Amino acid dipepetide frequency for Listeria phage B054

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.016AlaAla: 5.016 ± 0.735
0.391AlaCys: 0.391 ± 0.172
3.909AlaAsp: 3.909 ± 0.46
5.277AlaGlu: 5.277 ± 0.63
2.085AlaPhe: 2.085 ± 0.393
4.625AlaGly: 4.625 ± 0.875
0.977AlaHis: 0.977 ± 0.212
5.537AlaIle: 5.537 ± 0.659
7.817AlaLys: 7.817 ± 0.939
6.384AlaLeu: 6.384 ± 0.733
2.15AlaMet: 2.15 ± 0.338
5.342AlaAsn: 5.342 ± 0.462
1.173AlaPro: 1.173 ± 0.223
2.215AlaGln: 2.215 ± 0.518
2.736AlaArg: 2.736 ± 0.348
5.733AlaSer: 5.733 ± 0.797
4.234AlaThr: 4.234 ± 0.572
5.342AlaVal: 5.342 ± 0.537
0.326AlaTrp: 0.326 ± 0.146
1.303AlaTyr: 1.303 ± 0.304
0.0AlaXaa: 0.0 ± 0.0
Cys
0.261CysAla: 0.261 ± 0.127
0.195CysCys: 0.195 ± 0.148
0.261CysAsp: 0.261 ± 0.138
1.107CysGlu: 1.107 ± 0.339
0.391CysPhe: 0.391 ± 0.143
0.391CysGly: 0.391 ± 0.165
0.065CysHis: 0.065 ± 0.066
0.261CysIle: 0.261 ± 0.13
0.456CysLys: 0.456 ± 0.178
0.391CysLeu: 0.391 ± 0.162
0.065CysMet: 0.065 ± 0.066
0.391CysAsn: 0.391 ± 0.138
0.391CysPro: 0.391 ± 0.148
0.326CysGln: 0.326 ± 0.142
0.326CysArg: 0.326 ± 0.129
0.326CysSer: 0.326 ± 0.133
0.195CysThr: 0.195 ± 0.131
0.456CysVal: 0.456 ± 0.185
0.065CysTrp: 0.065 ± 0.066
0.586CysTyr: 0.586 ± 0.217
0.0CysXaa: 0.0 ± 0.0
Asp
4.169AspAla: 4.169 ± 0.726
0.912AspCys: 0.912 ± 0.276
3.322AspAsp: 3.322 ± 0.557
4.951AspGlu: 4.951 ± 0.638
2.866AspPhe: 2.866 ± 0.442
2.931AspGly: 2.931 ± 0.476
0.717AspHis: 0.717 ± 0.263
4.234AspIle: 4.234 ± 0.513
4.43AspLys: 4.43 ± 0.593
4.951AspLeu: 4.951 ± 0.604
1.173AspMet: 1.173 ± 0.252
2.801AspAsn: 2.801 ± 0.533
1.433AspPro: 1.433 ± 0.358
1.433AspGln: 1.433 ± 0.269
2.28AspArg: 2.28 ± 0.356
4.755AspSer: 4.755 ± 0.79
2.671AspThr: 2.671 ± 0.424
3.518AspVal: 3.518 ± 0.632
1.107AspTrp: 1.107 ± 0.358
2.541AspTyr: 2.541 ± 0.488
0.0AspXaa: 0.0 ± 0.0
Glu
5.342GluAla: 5.342 ± 0.621
0.326GluCys: 0.326 ± 0.182
2.931GluAsp: 2.931 ± 0.457
7.426GluGlu: 7.426 ± 0.878
3.583GluPhe: 3.583 ± 0.497
4.104GluGly: 4.104 ± 0.438
1.238GluHis: 1.238 ± 0.27
7.491GluIle: 7.491 ± 0.568
8.208GluLys: 8.208 ± 0.762
8.534GluLeu: 8.534 ± 1.12
2.085GluMet: 2.085 ± 0.431
4.755GluAsn: 4.755 ± 0.49
1.563GluPro: 1.563 ± 0.289
4.039GluGln: 4.039 ± 0.633
3.974GluArg: 3.974 ± 0.624
4.43GluSer: 4.43 ± 0.545
3.713GluThr: 3.713 ± 0.532
5.146GluVal: 5.146 ± 0.689
0.717GluTrp: 0.717 ± 0.22
2.931GluTyr: 2.931 ± 0.555
0.0GluXaa: 0.0 ± 0.0
Phe
2.541PheAla: 2.541 ± 0.462
0.456PheCys: 0.456 ± 0.191
3.322PheAsp: 3.322 ± 0.574
3.778PheGlu: 3.778 ± 0.487
1.433PhePhe: 1.433 ± 0.331
2.541PheGly: 2.541 ± 0.456
0.391PheHis: 0.391 ± 0.15
2.931PheIle: 2.931 ± 0.414
3.778PheLys: 3.778 ± 0.614
3.322PheLeu: 3.322 ± 0.52
1.173PheMet: 1.173 ± 0.291
2.997PheAsn: 2.997 ± 0.519
1.368PhePro: 1.368 ± 0.349
1.107PheGln: 1.107 ± 0.296
1.173PheArg: 1.173 ± 0.209
2.671PheSer: 2.671 ± 0.403
2.28PheThr: 2.28 ± 0.378
1.433PheVal: 1.433 ± 0.293
0.195PheTrp: 0.195 ± 0.125
1.303PheTyr: 1.303 ± 0.331
0.0PheXaa: 0.0 ± 0.0
Gly
4.299GlyAla: 4.299 ± 0.841
0.13GlyCys: 0.13 ± 0.092
2.215GlyAsp: 2.215 ± 0.431
4.43GlyGlu: 4.43 ± 0.504
2.801GlyPhe: 2.801 ± 0.378
4.56GlyGly: 4.56 ± 1.034
1.173GlyHis: 1.173 ± 0.279
4.886GlyIle: 4.886 ± 0.547
5.993GlyLys: 5.993 ± 0.785
3.909GlyLeu: 3.909 ± 0.473
1.303GlyMet: 1.303 ± 0.374
3.453GlyAsn: 3.453 ± 0.497
1.498GlyPro: 1.498 ± 0.424
1.889GlyGln: 1.889 ± 0.291
2.41GlyArg: 2.41 ± 0.35
3.192GlySer: 3.192 ± 0.684
3.387GlyThr: 3.387 ± 0.583
3.648GlyVal: 3.648 ± 0.675
0.847GlyTrp: 0.847 ± 0.208
1.824GlyTyr: 1.824 ± 0.393
0.0GlyXaa: 0.0 ± 0.0
His
1.107HisAla: 1.107 ± 0.266
0.065HisCys: 0.065 ± 0.062
0.912HisAsp: 0.912 ± 0.234
1.433HisGlu: 1.433 ± 0.371
0.521HisPhe: 0.521 ± 0.168
0.847HisGly: 0.847 ± 0.234
0.456HisHis: 0.456 ± 0.195
0.847HisIle: 0.847 ± 0.215
1.238HisLys: 1.238 ± 0.294
0.977HisLeu: 0.977 ± 0.218
0.195HisMet: 0.195 ± 0.118
0.391HisAsn: 0.391 ± 0.147
0.586HisPro: 0.586 ± 0.189
0.782HisGln: 0.782 ± 0.223
0.586HisArg: 0.586 ± 0.17
1.694HisSer: 1.694 ± 0.33
1.368HisThr: 1.368 ± 0.328
0.977HisVal: 0.977 ± 0.239
0.0HisTrp: 0.0 ± 0.0
0.195HisTyr: 0.195 ± 0.096
0.0HisXaa: 0.0 ± 0.0
Ile
5.537IleAla: 5.537 ± 0.614
0.456IleCys: 0.456 ± 0.155
5.602IleAsp: 5.602 ± 0.624
6.384IleGlu: 6.384 ± 0.867
2.866IlePhe: 2.866 ± 0.398
3.518IleGly: 3.518 ± 0.663
1.759IleHis: 1.759 ± 0.306
4.886IleIle: 4.886 ± 0.854
6.514IleLys: 6.514 ± 0.626
5.016IleLeu: 5.016 ± 0.561
1.824IleMet: 1.824 ± 0.286
5.537IleAsn: 5.537 ± 0.503
2.997IlePro: 2.997 ± 0.439
2.931IleGln: 2.931 ± 0.473
2.866IleArg: 2.866 ± 0.563
4.43IleSer: 4.43 ± 0.744
4.365IleThr: 4.365 ± 0.436
4.299IleVal: 4.299 ± 0.531
0.651IleTrp: 0.651 ± 0.235
2.801IleTyr: 2.801 ± 0.501
0.0IleXaa: 0.0 ± 0.0
Lys
6.905LysAla: 6.905 ± 0.703
0.717LysCys: 0.717 ± 0.238
4.365LysAsp: 4.365 ± 0.464
7.622LysGlu: 7.622 ± 0.736
2.41LysPhe: 2.41 ± 0.349
4.43LysGly: 4.43 ± 0.74
1.433LysHis: 1.433 ± 0.295
7.035LysIle: 7.035 ± 0.587
8.925LysLys: 8.925 ± 0.891
8.664LysLeu: 8.664 ± 0.867
3.127LysMet: 3.127 ± 0.461
6.058LysAsn: 6.058 ± 0.712
2.085LysPro: 2.085 ± 0.376
4.039LysGln: 4.039 ± 0.512
3.713LysArg: 3.713 ± 0.417
5.733LysSer: 5.733 ± 0.552
6.579LysThr: 6.579 ± 0.708
5.146LysVal: 5.146 ± 0.519
1.629LysTrp: 1.629 ± 0.287
3.583LysTyr: 3.583 ± 0.512
0.0LysXaa: 0.0 ± 0.0
Leu
5.211LeuAla: 5.211 ± 0.566
0.912LeuCys: 0.912 ± 0.226
5.407LeuAsp: 5.407 ± 0.525
6.254LeuGlu: 6.254 ± 0.885
3.583LeuPhe: 3.583 ± 0.556
5.407LeuGly: 5.407 ± 0.622
0.912LeuHis: 0.912 ± 0.262
5.993LeuIle: 5.993 ± 0.652
6.645LeuLys: 6.645 ± 0.559
6.84LeuLeu: 6.84 ± 0.899
1.824LeuMet: 1.824 ± 0.377
6.123LeuAsn: 6.123 ± 0.638
2.41LeuPro: 2.41 ± 0.388
2.997LeuGln: 2.997 ± 0.469
3.909LeuArg: 3.909 ± 0.512
4.886LeuSer: 4.886 ± 0.59
5.407LeuThr: 5.407 ± 0.664
3.518LeuVal: 3.518 ± 0.4
0.261LeuTrp: 0.261 ± 0.164
2.345LeuTyr: 2.345 ± 0.477
0.0LeuXaa: 0.0 ± 0.0
Met
1.694MetAla: 1.694 ± 0.303
0.195MetCys: 0.195 ± 0.093
0.651MetAsp: 0.651 ± 0.227
1.433MetGlu: 1.433 ± 0.296
0.651MetPhe: 0.651 ± 0.215
1.107MetGly: 1.107 ± 0.258
0.261MetHis: 0.261 ± 0.121
2.085MetIle: 2.085 ± 0.334
2.736MetLys: 2.736 ± 0.44
1.238MetLeu: 1.238 ± 0.244
0.651MetMet: 0.651 ± 0.222
1.629MetAsn: 1.629 ± 0.295
1.107MetPro: 1.107 ± 0.264
1.107MetGln: 1.107 ± 0.295
1.303MetArg: 1.303 ± 0.373
1.629MetSer: 1.629 ± 0.408
1.954MetThr: 1.954 ± 0.396
1.173MetVal: 1.173 ± 0.257
0.326MetTrp: 0.326 ± 0.109
0.717MetTyr: 0.717 ± 0.216
0.0MetXaa: 0.0 ± 0.0
Asn
5.016AsnAla: 5.016 ± 0.561
0.326AsnCys: 0.326 ± 0.162
3.453AsnAsp: 3.453 ± 0.53
5.016AsnGlu: 5.016 ± 0.549
2.736AsnPhe: 2.736 ± 0.431
4.169AsnGly: 4.169 ± 0.438
0.847AsnHis: 0.847 ± 0.223
3.909AsnIle: 3.909 ± 0.518
6.189AsnLys: 6.189 ± 0.574
5.081AsnLeu: 5.081 ± 0.648
0.717AsnMet: 0.717 ± 0.248
3.778AsnAsn: 3.778 ± 0.506
1.824AsnPro: 1.824 ± 0.367
1.889AsnGln: 1.889 ± 0.344
2.801AsnArg: 2.801 ± 0.461
4.234AsnSer: 4.234 ± 0.586
3.062AsnThr: 3.062 ± 0.378
3.453AsnVal: 3.453 ± 0.442
0.586AsnTrp: 0.586 ± 0.221
2.541AsnTyr: 2.541 ± 0.454
0.0AsnXaa: 0.0 ± 0.0
Pro
2.28ProAla: 2.28 ± 0.387
0.065ProCys: 0.065 ± 0.06
1.824ProAsp: 1.824 ± 0.374
2.475ProGlu: 2.475 ± 0.376
1.173ProPhe: 1.173 ± 0.261
2.215ProGly: 2.215 ± 0.48
0.456ProHis: 0.456 ± 0.15
1.498ProIle: 1.498 ± 0.338
2.475ProLys: 2.475 ± 0.399
2.085ProLeu: 2.085 ± 0.335
0.326ProMet: 0.326 ± 0.129
1.042ProAsn: 1.042 ± 0.285
1.303ProPro: 1.303 ± 0.365
0.586ProGln: 0.586 ± 0.222
1.433ProArg: 1.433 ± 0.328
2.019ProSer: 2.019 ± 0.321
1.238ProThr: 1.238 ± 0.274
1.563ProVal: 1.563 ± 0.39
0.521ProTrp: 0.521 ± 0.203
0.586ProTyr: 0.586 ± 0.191
0.0ProXaa: 0.0 ± 0.0
Gln
2.866GlnAla: 2.866 ± 0.44
0.195GlnCys: 0.195 ± 0.118
1.759GlnAsp: 1.759 ± 0.33
4.169GlnGlu: 4.169 ± 0.67
1.303GlnPhe: 1.303 ± 0.246
1.238GlnGly: 1.238 ± 0.25
0.521GlnHis: 0.521 ± 0.197
2.997GlnIle: 2.997 ± 0.57
3.713GlnLys: 3.713 ± 0.471
3.583GlnLeu: 3.583 ± 0.62
0.651GlnMet: 0.651 ± 0.214
2.019GlnAsn: 2.019 ± 0.35
0.391GlnPro: 0.391 ± 0.151
1.368GlnGln: 1.368 ± 0.324
1.238GlnArg: 1.238 ± 0.263
1.629GlnSer: 1.629 ± 0.294
1.759GlnThr: 1.759 ± 0.328
1.954GlnVal: 1.954 ± 0.359
0.261GlnTrp: 0.261 ± 0.131
1.042GlnTyr: 1.042 ± 0.277
0.0GlnXaa: 0.0 ± 0.0
Arg
2.736ArgAla: 2.736 ± 0.314
0.195ArgCys: 0.195 ± 0.136
2.475ArgAsp: 2.475 ± 0.397
3.648ArgGlu: 3.648 ± 0.479
1.889ArgPhe: 1.889 ± 0.373
2.085ArgGly: 2.085 ± 0.344
0.782ArgHis: 0.782 ± 0.231
3.192ArgIle: 3.192 ± 0.464
4.039ArgLys: 4.039 ± 0.498
3.648ArgLeu: 3.648 ± 0.575
1.368ArgMet: 1.368 ± 0.318
2.15ArgAsn: 2.15 ± 0.321
1.303ArgPro: 1.303 ± 0.342
1.042ArgGln: 1.042 ± 0.291
2.606ArgArg: 2.606 ± 0.432
3.127ArgSer: 3.127 ± 0.406
1.629ArgThr: 1.629 ± 0.341
2.606ArgVal: 2.606 ± 0.34
0.717ArgTrp: 0.717 ± 0.224
2.019ArgTyr: 2.019 ± 0.353
0.0ArgXaa: 0.0 ± 0.0
Ser
5.277SerAla: 5.277 ± 0.95
0.261SerCys: 0.261 ± 0.15
5.016SerAsp: 5.016 ± 0.472
4.886SerGlu: 4.886 ± 0.57
2.866SerPhe: 2.866 ± 0.455
4.69SerGly: 4.69 ± 0.541
0.782SerHis: 0.782 ± 0.234
5.211SerIle: 5.211 ± 0.679
5.733SerLys: 5.733 ± 0.631
4.299SerLeu: 4.299 ± 0.498
1.368SerMet: 1.368 ± 0.263
3.843SerAsn: 3.843 ± 0.415
1.173SerPro: 1.173 ± 0.285
1.629SerGln: 1.629 ± 0.277
1.954SerArg: 1.954 ± 0.323
4.234SerSer: 4.234 ± 0.695
3.713SerThr: 3.713 ± 0.454
4.56SerVal: 4.56 ± 0.591
0.912SerTrp: 0.912 ± 0.286
2.606SerTyr: 2.606 ± 0.403
0.0SerXaa: 0.0 ± 0.0
Thr
5.016ThrAla: 5.016 ± 0.688
0.326ThrCys: 0.326 ± 0.145
2.801ThrAsp: 2.801 ± 0.4
4.821ThrGlu: 4.821 ± 0.587
2.671ThrPhe: 2.671 ± 0.4
3.778ThrGly: 3.778 ± 0.595
0.847ThrHis: 0.847 ± 0.281
4.886ThrIle: 4.886 ± 0.533
4.886ThrLys: 4.886 ± 0.558
3.778ThrLeu: 3.778 ± 0.472
0.847ThrMet: 0.847 ± 0.257
2.606ThrAsn: 2.606 ± 0.402
1.629ThrPro: 1.629 ± 0.29
1.889ThrGln: 1.889 ± 0.343
2.475ThrArg: 2.475 ± 0.4
3.518ThrSer: 3.518 ± 0.405
4.039ThrThr: 4.039 ± 0.58
3.909ThrVal: 3.909 ± 0.46
0.586ThrTrp: 0.586 ± 0.18
1.824ThrTyr: 1.824 ± 0.385
0.0ThrXaa: 0.0 ± 0.0
Val
3.909ValAla: 3.909 ± 0.581
0.326ValCys: 0.326 ± 0.159
4.104ValAsp: 4.104 ± 0.484
4.039ValGlu: 4.039 ± 0.594
2.28ValPhe: 2.28 ± 0.302
2.931ValGly: 2.931 ± 0.638
0.782ValHis: 0.782 ± 0.194
4.039ValIle: 4.039 ± 0.444
5.667ValLys: 5.667 ± 0.827
4.43ValLeu: 4.43 ± 0.477
1.954ValMet: 1.954 ± 0.354
4.104ValAsn: 4.104 ± 0.565
1.759ValPro: 1.759 ± 0.411
1.889ValGln: 1.889 ± 0.361
3.127ValArg: 3.127 ± 0.558
4.169ValSer: 4.169 ± 0.562
3.257ValThr: 3.257 ± 0.55
4.039ValVal: 4.039 ± 0.621
0.521ValTrp: 0.521 ± 0.167
2.019ValTyr: 2.019 ± 0.382
0.0ValXaa: 0.0 ± 0.0
Trp
0.586TrpAla: 0.586 ± 0.212
0.13TrpCys: 0.13 ± 0.087
0.977TrpAsp: 0.977 ± 0.197
0.977TrpGlu: 0.977 ± 0.25
0.586TrpPhe: 0.586 ± 0.178
0.391TrpGly: 0.391 ± 0.168
0.13TrpHis: 0.13 ± 0.079
0.782TrpIle: 0.782 ± 0.22
1.238TrpLys: 1.238 ± 0.282
1.107TrpLeu: 1.107 ± 0.27
0.261TrpMet: 0.261 ± 0.13
0.782TrpAsn: 0.782 ± 0.214
0.195TrpPro: 0.195 ± 0.123
0.13TrpGln: 0.13 ± 0.096
0.521TrpArg: 0.521 ± 0.185
0.586TrpSer: 0.586 ± 0.169
0.586TrpThr: 0.586 ± 0.26
0.456TrpVal: 0.456 ± 0.206
0.065TrpTrp: 0.065 ± 0.06
0.391TrpTyr: 0.391 ± 0.308
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.801TyrAla: 2.801 ± 0.364
0.326TyrCys: 0.326 ± 0.162
1.889TyrAsp: 1.889 ± 0.412
2.41TyrGlu: 2.41 ± 0.514
1.498TyrPhe: 1.498 ± 0.304
1.954TyrGly: 1.954 ± 0.269
0.651TyrHis: 0.651 ± 0.186
2.541TyrIle: 2.541 ± 0.51
3.518TyrLys: 3.518 ± 0.443
2.606TyrLeu: 2.606 ± 0.521
0.521TyrMet: 0.521 ± 0.169
1.824TyrAsn: 1.824 ± 0.288
0.977TyrPro: 0.977 ± 0.274
1.368TyrGln: 1.368 ± 0.297
1.824TyrArg: 1.824 ± 0.354
2.019TyrSer: 2.019 ± 0.41
1.694TyrThr: 1.694 ± 0.278
2.15TyrVal: 2.15 ± 0.346
0.586TyrTrp: 0.586 ± 0.174
1.433TyrTyr: 1.433 ± 0.297
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 80 proteins (15352 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski