Amino acid dipepetide frequency for Ruminococcus sp. CAG:57

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.703AlaAla: 6.703 ± 0.127
1.294AlaCys: 1.294 ± 0.044
5.409AlaAsp: 5.409 ± 0.102
5.91AlaGlu: 5.91 ± 0.11
3.16AlaPhe: 3.16 ± 0.069
5.239AlaGly: 5.239 ± 0.106
1.073AlaHis: 1.073 ± 0.042
4.951AlaIle: 4.951 ± 0.102
5.691AlaLys: 5.691 ± 0.093
6.421AlaLeu: 6.421 ± 0.109
2.28AlaMet: 2.28 ± 0.057
2.731AlaAsn: 2.731 ± 0.07
1.906AlaPro: 1.906 ± 0.054
2.476AlaGln: 2.476 ± 0.062
2.564AlaArg: 2.564 ± 0.061
3.785AlaSer: 3.785 ± 0.099
3.279AlaThr: 3.279 ± 0.082
7.096AlaVal: 7.096 ± 0.103
0.458AlaTrp: 0.458 ± 0.031
2.705AlaTyr: 2.705 ± 0.067
0.0AlaXaa: 0.0 ± 0.0
Cys
1.36CysAla: 1.36 ± 0.048
0.385CysCys: 0.385 ± 0.024
1.257CysAsp: 1.257 ± 0.045
1.298CysGlu: 1.298 ± 0.042
0.715CysPhe: 0.715 ± 0.034
1.857CysGly: 1.857 ± 0.062
0.334CysHis: 0.334 ± 0.022
1.197CysIle: 1.197 ± 0.046
1.127CysLys: 1.127 ± 0.041
1.241CysLeu: 1.241 ± 0.043
0.432CysMet: 0.432 ± 0.027
0.66CysAsn: 0.66 ± 0.031
0.727CysPro: 0.727 ± 0.038
0.363CysGln: 0.363 ± 0.026
0.76CysArg: 0.76 ± 0.033
1.186CysSer: 1.186 ± 0.04
1.157CysThr: 1.157 ± 0.05
1.172CysVal: 1.172 ± 0.043
0.153CysTrp: 0.153 ± 0.015
0.671CysTyr: 0.671 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
3.575AspAla: 3.575 ± 0.066
1.059AspCys: 1.059 ± 0.04
4.098AspAsp: 4.098 ± 0.099
5.178AspGlu: 5.178 ± 0.092
3.093AspPhe: 3.093 ± 0.072
4.692AspGly: 4.692 ± 0.108
0.852AspHis: 0.852 ± 0.038
5.407AspIle: 5.407 ± 0.096
5.68AspLys: 5.68 ± 0.092
4.552AspLeu: 4.552 ± 0.091
2.176AspMet: 2.176 ± 0.05
3.292AspAsn: 3.292 ± 0.08
1.918AspPro: 1.918 ± 0.056
1.013AspGln: 1.013 ± 0.037
2.434AspArg: 2.434 ± 0.067
4.13AspSer: 4.13 ± 0.093
3.566AspThr: 3.566 ± 0.085
3.897AspVal: 3.897 ± 0.086
0.58AspTrp: 0.58 ± 0.031
3.204AspTyr: 3.204 ± 0.084
0.0AspXaa: 0.0 ± 0.0
Glu
4.545GluAla: 4.545 ± 0.096
1.025GluCys: 1.025 ± 0.038
3.985GluAsp: 3.985 ± 0.082
5.024GluGlu: 5.024 ± 0.098
2.547GluPhe: 2.547 ± 0.068
4.079GluGly: 4.079 ± 0.081
1.167GluHis: 1.167 ± 0.044
5.61GluIle: 5.61 ± 0.102
6.82GluLys: 6.82 ± 0.101
6.414GluLeu: 6.414 ± 0.119
2.208GluMet: 2.208 ± 0.048
4.522GluAsn: 4.522 ± 0.084
1.827GluPro: 1.827 ± 0.051
2.527GluGln: 2.527 ± 0.075
2.983GluArg: 2.983 ± 0.083
3.49GluSer: 3.49 ± 0.075
3.297GluThr: 3.297 ± 0.071
3.911GluVal: 3.911 ± 0.08
0.509GluTrp: 0.509 ± 0.025
3.184GluTyr: 3.184 ± 0.07
0.0GluXaa: 0.0 ± 0.0
Phe
3.257PheAla: 3.257 ± 0.072
0.885PheCys: 0.885 ± 0.041
3.307PheAsp: 3.307 ± 0.064
2.993PheGlu: 2.993 ± 0.078
1.864PhePhe: 1.864 ± 0.069
3.136PheGly: 3.136 ± 0.071
0.663PheHis: 0.663 ± 0.032
3.081PheIle: 3.081 ± 0.081
2.648PheLys: 2.648 ± 0.056
3.067PheLeu: 3.067 ± 0.076
1.239PheMet: 1.239 ± 0.04
1.713PheAsn: 1.713 ± 0.043
1.21PhePro: 1.21 ± 0.038
0.852PheGln: 0.852 ± 0.031
1.521PheArg: 1.521 ± 0.047
3.197PheSer: 3.197 ± 0.079
2.692PheThr: 2.692 ± 0.078
3.016PheVal: 3.016 ± 0.071
0.346PheTrp: 0.346 ± 0.023
1.777PheTyr: 1.777 ± 0.05
0.0PheXaa: 0.0 ± 0.0
Gly
4.72GlyAla: 4.72 ± 0.118
1.484GlyCys: 1.484 ± 0.052
3.942GlyAsp: 3.942 ± 0.075
4.877GlyGlu: 4.877 ± 0.08
3.155GlyPhe: 3.155 ± 0.073
5.024GlyGly: 5.024 ± 0.127
1.159GlyHis: 1.159 ± 0.04
5.527GlyIle: 5.527 ± 0.107
5.765GlyLys: 5.765 ± 0.097
5.483GlyLeu: 5.483 ± 0.109
2.178GlyMet: 2.178 ± 0.057
2.839GlyAsn: 2.839 ± 0.081
0.959GlyPro: 0.959 ± 0.044
1.679GlyGln: 1.679 ± 0.045
2.858GlyArg: 2.858 ± 0.071
4.199GlySer: 4.199 ± 0.086
4.012GlyThr: 4.012 ± 0.109
5.234GlyVal: 5.234 ± 0.096
0.668GlyTrp: 0.668 ± 0.042
3.195GlyTyr: 3.195 ± 0.083
0.0GlyXaa: 0.0 ± 0.0
His
0.911HisAla: 0.911 ± 0.035
0.368HisCys: 0.368 ± 0.024
0.926HisAsp: 0.926 ± 0.041
0.999HisGlu: 0.999 ± 0.042
0.765HisPhe: 0.765 ± 0.029
1.26HisGly: 1.26 ± 0.052
0.308HisHis: 0.308 ± 0.024
1.314HisIle: 1.314 ± 0.046
1.153HisLys: 1.153 ± 0.046
1.156HisLeu: 1.156 ± 0.045
0.386HisMet: 0.386 ± 0.023
0.733HisAsn: 0.733 ± 0.031
0.663HisPro: 0.663 ± 0.03
0.349HisGln: 0.349 ± 0.019
0.698HisArg: 0.698 ± 0.03
1.043HisSer: 1.043 ± 0.038
0.904HisThr: 0.904 ± 0.038
0.791HisVal: 0.791 ± 0.039
0.168HisTrp: 0.168 ± 0.016
0.761HisTyr: 0.761 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
5.657IleAla: 5.657 ± 0.114
1.508IleCys: 1.508 ± 0.048
4.83IleAsp: 4.83 ± 0.086
4.604IleGlu: 4.604 ± 0.084
3.071IlePhe: 3.071 ± 0.079
4.88IleGly: 4.88 ± 0.105
1.107IleHis: 1.107 ± 0.043
5.41IleIle: 5.41 ± 0.132
5.37IleLys: 5.37 ± 0.09
5.69IleLeu: 5.69 ± 0.114
2.104IleMet: 2.104 ± 0.058
3.485IleAsn: 3.485 ± 0.081
2.818IlePro: 2.818 ± 0.066
1.666IleGln: 1.666 ± 0.054
2.933IleArg: 2.933 ± 0.068
5.546IleSer: 5.546 ± 0.099
4.75IleThr: 4.75 ± 0.094
5.154IleVal: 5.154 ± 0.099
0.462IleTrp: 0.462 ± 0.027
2.748IleTyr: 2.748 ± 0.072
0.0IleXaa: 0.0 ± 0.0
Lys
6.359LysAla: 6.359 ± 0.094
1.013LysCys: 1.013 ± 0.039
4.394LysAsp: 4.394 ± 0.077
5.228LysGlu: 5.228 ± 0.091
2.545LysPhe: 2.545 ± 0.068
4.79LysGly: 4.79 ± 0.09
1.097LysHis: 1.097 ± 0.045
5.684LysIle: 5.684 ± 0.088
6.88LysLys: 6.88 ± 0.093
7.126LysLeu: 7.126 ± 0.107
2.366LysMet: 2.366 ± 0.056
4.247LysAsn: 4.247 ± 0.09
2.373LysPro: 2.373 ± 0.063
2.164LysGln: 2.164 ± 0.061
3.154LysArg: 3.154 ± 0.074
4.219LysSer: 4.219 ± 0.073
4.626LysThr: 4.626 ± 0.081
4.619LysVal: 4.619 ± 0.082
0.601LysTrp: 0.601 ± 0.028
3.344LysTyr: 3.344 ± 0.069
0.0LysXaa: 0.0 ± 0.0
Leu
6.141LeuAla: 6.141 ± 0.112
1.93LeuCys: 1.93 ± 0.055
5.387LeuAsp: 5.387 ± 0.103
5.38LeuGlu: 5.38 ± 0.095
3.543LeuPhe: 3.543 ± 0.096
5.514LeuGly: 5.514 ± 0.091
1.314LeuHis: 1.314 ± 0.048
5.615LeuIle: 5.615 ± 0.135
6.036LeuLys: 6.036 ± 0.105
6.706LeuLeu: 6.706 ± 0.142
2.524LeuMet: 2.524 ± 0.065
3.488LeuAsn: 3.488 ± 0.069
3.031LeuPro: 3.031 ± 0.066
1.833LeuGln: 1.833 ± 0.051
3.284LeuArg: 3.284 ± 0.078
6.355LeuSer: 6.355 ± 0.118
5.084LeuThr: 5.084 ± 0.097
5.142LeuVal: 5.142 ± 0.104
0.674LeuTrp: 0.674 ± 0.033
3.079LeuTyr: 3.079 ± 0.069
0.0LeuXaa: 0.0 ± 0.0
Met
2.325MetAla: 2.325 ± 0.057
0.487MetCys: 0.487 ± 0.025
1.621MetAsp: 1.621 ± 0.053
1.63MetGlu: 1.63 ± 0.046
1.092MetPhe: 1.092 ± 0.046
2.175MetGly: 2.175 ± 0.066
0.386MetHis: 0.386 ± 0.024
2.012MetIle: 2.012 ± 0.06
2.444MetLys: 2.444 ± 0.063
2.829MetLeu: 2.829 ± 0.069
0.718MetMet: 0.718 ± 0.037
1.434MetAsn: 1.434 ± 0.045
1.122MetPro: 1.122 ± 0.043
0.788MetGln: 0.788 ± 0.035
1.172MetArg: 1.172 ± 0.039
1.974MetSer: 1.974 ± 0.061
2.008MetThr: 2.008 ± 0.057
1.516MetVal: 1.516 ± 0.045
0.202MetTrp: 0.202 ± 0.016
0.988MetTyr: 0.988 ± 0.038
0.0MetXaa: 0.0 ± 0.0
Asn
3.681AsnAla: 3.681 ± 0.078
0.894AsnCys: 0.894 ± 0.04
3.002AsnAsp: 3.002 ± 0.075
3.091AsnGlu: 3.091 ± 0.062
1.814AsnPhe: 1.814 ± 0.051
4.038AsnGly: 4.038 ± 0.092
0.601AsnHis: 0.601 ± 0.032
3.942AsnIle: 3.942 ± 0.078
3.408AsnLys: 3.408 ± 0.075
3.138AsnLeu: 3.138 ± 0.07
1.268AsnMet: 1.268 ± 0.046
2.382AsnAsn: 2.382 ± 0.088
1.706AsnPro: 1.706 ± 0.052
0.924AsnGln: 0.924 ± 0.036
1.722AsnArg: 1.722 ± 0.049
2.989AsnSer: 2.989 ± 0.079
2.63AsnThr: 2.63 ± 0.067
3.337AsnVal: 3.337 ± 0.067
0.403AsnTrp: 0.403 ± 0.026
1.913AsnTyr: 1.913 ± 0.058
0.0AsnXaa: 0.0 ± 0.0
Pro
2.501ProAla: 2.501 ± 0.066
0.543ProCys: 0.543 ± 0.028
2.527ProAsp: 2.527 ± 0.059
2.977ProGlu: 2.977 ± 0.072
1.495ProPhe: 1.495 ± 0.05
1.143ProGly: 1.143 ± 0.047
0.557ProHis: 0.557 ± 0.027
1.937ProIle: 1.937 ± 0.06
2.125ProLys: 2.125 ± 0.059
2.476ProLeu: 2.476 ± 0.055
0.824ProMet: 0.824 ± 0.033
1.371ProAsn: 1.371 ± 0.049
0.734ProPro: 0.734 ± 0.036
1.08ProGln: 1.08 ± 0.047
0.916ProArg: 0.916 ± 0.036
1.719ProSer: 1.719 ± 0.047
1.658ProThr: 1.658 ± 0.05
2.813ProVal: 2.813 ± 0.059
0.228ProTrp: 0.228 ± 0.019
1.28ProTyr: 1.28 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
2.149GlnAla: 2.149 ± 0.06
0.358GlnCys: 0.358 ± 0.021
1.286GlnAsp: 1.286 ± 0.043
1.586GlnGlu: 1.586 ± 0.044
1.026GlnPhe: 1.026 ± 0.04
1.65GlnGly: 1.65 ± 0.053
0.465GlnHis: 0.465 ± 0.029
2.017GlnIle: 2.017 ± 0.055
2.175GlnLys: 2.175 ± 0.066
2.48GlnLeu: 2.48 ± 0.064
0.75GlnMet: 0.75 ± 0.04
1.421GlnAsn: 1.421 ± 0.044
0.864GlnPro: 0.864 ± 0.039
1.018GlnGln: 1.018 ± 0.038
1.26GlnArg: 1.26 ± 0.05
1.558GlnSer: 1.558 ± 0.053
1.581GlnThr: 1.581 ± 0.054
1.511GlnVal: 1.511 ± 0.048
0.258GlnTrp: 0.258 ± 0.02
1.16GlnTyr: 1.16 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
2.456ArgAla: 2.456 ± 0.062
0.631ArgCys: 0.631 ± 0.031
2.072ArgAsp: 2.072 ± 0.055
3.034ArgGlu: 3.034 ± 0.078
1.787ArgPhe: 1.787 ± 0.055
2.104ArgGly: 2.104 ± 0.049
0.767ArgHis: 0.767 ± 0.035
3.074ArgIle: 3.074 ± 0.073
3.0ArgLys: 3.0 ± 0.067
3.828ArgLeu: 3.828 ± 0.094
1.132ArgMet: 1.132 ± 0.039
1.856ArgAsn: 1.856 ± 0.059
1.137ArgPro: 1.137 ± 0.047
1.288ArgGln: 1.288 ± 0.042
1.84ArgArg: 1.84 ± 0.059
2.335ArgSer: 2.335 ± 0.059
1.997ArgThr: 1.997 ± 0.056
2.5ArgVal: 2.5 ± 0.07
0.308ArgTrp: 0.308 ± 0.022
1.767ArgTyr: 1.767 ± 0.058
0.0ArgXaa: 0.0 ± 0.0
Ser
5.07SerAla: 5.07 ± 0.094
1.069SerCys: 1.069 ± 0.041
4.631SerAsp: 4.631 ± 0.093
4.564SerGlu: 4.564 ± 0.081
2.917SerPhe: 2.917 ± 0.076
5.343SerGly: 5.343 ± 0.104
1.023SerHis: 1.023 ± 0.041
3.974SerIle: 3.974 ± 0.073
4.206SerLys: 4.206 ± 0.088
4.739SerLeu: 4.739 ± 0.089
1.66SerMet: 1.66 ± 0.055
2.54SerAsn: 2.54 ± 0.075
1.834SerPro: 1.834 ± 0.056
2.0SerGln: 2.0 ± 0.062
2.453SerArg: 2.453 ± 0.065
4.209SerSer: 4.209 ± 0.124
3.331SerThr: 3.331 ± 0.081
4.995SerVal: 4.995 ± 0.083
0.526SerTrp: 0.526 ± 0.032
2.685SerTyr: 2.685 ± 0.076
0.0SerXaa: 0.0 ± 0.0
Thr
5.409ThrAla: 5.409 ± 0.104
0.795ThrCys: 0.795 ± 0.04
3.939ThrAsp: 3.939 ± 0.086
3.825ThrGlu: 3.825 ± 0.079
2.449ThrPhe: 2.449 ± 0.062
4.336ThrGly: 4.336 ± 0.099
0.914ThrHis: 0.914 ± 0.04
3.925ThrIle: 3.925 ± 0.084
3.596ThrLys: 3.596 ± 0.078
4.763ThrLeu: 4.763 ± 0.094
1.405ThrMet: 1.405 ± 0.046
2.353ThrAsn: 2.353 ± 0.077
2.256ThrPro: 2.256 ± 0.055
1.497ThrGln: 1.497 ± 0.049
1.759ThrArg: 1.759 ± 0.05
3.368ThrSer: 3.368 ± 0.088
3.422ThrThr: 3.422 ± 0.135
5.107ThrVal: 5.107 ± 0.118
0.408ThrTrp: 0.408 ± 0.026
2.145ThrTyr: 2.145 ± 0.065
0.0ThrXaa: 0.0 ± 0.0
Val
4.951ValAla: 4.951 ± 0.093
1.494ValCys: 1.494 ± 0.05
4.096ValAsp: 4.096 ± 0.079
4.185ValGlu: 4.185 ± 0.085
3.126ValPhe: 3.126 ± 0.068
4.232ValGly: 4.232 ± 0.097
1.006ValHis: 1.006 ± 0.036
5.678ValIle: 5.678 ± 0.096
5.359ValLys: 5.359 ± 0.098
6.013ValLeu: 6.013 ± 0.106
2.102ValMet: 2.102 ± 0.056
3.15ValAsn: 3.15 ± 0.079
2.339ValPro: 2.339 ± 0.064
1.662ValGln: 1.662 ± 0.052
2.621ValArg: 2.621 ± 0.072
5.021ValSer: 5.021 ± 0.099
4.672ValThr: 4.672 ± 0.103
4.679ValVal: 4.679 ± 0.104
0.517ValTrp: 0.517 ± 0.027
2.775ValTyr: 2.775 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
0.543TrpAla: 0.543 ± 0.029
0.14TrpCys: 0.14 ± 0.015
0.513TrpAsp: 0.513 ± 0.03
0.492TrpGlu: 0.492 ± 0.027
0.368TrpPhe: 0.368 ± 0.025
0.658TrpGly: 0.658 ± 0.039
0.164TrpHis: 0.164 ± 0.016
0.503TrpIle: 0.503 ± 0.031
0.516TrpLys: 0.516 ± 0.026
0.785TrpLeu: 0.785 ± 0.04
0.138TrpMet: 0.138 ± 0.015
0.449TrpAsn: 0.449 ± 0.029
0.101TrpPro: 0.101 ± 0.012
0.346TrpGln: 0.346 ± 0.024
0.321TrpArg: 0.321 ± 0.025
0.512TrpSer: 0.512 ± 0.032
0.415TrpThr: 0.415 ± 0.028
0.463TrpVal: 0.463 ± 0.025
0.086TrpTrp: 0.086 ± 0.012
0.381TrpTyr: 0.381 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.819TyrAla: 2.819 ± 0.065
0.691TyrCys: 0.691 ± 0.032
3.175TyrAsp: 3.175 ± 0.076
2.796TyrGlu: 2.796 ± 0.074
1.93TyrPhe: 1.93 ± 0.059
2.808TyrGly: 2.808 ± 0.061
0.698TyrHis: 0.698 ± 0.031
2.932TyrIle: 2.932 ± 0.06
2.832TyrLys: 2.832 ± 0.072
3.154TyrLeu: 3.154 ± 0.075
1.032TyrMet: 1.032 ± 0.045
2.218TyrAsn: 2.218 ± 0.06
1.38TyrPro: 1.38 ± 0.044
1.046TyrGln: 1.046 ± 0.037
1.662TyrArg: 1.662 ± 0.054
2.935TyrSer: 2.935 ± 0.078
2.59TyrThr: 2.59 ± 0.068
2.725TyrVal: 2.725 ± 0.074
0.338TyrTrp: 0.338 ± 0.023
2.02TyrTyr: 2.02 ± 0.067
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2264 proteins (701634 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski