Amino acid dipepetide frequency for Clostridium sp. CAG:307

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.907AlaAla: 2.907 ± 0.106
0.94AlaCys: 0.94 ± 0.045
2.567AlaAsp: 2.567 ± 0.072
2.331AlaGlu: 2.331 ± 0.081
2.95AlaPhe: 2.95 ± 0.186
3.269AlaGly: 3.269 ± 0.097
1.068AlaHis: 1.068 ± 0.054
5.669AlaIle: 5.669 ± 0.136
4.941AlaLys: 4.941 ± 0.117
6.655AlaLeu: 6.655 ± 0.151
1.38AlaMet: 1.38 ± 0.053
3.358AlaAsn: 3.358 ± 0.103
1.388AlaPro: 1.388 ± 0.049
1.365AlaGln: 1.365 ± 0.058
1.948AlaArg: 1.948 ± 0.075
4.692AlaSer: 4.692 ± 0.106
2.939AlaThr: 2.939 ± 0.088
3.193AlaVal: 3.193 ± 0.098
0.293AlaTrp: 0.293 ± 0.027
2.896AlaTyr: 2.896 ± 0.083
0.002AlaXaa: 0.002 ± 0.002
Cys
0.834CysAla: 0.834 ± 0.044
0.176CysCys: 0.176 ± 0.018
1.016CysAsp: 1.016 ± 0.048
0.812CysGlu: 0.812 ± 0.038
0.678CysPhe: 0.678 ± 0.04
1.189CysGly: 1.189 ± 0.055
0.336CysHis: 0.336 ± 0.027
0.944CysIle: 0.944 ± 0.043
0.899CysLys: 0.899 ± 0.041
1.205CysLeu: 1.205 ± 0.053
0.266CysMet: 0.266 ± 0.023
0.752CysAsn: 0.752 ± 0.038
0.487CysPro: 0.487 ± 0.032
0.388CysGln: 0.388 ± 0.029
0.305CysArg: 0.305 ± 0.023
0.808CysSer: 0.808 ± 0.044
0.548CysThr: 0.548 ± 0.059
0.83CysVal: 0.83 ± 0.042
0.074CysTrp: 0.074 ± 0.012
0.726CysTyr: 0.726 ± 0.038
0.0CysXaa: 0.0 ± 0.0
Asp
3.494AspAla: 3.494 ± 0.081
0.691AspCys: 0.691 ± 0.037
4.007AspAsp: 4.007 ± 0.107
4.924AspGlu: 4.924 ± 0.122
3.26AspPhe: 3.26 ± 0.087
4.016AspGly: 4.016 ± 0.112
0.78AspHis: 0.78 ± 0.036
5.533AspIle: 5.533 ± 0.117
4.677AspLys: 4.677 ± 0.124
5.487AspLeu: 5.487 ± 0.111
1.438AspMet: 1.438 ± 0.053
3.559AspAsn: 3.559 ± 0.083
1.375AspPro: 1.375 ± 0.051
0.912AspGln: 0.912 ± 0.044
1.456AspArg: 1.456 ± 0.057
3.895AspSer: 3.895 ± 0.112
2.922AspThr: 2.922 ± 0.076
3.787AspVal: 3.787 ± 0.083
0.321AspTrp: 0.321 ± 0.025
3.55AspTyr: 3.55 ± 0.091
0.0AspXaa: 0.0 ± 0.0
Glu
4.913GluAla: 4.913 ± 0.127
0.775GluCys: 0.775 ± 0.038
3.416GluAsp: 3.416 ± 0.094
5.619GluGlu: 5.619 ± 0.152
2.645GluPhe: 2.645 ± 0.077
3.498GluGly: 3.498 ± 0.087
1.113GluHis: 1.113 ± 0.05
6.52GluIle: 6.52 ± 0.104
4.941GluLys: 4.941 ± 0.125
6.375GluLeu: 6.375 ± 0.143
1.791GluMet: 1.791 ± 0.058
4.824GluAsn: 4.824 ± 0.101
1.382GluPro: 1.382 ± 0.059
1.471GluGln: 1.471 ± 0.054
2.231GluArg: 2.231 ± 0.082
3.293GluSer: 3.293 ± 0.08
3.011GluThr: 3.011 ± 0.106
3.962GluVal: 3.962 ± 0.099
0.344GluTrp: 0.344 ± 0.027
3.368GluTyr: 3.368 ± 0.089
0.0GluXaa: 0.0 ± 0.0
Phe
2.348PheAla: 2.348 ± 0.114
0.492PheCys: 0.492 ± 0.032
3.199PheAsp: 3.199 ± 0.08
3.017PheGlu: 3.017 ± 0.081
2.196PhePhe: 2.196 ± 0.076
2.717PheGly: 2.717 ± 0.105
0.578PheHis: 0.578 ± 0.03
4.352PheIle: 4.352 ± 0.106
4.475PheLys: 4.475 ± 0.084
4.057PheLeu: 4.057 ± 0.134
1.202PheMet: 1.202 ± 0.054
3.312PheAsn: 3.312 ± 0.075
0.955PhePro: 0.955 ± 0.049
0.914PheGln: 0.914 ± 0.042
1.146PheArg: 1.146 ± 0.05
3.178PheSer: 3.178 ± 0.092
2.472PheThr: 2.472 ± 0.097
2.693PheVal: 2.693 ± 0.089
0.295PheTrp: 0.295 ± 0.025
2.32PheTyr: 2.32 ± 0.096
0.0PheXaa: 0.0 ± 0.0
Gly
3.633GlyAla: 3.633 ± 0.121
0.981GlyCys: 0.981 ± 0.061
3.152GlyAsp: 3.152 ± 0.092
3.108GlyGlu: 3.108 ± 0.088
2.996GlyPhe: 2.996 ± 0.085
3.525GlyGly: 3.525 ± 0.114
1.252GlyHis: 1.252 ± 0.058
5.753GlyIle: 5.753 ± 0.127
4.413GlyLys: 4.413 ± 0.093
5.47GlyLeu: 5.47 ± 0.118
1.389GlyMet: 1.389 ± 0.05
3.111GlyAsn: 3.111 ± 0.097
1.129GlyPro: 1.129 ± 0.054
1.523GlyGln: 1.523 ± 0.06
1.978GlyArg: 1.978 ± 0.07
3.613GlySer: 3.613 ± 0.092
3.262GlyThr: 3.262 ± 0.123
4.17GlyVal: 4.17 ± 0.101
0.437GlyTrp: 0.437 ± 0.04
3.325GlyTyr: 3.325 ± 0.09
0.0GlyXaa: 0.0 ± 0.0
His
0.847HisAla: 0.847 ± 0.045
0.176HisCys: 0.176 ± 0.019
1.085HisAsp: 1.085 ± 0.053
1.122HisGlu: 1.122 ± 0.056
0.845HisPhe: 0.845 ± 0.045
0.893HisGly: 0.893 ± 0.039
0.366HisHis: 0.366 ± 0.033
1.486HisIle: 1.486 ± 0.055
1.194HisLys: 1.194 ± 0.05
1.62HisLeu: 1.62 ± 0.059
0.396HisMet: 0.396 ± 0.027
1.046HisAsn: 1.046 ± 0.047
0.656HisPro: 0.656 ± 0.041
0.507HisGln: 0.507 ± 0.034
0.535HisArg: 0.535 ± 0.035
0.866HisSer: 0.866 ± 0.039
0.832HisThr: 0.832 ± 0.046
0.897HisVal: 0.897 ± 0.042
0.089HisTrp: 0.089 ± 0.014
0.815HisTyr: 0.815 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
5.069IleAla: 5.069 ± 0.126
1.462IleCys: 1.462 ± 0.058
5.695IleAsp: 5.695 ± 0.123
6.042IleGlu: 6.042 ± 0.109
4.012IlePhe: 4.012 ± 0.099
5.154IleGly: 5.154 ± 0.149
1.22IleHis: 1.22 ± 0.053
9.2IleIle: 9.2 ± 0.212
8.782IleLys: 8.782 ± 0.177
8.988IleLeu: 8.988 ± 0.192
2.11IleMet: 2.11 ± 0.075
6.445IleAsn: 6.445 ± 0.139
2.966IlePro: 2.966 ± 0.1
1.653IleGln: 1.653 ± 0.058
2.834IleArg: 2.834 ± 0.079
7.081IleSer: 7.081 ± 0.139
5.245IleThr: 5.245 ± 0.173
5.819IleVal: 5.819 ± 0.113
0.455IleTrp: 0.455 ± 0.029
4.164IleTyr: 4.164 ± 0.087
0.0IleXaa: 0.0 ± 0.0
Lys
4.818LysAla: 4.818 ± 0.111
0.934LysCys: 0.934 ± 0.043
5.036LysAsp: 5.036 ± 0.108
7.72LysGlu: 7.72 ± 0.187
2.574LysPhe: 2.574 ± 0.07
4.306LysGly: 4.306 ± 0.113
1.248LysHis: 1.248 ± 0.05
7.642LysIle: 7.642 ± 0.167
8.201LysLys: 8.201 ± 0.175
7.357LysLeu: 7.357 ± 0.128
2.814LysMet: 2.814 ± 0.072
6.581LysAsn: 6.581 ± 0.133
2.147LysPro: 2.147 ± 0.074
1.891LysGln: 1.891 ± 0.064
3.278LysArg: 3.278 ± 0.095
4.696LysSer: 4.696 ± 0.101
4.703LysThr: 4.703 ± 0.102
4.332LysVal: 4.332 ± 0.098
0.552LysTrp: 0.552 ± 0.035
4.948LysTyr: 4.948 ± 0.107
0.0LysXaa: 0.0 ± 0.0
Leu
5.552LeuAla: 5.552 ± 0.112
1.254LeuCys: 1.254 ± 0.056
6.269LeuAsp: 6.269 ± 0.121
6.289LeuGlu: 6.289 ± 0.142
4.166LeuPhe: 4.166 ± 0.116
5.779LeuGly: 5.779 ± 0.107
1.492LeuHis: 1.492 ± 0.063
8.453LeuIle: 8.453 ± 0.17
9.061LeuLys: 9.061 ± 0.18
8.011LeuLeu: 8.011 ± 0.169
2.262LeuMet: 2.262 ± 0.088
6.964LeuAsn: 6.964 ± 0.141
2.872LeuPro: 2.872 ± 0.082
1.898LeuGln: 1.898 ± 0.064
3.043LeuArg: 3.043 ± 0.085
6.585LeuSer: 6.585 ± 0.152
4.852LeuThr: 4.852 ± 0.128
5.582LeuVal: 5.582 ± 0.112
0.448LeuTrp: 0.448 ± 0.03
4.226LeuTyr: 4.226 ± 0.109
0.0LeuXaa: 0.0 ± 0.0
Met
1.616MetAla: 1.616 ± 0.078
0.292MetCys: 0.292 ± 0.026
1.365MetAsp: 1.365 ± 0.058
1.384MetGlu: 1.384 ± 0.05
1.042MetPhe: 1.042 ± 0.051
1.343MetGly: 1.343 ± 0.052
0.364MetHis: 0.364 ± 0.025
2.402MetIle: 2.402 ± 0.07
2.363MetLys: 2.363 ± 0.077
2.573MetLeu: 2.573 ± 0.077
0.697MetMet: 0.697 ± 0.04
1.466MetAsn: 1.466 ± 0.052
0.914MetPro: 0.914 ± 0.038
0.708MetGln: 0.708 ± 0.037
0.728MetArg: 0.728 ± 0.038
1.668MetSer: 1.668 ± 0.059
1.324MetThr: 1.324 ± 0.056
1.337MetVal: 1.337 ± 0.049
0.154MetTrp: 0.154 ± 0.02
0.912MetTyr: 0.912 ± 0.046
0.0MetXaa: 0.0 ± 0.0
Asn
3.639AsnAla: 3.639 ± 0.093
0.901AsnCys: 0.901 ± 0.069
4.627AsnAsp: 4.627 ± 0.116
4.796AsnGlu: 4.796 ± 0.112
2.651AsnPhe: 2.651 ± 0.072
3.875AsnGly: 3.875 ± 0.117
1.17AsnHis: 1.17 ± 0.053
6.379AsnIle: 6.379 ± 0.136
5.721AsnLys: 5.721 ± 0.121
6.252AsnLeu: 6.252 ± 0.143
1.612AsnMet: 1.612 ± 0.06
4.861AsnAsn: 4.861 ± 0.142
2.222AsnPro: 2.222 ± 0.075
1.85AsnGln: 1.85 ± 0.075
1.783AsnArg: 1.783 ± 0.061
3.797AsnSer: 3.797 ± 0.116
3.122AsnThr: 3.122 ± 0.093
4.203AsnVal: 4.203 ± 0.125
0.338AsnTrp: 0.338 ± 0.025
3.758AsnTyr: 3.758 ± 0.111
0.0AsnXaa: 0.0 ± 0.0
Pro
1.2ProAla: 1.2 ± 0.051
0.332ProCys: 0.332 ± 0.025
1.49ProAsp: 1.49 ± 0.059
1.683ProGlu: 1.683 ± 0.067
1.514ProPhe: 1.514 ± 0.065
1.477ProGly: 1.477 ± 0.068
0.542ProHis: 0.542 ± 0.035
2.4ProIle: 2.4 ± 0.074
2.123ProLys: 2.123 ± 0.066
2.535ProLeu: 2.535 ± 0.079
0.591ProMet: 0.591 ± 0.03
1.768ProAsn: 1.768 ± 0.062
0.377ProPro: 0.377 ± 0.027
0.821ProGln: 0.821 ± 0.041
0.695ProArg: 0.695 ± 0.036
1.924ProSer: 1.924 ± 0.069
1.703ProThr: 1.703 ± 0.07
1.761ProVal: 1.761 ± 0.062
0.173ProTrp: 0.173 ± 0.017
1.514ProTyr: 1.514 ± 0.054
0.0ProXaa: 0.0 ± 0.0
Gln
1.69GlnAla: 1.69 ± 0.061
0.217GlnCys: 0.217 ± 0.022
1.064GlnAsp: 1.064 ± 0.039
1.531GlnGlu: 1.531 ± 0.061
0.966GlnPhe: 0.966 ± 0.044
1.274GlnGly: 1.274 ± 0.04
0.271GlnHis: 0.271 ± 0.023
2.66GlnIle: 2.66 ± 0.076
1.88GlnLys: 1.88 ± 0.067
1.492GlnLeu: 1.492 ± 0.055
0.802GlnMet: 0.802 ± 0.039
1.945GlnAsn: 1.945 ± 0.056
0.44GlnPro: 0.44 ± 0.026
0.479GlnGln: 0.479 ± 0.033
0.921GlnArg: 0.921 ± 0.046
1.25GlnSer: 1.25 ± 0.055
1.492GlnThr: 1.492 ± 0.062
1.285GlnVal: 1.285 ± 0.055
0.124GlnTrp: 0.124 ± 0.019
1.059GlnTyr: 1.059 ± 0.057
0.0GlnXaa: 0.0 ± 0.0
Arg
1.705ArgAla: 1.705 ± 0.059
0.381ArgCys: 0.381 ± 0.028
1.681ArgAsp: 1.681 ± 0.061
2.019ArgGlu: 2.019 ± 0.072
1.395ArgPhe: 1.395 ± 0.058
1.692ArgGly: 1.692 ± 0.05
0.57ArgHis: 0.57 ± 0.037
3.028ArgIle: 3.028 ± 0.083
2.61ArgLys: 2.61 ± 0.079
3.141ArgLeu: 3.141 ± 0.091
0.88ArgMet: 0.88 ± 0.047
1.926ArgAsn: 1.926 ± 0.071
0.962ArgPro: 0.962 ± 0.053
0.984ArgGln: 0.984 ± 0.051
1.302ArgArg: 1.302 ± 0.056
1.597ArgSer: 1.597 ± 0.065
1.441ArgThr: 1.441 ± 0.057
1.963ArgVal: 1.963 ± 0.078
0.176ArgTrp: 0.176 ± 0.019
1.536ArgTyr: 1.536 ± 0.056
0.0ArgXaa: 0.0 ± 0.0
Ser
3.143SerAla: 3.143 ± 0.085
0.895SerCys: 0.895 ± 0.031
3.884SerAsp: 3.884 ± 0.105
3.36SerGlu: 3.36 ± 0.095
3.969SerPhe: 3.969 ± 0.107
4.085SerGly: 4.085 ± 0.114
1.148SerHis: 1.148 ± 0.045
5.864SerIle: 5.864 ± 0.125
5.582SerLys: 5.582 ± 0.114
6.973SerLeu: 6.973 ± 0.128
1.438SerMet: 1.438 ± 0.041
4.384SerAsn: 4.384 ± 0.151
1.534SerPro: 1.534 ± 0.054
1.64SerGln: 1.64 ± 0.063
1.876SerArg: 1.876 ± 0.065
5.203SerSer: 5.203 ± 0.16
3.377SerThr: 3.377 ± 0.119
3.525SerVal: 3.525 ± 0.097
0.377SerTrp: 0.377 ± 0.028
3.893SerTyr: 3.893 ± 0.108
0.0SerXaa: 0.0 ± 0.0
Thr
2.695ThrAla: 2.695 ± 0.096
0.622ThrCys: 0.622 ± 0.05
2.836ThrAsp: 2.836 ± 0.089
2.586ThrGlu: 2.586 ± 0.083
2.476ThrPhe: 2.476 ± 0.09
3.293ThrGly: 3.293 ± 0.097
0.854ThrHis: 0.854 ± 0.05
5.619ThrIle: 5.619 ± 0.185
4.569ThrLys: 4.569 ± 0.097
5.147ThrLeu: 5.147 ± 0.119
1.007ThrMet: 1.007 ± 0.046
3.486ThrAsn: 3.486 ± 0.123
1.733ThrPro: 1.733 ± 0.077
1.107ThrGln: 1.107 ± 0.047
1.497ThrArg: 1.497 ± 0.047
3.752ThrSer: 3.752 ± 0.121
3.275ThrThr: 3.275 ± 0.133
3.271ThrVal: 3.271 ± 0.12
0.31ThrTrp: 0.31 ± 0.025
2.706ThrTyr: 2.706 ± 0.103
0.0ThrXaa: 0.0 ± 0.0
Val
3.533ValAla: 3.533 ± 0.098
1.042ValCys: 1.042 ± 0.051
3.537ValAsp: 3.537 ± 0.085
3.434ValGlu: 3.434 ± 0.101
2.697ValPhe: 2.697 ± 0.072
3.724ValGly: 3.724 ± 0.107
0.789ValHis: 0.789 ± 0.046
5.767ValIle: 5.767 ± 0.11
4.761ValLys: 4.761 ± 0.099
5.959ValLeu: 5.959 ± 0.117
1.36ValMet: 1.36 ± 0.045
3.501ValAsn: 3.501 ± 0.092
1.59ValPro: 1.59 ± 0.069
0.942ValGln: 0.942 ± 0.046
1.893ValArg: 1.893 ± 0.058
4.672ValSer: 4.672 ± 0.108
3.498ValThr: 3.498 ± 0.115
4.012ValVal: 4.012 ± 0.097
0.323ValTrp: 0.323 ± 0.024
2.719ValTyr: 2.719 ± 0.069
0.0ValXaa: 0.0 ± 0.0
Trp
0.286TrpAla: 0.286 ± 0.024
0.11TrpCys: 0.11 ± 0.013
0.273TrpAsp: 0.273 ± 0.024
0.286TrpGlu: 0.286 ± 0.023
0.301TrpPhe: 0.301 ± 0.025
0.306TrpGly: 0.306 ± 0.028
0.132TrpHis: 0.132 ± 0.017
0.468TrpIle: 0.468 ± 0.035
0.418TrpLys: 0.418 ± 0.031
0.574TrpLeu: 0.574 ± 0.033
0.134TrpMet: 0.134 ± 0.017
0.383TrpAsn: 0.383 ± 0.029
0.178TrpPro: 0.178 ± 0.019
0.221TrpGln: 0.221 ± 0.024
0.167TrpArg: 0.167 ± 0.018
0.422TrpSer: 0.422 ± 0.033
0.271TrpThr: 0.271 ± 0.024
0.262TrpVal: 0.262 ± 0.023
0.08TrpTrp: 0.08 ± 0.013
0.37TrpTyr: 0.37 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.827TyrAla: 2.827 ± 0.111
0.6TyrCys: 0.6 ± 0.038
3.886TyrAsp: 3.886 ± 0.107
3.429TyrGlu: 3.429 ± 0.09
2.584TyrPhe: 2.584 ± 0.077
2.805TyrGly: 2.805 ± 0.083
0.979TyrHis: 0.979 ± 0.046
4.263TyrIle: 4.263 ± 0.094
4.168TyrLys: 4.168 ± 0.106
5.184TyrLeu: 5.184 ± 0.107
1.081TyrMet: 1.081 ± 0.05
3.884TyrAsn: 3.884 ± 0.121
1.317TyrPro: 1.317 ± 0.062
1.568TyrGln: 1.568 ± 0.055
1.375TyrArg: 1.375 ± 0.06
3.16TyrSer: 3.16 ± 0.096
2.554TyrThr: 2.554 ± 0.096
2.866TyrVal: 2.866 ± 0.08
0.277TyrTrp: 0.277 ± 0.024
2.9TyrTyr: 2.9 ± 0.104
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.002XaaAla: 0.002 ± 0.002
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.002XaaXaa: 0.002 ± 0.002
Statistics based on 1655 proteins (538369 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski