Amino acid dipepetide frequency for Streptomyces yokosukanensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.653AlaAla: 21.653 ± 0.13	1.17AlaCys: 1.17 ± 0.022	8.492AlaAsp: 8.492 ± 0.071	8.847AlaGlu: 8.847 ± 0.081	3.61AlaPhe: 3.61 ± 0.04	12.921AlaGly: 12.921 ± 0.089	3.167AlaHis: 3.167 ± 0.045	3.336AlaIle: 3.336 ± 0.038	2.802AlaLys: 2.802 ± 0.041	15.109AlaLeu: 15.109 ± 0.097	2.468AlaMet: 2.468 ± 0.03	1.853AlaAsn: 1.853 ± 0.027	7.293AlaPro: 7.293 ± 0.082	4.141AlaGln: 4.141 ± 0.043	10.622AlaArg: 10.622 ± 0.076	5.935AlaSer: 5.935 ± 0.048	7.128AlaThr: 7.128 ± 0.055	12.476AlaVal: 12.476 ± 0.094	1.912AlaTrp: 1.912 ± 0.03	2.789AlaTyr: 2.789 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	1.169CysAla: 1.169 ± 0.023	0.096CysCys: 0.096 ± 0.007	0.499CysAsp: 0.499 ± 0.014	0.41CysGlu: 0.41 ± 0.013	0.222CysPhe: 0.222 ± 0.01	0.996CysGly: 0.996 ± 0.022	0.21CysHis: 0.21 ± 0.008	0.167CysIle: 0.167 ± 0.008	0.128CysLys: 0.128 ± 0.007	0.793CysLeu: 0.793 ± 0.016	0.122CysMet: 0.122 ± 0.007	0.142CysAsn: 0.142 ± 0.007	0.503CysPro: 0.503 ± 0.015	0.18CysGln: 0.18 ± 0.009	0.658CysArg: 0.658 ± 0.017	0.449CysSer: 0.449 ± 0.016	0.546CysThr: 0.546 ± 0.015	0.698CysVal: 0.698 ± 0.017	0.132CysTrp: 0.132 ± 0.007	0.151CysTyr: 0.151 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.682AspAla: 7.682 ± 0.062	0.456AspCys: 0.456 ± 0.016	3.44AspAsp: 3.44 ± 0.044	3.636AspGlu: 3.636 ± 0.042	1.66AspPhe: 1.66 ± 0.022	6.317AspGly: 6.317 ± 0.061	1.55AspHis: 1.55 ± 0.026	1.859AspIle: 1.859 ± 0.028	1.183AspLys: 1.183 ± 0.025	6.319AspLeu: 6.319 ± 0.05	0.816AspMet: 0.816 ± 0.017	0.938AspAsn: 0.938 ± 0.02	4.499AspPro: 4.499 ± 0.042	1.595AspGln: 1.595 ± 0.023	4.952AspArg: 4.952 ± 0.043	2.542AspSer: 2.542 ± 0.031	3.328AspThr: 3.328 ± 0.036	4.735AspVal: 4.735 ± 0.045	1.042AspTrp: 1.042 ± 0.02	1.109AspTyr: 1.109 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	7.3GluAla: 7.3 ± 0.062	0.378GluCys: 0.378 ± 0.011	2.726GluAsp: 2.726 ± 0.031	3.447GluGlu: 3.447 ± 0.045	1.435GluPhe: 1.435 ± 0.022	4.077GluGly: 4.077 ± 0.043	1.551GluHis: 1.551 ± 0.026	2.185GluIle: 2.185 ± 0.033	1.321GluLys: 1.321 ± 0.025	6.713GluLeu: 6.713 ± 0.068	0.835GluMet: 0.835 ± 0.018	0.966GluAsn: 0.966 ± 0.019	3.305GluPro: 3.305 ± 0.041	2.306GluGln: 2.306 ± 0.032	5.433GluArg: 5.433 ± 0.054	2.464GluSer: 2.464 ± 0.029	2.775GluThr: 2.775 ± 0.037	4.305GluVal: 4.305 ± 0.041	0.711GluTrp: 0.711 ± 0.018	1.047GluTyr: 1.047 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.75PheAla: 3.75 ± 0.045	0.274PheCys: 0.274 ± 0.011	1.952PheAsp: 1.952 ± 0.027	1.42PheGlu: 1.42 ± 0.026	0.858PhePhe: 0.858 ± 0.021	2.966PheGly: 2.966 ± 0.036	0.651PheHis: 0.651 ± 0.015	0.669PheIle: 0.669 ± 0.017	0.513PheLys: 0.513 ± 0.013	2.554PheLeu: 2.554 ± 0.041	0.387PheMet: 0.387 ± 0.013	0.531PheAsn: 0.531 ± 0.014	1.425PhePro: 1.425 ± 0.021	0.701PheGln: 0.701 ± 0.015	1.804PheArg: 1.804 ± 0.025	1.481PheSer: 1.481 ± 0.024	2.037PheThr: 2.037 ± 0.032	2.183PheVal: 2.183 ± 0.028	0.42PheTrp: 0.42 ± 0.013	0.57PheTyr: 0.57 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	11.226GlyAla: 11.226 ± 0.083	0.863GlyCys: 0.863 ± 0.02	5.056GlyAsp: 5.056 ± 0.048	4.878GlyGlu: 4.878 ± 0.047	2.842GlyPhe: 2.842 ± 0.037	8.659GlyGly: 8.659 ± 0.083	2.495GlyHis: 2.495 ± 0.035	3.404GlyIle: 3.404 ± 0.043	2.331GlyLys: 2.331 ± 0.038	9.337GlyLeu: 9.337 ± 0.063	1.925GlyMet: 1.925 ± 0.028	1.712GlyAsn: 1.712 ± 0.028	5.071GlyPro: 5.071 ± 0.05	2.721GlyGln: 2.721 ± 0.036	7.802GlyArg: 7.802 ± 0.061	5.297GlySer: 5.297 ± 0.056	6.482GlyThr: 6.482 ± 0.051	7.476GlyVal: 7.476 ± 0.06	1.733GlyTrp: 1.733 ± 0.029	2.285GlyTyr: 2.285 ± 0.03	0.0GlyXaa: 0.0 ± 0.0
His	2.885HisAla: 2.885 ± 0.033	0.235HisCys: 0.235 ± 0.009	1.418HisAsp: 1.418 ± 0.024	1.279HisGlu: 1.279 ± 0.021	0.671HisPhe: 0.671 ± 0.016	2.604HisGly: 2.604 ± 0.03	0.74HisHis: 0.74 ± 0.018	0.708HisIle: 0.708 ± 0.016	0.391HisLys: 0.391 ± 0.013	2.558HisLeu: 2.558 ± 0.031	0.369HisMet: 0.369 ± 0.01	0.37HisAsn: 0.37 ± 0.013	1.94HisPro: 1.94 ± 0.029	0.675HisGln: 0.675 ± 0.015	2.227HisArg: 2.227 ± 0.031	1.107HisSer: 1.107 ± 0.02	1.514HisThr: 1.514 ± 0.023	1.818HisVal: 1.818 ± 0.025	0.391HisTrp: 0.391 ± 0.011	0.51HisTyr: 0.51 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.752IleAla: 4.752 ± 0.051	0.283IleCys: 0.283 ± 0.01	2.186IleAsp: 2.186 ± 0.025	1.946IleGlu: 1.946 ± 0.026	0.662IlePhe: 0.662 ± 0.017	3.497IleGly: 3.497 ± 0.039	0.624IleHis: 0.624 ± 0.014	0.809IleIle: 0.809 ± 0.02	0.7IleLys: 0.7 ± 0.019	2.335IleLeu: 2.335 ± 0.038	0.423IleMet: 0.423 ± 0.014	0.661IleAsn: 0.661 ± 0.014	1.705IlePro: 1.705 ± 0.026	0.732IleGln: 0.732 ± 0.018	2.247IleArg: 2.247 ± 0.034	1.623IleSer: 1.623 ± 0.026	2.219IleThr: 2.219 ± 0.029	2.647IleVal: 2.647 ± 0.032	0.366IleTrp: 0.366 ± 0.011	0.53IleTyr: 0.53 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.93LysAla: 2.93 ± 0.04	0.118LysCys: 0.118 ± 0.007	1.37LysAsp: 1.37 ± 0.029	1.118LysGlu: 1.118 ± 0.022	0.446LysPhe: 0.446 ± 0.012	1.813LysGly: 1.813 ± 0.03	0.425LysHis: 0.425 ± 0.012	0.849LysIle: 0.849 ± 0.02	0.852LysLys: 0.852 ± 0.025	1.951LysLeu: 1.951 ± 0.031	0.38LysMet: 0.38 ± 0.012	0.557LysAsn: 0.557 ± 0.016	1.285LysPro: 1.285 ± 0.026	0.706LysGln: 0.706 ± 0.017	1.335LysArg: 1.335 ± 0.024	1.126LysSer: 1.126 ± 0.022	1.244LysThr: 1.244 ± 0.024	1.849LysVal: 1.849 ± 0.029	0.263LysTrp: 0.263 ± 0.01	0.447LysTyr: 0.447 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	15.631LeuAla: 15.631 ± 0.104	0.854LeuCys: 0.854 ± 0.018	6.826LeuAsp: 6.826 ± 0.059	4.562LeuGlu: 4.562 ± 0.046	2.591LeuPhe: 2.591 ± 0.033	9.378LeuGly: 9.378 ± 0.079	2.459LeuHis: 2.459 ± 0.034	3.27LeuIle: 3.27 ± 0.045	2.057LeuLys: 2.057 ± 0.028	11.472LeuLeu: 11.472 ± 0.091	1.631LeuMet: 1.631 ± 0.026	1.657LeuAsn: 1.657 ± 0.027	6.559LeuPro: 6.559 ± 0.05	2.336LeuGln: 2.336 ± 0.033	8.777LeuArg: 8.777 ± 0.073	5.326LeuSer: 5.326 ± 0.047	6.995LeuThr: 6.995 ± 0.054	8.83LeuVal: 8.83 ± 0.062	1.371LeuTrp: 1.371 ± 0.022	1.92LeuTyr: 1.92 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.219MetAla: 2.219 ± 0.035	0.148MetCys: 0.148 ± 0.008	0.878MetAsp: 0.878 ± 0.017	0.712MetGlu: 0.712 ± 0.017	0.444MetPhe: 0.444 ± 0.012	1.257MetGly: 1.257 ± 0.022	0.381MetHis: 0.381 ± 0.012	0.622MetIle: 0.622 ± 0.015	0.402MetLys: 0.402 ± 0.014	1.67MetLeu: 1.67 ± 0.022	0.28MetMet: 0.28 ± 0.01	0.446MetAsn: 0.446 ± 0.014	1.119MetPro: 1.119 ± 0.023	0.45MetGln: 0.45 ± 0.014	1.387MetArg: 1.387 ± 0.025	1.284MetSer: 1.284 ± 0.023	1.518MetThr: 1.518 ± 0.026	1.255MetVal: 1.255 ± 0.025	0.227MetTrp: 0.227 ± 0.009	0.331MetTyr: 0.331 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.19AsnAla: 2.19 ± 0.029	0.168AsnCys: 0.168 ± 0.008	0.926AsnAsp: 0.926 ± 0.018	0.736AsnGlu: 0.736 ± 0.016	0.467AsnPhe: 0.467 ± 0.014	1.818AsnGly: 1.818 ± 0.029	0.411AsnHis: 0.411 ± 0.014	0.642AsnIle: 0.642 ± 0.019	0.386AsnLys: 0.386 ± 0.012	1.624AsnLeu: 1.624 ± 0.027	0.299AsnMet: 0.299 ± 0.012	0.406AsnAsn: 0.406 ± 0.014	1.344AsnPro: 1.344 ± 0.026	0.524AsnGln: 0.524 ± 0.015	1.247AsnArg: 1.247 ± 0.023	0.924AsnSer: 0.924 ± 0.021	1.083AsnThr: 1.083 ± 0.023	1.312AsnVal: 1.312 ± 0.022	0.28AsnTrp: 0.28 ± 0.011	0.392AsnTyr: 0.392 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.824ProAla: 8.824 ± 0.079	0.363ProCys: 0.363 ± 0.013	4.475ProAsp: 4.475 ± 0.042	4.16ProGlu: 4.16 ± 0.044	1.527ProPhe: 1.527 ± 0.024	6.57ProGly: 6.57 ± 0.06	1.514ProHis: 1.514 ± 0.024	1.265ProIle: 1.265 ± 0.021	1.179ProLys: 1.179 ± 0.02	5.41ProLeu: 5.41 ± 0.046	0.979ProMet: 0.979 ± 0.019	0.905ProAsn: 0.905 ± 0.017	3.433ProPro: 3.433 ± 0.059	1.913ProGln: 1.913 ± 0.037	4.077ProArg: 4.077 ± 0.044	3.126ProSer: 3.126 ± 0.037	3.183ProThr: 3.183 ± 0.037	5.522ProVal: 5.522 ± 0.053	0.902ProTrp: 0.902 ± 0.018	1.47ProTyr: 1.47 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	4.023GlnAla: 4.023 ± 0.045	0.19GlnCys: 0.19 ± 0.009	1.501GlnAsp: 1.501 ± 0.026	1.504GlnGlu: 1.504 ± 0.025	0.694GlnPhe: 0.694 ± 0.019	2.416GlnGly: 2.416 ± 0.031	0.696GlnHis: 0.696 ± 0.016	1.104GlnIle: 1.104 ± 0.021	0.654GlnLys: 0.654 ± 0.015	3.151GlnLeu: 3.151 ± 0.043	0.515GlnMet: 0.515 ± 0.013	0.521GlnAsn: 0.521 ± 0.016	1.778GlnPro: 1.778 ± 0.033	1.324GlnGln: 1.324 ± 0.032	2.45GlnArg: 2.45 ± 0.034	1.359GlnSer: 1.359 ± 0.021	1.411GlnThr: 1.411 ± 0.024	2.44GlnVal: 2.44 ± 0.029	0.509GlnTrp: 0.509 ± 0.014	0.635GlnTyr: 0.635 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	10.159ArgAla: 10.159 ± 0.072	0.635ArgCys: 0.635 ± 0.017	4.216ArgAsp: 4.216 ± 0.044	4.659ArgGlu: 4.659 ± 0.046	2.303ArgPhe: 2.303 ± 0.03	5.733ArgGly: 5.733 ± 0.052	2.318ArgHis: 2.318 ± 0.033	3.289ArgIle: 3.289 ± 0.035	1.553ArgLys: 1.553 ± 0.028	9.241ArgLeu: 9.241 ± 0.082	1.697ArgMet: 1.697 ± 0.028	1.279ArgAsn: 1.279 ± 0.026	5.067ArgPro: 5.067 ± 0.051	2.418ArgGln: 2.418 ± 0.027	7.764ArgArg: 7.764 ± 0.067	3.986ArgSer: 3.986 ± 0.038	5.568ArgThr: 5.568 ± 0.045	5.767ArgVal: 5.767 ± 0.047	1.348ArgTrp: 1.348 ± 0.022	1.816ArgTyr: 1.816 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	6.928SerAla: 6.928 ± 0.065	0.427SerCys: 0.427 ± 0.012	2.608SerAsp: 2.608 ± 0.03	2.233SerGlu: 2.233 ± 0.028	1.515SerPhe: 1.515 ± 0.021	5.934SerGly: 5.934 ± 0.057	1.048SerHis: 1.048 ± 0.021	1.36SerIle: 1.36 ± 0.023	1.007SerLys: 1.007 ± 0.025	4.924SerLeu: 4.924 ± 0.048	1.07SerMet: 1.07 ± 0.022	0.876SerAsn: 0.876 ± 0.019	3.15SerPro: 3.15 ± 0.039	1.243SerGln: 1.243 ± 0.023	3.637SerArg: 3.637 ± 0.042	2.844SerSer: 2.844 ± 0.046	3.054SerThr: 3.054 ± 0.036	4.258SerVal: 4.258 ± 0.04	0.913SerTrp: 0.913 ± 0.021	1.251SerTyr: 1.251 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	9.235ThrAla: 9.235 ± 0.064	0.466ThrCys: 0.466 ± 0.013	3.733ThrAsp: 3.733 ± 0.042	3.249ThrGlu: 3.249 ± 0.038	1.616ThrPhe: 1.616 ± 0.027	6.824ThrGly: 6.824 ± 0.05	1.279ThrHis: 1.279 ± 0.022	1.638ThrIle: 1.638 ± 0.028	1.13ThrLys: 1.13 ± 0.024	5.861ThrLeu: 5.861 ± 0.047	0.904ThrMet: 0.904 ± 0.02	0.964ThrAsn: 0.964 ± 0.021	4.109ThrPro: 4.109 ± 0.045	1.393ThrGln: 1.393 ± 0.024	4.0ThrArg: 4.0 ± 0.036	3.163ThrSer: 3.163 ± 0.041	3.842ThrThr: 3.842 ± 0.046	6.159ThrVal: 6.159 ± 0.051	0.921ThrTrp: 0.921 ± 0.019	1.343ThrTyr: 1.343 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	10.612ValAla: 10.612 ± 0.069	0.806ValCys: 0.806 ± 0.017	4.943ValAsp: 4.943 ± 0.049	4.534ValGlu: 4.534 ± 0.045	2.439ValPhe: 2.439 ± 0.028	6.385ValGly: 6.385 ± 0.055	2.069ValHis: 2.069 ± 0.027	2.728ValIle: 2.728 ± 0.034	1.711ValLys: 1.711 ± 0.03	9.599ValLeu: 9.599 ± 0.07	1.395ValMet: 1.395 ± 0.022	1.601ValAsn: 1.601 ± 0.023	5.339ValPro: 5.339 ± 0.055	2.232ValGln: 2.232 ± 0.033	7.275ValArg: 7.275 ± 0.058	4.311ValSer: 4.311 ± 0.042	5.639ValThr: 5.639 ± 0.05	7.864ValVal: 7.864 ± 0.075	1.167ValTrp: 1.167 ± 0.022	1.611ValTyr: 1.611 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	1.731TrpAla: 1.731 ± 0.026	0.154TrpCys: 0.154 ± 0.009	0.839TrpAsp: 0.839 ± 0.017	0.716TrpGlu: 0.716 ± 0.016	0.481TrpPhe: 0.481 ± 0.015	1.066TrpGly: 1.066 ± 0.017	0.409TrpHis: 0.409 ± 0.014	0.575TrpIle: 0.575 ± 0.014	0.356TrpLys: 0.356 ± 0.012	1.807TrpLeu: 1.807 ± 0.03	0.28TrpMet: 0.28 ± 0.009	0.399TrpAsn: 0.399 ± 0.012	0.783TrpPro: 0.783 ± 0.016	0.668TrpGln: 0.668 ± 0.017	1.321TrpArg: 1.321 ± 0.024	0.981TrpSer: 0.981 ± 0.021	1.031TrpThr: 1.031 ± 0.02	0.998TrpVal: 0.998 ± 0.018	0.322TrpTrp: 0.322 ± 0.011	0.374TrpTyr: 0.374 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.827TyrAla: 2.827 ± 0.036	0.188TyrCys: 0.188 ± 0.008	1.577TyrAsp: 1.577 ± 0.027	1.234TyrGlu: 1.234 ± 0.023	0.662TyrPhe: 0.662 ± 0.018	2.364TyrGly: 2.364 ± 0.029	0.412TyrHis: 0.412 ± 0.013	0.47TyrIle: 0.47 ± 0.012	0.409TyrLys: 0.409 ± 0.012	2.076TyrLeu: 2.076 ± 0.026	0.255TyrMet: 0.255 ± 0.009	0.394TyrAsn: 0.394 ± 0.013	1.086TyrPro: 1.086 ± 0.023	0.616TyrGln: 0.616 ± 0.014	1.799TyrArg: 1.799 ± 0.028	0.951TyrSer: 0.951 ± 0.023	1.233TyrThr: 1.233 ± 0.025	1.668TyrVal: 1.668 ± 0.027	0.362TyrTrp: 0.362 ± 0.012	0.458TyrTyr: 0.458 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8391 proteins (2751139 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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