Amino acid dipepetide frequency for [Clostridium] bolteae 90A9

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.166AlaAla: 9.166 ± 0.101
1.336AlaCys: 1.336 ± 0.026
4.726AlaAsp: 4.726 ± 0.054
5.338AlaGlu: 5.338 ± 0.059
3.147AlaPhe: 3.147 ± 0.047
7.793AlaGly: 7.793 ± 0.094
1.169AlaHis: 1.169 ± 0.029
4.781AlaIle: 4.781 ± 0.063
3.869AlaLys: 3.869 ± 0.054
7.294AlaLeu: 7.294 ± 0.068
2.871AlaMet: 2.871 ± 0.041
2.243AlaAsn: 2.243 ± 0.034
2.416AlaPro: 2.416 ± 0.038
2.575AlaGln: 2.575 ± 0.039
3.826AlaArg: 3.826 ± 0.047
4.371AlaSer: 4.371 ± 0.055
2.966AlaThr: 2.966 ± 0.048
7.205AlaVal: 7.205 ± 0.075
0.755AlaTrp: 0.755 ± 0.021
2.795AlaTyr: 2.795 ± 0.038
0.0AlaXaa: 0.0 ± 0.0
Cys
1.163CysAla: 1.163 ± 0.024
0.339CysCys: 0.339 ± 0.014
0.817CysAsp: 0.817 ± 0.024
0.776CysGlu: 0.776 ± 0.021
0.701CysPhe: 0.701 ± 0.017
1.619CysGly: 1.619 ± 0.036
0.32CysHis: 0.32 ± 0.015
1.107CysIle: 1.107 ± 0.024
0.652CysLys: 0.652 ± 0.017
1.472CysLeu: 1.472 ± 0.031
0.5CysMet: 0.5 ± 0.017
0.555CysAsn: 0.555 ± 0.018
0.698CysPro: 0.698 ± 0.023
0.475CysGln: 0.475 ± 0.016
1.08CysArg: 1.08 ± 0.025
1.024CysSer: 1.024 ± 0.025
0.792CysThr: 0.792 ± 0.021
1.042CysVal: 1.042 ± 0.024
0.139CysTrp: 0.139 ± 0.01
0.576CysTyr: 0.576 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
4.018AspAla: 4.018 ± 0.05
0.894AspCys: 0.894 ± 0.023
2.671AspAsp: 2.671 ± 0.058
4.173AspGlu: 4.173 ± 0.057
2.479AspPhe: 2.479 ± 0.035
4.979AspGly: 4.979 ± 0.072
0.875AspHis: 0.875 ± 0.022
4.311AspIle: 4.311 ± 0.047
3.088AspLys: 3.088 ± 0.045
4.383AspLeu: 4.383 ± 0.052
2.151AspMet: 2.151 ± 0.036
2.017AspAsn: 2.017 ± 0.037
1.766AspPro: 1.766 ± 0.032
1.619AspGln: 1.619 ± 0.034
3.083AspArg: 3.083 ± 0.047
3.408AspSer: 3.408 ± 0.044
3.108AspThr: 3.108 ± 0.05
3.795AspVal: 3.795 ± 0.05
0.636AspTrp: 0.636 ± 0.018
2.616AspTyr: 2.616 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
5.999GluAla: 5.999 ± 0.066
0.837GluCys: 0.837 ± 0.023
4.341GluAsp: 4.341 ± 0.055
6.472GluGlu: 6.472 ± 0.078
2.365GluPhe: 2.365 ± 0.037
4.923GluGly: 4.923 ± 0.063
1.483GluHis: 1.483 ± 0.029
4.681GluIle: 4.681 ± 0.047
5.006GluLys: 5.006 ± 0.056
6.562GluLeu: 6.562 ± 0.065
2.349GluMet: 2.349 ± 0.036
3.239GluAsn: 3.239 ± 0.043
2.178GluPro: 2.178 ± 0.038
3.164GluGln: 3.164 ± 0.05
3.757GluArg: 3.757 ± 0.052
3.307GluSer: 3.307 ± 0.046
3.692GluThr: 3.692 ± 0.05
3.935GluVal: 3.935 ± 0.049
0.667GluTrp: 0.667 ± 0.018
2.857GluTyr: 2.857 ± 0.045
0.0GluXaa: 0.0 ± 0.0
Phe
2.959PheAla: 2.959 ± 0.044
0.744PheCys: 0.744 ± 0.02
2.376PheAsp: 2.376 ± 0.039
2.351PheGlu: 2.351 ± 0.036
1.782PhePhe: 1.782 ± 0.037
3.108PheGly: 3.108 ± 0.044
0.798PheHis: 0.798 ± 0.021
2.682PheIle: 2.682 ± 0.048
1.931PheLys: 1.931 ± 0.03
3.988PheLeu: 3.988 ± 0.069
1.32PheMet: 1.32 ± 0.027
1.441PheAsn: 1.441 ± 0.028
1.431PhePro: 1.431 ± 0.024
1.216PheGln: 1.216 ± 0.027
1.847PheArg: 1.847 ± 0.032
2.674PheSer: 2.674 ± 0.041
2.303PheThr: 2.303 ± 0.039
2.603PheVal: 2.603 ± 0.037
0.448PheTrp: 0.448 ± 0.017
1.68PheTyr: 1.68 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
5.949GlyAla: 5.949 ± 0.069
1.486GlyCys: 1.486 ± 0.033
3.828GlyAsp: 3.828 ± 0.051
4.992GlyGlu: 4.992 ± 0.062
3.256GlyPhe: 3.256 ± 0.045
5.873GlyGly: 5.873 ± 0.078
1.392GlyHis: 1.392 ± 0.033
6.565GlyIle: 6.565 ± 0.071
4.884GlyLys: 4.884 ± 0.06
6.804GlyLeu: 6.804 ± 0.071
2.933GlyMet: 2.933 ± 0.049
3.229GlyAsn: 3.229 ± 0.055
1.935GlyPro: 1.935 ± 0.052
2.694GlyGln: 2.694 ± 0.05
4.301GlyArg: 4.301 ± 0.06
4.752GlySer: 4.752 ± 0.066
4.742GlyThr: 4.742 ± 0.064
5.301GlyVal: 5.301 ± 0.065
0.931GlyTrp: 0.931 ± 0.026
3.422GlyTyr: 3.422 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
1.1HisAla: 1.1 ± 0.027
0.306HisCys: 0.306 ± 0.014
0.909HisAsp: 0.909 ± 0.02
1.077HisGlu: 1.077 ± 0.028
0.818HisPhe: 0.818 ± 0.023
1.407HisGly: 1.407 ± 0.032
0.397HisHis: 0.397 ± 0.02
1.374HisIle: 1.374 ± 0.026
0.907HisLys: 0.907 ± 0.022
1.571HisLeu: 1.571 ± 0.03
0.642HisMet: 0.642 ± 0.02
0.644HisAsn: 0.644 ± 0.017
0.925HisPro: 0.925 ± 0.022
0.58HisGln: 0.58 ± 0.016
0.865HisArg: 0.865 ± 0.024
1.001HisSer: 1.001 ± 0.023
0.922HisThr: 0.922 ± 0.023
1.202HisVal: 1.202 ± 0.024
0.17HisTrp: 0.17 ± 0.008
0.775HisTyr: 0.775 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
5.274IleAla: 5.274 ± 0.063
1.33IleCys: 1.33 ± 0.026
3.472IleAsp: 3.472 ± 0.049
3.978IleGlu: 3.978 ± 0.053
2.601IlePhe: 2.601 ± 0.049
4.995IleGly: 4.995 ± 0.059
1.399IleHis: 1.399 ± 0.028
4.588IleIle: 4.588 ± 0.057
3.381IleLys: 3.381 ± 0.05
6.805IleLeu: 6.805 ± 0.066
2.041IleMet: 2.041 ± 0.038
2.6IleAsn: 2.6 ± 0.043
3.286IlePro: 3.286 ± 0.049
2.359IleGln: 2.359 ± 0.038
3.912IleArg: 3.912 ± 0.048
4.53IleSer: 4.53 ± 0.056
3.966IleThr: 3.966 ± 0.049
4.284IleVal: 4.284 ± 0.051
0.705IleTrp: 0.705 ± 0.022
2.516IleTyr: 2.516 ± 0.042
0.0IleXaa: 0.0 ± 0.0
Lys
4.876LysAla: 4.876 ± 0.058
0.616LysCys: 0.616 ± 0.018
3.528LysAsp: 3.528 ± 0.046
5.319LysGlu: 5.319 ± 0.059
1.436LysPhe: 1.436 ± 0.029
4.194LysGly: 4.194 ± 0.046
0.895LysHis: 0.895 ± 0.021
3.563LysIle: 3.563 ± 0.049
4.378LysLys: 4.378 ± 0.057
4.533LysLeu: 4.533 ± 0.054
1.847LysMet: 1.847 ± 0.031
2.538LysAsn: 2.538 ± 0.037
1.949LysPro: 1.949 ± 0.04
2.065LysGln: 2.065 ± 0.036
2.944LysArg: 2.944 ± 0.042
2.876LysSer: 2.876 ± 0.045
3.134LysThr: 3.134 ± 0.042
3.531LysVal: 3.531 ± 0.044
0.579LysTrp: 0.579 ± 0.018
2.131LysTyr: 2.131 ± 0.035
0.0LysXaa: 0.0 ± 0.0
Leu
7.476LeuAla: 7.476 ± 0.073
1.591LeuCys: 1.591 ± 0.032
5.239LeuAsp: 5.239 ± 0.055
6.475LeuGlu: 6.475 ± 0.07
3.868LeuPhe: 3.868 ± 0.063
6.607LeuGly: 6.607 ± 0.075
1.524LeuHis: 1.524 ± 0.029
5.524LeuIle: 5.524 ± 0.065
5.818LeuLys: 5.818 ± 0.055
8.433LeuLeu: 8.433 ± 0.101
2.985LeuMet: 2.985 ± 0.045
3.535LeuAsn: 3.535 ± 0.043
3.751LeuPro: 3.751 ± 0.047
2.472LeuGln: 2.472 ± 0.036
4.011LeuArg: 4.011 ± 0.05
6.22LeuSer: 6.22 ± 0.074
5.074LeuThr: 5.074 ± 0.058
5.81LeuVal: 5.81 ± 0.065
0.83LeuTrp: 0.83 ± 0.021
3.318LeuTyr: 3.318 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
3.055MetAla: 3.055 ± 0.047
0.393MetCys: 0.393 ± 0.014
2.294MetAsp: 2.294 ± 0.039
3.087MetGlu: 3.087 ± 0.042
1.139MetPhe: 1.139 ± 0.028
2.711MetGly: 2.711 ± 0.044
0.44MetHis: 0.44 ± 0.015
2.095MetIle: 2.095 ± 0.041
2.457MetLys: 2.457 ± 0.04
2.851MetLeu: 2.851 ± 0.04
1.117MetMet: 1.117 ± 0.031
1.538MetAsn: 1.538 ± 0.029
1.275MetPro: 1.275 ± 0.025
0.985MetGln: 0.985 ± 0.024
1.452MetArg: 1.452 ± 0.028
1.878MetSer: 1.878 ± 0.033
1.909MetThr: 1.909 ± 0.034
2.406MetVal: 2.406 ± 0.039
0.259MetTrp: 0.259 ± 0.012
0.923MetTyr: 0.923 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
2.801AsnAla: 2.801 ± 0.038
0.575AsnCys: 0.575 ± 0.019
1.738AsnAsp: 1.738 ± 0.032
2.194AsnGlu: 2.194 ± 0.036
1.324AsnPhe: 1.324 ± 0.029
3.229AsnGly: 3.229 ± 0.049
0.803AsnHis: 0.803 ± 0.023
2.811AsnIle: 2.811 ± 0.043
1.859AsnLys: 1.859 ± 0.032
3.475AsnLeu: 3.475 ± 0.045
1.343AsnMet: 1.343 ± 0.025
1.354AsnAsn: 1.354 ± 0.03
2.06AsnPro: 2.06 ± 0.036
1.573AsnGln: 1.573 ± 0.034
2.243AsnArg: 2.243 ± 0.039
2.093AsnSer: 2.093 ± 0.037
2.071AsnThr: 2.071 ± 0.036
2.562AsnVal: 2.562 ± 0.042
0.389AsnTrp: 0.389 ± 0.016
1.556AsnTyr: 1.556 ± 0.03
0.0AsnXaa: 0.0 ± 0.0
Pro
3.042ProAla: 3.042 ± 0.049
0.508ProCys: 0.508 ± 0.019
2.649ProAsp: 2.649 ± 0.044
3.545ProGlu: 3.545 ± 0.05
1.591ProPhe: 1.591 ± 0.026
3.101ProGly: 3.101 ± 0.051
0.66ProHis: 0.66 ± 0.02
1.987ProIle: 1.987 ± 0.035
1.573ProLys: 1.573 ± 0.032
2.996ProLeu: 2.996 ± 0.044
1.108ProMet: 1.108 ± 0.025
1.119ProAsn: 1.119 ± 0.025
1.036ProPro: 1.036 ± 0.026
1.197ProGln: 1.197 ± 0.029
1.341ProArg: 1.341 ± 0.03
2.092ProSer: 2.092 ± 0.036
1.486ProThr: 1.486 ± 0.034
3.517ProVal: 3.517 ± 0.048
0.378ProTrp: 0.378 ± 0.014
1.547ProTyr: 1.547 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
3.064GlnAla: 3.064 ± 0.048
0.428GlnCys: 0.428 ± 0.015
1.82GlnAsp: 1.82 ± 0.035
2.794GlnGlu: 2.794 ± 0.047
1.185GlnPhe: 1.185 ± 0.026
2.467GlnGly: 2.467 ± 0.046
0.423GlnHis: 0.423 ± 0.015
2.388GlnIle: 2.388 ± 0.034
2.235GlnLys: 2.235 ± 0.039
2.85GlnLeu: 2.85 ± 0.045
1.372GlnMet: 1.372 ± 0.029
1.398GlnAsn: 1.398 ± 0.034
1.12GlnPro: 1.12 ± 0.029
1.171GlnGln: 1.171 ± 0.026
1.438GlnArg: 1.438 ± 0.031
1.763GlnSer: 1.763 ± 0.032
1.679GlnThr: 1.679 ± 0.032
2.441GlnVal: 2.441 ± 0.042
0.405GlnTrp: 0.405 ± 0.014
1.412GlnTyr: 1.412 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
3.258ArgAla: 3.258 ± 0.042
0.728ArgCys: 0.728 ± 0.019
2.787ArgAsp: 2.787 ± 0.041
4.531ArgGlu: 4.531 ± 0.054
2.1ArgPhe: 2.1 ± 0.032
3.056ArgGly: 3.056 ± 0.047
0.935ArgHis: 0.935 ± 0.022
3.809ArgIle: 3.809 ± 0.045
3.219ArgLys: 3.219 ± 0.043
4.859ArgLeu: 4.859 ± 0.057
1.927ArgMet: 1.927 ± 0.032
2.126ArgAsn: 2.126 ± 0.033
1.746ArgPro: 1.746 ± 0.036
2.153ArgGln: 2.153 ± 0.038
2.99ArgArg: 2.99 ± 0.05
2.48ArgSer: 2.48 ± 0.04
2.628ArgThr: 2.628 ± 0.036
2.993ArgVal: 2.993 ± 0.043
0.517ArgTrp: 0.517 ± 0.019
2.174ArgTyr: 2.174 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
4.393SerAla: 4.393 ± 0.049
0.939SerCys: 0.939 ± 0.026
3.039SerAsp: 3.039 ± 0.046
3.366SerGlu: 3.366 ± 0.049
2.614SerPhe: 2.614 ± 0.042
5.625SerGly: 5.625 ± 0.075
1.183SerHis: 1.183 ± 0.028
3.988SerIle: 3.988 ± 0.044
2.534SerLys: 2.534 ± 0.045
5.583SerLeu: 5.583 ± 0.068
2.063SerMet: 2.063 ± 0.035
1.918SerAsn: 1.918 ± 0.039
2.065SerPro: 2.065 ± 0.031
2.192SerGln: 2.192 ± 0.039
3.469SerArg: 3.469 ± 0.046
3.686SerSer: 3.686 ± 0.063
2.774SerThr: 2.774 ± 0.042
4.206SerVal: 4.206 ± 0.046
0.624SerTrp: 0.624 ± 0.02
2.346SerTyr: 2.346 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
4.964ThrAla: 4.964 ± 0.064
0.694ThrCys: 0.694 ± 0.018
3.04ThrAsp: 3.04 ± 0.046
3.473ThrGlu: 3.473 ± 0.055
2.033ThrPhe: 2.033 ± 0.036
5.296ThrGly: 5.296 ± 0.074
0.816ThrHis: 0.816 ± 0.018
3.557ThrIle: 3.557 ± 0.057
2.348ThrLys: 2.348 ± 0.035
4.57ThrLeu: 4.57 ± 0.054
1.578ThrMet: 1.578 ± 0.029
1.693ThrAsn: 1.693 ± 0.032
2.257ThrPro: 2.257 ± 0.037
1.499ThrGln: 1.499 ± 0.029
2.263ThrArg: 2.263 ± 0.034
2.983ThrSer: 2.983 ± 0.041
2.571ThrThr: 2.571 ± 0.044
4.44ThrVal: 4.44 ± 0.051
0.526ThrTrp: 0.526 ± 0.016
1.902ThrTyr: 1.902 ± 0.028
0.0ThrXaa: 0.0 ± 0.0
Val
4.718ValAla: 4.718 ± 0.061
1.283ValCys: 1.283 ± 0.029
3.733ValAsp: 3.733 ± 0.047
4.419ValGlu: 4.419 ± 0.049
3.073ValPhe: 3.073 ± 0.039
4.302ValGly: 4.302 ± 0.053
1.077ValHis: 1.077 ± 0.022
5.0ValIle: 5.0 ± 0.055
4.09ValLys: 4.09 ± 0.053
6.933ValLeu: 6.933 ± 0.069
2.46ValMet: 2.46 ± 0.034
2.781ValAsn: 2.781 ± 0.042
2.846ValPro: 2.846 ± 0.039
2.017ValGln: 2.017 ± 0.03
3.521ValArg: 3.521 ± 0.053
4.678ValSer: 4.678 ± 0.056
4.054ValThr: 4.054 ± 0.051
4.766ValVal: 4.766 ± 0.064
0.693ValTrp: 0.693 ± 0.021
2.705ValTyr: 2.705 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
0.648TrpAla: 0.648 ± 0.019
0.177TrpCys: 0.177 ± 0.01
0.654TrpAsp: 0.654 ± 0.021
0.696TrpGlu: 0.696 ± 0.022
0.441TrpPhe: 0.441 ± 0.017
0.757TrpGly: 0.757 ± 0.019
0.18TrpHis: 0.18 ± 0.01
0.649TrpIle: 0.649 ± 0.02
0.773TrpLys: 0.773 ± 0.022
0.98TrpLeu: 0.98 ± 0.023
0.379TrpMet: 0.379 ± 0.015
0.561TrpAsn: 0.561 ± 0.016
0.271TrpPro: 0.271 ± 0.013
0.408TrpGln: 0.408 ± 0.016
0.418TrpArg: 0.418 ± 0.016
0.52TrpSer: 0.52 ± 0.018
0.468TrpThr: 0.468 ± 0.016
0.586TrpVal: 0.586 ± 0.02
0.121TrpTrp: 0.121 ± 0.008
0.452TrpTyr: 0.452 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.721TyrAla: 2.721 ± 0.046
0.642TyrCys: 0.642 ± 0.019
2.408TyrAsp: 2.408 ± 0.041
2.757TyrGlu: 2.757 ± 0.041
1.731TyrPhe: 1.731 ± 0.038
3.227TyrGly: 3.227 ± 0.042
0.821TyrHis: 0.821 ± 0.019
2.566TyrIle: 2.566 ± 0.037
1.932TyrLys: 1.932 ± 0.04
3.621TyrLeu: 3.621 ± 0.057
1.277TyrMet: 1.277 ± 0.026
1.518TyrAsn: 1.518 ± 0.027
1.461TyrPro: 1.461 ± 0.027
1.438TyrGln: 1.438 ± 0.03
2.256TyrArg: 2.256 ± 0.036
2.273TyrSer: 2.273 ± 0.04
2.165TyrThr: 2.165 ± 0.036
2.525TyrVal: 2.525 ± 0.039
0.364TyrTrp: 0.364 ± 0.014
1.815TyrTyr: 1.815 ± 0.045
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5741 proteins (1888569 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski