Amino acid dipepetide frequency for Grapevine leafroll-associated virus 10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.355AlaAla: 6.355 ± 0.738
0.908AlaCys: 0.908 ± 0.307
2.724AlaAsp: 2.724 ± 0.853
3.177AlaGlu: 3.177 ± 0.645
3.177AlaPhe: 3.177 ± 1.086
3.404AlaGly: 3.404 ± 0.915
0.908AlaHis: 0.908 ± 0.658
3.177AlaIle: 3.177 ± 0.814
3.858AlaLys: 3.858 ± 0.911
7.944AlaLeu: 7.944 ± 0.978
0.681AlaMet: 0.681 ± 0.298
1.816AlaAsn: 1.816 ± 0.586
2.951AlaPro: 2.951 ± 0.819
2.724AlaGln: 2.724 ± 0.797
2.27AlaArg: 2.27 ± 0.755
4.993AlaSer: 4.993 ± 0.944
2.951AlaThr: 2.951 ± 0.977
7.263AlaVal: 7.263 ± 1.356
1.135AlaTrp: 1.135 ± 0.514
1.135AlaTyr: 1.135 ± 0.541
0.0AlaXaa: 0.0 ± 0.0
Cys
2.043CysAla: 2.043 ± 0.774
0.908CysCys: 0.908 ± 0.338
0.454CysAsp: 0.454 ± 0.531
1.135CysGlu: 1.135 ± 0.527
2.043CysPhe: 2.043 ± 0.652
1.589CysGly: 1.589 ± 0.525
0.227CysHis: 0.227 ± 0.129
0.681CysIle: 0.681 ± 0.32
0.454CysLys: 0.454 ± 0.272
2.27CysLeu: 2.27 ± 0.639
0.454CysMet: 0.454 ± 0.272
1.362CysAsn: 1.362 ± 0.616
0.454CysPro: 0.454 ± 0.259
0.0CysGln: 0.0 ± 0.0
0.227CysArg: 0.227 ± 0.249
2.043CysSer: 2.043 ± 0.396
0.227CysThr: 0.227 ± 0.129
1.816CysVal: 1.816 ± 1.06
0.454CysTrp: 0.454 ± 0.259
1.135CysTyr: 1.135 ± 0.499
0.0CysXaa: 0.0 ± 0.0
Asp
3.631AspAla: 3.631 ± 0.958
1.589AspCys: 1.589 ± 0.443
1.816AspAsp: 1.816 ± 0.53
1.816AspGlu: 1.816 ± 0.797
3.858AspPhe: 3.858 ± 0.758
2.724AspGly: 2.724 ± 0.559
0.454AspHis: 0.454 ± 0.247
3.858AspIle: 3.858 ± 0.8
3.404AspLys: 3.404 ± 0.734
2.27AspLeu: 2.27 ± 0.869
0.681AspMet: 0.681 ± 0.434
2.724AspAsn: 2.724 ± 1.333
1.816AspPro: 1.816 ± 0.361
0.908AspGln: 0.908 ± 0.718
4.085AspArg: 4.085 ± 0.507
6.128AspSer: 6.128 ± 1.595
2.951AspThr: 2.951 ± 0.497
6.809AspVal: 6.809 ± 1.423
0.454AspTrp: 0.454 ± 0.242
1.135AspTyr: 1.135 ± 0.381
0.0AspXaa: 0.0 ± 0.0
Glu
2.497GluAla: 2.497 ± 0.849
0.681GluCys: 0.681 ± 0.388
4.312GluAsp: 4.312 ± 1.055
4.312GluGlu: 4.312 ± 0.965
2.497GluPhe: 2.497 ± 0.847
3.177GluGly: 3.177 ± 0.817
0.908GluHis: 0.908 ± 0.426
4.085GluIle: 4.085 ± 1.331
4.766GluLys: 4.766 ± 1.011
4.993GluLeu: 4.993 ± 0.659
0.227GluMet: 0.227 ± 0.321
1.362GluAsn: 1.362 ± 0.494
2.043GluPro: 2.043 ± 0.719
1.589GluGln: 1.589 ± 0.446
3.404GluArg: 3.404 ± 1.132
3.631GluSer: 3.631 ± 0.86
2.27GluThr: 2.27 ± 0.649
6.355GluVal: 6.355 ± 1.185
0.0GluTrp: 0.0 ± 0.0
1.816GluTyr: 1.816 ± 0.86
0.0GluXaa: 0.0 ± 0.0
Phe
3.631PheAla: 3.631 ± 2.158
1.816PheCys: 1.816 ± 0.925
3.177PheAsp: 3.177 ± 1.199
2.951PheGlu: 2.951 ± 0.316
2.27PhePhe: 2.27 ± 0.77
3.404PheGly: 3.404 ± 0.992
0.681PheHis: 0.681 ± 0.475
2.043PheIle: 2.043 ± 0.753
2.951PheLys: 2.951 ± 1.384
5.22PheLeu: 5.22 ± 1.287
1.135PheMet: 1.135 ± 0.497
2.043PheAsn: 2.043 ± 0.705
2.724PhePro: 2.724 ± 0.985
2.497PheGln: 2.497 ± 0.578
2.27PheArg: 2.27 ± 0.761
5.901PheSer: 5.901 ± 1.24
2.043PheThr: 2.043 ± 0.453
3.631PheVal: 3.631 ± 0.914
0.227PheTrp: 0.227 ± 0.129
2.497PheTyr: 2.497 ± 0.702
0.0PheXaa: 0.0 ± 0.0
Gly
4.085GlyAla: 4.085 ± 0.594
0.908GlyCys: 0.908 ± 0.543
4.312GlyAsp: 4.312 ± 1.021
3.404GlyGlu: 3.404 ± 0.442
2.043GlyPhe: 2.043 ± 0.706
4.539GlyGly: 4.539 ± 1.11
0.681GlyHis: 0.681 ± 0.279
1.816GlyIle: 1.816 ± 0.672
6.355GlyLys: 6.355 ± 0.816
6.582GlyLeu: 6.582 ± 1.132
2.27GlyMet: 2.27 ± 0.591
2.951GlyAsn: 2.951 ± 0.874
2.27GlyPro: 2.27 ± 0.855
0.908GlyGln: 0.908 ± 0.485
4.312GlyArg: 4.312 ± 0.85
6.128GlySer: 6.128 ± 0.713
2.951GlyThr: 2.951 ± 1.162
4.766GlyVal: 4.766 ± 2.23
0.681GlyTrp: 0.681 ± 0.265
1.362GlyTyr: 1.362 ± 0.68
0.0GlyXaa: 0.0 ± 0.0
His
0.681HisAla: 0.681 ± 0.388
0.227HisCys: 0.227 ± 0.129
0.908HisAsp: 0.908 ± 0.509
0.681HisGlu: 0.681 ± 0.464
0.681HisPhe: 0.681 ± 0.475
0.227HisGly: 0.227 ± 0.36
0.227HisHis: 0.227 ± 0.361
0.908HisIle: 0.908 ± 0.409
1.362HisLys: 1.362 ± 0.606
2.497HisLeu: 2.497 ± 0.679
0.681HisMet: 0.681 ± 0.525
1.135HisAsn: 1.135 ± 0.379
0.681HisPro: 0.681 ± 0.332
0.454HisGln: 0.454 ± 0.332
0.454HisArg: 0.454 ± 0.259
1.816HisSer: 1.816 ± 0.586
0.681HisThr: 0.681 ± 0.265
2.043HisVal: 2.043 ± 0.467
0.0HisTrp: 0.0 ± 0.0
0.908HisTyr: 0.908 ± 0.336
0.0HisXaa: 0.0 ± 0.0
Ile
2.497IleAla: 2.497 ± 0.649
1.135IleCys: 1.135 ± 0.484
2.724IleAsp: 2.724 ± 1.145
2.497IleGlu: 2.497 ± 0.502
2.724IlePhe: 2.724 ± 0.442
2.724IleGly: 2.724 ± 0.911
1.135IleHis: 1.135 ± 0.505
2.043IleIle: 2.043 ± 1.059
2.951IleLys: 2.951 ± 0.716
5.674IleLeu: 5.674 ± 1.356
0.908IleMet: 0.908 ± 0.403
2.27IleAsn: 2.27 ± 0.888
3.177IlePro: 3.177 ± 0.681
0.681IleGln: 0.681 ± 0.542
0.908IleArg: 0.908 ± 0.518
4.312IleSer: 4.312 ± 0.713
2.043IleThr: 2.043 ± 0.689
2.724IleVal: 2.724 ± 0.421
0.454IleTrp: 0.454 ± 0.259
1.589IleTyr: 1.589 ± 0.532
0.0IleXaa: 0.0 ± 0.0
Lys
5.674LysAla: 5.674 ± 1.395
1.135LysCys: 1.135 ± 0.432
3.404LysAsp: 3.404 ± 0.821
2.043LysGlu: 2.043 ± 0.521
3.858LysPhe: 3.858 ± 1.029
4.766LysGly: 4.766 ± 1.011
1.135LysHis: 1.135 ± 0.484
2.724LysIle: 2.724 ± 0.648
1.816LysLys: 1.816 ± 0.45
6.809LysLeu: 6.809 ± 0.744
0.681LysMet: 0.681 ± 0.639
2.27LysAsn: 2.27 ± 0.548
4.539LysPro: 4.539 ± 1.052
0.908LysGln: 0.908 ± 0.336
4.312LysArg: 4.312 ± 1.029
6.128LysSer: 6.128 ± 1.891
5.447LysThr: 5.447 ± 0.624
5.901LysVal: 5.901 ± 1.215
0.227LysTrp: 0.227 ± 0.292
1.816LysTyr: 1.816 ± 0.604
0.0LysXaa: 0.0 ± 0.0
Leu
4.539LeuAla: 4.539 ± 0.827
1.589LeuCys: 1.589 ± 0.627
5.22LeuAsp: 5.22 ± 1.441
4.993LeuGlu: 4.993 ± 0.636
3.404LeuPhe: 3.404 ± 1.302
6.582LeuGly: 6.582 ± 1.025
1.816LeuHis: 1.816 ± 0.586
5.674LeuIle: 5.674 ± 0.92
9.305LeuLys: 9.305 ± 1.793
9.079LeuLeu: 9.079 ± 1.503
2.27LeuMet: 2.27 ± 0.631
4.085LeuAsn: 4.085 ± 0.835
4.993LeuPro: 4.993 ± 0.654
2.497LeuGln: 2.497 ± 1.017
5.901LeuArg: 5.901 ± 0.947
9.986LeuSer: 9.986 ± 1.557
4.993LeuThr: 4.993 ± 1.086
7.944LeuVal: 7.944 ± 0.956
0.681LeuTrp: 0.681 ± 0.556
1.589LeuTyr: 1.589 ± 0.546
0.0LeuXaa: 0.0 ± 0.0
Met
0.681MetAla: 0.681 ± 0.674
0.227MetCys: 0.227 ± 0.249
0.681MetAsp: 0.681 ± 0.279
1.816MetGlu: 1.816 ± 0.852
1.362MetPhe: 1.362 ± 0.54
0.454MetGly: 0.454 ± 0.259
0.0MetHis: 0.0 ± 0.0
0.681MetIle: 0.681 ± 0.388
1.362MetLys: 1.362 ± 0.463
1.589MetLeu: 1.589 ± 0.766
0.454MetMet: 0.454 ± 0.259
1.589MetAsn: 1.589 ± 0.754
0.681MetPro: 0.681 ± 0.279
0.454MetGln: 0.454 ± 0.332
0.908MetArg: 0.908 ± 0.581
1.135MetSer: 1.135 ± 0.435
1.362MetThr: 1.362 ± 0.49
1.362MetVal: 1.362 ± 0.324
0.0MetTrp: 0.0 ± 0.0
0.681MetTyr: 0.681 ± 0.32
0.0MetXaa: 0.0 ± 0.0
Asn
3.404AsnAla: 3.404 ± 0.577
0.681AsnCys: 0.681 ± 0.332
1.135AsnAsp: 1.135 ± 0.335
2.497AsnGlu: 2.497 ± 0.652
2.497AsnPhe: 2.497 ± 1.173
2.724AsnGly: 2.724 ± 0.615
0.0AsnHis: 0.0 ± 0.0
2.043AsnIle: 2.043 ± 1.129
3.631AsnLys: 3.631 ± 0.353
4.766AsnLeu: 4.766 ± 1.291
0.681AsnMet: 0.681 ± 0.557
1.816AsnAsn: 1.816 ± 0.499
2.497AsnPro: 2.497 ± 0.523
0.681AsnGln: 0.681 ± 0.265
1.589AsnArg: 1.589 ± 0.758
4.312AsnSer: 4.312 ± 1.254
4.085AsnThr: 4.085 ± 1.221
3.858AsnVal: 3.858 ± 0.826
1.362AsnTrp: 1.362 ± 0.498
0.908AsnTyr: 0.908 ± 0.762
0.0AsnXaa: 0.0 ± 0.0
Pro
2.724ProAla: 2.724 ± 0.693
1.135ProCys: 1.135 ± 0.647
2.951ProAsp: 2.951 ± 0.618
4.085ProGlu: 4.085 ± 0.872
2.043ProPhe: 2.043 ± 0.463
2.724ProGly: 2.724 ± 0.746
0.681ProHis: 0.681 ± 0.388
2.043ProIle: 2.043 ± 0.898
2.951ProLys: 2.951 ± 0.675
4.085ProLeu: 4.085 ± 0.796
0.227ProMet: 0.227 ± 0.129
2.497ProAsn: 2.497 ± 0.677
2.043ProPro: 2.043 ± 0.868
1.589ProGln: 1.589 ± 0.906
2.27ProArg: 2.27 ± 0.568
5.447ProSer: 5.447 ± 1.89
2.043ProThr: 2.043 ± 0.689
5.22ProVal: 5.22 ± 1.424
0.0ProTrp: 0.0 ± 0.0
0.681ProTyr: 0.681 ± 0.422
0.0ProXaa: 0.0 ± 0.0
Gln
1.362GlnAla: 1.362 ± 0.294
0.681GlnCys: 0.681 ± 0.475
0.908GlnAsp: 0.908 ± 0.389
0.908GlnGlu: 0.908 ± 0.336
2.043GlnPhe: 2.043 ± 1.184
2.043GlnGly: 2.043 ± 0.532
0.681GlnHis: 0.681 ± 0.388
1.362GlnIle: 1.362 ± 0.545
1.816GlnLys: 1.816 ± 0.834
1.362GlnLeu: 1.362 ± 0.546
0.454GlnMet: 0.454 ± 0.272
1.362GlnAsn: 1.362 ± 0.949
1.816GlnPro: 1.816 ± 0.834
1.135GlnGln: 1.135 ± 0.647
1.135GlnArg: 1.135 ± 1.183
1.816GlnSer: 1.816 ± 0.618
2.951GlnThr: 2.951 ± 0.691
1.362GlnVal: 1.362 ± 0.807
0.0GlnTrp: 0.0 ± 0.0
0.454GlnTyr: 0.454 ± 0.259
0.0GlnXaa: 0.0 ± 0.0
Arg
3.177ArgAla: 3.177 ± 0.361
1.362ArgCys: 1.362 ± 0.412
2.497ArgAsp: 2.497 ± 1.087
4.085ArgGlu: 4.085 ± 0.84
2.043ArgPhe: 2.043 ± 1.255
4.312ArgGly: 4.312 ± 1.17
1.135ArgHis: 1.135 ± 0.59
1.589ArgIle: 1.589 ± 0.436
2.724ArgLys: 2.724 ± 0.295
4.766ArgLeu: 4.766 ± 0.644
0.681ArgMet: 0.681 ± 0.321
2.951ArgAsn: 2.951 ± 0.686
2.043ArgPro: 2.043 ± 0.887
1.135ArgGln: 1.135 ± 0.379
3.631ArgArg: 3.631 ± 0.598
4.312ArgSer: 4.312 ± 1.784
3.177ArgThr: 3.177 ± 0.638
5.447ArgVal: 5.447 ± 1.138
0.0ArgTrp: 0.0 ± 0.0
1.816ArgTyr: 1.816 ± 0.851
0.0ArgXaa: 0.0 ± 0.0
Ser
6.128SerAla: 6.128 ± 1.055
1.362SerCys: 1.362 ± 0.541
5.447SerAsp: 5.447 ± 1.233
5.674SerGlu: 5.674 ± 1.002
5.22SerPhe: 5.22 ± 1.036
6.809SerGly: 6.809 ± 1.238
2.724SerHis: 2.724 ± 0.75
2.951SerIle: 2.951 ± 0.717
5.901SerLys: 5.901 ± 1.336
10.667SerLeu: 10.667 ± 1.56
0.908SerMet: 0.908 ± 0.438
4.766SerAsn: 4.766 ± 0.733
3.631SerPro: 3.631 ± 0.915
2.27SerGln: 2.27 ± 0.746
4.766SerArg: 4.766 ± 0.903
13.618SerSer: 13.618 ± 1.76
4.766SerThr: 4.766 ± 0.453
7.717SerVal: 7.717 ± 1.14
0.227SerTrp: 0.227 ± 0.249
3.404SerTyr: 3.404 ± 0.882
0.0SerXaa: 0.0 ± 0.0
Thr
3.404ThrAla: 3.404 ± 1.27
0.908ThrCys: 0.908 ± 0.39
0.908ThrAsp: 0.908 ± 0.409
2.043ThrGlu: 2.043 ± 0.674
4.085ThrPhe: 4.085 ± 0.84
4.539ThrGly: 4.539 ± 0.623
1.589ThrHis: 1.589 ± 0.647
2.951ThrIle: 2.951 ± 0.512
3.177ThrLys: 3.177 ± 1.077
4.539ThrLeu: 4.539 ± 0.965
0.908ThrMet: 0.908 ± 0.34
2.27ThrAsn: 2.27 ± 0.427
2.27ThrPro: 2.27 ± 0.631
1.589ThrGln: 1.589 ± 0.387
2.951ThrArg: 2.951 ± 0.966
4.993ThrSer: 4.993 ± 1.413
1.589ThrThr: 1.589 ± 0.703
6.355ThrVal: 6.355 ± 1.282
0.908ThrTrp: 0.908 ± 0.562
1.135ThrTyr: 1.135 ± 0.669
0.0ThrXaa: 0.0 ± 0.0
Val
5.674ValAla: 5.674 ± 2.911
1.816ValCys: 1.816 ± 0.681
6.809ValAsp: 6.809 ± 1.793
5.22ValGlu: 5.22 ± 1.645
4.993ValPhe: 4.993 ± 2.365
5.22ValGly: 5.22 ± 1.043
1.362ValHis: 1.362 ± 0.6
3.177ValIle: 3.177 ± 1.078
5.22ValLys: 5.22 ± 0.933
9.079ValLeu: 9.079 ± 1.082
1.589ValMet: 1.589 ± 0.749
4.993ValAsn: 4.993 ± 1.158
4.766ValPro: 4.766 ± 1.229
2.951ValGln: 2.951 ± 0.618
4.993ValArg: 4.993 ± 0.932
7.036ValSer: 7.036 ± 1.229
5.22ValThr: 5.22 ± 1.327
6.809ValVal: 6.809 ± 1.807
0.454ValTrp: 0.454 ± 0.259
2.724ValTyr: 2.724 ± 0.889
0.0ValXaa: 0.0 ± 0.0
Trp
0.681TrpAla: 0.681 ± 0.349
0.454TrpCys: 0.454 ± 0.584
0.227TrpAsp: 0.227 ± 0.129
0.454TrpGlu: 0.454 ± 0.332
0.908TrpPhe: 0.908 ± 0.39
0.454TrpGly: 0.454 ± 0.247
0.227TrpHis: 0.227 ± 0.249
0.227TrpIle: 0.227 ± 0.249
0.227TrpLys: 0.227 ± 0.292
0.908TrpLeu: 0.908 ± 0.518
0.227TrpMet: 0.227 ± 0.129
0.0TrpAsn: 0.0 ± 0.0
0.227TrpPro: 0.227 ± 0.292
0.0TrpGln: 0.0 ± 0.0
0.681TrpArg: 0.681 ± 0.298
0.454TrpSer: 0.454 ± 0.272
0.0TrpThr: 0.0 ± 0.0
0.454TrpVal: 0.454 ± 0.509
0.0TrpTrp: 0.0 ± 0.0
0.908TrpTyr: 0.908 ± 0.302
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.681TyrAla: 0.681 ± 0.332
0.454TyrCys: 0.454 ± 0.331
2.497TyrAsp: 2.497 ± 0.758
1.135TyrGlu: 1.135 ± 0.744
1.362TyrPhe: 1.362 ± 0.406
0.908TyrGly: 0.908 ± 0.39
0.681TyrHis: 0.681 ± 0.388
1.135TyrIle: 1.135 ± 0.713
1.362TyrLys: 1.362 ± 0.489
2.043TyrLeu: 2.043 ± 0.615
1.135TyrMet: 1.135 ± 0.886
0.908TyrAsn: 0.908 ± 0.553
1.816TyrPro: 1.816 ± 0.873
0.681TyrGln: 0.681 ± 0.525
1.816TyrArg: 1.816 ± 1.124
4.993TyrSer: 4.993 ± 0.544
1.362TyrThr: 1.362 ± 0.294
2.27TyrVal: 2.27 ± 0.81
0.454TyrTrp: 0.454 ± 0.259
0.681TyrTyr: 0.681 ± 0.422
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (4407 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski