAsn: 2.355 ± 0.133
1.758PhePro: 1.758 ± 0.117
0.836PheGln: 0.836 ± 0.09
1.485PheArg: 1.485 ± 0.105
3.021PheSer: 3.021 ± 0.162
2.799PheThr: 2.799 ± 0.17
3.072PheVal: 3.072 ± 0.177
0.41PheTrp: 0.41 ± 0.06
1.545PheTyr: 1.545 ± 0.116
0.0PheXaa: 0.0 ± 0.0
Gly
3.465GlyAla: 3.465 ± 0.188
1.058GlyCys: 1.058 ± 0.112
3.055GlyAsp: 3.055 ± 0.165
2.236GlyGlu: 2.236 ± 0.164
2.296GlyPhe: 2.296 ± 0.158
3.277GlyGly: 3.277 ± 0.225
1.212GlyHis: 1.212 ± 0.115
4.369GlyIle: 4.369 ± 0.25
3.294GlyLys: 3.294 ± 0.218
3.43GlyLeu: 3.43 ± 0.193
1.775GlyMet: 1.775 ± 0.144
2.918GlyAsn: 2.918 ± 0.191
1.758GlyPro: 1.758 ± 0.12
1.348GlyGln: 1.348 ± 0.118
2.261GlyArg: 2.261 ± 0.126
3.686GlySer: 3.686 ± 0.21
3.499GlyThr: 3.499 ± 0.213
3.49GlyVal: 3.49 ± 0.188
0.768GlyTrp: 0.768 ± 0.078
2.347GlyTyr: 2.347 ± 0.147
0.0GlyXaa: 0.0 ± 0.0
His
1.826HisAla: 1.826 ± 0.14
0.512HisCys: 0.512 ± 0.071
1.374HisAsp: 1.374 ± 0.103
1.195HisGlu: 1.195 ± 0.088
0.998HisPhe: 0.998 ± 0.081
1.399HisGly: 1.399 ± 0.118
0.913HisHis: 0.913 ± 0.178
1.912HisIle: 1.912 ± 0.14
1.442HisLys: 1.442 ± 0.12
1.758HisLeu: 1.758 ± 0.141
0.836HisMet: 0.836 ± 0.076
1.246HisAsn: 1.246 ± 0.103
1.417HisPro: 1.417 ± 0.123
0.828HisGln: 0.828 ± 0.091
1.178HisArg: 1.178 ± 0.104
1.417HisSer: 1.417 ± 0.12
1.613HisThr: 1.613 ± 0.132
1.886HisVal: 1.886 ± 0.121
0.213HisTrp: 0.213 ± 0.041
0.973HisTyr: 0.973 ± 0.092
0.0HisXaa: 0.0 ± 0.0
Ile
5.368IleAla: 5.368 ± 0.211
1.468IleCys: 1.468 ± 0.102
4.216IleAsp: 4.216 ± 0.189
3.533IleGlu: 3.533 ± 0.184
3.021IlePhe: 3.021 ± 0.17
4.207IleGly: 4.207 ± 0.174
2.022IleHis: 2.022 ± 0.133
5.453IleIle: 5.453 ± 0.262
4.446IleLys: 4.446 ± 0.247
5.513IleLeu: 5.513 ± 0.234
1.988IleMet: 1.988 ± 0.11
3.78IleAsn: 3.78 ± 0.21
3.593IlePro: 3.593 ± 0.175
2.253IleGln: 2.253 ± 0.143
3.294IleArg: 3.294 ± 0.189
5.103IleSer: 5.103 ± 0.182
4.77IleThr: 4.77 ± 0.225
5.146IleVal: 5.146 ± 0.185
0.7IleTrp: 0.7 ± 0.077
2.876IleTyr: 2.876 ± 0.185
0.0IleXaa: 0.0 ± 0.0
Lys
2.978LysAla: 2.978 ± 0.187
1.271LysCys: 1.271 ± 0.113
2.825LysAsp: 2.825 ± 0.183
3.064LysGlu: 3.064 ± 0.194
2.33LysPhe: 2.33 ± 0.139
2.065LysGly: 2.065 ± 0.157
1.98LysHis: 1.98 ± 0.151
3.891LysIle: 3.891 ± 0.216
5.538LysLys: 5.538 ± 0.302
4.753LysLeu: 4.753 ± 0.266
2.022LysMet: 2.022 ± 0.162
3.985LysAsn: 3.985 ± 0.204
2.543LysPro: 2.543 ± 0.182
2.338LysGln: 2.338 ± 0.141
3.823LysArg: 3.823 ± 0.227
3.661LysSer: 3.661 ± 0.174
4.011LysThr: 4.011 ± 0.213
3.311LysVal: 3.311 ± 0.205
0.785LysTrp: 0.785 ± 0.094
3.61LysTyr: 3.61 ± 0.191
0.0LysXaa: 0.0 ± 0.0
Leu
5.137LeuAla: 5.137 ± 0.204
1.323LeuCys: 1.323 ± 0.109
3.942LeuAsp: 3.942 ± 0.198
3.661LeuGlu: 3.661 ± 0.187
3.712LeuPhe: 3.712 ± 0.209
3.601LeuGly: 3.601 ± 0.214
1.843LeuHis: 1.843 ± 0.141
5.077LeuIle: 5.077 ± 0.216
4.497LeuLys: 4.497 ± 0.24
6.4LeuLeu: 6.4 ± 0.265
2.048LeuMet: 2.048 ± 0.141
3.874LeuAsn: 3.874 ± 0.186
4.036LeuPro: 4.036 ± 0.218
2.33LeuGln: 2.33 ± 0.138
3.448LeuArg: 3.448 ± 0.187
6.101LeuSer: 6.101 ± 0.244
5.188LeuThr: 5.188 ± 0.221
4.625LeuVal: 4.625 ± 0.215
0.811LeuTrp: 0.811 ± 0.085
3.413LeuTyr: 3.413 ± 0.201
0.0LeuXaa: 0.0 ± 0.0
Met
2.099MetAla: 2.099 ± 0.154
0.452MetCys: 0.452 ± 0.06
1.886MetAsp: 1.886 ± 0.135
1.724MetGlu: 1.724 ± 0.134
1.365MetPhe: 1.365 ± 0.113
1.391MetGly: 1.391 ± 0.115
1.05MetHis: 1.05 ± 0.091
1.894MetIle: 1.894 ± 0.118
1.886MetLys: 1.886 ± 0.134
2.381MetLeu: 2.381 ± 0.147
1.118MetMet: 1.118 ± 0.121
1.425MetAsn: 1.425 ± 0.114
1.553MetPro: 1.553 ± 0.113
1.135MetGln: 1.135 ± 0.079
1.382MetArg: 1.382 ± 0.116
2.79MetSer: 2.79 ± 0.14
1.954MetThr: 1.954 ± 0.122
1.51MetVal: 1.51 ± 0.125
0.444MetTrp: 0.444 ± 0.07
1.818MetTyr: 1.818 ± 0.144
0.0MetXaa: 0.0 ± 0.0
Asn
4.122AsnAla: 4.122 ± 0.233
0.751AsnCys: 0.751 ± 0.095
3.635AsnAsp: 3.635 ± 0.181
2.893AsnGlu: 2.893 ± 0.168
1.715AsnPhe: 1.715 ± 0.119
3.729AsnGly: 3.729 ± 0.22
1.109AsnHis: 1.109 ± 0.092
4.233AsnIle: 4.233 ± 0.189
3.891AsnLys: 3.891 ± 0.213
3.823AsnLeu: 3.823 ± 0.208
1.664AsnMet: 1.664 ± 0.115
3.627AsnAsn: 3.627 ± 0.299
2.611AsnPro: 2.611 ± 0.143
1.476AsnGln: 1.476 ± 0.112
2.534AsnArg: 2.534 ± 0.175
3.379AsnSer: 3.379 ± 0.163
3.891AsnThr: 3.891 ± 0.184
3.55AsnVal: 3.55 ± 0.185
0.503AsnTrp: 0.503 ± 0.059
2.031AsnTyr: 2.031 ± 0.151
0.0AsnXaa: 0.0 ± 0.0
Pro
2.688ProAla: 2.688 ± 0.18
0.819ProCys: 0.819 ± 0.095
2.867ProAsp: 2.867 ± 0.145
2.654ProGlu: 2.654 ± 0.189
1.954ProPhe: 1.954 ± 0.132
2.603ProGly: 2.603 ± 0.156
0.998ProHis: 0.998 ± 0.101
3.055ProIle: 3.055 ± 0.154
2.432ProLys: 2.432 ± 0.149
3.627ProLeu: 3.627 ± 0.22
1.169ProMet: 1.169 ± 0.102
2.415ProAsn: 2.415 ± 0.156
10.616ProPro: 10.616 ± 2.87
1.314ProGln: 1.314 ± 0.105
2.185ProArg: 2.185 ± 0.159
6.562ProSer: 6.562 ± 1.07
3.533ProThr: 3.533 ± 0.213
3.866ProVal: 3.866 ± 0.205
0.486ProTrp: 0.486 ± 0.071
1.903ProTyr: 1.903 ± 0.134
0.0ProXaa: 0.0 ± 0.0
Gln
1.766GlnAla: 1.766 ± 0.114
0.683GlnCys: 0.683 ± 0.092
1.118GlnAsp: 1.118 ± 0.105
1.417GlnGlu: 1.417 ± 0.12
1.229GlnPhe: 1.229 ± 0.112
1.161GlnGly: 1.161 ± 0.101
0.853GlnHis: 0.853 ± 0.076
2.236GlnIle: 2.236 ± 0.134
2.082GlnLys: 2.082 ± 0.157
2.765GlnLeu: 2.765 ± 0.16
1.024GlnMet: 1.024 ± 0.084
1.673GlnAsn: 1.673 ± 0.127
1.459GlnPro: 1.459 ± 0.12
1.271GlnGln: 1.271 ± 0.135
1.852GlnArg: 1.852 ± 0.143
2.168GlnSer: 2.168 ± 0.171
1.988GlnThr: 1.988 ± 0.145
1.801GlnVal: 1.801 ± 0.121
0.375GlnTrp: 0.375 ± 0.056
1.382GlnTyr: 1.382 ± 0.114
0.0GlnXaa: 0.0 ± 0.0
Arg
3.183ArgAla: 3.183 ± 0.176
0.819ArgCys: 0.819 ± 0.095
2.552ArgAsp: 2.552 ± 0.175
2.321ArgGlu: 2.321 ± 0.158
1.758ArgPhe: 1.758 ± 0.119
2.219ArgGly: 2.219 ± 0.137
1.306ArgHis: 1.306 ± 0.113
3.388ArgIle: 3.388 ± 0.195
3.081ArgLys: 3.081 ± 0.161
3.456ArgLeu: 3.456 ± 0.171
1.656ArgMet: 1.656 ± 0.121
3.055ArgAsn: 3.055 ± 0.161
2.236ArgPro: 2.236 ± 0.142
1.749ArgGln: 1.749 ± 0.121
3.081ArgArg: 3.081 ± 0.223
3.345ArgSer: 3.345 ± 0.206
2.79ArgThr: 2.79 ± 0.128
3.081ArgVal: 3.081 ± 0.162
0.503ArgTrp: 0.503 ± 0.06
1.98ArgTyr: 1.98 ± 0.123
0.0ArgXaa: 0.0 ± 0.0
Ser
4.523SerAla: 4.523 ± 0.187
1.391SerCys: 1.391 ± 0.101
4.42SerAsp: 4.42 ± 0.217
3.874SerGlu: 3.874 ± 0.198
2.944SerPhe: 2.944 ± 0.149
4.028SerGly: 4.028 ± 0.195
1.715SerHis: 1.715 ± 0.113
4.967SerIle: 4.967 ± 0.224
3.934SerLys: 3.934 ± 0.212
5.188SerLeu: 5.188 ± 0.218
2.159SerMet: 2.159 ± 0.139
3.797SerAsn: 3.797 ± 0.192
5.24SerPro: 5.24 ± 0.92
2.074SerGln: 2.074 ± 0.154
3.593SerArg: 3.593 ± 0.22
6.195SerSer: 6.195 ± 0.314
4.839SerThr: 4.839 ± 0.22
5.419SerVal: 5.419 ± 0.222
0.777SerTrp: 0.777 ± 0.078
3.302SerTyr: 3.302 ± 0.182
0.0SerXaa: 0.0 ± 0.0
Thr
4.301ThrAla: 4.301 ± 0.212
1.297ThrCys: 1.297 ± 0.123
3.763ThrAsp: 3.763 ± 0.179
3.712ThrGlu: 3.712 ± 0.196
2.466ThrPhe: 2.466 ± 0.139
3.644ThrGly: 3.644 ± 0.181
1.681ThrHis: 1.681 ± 0.106
4.489ThrIle: 4.489 ± 0.183
3.857ThrLys: 3.857 ± 0.193
5.316ThrLeu: 5.316 ± 0.226
1.997ThrMet: 1.997 ± 0.13
3.072ThrAsn: 3.072 ± 0.145
4.036ThrPro: 4.036 ± 0.207
1.954ThrGln: 1.954 ± 0.135
3.32ThrArg: 3.32 ± 0.175
4.932ThrSer: 4.932 ± 0.196
4.711ThrThr: 4.711 ± 0.24
4.113ThrVal: 4.113 ± 0.211
0.828ThrTrp: 0.828 ± 0.09
2.458ThrTyr: 2.458 ± 0.161
0.0ThrXaa: 0.0 ± 0.0
Val
4.156ValAla: 4.156 ± 0.212
1.246ValCys: 1.246 ± 0.108
4.036ValAsp: 4.036 ± 0.187
3.226ValGlu: 3.226 ± 0.152
2.748ValPhe: 2.748 ± 0.147
3.26ValGly: 3.26 ± 0.2
1.417ValHis: 1.417 ± 0.12
4.864ValIle: 4.864 ± 0.208
3.507ValLys: 3.507 ± 0.174
5.316ValLeu: 5.316 ± 0.22
2.116ValMet: 2.116 ± 0.133
3.618ValAsn: 3.618 ± 0.169
3.772ValPro: 3.772 ± 0.21
1.843ValGln: 1.843 ± 0.123
2.978ValArg: 2.978 ± 0.164
5.291ValSer: 5.291 ± 0.254
4.292ValThr: 4.292 ± 0.168
4.514ValVal: 4.514 ± 0.233
0.683ValTrp: 0.683 ± 0.073
2.799ValTyr: 2.799 ± 0.169
0.0ValXaa: 0.0 ± 0.0
Trp
0.64TrpAla: 0.64 ± 0.082
0.265TrpCys: 0.265 ± 0.048
0.529TrpAsp: 0.529 ± 0.07
0.384TrpGlu: 0.384 ± 0.058
0.555TrpPhe: 0.555 ± 0.067
0.631TrpGly: 0.631 ± 0.077
0.393TrpHis: 0.393 ± 0.058
0.649TrpIle: 0.649 ± 0.057
0.777TrpLys: 0.777 ± 0.079
0.879TrpLeu: 0.879 ± 0.088
0.375TrpMet: 0.375 ± 0.065
0.7TrpAsn: 0.7 ± 0.08
0.41TrpPro: 0.41 ± 0.063
0.341TrpGln: 0.341 ± 0.053
0.435TrpArg: 0.435 ± 0.058
0.828TrpSer: 0.828 ± 0.069
0.725TrpThr: 0.725 ± 0.082
0.657TrpVal: 0.657 ± 0.086
0.256TrpTrp: 0.256 ± 0.047
0.606TrpTyr: 0.606 ± 0.074
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.517TyrAla: 2.517 ± 0.143
0.7TyrCys: 0.7 ± 0.093
2.714TyrAsp: 2.714 ± 0.161
2.424TyrGlu: 2.424 ± 0.134
1.63TyrPhe: 1.63 ± 0.136
2.116TyrGly: 2.116 ± 0.132
1.067TyrHis: 1.067 ± 0.1
3.772TyrIle: 3.772 ± 0.186
2.748TyrLys: 2.748 ± 0.199
2.859TyrLeu: 2.859 ± 0.156
1.28TyrMet: 1.28 ± 0.101
3.081TyrAsn: 3.081 ± 0.155
1.621TyrPro: 1.621 ± 0.112
1.212TyrGln: 1.212 ± 0.118
1.869TyrArg: 1.869 ± 0.125
3.012TyrSer: 3.012 ± 0.168
3.166TyrThr: 3.166 ± 0.18
2.816TyrVal: 2.816 ± 0.162
0.418TyrTrp: 0.418 ± 0.053
2.074TyrTyr: 2.074 ± 0.149
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 482 proteins (117186 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski