Amino acid dipepetide frequency for Listeria phage A006

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.317AlaAla: 5.317 ± 1.037
0.338AlaCys: 0.338 ± 0.178
3.123AlaAsp: 3.123 ± 0.553
4.811AlaGlu: 4.811 ± 0.692
1.772AlaPhe: 1.772 ± 0.455
5.149AlaGly: 5.149 ± 0.937
1.266AlaHis: 1.266 ± 0.322
5.317AlaIle: 5.317 ± 0.662
6.161AlaLys: 6.161 ± 0.798
5.824AlaLeu: 5.824 ± 0.728
2.11AlaMet: 2.11 ± 0.433
4.811AlaAsn: 4.811 ± 0.967
2.11AlaPro: 2.11 ± 0.477
3.038AlaGln: 3.038 ± 0.637
1.857AlaArg: 1.857 ± 0.44
4.727AlaSer: 4.727 ± 0.645
4.389AlaThr: 4.389 ± 0.494
3.123AlaVal: 3.123 ± 0.522
0.844AlaTrp: 0.844 ± 0.24
1.772AlaTyr: 1.772 ± 0.343
0.0AlaXaa: 0.0 ± 0.0
Cys
0.169CysAla: 0.169 ± 0.113
0.253CysCys: 0.253 ± 0.2
0.253CysAsp: 0.253 ± 0.13
0.675CysGlu: 0.675 ± 0.265
0.338CysPhe: 0.338 ± 0.18
0.506CysGly: 0.506 ± 0.25
0.084CysHis: 0.084 ± 0.079
0.338CysIle: 0.338 ± 0.196
0.591CysLys: 0.591 ± 0.265
0.591CysLeu: 0.591 ± 0.241
0.338CysMet: 0.338 ± 0.173
0.422CysAsn: 0.422 ± 0.174
0.253CysPro: 0.253 ± 0.158
0.0CysGln: 0.0 ± 0.0
0.338CysArg: 0.338 ± 0.177
0.169CysSer: 0.169 ± 0.098
0.338CysThr: 0.338 ± 0.182
0.506CysVal: 0.506 ± 0.199
0.0CysTrp: 0.0 ± 0.0
0.591CysTyr: 0.591 ± 0.233
0.0CysXaa: 0.0 ± 0.0
Asp
3.714AspAla: 3.714 ± 0.53
0.506AspCys: 0.506 ± 0.263
3.883AspAsp: 3.883 ± 0.614
5.317AspGlu: 5.317 ± 0.685
3.714AspPhe: 3.714 ± 0.479
3.967AspGly: 3.967 ± 0.637
0.675AspHis: 0.675 ± 0.263
4.473AspIle: 4.473 ± 0.605
5.571AspLys: 5.571 ± 0.999
5.739AspLeu: 5.739 ± 0.609
1.688AspMet: 1.688 ± 0.308
4.136AspAsn: 4.136 ± 0.569
1.519AspPro: 1.519 ± 0.381
1.435AspGln: 1.435 ± 0.384
1.688AspArg: 1.688 ± 0.406
3.714AspSer: 3.714 ± 0.658
2.616AspThr: 2.616 ± 0.409
2.87AspVal: 2.87 ± 0.422
1.097AspTrp: 1.097 ± 0.333
2.701AspTyr: 2.701 ± 0.373
0.0AspXaa: 0.0 ± 0.0
Glu
6.33GluAla: 6.33 ± 0.723
0.422GluCys: 0.422 ± 0.228
3.798GluAsp: 3.798 ± 0.605
6.077GluGlu: 6.077 ± 0.927
3.207GluPhe: 3.207 ± 0.511
3.376GluGly: 3.376 ± 0.42
1.35GluHis: 1.35 ± 0.407
6.415GluIle: 6.415 ± 0.564
8.356GluLys: 8.356 ± 1.279
7.765GluLeu: 7.765 ± 1.081
2.954GluMet: 2.954 ± 0.519
4.22GluAsn: 4.22 ± 0.806
1.857GluPro: 1.857 ± 0.463
3.292GluGln: 3.292 ± 0.558
3.798GluArg: 3.798 ± 0.645
4.389GluSer: 4.389 ± 0.506
4.22GluThr: 4.22 ± 0.748
5.908GluVal: 5.908 ± 0.603
1.013GluTrp: 1.013 ± 0.256
2.701GluTyr: 2.701 ± 0.524
0.0GluXaa: 0.0 ± 0.0
Phe
2.954PheAla: 2.954 ± 0.398
0.591PheCys: 0.591 ± 0.255
2.616PheAsp: 2.616 ± 0.522
3.545PheGlu: 3.545 ± 0.767
1.182PhePhe: 1.182 ± 0.34
2.532PheGly: 2.532 ± 0.429
0.338PheHis: 0.338 ± 0.152
3.376PheIle: 3.376 ± 0.599
3.123PheLys: 3.123 ± 0.38
2.532PheLeu: 2.532 ± 0.637
1.604PheMet: 1.604 ± 0.413
3.123PheAsn: 3.123 ± 0.472
0.928PhePro: 0.928 ± 0.256
1.266PheGln: 1.266 ± 0.37
1.435PheArg: 1.435 ± 0.417
2.448PheSer: 2.448 ± 0.498
2.701PheThr: 2.701 ± 0.473
2.616PheVal: 2.616 ± 0.625
0.506PheTrp: 0.506 ± 0.244
1.097PheTyr: 1.097 ± 0.395
0.0PheXaa: 0.0 ± 0.0
Gly
3.714GlyAla: 3.714 ± 0.663
0.506GlyCys: 0.506 ± 0.24
3.46GlyAsp: 3.46 ± 0.516
4.136GlyGlu: 4.136 ± 0.507
2.785GlyPhe: 2.785 ± 0.436
3.967GlyGly: 3.967 ± 0.677
0.506GlyHis: 0.506 ± 0.202
4.22GlyIle: 4.22 ± 0.479
3.967GlyLys: 3.967 ± 0.6
4.389GlyLeu: 4.389 ± 0.802
2.363GlyMet: 2.363 ± 0.476
3.038GlyAsn: 3.038 ± 0.676
1.266GlyPro: 1.266 ± 0.361
2.11GlyGln: 2.11 ± 0.398
2.701GlyArg: 2.701 ± 0.411
3.714GlySer: 3.714 ± 0.437
3.376GlyThr: 3.376 ± 0.561
3.629GlyVal: 3.629 ± 0.628
1.182GlyTrp: 1.182 ± 0.33
2.701GlyTyr: 2.701 ± 0.532
0.0GlyXaa: 0.0 ± 0.0
His
1.266HisAla: 1.266 ± 0.353
0.169HisCys: 0.169 ± 0.12
1.097HisAsp: 1.097 ± 0.325
0.76HisGlu: 0.76 ± 0.282
1.182HisPhe: 1.182 ± 0.339
0.844HisGly: 0.844 ± 0.319
0.591HisHis: 0.591 ± 0.266
0.928HisIle: 0.928 ± 0.357
0.506HisLys: 0.506 ± 0.179
1.182HisLeu: 1.182 ± 0.335
0.0HisMet: 0.0 ± 0.0
0.675HisAsn: 0.675 ± 0.333
0.675HisPro: 0.675 ± 0.254
0.253HisGln: 0.253 ± 0.179
0.506HisArg: 0.506 ± 0.207
1.097HisSer: 1.097 ± 0.292
0.76HisThr: 0.76 ± 0.251
1.266HisVal: 1.266 ± 0.363
0.338HisTrp: 0.338 ± 0.16
0.591HisTyr: 0.591 ± 0.244
0.0HisXaa: 0.0 ± 0.0
Ile
4.305IleAla: 4.305 ± 0.654
0.591IleCys: 0.591 ± 0.284
5.655IleAsp: 5.655 ± 0.56
6.921IleGlu: 6.921 ± 0.807
2.363IlePhe: 2.363 ± 0.572
3.798IleGly: 3.798 ± 0.659
1.604IleHis: 1.604 ± 0.37
4.389IleIle: 4.389 ± 0.675
7.343IleLys: 7.343 ± 0.76
4.727IleLeu: 4.727 ± 0.607
1.435IleMet: 1.435 ± 0.355
5.655IleAsn: 5.655 ± 0.859
2.11IlePro: 2.11 ± 0.523
3.292IleGln: 3.292 ± 0.53
2.363IleArg: 2.363 ± 0.447
3.798IleSer: 3.798 ± 0.513
4.389IleThr: 4.389 ± 0.773
3.46IleVal: 3.46 ± 0.534
0.76IleTrp: 0.76 ± 0.209
2.448IleTyr: 2.448 ± 0.438
0.0IleXaa: 0.0 ± 0.0
Lys
5.655LysAla: 5.655 ± 0.999
0.169LysCys: 0.169 ± 0.122
5.655LysAsp: 5.655 ± 0.459
9.031LysGlu: 9.031 ± 1.149
2.701LysPhe: 2.701 ± 0.464
5.064LysGly: 5.064 ± 0.669
1.772LysHis: 1.772 ± 0.366
6.077LysIle: 6.077 ± 0.733
8.44LysLys: 8.44 ± 1.092
7.596LysLeu: 7.596 ± 0.862
1.519LysMet: 1.519 ± 0.396
4.895LysAsn: 4.895 ± 0.638
2.448LysPro: 2.448 ± 0.352
4.558LysGln: 4.558 ± 0.565
3.46LysArg: 3.46 ± 0.522
5.824LysSer: 5.824 ± 0.828
7.343LysThr: 7.343 ± 1.069
4.98LysVal: 4.98 ± 0.627
0.928LysTrp: 0.928 ± 0.249
4.305LysTyr: 4.305 ± 0.691
0.0LysXaa: 0.0 ± 0.0
Leu
5.655LeuAla: 5.655 ± 0.851
0.591LeuCys: 0.591 ± 0.251
5.571LeuAsp: 5.571 ± 0.645
6.583LeuGlu: 6.583 ± 0.817
3.292LeuPhe: 3.292 ± 0.542
4.22LeuGly: 4.22 ± 0.55
0.76LeuHis: 0.76 ± 0.265
6.33LeuIle: 6.33 ± 0.886
7.512LeuLys: 7.512 ± 0.871
6.583LeuLeu: 6.583 ± 0.752
2.279LeuMet: 2.279 ± 0.441
7.09LeuAsn: 7.09 ± 0.707
2.785LeuPro: 2.785 ± 0.495
1.772LeuGln: 1.772 ± 0.361
3.629LeuArg: 3.629 ± 0.608
4.727LeuSer: 4.727 ± 0.582
4.98LeuThr: 4.98 ± 0.624
3.883LeuVal: 3.883 ± 0.56
0.675LeuTrp: 0.675 ± 0.276
2.448LeuTyr: 2.448 ± 0.571
0.0LeuXaa: 0.0 ± 0.0
Met
2.194MetAla: 2.194 ± 0.4
0.0MetCys: 0.0 ± 0.0
1.35MetAsp: 1.35 ± 0.302
1.266MetGlu: 1.266 ± 0.327
0.844MetPhe: 0.844 ± 0.289
1.266MetGly: 1.266 ± 0.367
0.338MetHis: 0.338 ± 0.178
1.519MetIle: 1.519 ± 0.41
2.616MetLys: 2.616 ± 0.533
2.363MetLeu: 2.363 ± 0.614
0.675MetMet: 0.675 ± 0.252
2.11MetAsn: 2.11 ± 0.427
0.844MetPro: 0.844 ± 0.266
1.266MetGln: 1.266 ± 0.318
1.013MetArg: 1.013 ± 0.251
2.785MetSer: 2.785 ± 0.422
2.026MetThr: 2.026 ± 0.386
0.928MetVal: 0.928 ± 0.254
0.169MetTrp: 0.169 ± 0.161
1.013MetTyr: 1.013 ± 0.32
0.0MetXaa: 0.0 ± 0.0
Asn
4.22AsnAla: 4.22 ± 0.979
0.338AsnCys: 0.338 ± 0.158
4.473AsnAsp: 4.473 ± 0.774
5.655AsnGlu: 5.655 ± 0.634
2.11AsnPhe: 2.11 ± 0.469
3.967AsnGly: 3.967 ± 0.608
1.266AsnHis: 1.266 ± 0.332
4.558AsnIle: 4.558 ± 0.653
6.921AsnLys: 6.921 ± 0.767
3.967AsnLeu: 3.967 ± 0.508
1.772AsnMet: 1.772 ± 0.493
4.389AsnAsn: 4.389 ± 0.738
1.519AsnPro: 1.519 ± 0.332
3.123AsnGln: 3.123 ± 0.607
2.363AsnArg: 2.363 ± 0.357
4.22AsnSer: 4.22 ± 0.537
3.038AsnThr: 3.038 ± 0.49
4.473AsnVal: 4.473 ± 0.553
0.76AsnTrp: 0.76 ± 0.443
2.616AsnTyr: 2.616 ± 0.498
0.0AsnXaa: 0.0 ± 0.0
Pro
2.448ProAla: 2.448 ± 0.516
0.084ProCys: 0.084 ± 0.085
2.026ProAsp: 2.026 ± 0.466
2.11ProGlu: 2.11 ± 0.554
1.013ProPhe: 1.013 ± 0.267
0.675ProGly: 0.675 ± 0.245
0.422ProHis: 0.422 ± 0.171
1.519ProIle: 1.519 ± 0.31
1.604ProLys: 1.604 ± 0.364
2.279ProLeu: 2.279 ± 0.517
0.506ProMet: 0.506 ± 0.264
1.604ProAsn: 1.604 ± 0.4
1.182ProPro: 1.182 ± 0.333
1.266ProGln: 1.266 ± 0.467
1.097ProArg: 1.097 ± 0.296
2.026ProSer: 2.026 ± 0.352
2.11ProThr: 2.11 ± 0.434
1.772ProVal: 1.772 ± 0.485
0.084ProTrp: 0.084 ± 0.079
0.591ProTyr: 0.591 ± 0.223
0.0ProXaa: 0.0 ± 0.0
Gln
2.026GlnAla: 2.026 ± 0.351
0.338GlnCys: 0.338 ± 0.165
1.435GlnAsp: 1.435 ± 0.312
2.954GlnGlu: 2.954 ± 0.539
1.435GlnPhe: 1.435 ± 0.365
1.35GlnGly: 1.35 ± 0.292
0.338GlnHis: 0.338 ± 0.235
2.532GlnIle: 2.532 ± 0.425
4.98GlnLys: 4.98 ± 0.828
3.46GlnLeu: 3.46 ± 0.542
0.844GlnMet: 0.844 ± 0.349
2.701GlnAsn: 2.701 ± 0.543
0.422GlnPro: 0.422 ± 0.176
1.266GlnGln: 1.266 ± 0.286
1.35GlnArg: 1.35 ± 0.382
1.857GlnSer: 1.857 ± 0.356
1.941GlnThr: 1.941 ± 0.425
2.532GlnVal: 2.532 ± 0.383
0.675GlnTrp: 0.675 ± 0.21
1.688GlnTyr: 1.688 ± 0.399
0.0GlnXaa: 0.0 ± 0.0
Arg
1.772ArgAla: 1.772 ± 0.361
0.253ArgCys: 0.253 ± 0.161
2.701ArgAsp: 2.701 ± 0.375
3.714ArgGlu: 3.714 ± 0.613
2.194ArgPhe: 2.194 ± 0.555
2.194ArgGly: 2.194 ± 0.411
0.506ArgHis: 0.506 ± 0.235
2.701ArgIle: 2.701 ± 0.6
4.305ArgLys: 4.305 ± 0.663
2.701ArgLeu: 2.701 ± 0.454
1.013ArgMet: 1.013 ± 0.363
2.363ArgAsn: 2.363 ± 0.416
0.844ArgPro: 0.844 ± 0.282
0.928ArgGln: 0.928 ± 0.306
1.013ArgArg: 1.013 ± 0.438
2.026ArgSer: 2.026 ± 0.435
2.363ArgThr: 2.363 ± 0.429
1.941ArgVal: 1.941 ± 0.404
0.675ArgTrp: 0.675 ± 0.199
1.604ArgTyr: 1.604 ± 0.401
0.0ArgXaa: 0.0 ± 0.0
Ser
4.22SerAla: 4.22 ± 0.641
0.253SerCys: 0.253 ± 0.155
4.305SerAsp: 4.305 ± 0.687
5.149SerGlu: 5.149 ± 0.685
3.038SerPhe: 3.038 ± 0.497
4.895SerGly: 4.895 ± 0.648
0.844SerHis: 0.844 ± 0.214
4.558SerIle: 4.558 ± 0.577
5.571SerLys: 5.571 ± 0.852
5.064SerLeu: 5.064 ± 0.668
1.688SerMet: 1.688 ± 0.511
4.389SerAsn: 4.389 ± 0.464
1.182SerPro: 1.182 ± 0.312
1.35SerGln: 1.35 ± 0.338
2.026SerArg: 2.026 ± 0.362
3.545SerSer: 3.545 ± 0.589
3.376SerThr: 3.376 ± 0.822
4.22SerVal: 4.22 ± 0.842
0.422SerTrp: 0.422 ± 0.174
2.448SerTyr: 2.448 ± 0.467
0.0SerXaa: 0.0 ± 0.0
Thr
4.558ThrAla: 4.558 ± 0.957
0.253ThrCys: 0.253 ± 0.141
2.954ThrAsp: 2.954 ± 0.438
4.389ThrGlu: 4.389 ± 0.621
2.532ThrPhe: 2.532 ± 0.519
3.883ThrGly: 3.883 ± 0.753
0.76ThrHis: 0.76 ± 0.283
4.811ThrIle: 4.811 ± 0.66
4.727ThrLys: 4.727 ± 0.712
4.305ThrLeu: 4.305 ± 0.46
1.519ThrMet: 1.519 ± 0.349
3.292ThrAsn: 3.292 ± 0.568
2.448ThrPro: 2.448 ± 0.399
1.857ThrGln: 1.857 ± 0.378
2.448ThrArg: 2.448 ± 0.427
4.642ThrSer: 4.642 ± 0.712
3.967ThrThr: 3.967 ± 0.787
3.883ThrVal: 3.883 ± 0.584
0.76ThrTrp: 0.76 ± 0.246
2.785ThrTyr: 2.785 ± 0.504
0.0ThrXaa: 0.0 ± 0.0
Val
4.98ValAla: 4.98 ± 0.732
0.338ValCys: 0.338 ± 0.19
3.46ValAsp: 3.46 ± 0.451
4.136ValGlu: 4.136 ± 0.668
2.363ValPhe: 2.363 ± 0.51
3.292ValGly: 3.292 ± 0.519
0.76ValHis: 0.76 ± 0.308
4.136ValIle: 4.136 ± 0.603
5.064ValLys: 5.064 ± 0.759
4.389ValLeu: 4.389 ± 0.584
1.266ValMet: 1.266 ± 0.415
3.292ValAsn: 3.292 ± 0.529
1.35ValPro: 1.35 ± 0.321
2.616ValGln: 2.616 ± 0.366
2.363ValArg: 2.363 ± 0.422
3.714ValSer: 3.714 ± 0.603
4.642ValThr: 4.642 ± 0.441
3.714ValVal: 3.714 ± 0.704
0.506ValTrp: 0.506 ± 0.197
1.857ValTyr: 1.857 ± 0.485
0.0ValXaa: 0.0 ± 0.0
Trp
0.506TrpAla: 0.506 ± 0.196
0.084TrpCys: 0.084 ± 0.081
0.928TrpAsp: 0.928 ± 0.3
0.844TrpGlu: 0.844 ± 0.356
0.338TrpPhe: 0.338 ± 0.171
0.675TrpGly: 0.675 ± 0.178
0.169TrpHis: 0.169 ± 0.12
1.097TrpIle: 1.097 ± 0.301
1.35TrpLys: 1.35 ± 0.409
1.857TrpLeu: 1.857 ± 0.479
0.338TrpMet: 0.338 ± 0.165
0.591TrpAsn: 0.591 ± 0.21
0.0TrpPro: 0.0 ± 0.0
0.253TrpGln: 0.253 ± 0.178
0.422TrpArg: 0.422 ± 0.166
0.844TrpSer: 0.844 ± 0.392
0.591TrpThr: 0.591 ± 0.288
0.422TrpVal: 0.422 ± 0.202
0.084TrpTrp: 0.084 ± 0.081
0.591TrpTyr: 0.591 ± 0.23
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.857TyrAla: 1.857 ± 0.344
0.675TyrCys: 0.675 ± 0.235
2.279TyrAsp: 2.279 ± 0.539
3.376TyrGlu: 3.376 ± 0.537
2.11TyrPhe: 2.11 ± 0.491
2.11TyrGly: 2.11 ± 0.447
0.338TyrHis: 0.338 ± 0.17
2.11TyrIle: 2.11 ± 0.429
3.714TyrLys: 3.714 ± 0.614
4.051TyrLeu: 4.051 ± 0.752
0.591TyrMet: 0.591 ± 0.247
3.038TyrAsn: 3.038 ± 0.41
0.675TyrPro: 0.675 ± 0.26
1.182TyrGln: 1.182 ± 0.304
1.941TyrArg: 1.941 ± 0.392
2.279TyrSer: 2.279 ± 0.407
1.604TyrThr: 1.604 ± 0.34
2.11TyrVal: 2.11 ± 0.359
0.506TyrTrp: 0.506 ± 0.214
2.026TyrTyr: 2.026 ± 0.359
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 62 proteins (11849 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski