Amino acid dipepetide frequency for Bacteroides reticulotermitis JCM 10512

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.305AlaAla: 5.305 ± 0.071	0.955AlaCys: 0.955 ± 0.026	4.275AlaAsp: 4.275 ± 0.053	4.435AlaGlu: 4.435 ± 0.059	3.077AlaPhe: 3.077 ± 0.054	5.042AlaGly: 5.042 ± 0.054	1.177AlaHis: 1.177 ± 0.033	4.67AlaIle: 4.67 ± 0.064	4.014AlaLys: 4.014 ± 0.062	6.328AlaLeu: 6.328 ± 0.075	1.771AlaMet: 1.771 ± 0.036	3.481AlaAsn: 3.481 ± 0.052	2.299AlaPro: 2.299 ± 0.038	2.672AlaGln: 2.672 ± 0.047	2.922AlaArg: 2.922 ± 0.048	4.618AlaSer: 4.618 ± 0.063	4.231AlaThr: 4.231 ± 0.061	4.514AlaVal: 4.514 ± 0.055	0.913AlaTrp: 0.913 ± 0.026	3.146AlaTyr: 3.146 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.71CysAla: 0.71 ± 0.021	0.197CysCys: 0.197 ± 0.013	0.609CysAsp: 0.609 ± 0.019	0.649CysGlu: 0.649 ± 0.022	0.603CysPhe: 0.603 ± 0.019	0.94CysGly: 0.94 ± 0.026	0.271CysHis: 0.271 ± 0.013	0.829CysIle: 0.829 ± 0.022	0.612CysLys: 0.612 ± 0.023	1.058CysLeu: 1.058 ± 0.03	0.299CysMet: 0.299 ± 0.014	0.543CysAsn: 0.543 ± 0.019	0.507CysPro: 0.507 ± 0.02	0.348CysGln: 0.348 ± 0.014	0.6CysArg: 0.6 ± 0.022	0.786CysSer: 0.786 ± 0.024	0.687CysThr: 0.687 ± 0.024	0.687CysVal: 0.687 ± 0.022	0.161CysTrp: 0.161 ± 0.011	0.515CysTyr: 0.515 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.83AspAla: 3.83 ± 0.056	0.598AspCys: 0.598 ± 0.023	2.617AspAsp: 2.617 ± 0.048	3.703AspGlu: 3.703 ± 0.051	2.958AspPhe: 2.958 ± 0.043	4.397AspGly: 4.397 ± 0.071	0.9AspHis: 0.9 ± 0.026	3.799AspIle: 3.799 ± 0.052	3.963AspLys: 3.963 ± 0.057	4.796AspLeu: 4.796 ± 0.056	1.484AspMet: 1.484 ± 0.034	2.854AspAsn: 2.854 ± 0.047	2.097AspPro: 2.097 ± 0.041	1.523AspGln: 1.523 ± 0.033	2.502AspArg: 2.502 ± 0.041	3.108AspSer: 3.108 ± 0.053	2.649AspThr: 2.649 ± 0.041	3.562AspVal: 3.562 ± 0.054	0.929AspTrp: 0.929 ± 0.024	2.939AspTyr: 2.939 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	4.7GluAla: 4.7 ± 0.063	0.565GluCys: 0.565 ± 0.019	3.162GluAsp: 3.162 ± 0.054	4.746GluGlu: 4.746 ± 0.07	2.404GluPhe: 2.404 ± 0.042	4.074GluGly: 4.074 ± 0.062	1.158GluHis: 1.158 ± 0.027	4.328GluIle: 4.328 ± 0.056	4.957GluLys: 4.957 ± 0.068	6.094GluLeu: 6.094 ± 0.071	1.92GluMet: 1.92 ± 0.037	3.406GluAsn: 3.406 ± 0.05	1.753GluPro: 1.753 ± 0.032	2.587GluGln: 2.587 ± 0.049	3.135GluArg: 3.135 ± 0.048	3.405GluSer: 3.405 ± 0.05	3.225GluThr: 3.225 ± 0.043	4.306GluVal: 4.306 ± 0.062	0.904GluTrp: 0.904 ± 0.023	2.698GluTyr: 2.698 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.039PheAla: 3.039 ± 0.046	0.597PheCys: 0.597 ± 0.02	2.79PheAsp: 2.79 ± 0.046	2.411PheGlu: 2.411 ± 0.039	2.118PhePhe: 2.118 ± 0.046	3.143PheGly: 3.143 ± 0.049	0.844PheHis: 0.844 ± 0.025	2.984PheIle: 2.984 ± 0.052	2.407PheLys: 2.407 ± 0.04	3.863PheLeu: 3.863 ± 0.063	1.203PheMet: 1.203 ± 0.032	2.423PheAsn: 2.423 ± 0.036	1.788PhePro: 1.788 ± 0.032	1.365PheGln: 1.365 ± 0.026	2.205PheArg: 2.205 ± 0.036	3.45PheSer: 3.45 ± 0.05	3.026PheThr: 3.026 ± 0.048	2.781PheVal: 2.781 ± 0.045	0.59PheTrp: 0.59 ± 0.024	2.037PheTyr: 2.037 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	4.375GlyAla: 4.375 ± 0.073	0.877GlyCys: 0.877 ± 0.025	3.581GlyAsp: 3.581 ± 0.055	4.182GlyGlu: 4.182 ± 0.06	3.16GlyPhe: 3.16 ± 0.044	4.973GlyGly: 4.973 ± 0.078	1.263GlyHis: 1.263 ± 0.035	5.012GlyIle: 5.012 ± 0.057	5.298GlyLys: 5.298 ± 0.062	5.917GlyLeu: 5.917 ± 0.062	1.994GlyMet: 1.994 ± 0.039	3.647GlyAsn: 3.647 ± 0.062	1.308GlyPro: 1.308 ± 0.031	2.24GlyGln: 2.24 ± 0.039	2.924GlyArg: 2.924 ± 0.051	4.353GlySer: 4.353 ± 0.059	4.467GlyThr: 4.467 ± 0.071	5.014GlyVal: 5.014 ± 0.065	1.121GlyTrp: 1.121 ± 0.031	3.449GlyTyr: 3.449 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.232HisAla: 1.232 ± 0.031	0.279HisCys: 0.279 ± 0.015	0.856HisAsp: 0.856 ± 0.027	0.998HisGlu: 0.998 ± 0.026	1.057HisPhe: 1.057 ± 0.028	1.198HisGly: 1.198 ± 0.026	0.425HisHis: 0.425 ± 0.019	1.39HisIle: 1.39 ± 0.031	0.999HisLys: 0.999 ± 0.027	1.74HisLeu: 1.74 ± 0.035	0.369HisMet: 0.369 ± 0.015	0.882HisAsn: 0.882 ± 0.022	1.027HisPro: 1.027 ± 0.026	0.632HisGln: 0.632 ± 0.02	0.877HisArg: 0.877 ± 0.023	1.139HisSer: 1.139 ± 0.027	1.13HisThr: 1.13 ± 0.029	0.99HisVal: 0.99 ± 0.025	0.285HisTrp: 0.285 ± 0.015	0.908HisTyr: 0.908 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.056IleAla: 5.056 ± 0.063	0.888IleCys: 0.888 ± 0.026	4.174IleAsp: 4.174 ± 0.049	4.285IleGlu: 4.285 ± 0.055	2.535IlePhe: 2.535 ± 0.047	4.555IleGly: 4.555 ± 0.053	1.303IleHis: 1.303 ± 0.031	4.105IleIle: 4.105 ± 0.07	3.944IleLys: 3.944 ± 0.059	5.641IleLeu: 5.641 ± 0.071	1.364IleMet: 1.364 ± 0.032	3.435IleAsn: 3.435 ± 0.05	3.101IlePro: 3.101 ± 0.046	2.331IleGln: 2.331 ± 0.042	3.465IleArg: 3.465 ± 0.049	4.68IleSer: 4.68 ± 0.051	4.148IleThr: 4.148 ± 0.053	4.017IleVal: 4.017 ± 0.058	0.798IleTrp: 0.798 ± 0.024	2.867IleTyr: 2.867 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.693LysAla: 4.693 ± 0.064	0.489LysCys: 0.489 ± 0.018	3.984LysAsp: 3.984 ± 0.046	5.543LysGlu: 5.543 ± 0.073	2.076LysPhe: 2.076 ± 0.042	4.562LysGly: 4.562 ± 0.06	1.221LysHis: 1.221 ± 0.032	3.994LysIle: 3.994 ± 0.052	4.848LysLys: 4.848 ± 0.074	5.23LysLeu: 5.23 ± 0.067	2.039LysMet: 2.039 ± 0.037	3.417LysAsn: 3.417 ± 0.05	2.14LysPro: 2.14 ± 0.043	2.611LysGln: 2.611 ± 0.044	3.062LysArg: 3.062 ± 0.047	3.505LysSer: 3.505 ± 0.048	3.625LysThr: 3.625 ± 0.047	4.303LysVal: 4.303 ± 0.056	0.812LysTrp: 0.812 ± 0.025	3.043LysTyr: 3.043 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	6.244LeuAla: 6.244 ± 0.075	1.221LeuCys: 1.221 ± 0.03	4.551LeuAsp: 4.551 ± 0.061	4.902LeuGlu: 4.902 ± 0.063	4.469LeuPhe: 4.469 ± 0.064	5.423LeuGly: 5.423 ± 0.065	1.737LeuHis: 1.737 ± 0.035	5.581LeuIle: 5.581 ± 0.074	6.257LeuLys: 6.257 ± 0.067	8.87LeuLeu: 8.87 ± 0.107	2.252LeuMet: 2.252 ± 0.039	4.853LeuAsn: 4.853 ± 0.061	4.211LeuPro: 4.211 ± 0.055	3.325LeuGln: 3.325 ± 0.048	4.146LeuArg: 4.146 ± 0.053	6.833LeuSer: 6.833 ± 0.067	5.571LeuThr: 5.571 ± 0.062	5.033LeuVal: 5.033 ± 0.058	1.137LeuTrp: 1.137 ± 0.032	3.751LeuTyr: 3.751 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	1.808MetAla: 1.808 ± 0.035	0.24MetCys: 0.24 ± 0.011	1.459MetAsp: 1.459 ± 0.033	1.73MetGlu: 1.73 ± 0.038	0.908MetPhe: 0.908 ± 0.027	1.723MetGly: 1.723 ± 0.034	0.459MetHis: 0.459 ± 0.017	1.542MetIle: 1.542 ± 0.032	2.412MetLys: 2.412 ± 0.039	2.415MetLeu: 2.415 ± 0.038	0.695MetMet: 0.695 ± 0.019	1.567MetAsn: 1.567 ± 0.035	1.175MetPro: 1.175 ± 0.027	1.033MetGln: 1.033 ± 0.025	1.323MetArg: 1.323 ± 0.027	1.545MetSer: 1.545 ± 0.028	1.407MetThr: 1.407 ± 0.03	1.481MetVal: 1.481 ± 0.033	0.297MetTrp: 0.297 ± 0.013	0.935MetTyr: 0.935 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.537AsnAla: 3.537 ± 0.052	0.527AsnCys: 0.527 ± 0.02	2.695AsnAsp: 2.695 ± 0.043	3.163AsnGlu: 3.163 ± 0.045	2.238AsnPhe: 2.238 ± 0.042	4.123AsnGly: 4.123 ± 0.064	0.954AsnHis: 0.954 ± 0.024	3.655AsnIle: 3.655 ± 0.053	3.329AsnLys: 3.329 ± 0.042	4.616AsnLeu: 4.616 ± 0.057	1.297AsnMet: 1.297 ± 0.025	2.774AsnAsn: 2.774 ± 0.054	2.548AsnPro: 2.548 ± 0.043	1.835AsnGln: 1.835 ± 0.035	2.618AsnArg: 2.618 ± 0.046	3.167AsnSer: 3.167 ± 0.052	2.861AsnThr: 2.861 ± 0.053	3.266AsnVal: 3.266 ± 0.046	0.759AsnTrp: 0.759 ± 0.025	2.57AsnTyr: 2.57 ± 0.044	0.0AsnXaa: 0.0 ± 0.0
Pro	2.836ProAla: 2.836 ± 0.051	0.363ProCys: 0.363 ± 0.017	2.471ProAsp: 2.471 ± 0.041	3.192ProGlu: 3.192 ± 0.049	1.865ProPhe: 1.865 ± 0.037	2.496ProGly: 2.496 ± 0.044	0.709ProHis: 0.709 ± 0.021	2.479ProIle: 2.479 ± 0.041	2.053ProLys: 2.053 ± 0.034	3.283ProLeu: 3.283 ± 0.046	0.932ProMet: 0.932 ± 0.026	1.83ProAsn: 1.83 ± 0.034	0.854ProPro: 0.854 ± 0.025	1.44ProGln: 1.44 ± 0.031	1.34ProArg: 1.34 ± 0.031	2.401ProSer: 2.401 ± 0.048	2.2ProThr: 2.2 ± 0.037	2.891ProVal: 2.891 ± 0.045	0.489ProTrp: 0.489 ± 0.02	1.765ProTyr: 1.765 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	2.658GlnAla: 2.658 ± 0.042	0.294GlnCys: 0.294 ± 0.014	1.671GlnAsp: 1.671 ± 0.03	2.348GlnGlu: 2.348 ± 0.041	1.365GlnPhe: 1.365 ± 0.03	2.23GlnGly: 2.23 ± 0.04	0.662GlnHis: 0.662 ± 0.023	2.374GlnIle: 2.374 ± 0.045	2.44GlnLys: 2.44 ± 0.043	3.555GlnLeu: 3.555 ± 0.053	1.035GlnMet: 1.035 ± 0.027	1.803GlnAsn: 1.803 ± 0.036	1.354GlnPro: 1.354 ± 0.035	1.643GlnGln: 1.643 ± 0.038	1.69GlnArg: 1.69 ± 0.034	2.028GlnSer: 2.028 ± 0.037	2.281GlnThr: 2.281 ± 0.04	2.274GlnVal: 2.274 ± 0.038	0.489GlnTrp: 0.489 ± 0.019	1.534GlnTyr: 1.534 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	2.736ArgAla: 2.736 ± 0.05	0.467ArgCys: 0.467 ± 0.018	2.168ArgAsp: 2.168 ± 0.033	2.925ArgGlu: 2.925 ± 0.047	2.38ArgPhe: 2.38 ± 0.039	2.502ArgGly: 2.502 ± 0.044	0.843ArgHis: 0.843 ± 0.026	3.531ArgIle: 3.531 ± 0.046	3.31ArgLys: 3.31 ± 0.051	4.412ArgLeu: 4.412 ± 0.062	1.557ArgMet: 1.557 ± 0.029	2.518ArgAsn: 2.518 ± 0.039	1.607ArgPro: 1.607 ± 0.039	1.698ArgGln: 1.698 ± 0.035	2.221ArgArg: 2.221 ± 0.041	2.584ArgSer: 2.584 ± 0.038	2.604ArgThr: 2.604 ± 0.038	2.842ArgVal: 2.842 ± 0.051	0.7ArgTrp: 0.7 ± 0.019	2.258ArgTyr: 2.258 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	4.25SerAla: 4.25 ± 0.054	0.885SerCys: 0.885 ± 0.028	3.443SerAsp: 3.443 ± 0.047	3.566SerGlu: 3.566 ± 0.052	3.426SerPhe: 3.426 ± 0.05	4.896SerGly: 4.896 ± 0.075	1.169SerHis: 1.169 ± 0.029	4.468SerIle: 4.468 ± 0.06	3.544SerLys: 3.544 ± 0.053	6.075SerLeu: 6.075 ± 0.071	1.55SerMet: 1.55 ± 0.034	3.107SerAsn: 3.107 ± 0.049	2.521SerPro: 2.521 ± 0.04	2.072SerGln: 2.072 ± 0.031	2.698SerArg: 2.698 ± 0.048	4.3SerSer: 4.3 ± 0.069	3.686SerThr: 3.686 ± 0.051	4.337SerVal: 4.337 ± 0.054	0.902SerTrp: 0.902 ± 0.027	3.116SerTyr: 3.116 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	4.209ThrAla: 4.209 ± 0.06	0.583ThrCys: 0.583 ± 0.02	3.574ThrAsp: 3.574 ± 0.054	3.435ThrGlu: 3.435 ± 0.051	2.869ThrPhe: 2.869 ± 0.045	4.649ThrGly: 4.649 ± 0.063	1.095ThrHis: 1.095 ± 0.027	3.942ThrIle: 3.942 ± 0.053	2.967ThrLys: 2.967 ± 0.044	5.544ThrLeu: 5.544 ± 0.058	1.205ThrMet: 1.205 ± 0.032	2.897ThrAsn: 2.897 ± 0.048	2.895ThrPro: 2.895 ± 0.04	2.001ThrGln: 2.001 ± 0.039	2.232ThrArg: 2.232 ± 0.042	3.737ThrSer: 3.737 ± 0.05	3.488ThrThr: 3.488 ± 0.06	4.056ThrVal: 4.056 ± 0.051	0.771ThrTrp: 0.771 ± 0.024	2.808ThrTyr: 2.808 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	4.526ValAla: 4.526 ± 0.059	0.871ValCys: 0.871 ± 0.026	3.769ValAsp: 3.769 ± 0.059	3.994ValGlu: 3.994 ± 0.056	2.845ValPhe: 2.845 ± 0.043	4.141ValGly: 4.141 ± 0.053	1.059ValHis: 1.059 ± 0.026	4.214ValIle: 4.214 ± 0.058	4.123ValLys: 4.123 ± 0.054	5.601ValLeu: 5.601 ± 0.066	1.581ValMet: 1.581 ± 0.032	3.513ValAsn: 3.513 ± 0.056	2.452ValPro: 2.452 ± 0.046	2.03ValGln: 2.03 ± 0.034	2.983ValArg: 2.983 ± 0.046	4.514ValSer: 4.514 ± 0.064	3.939ValThr: 3.939 ± 0.057	4.37ValVal: 4.37 ± 0.064	0.822ValTrp: 0.822 ± 0.023	2.737ValTyr: 2.737 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.848TrpAla: 0.848 ± 0.024	0.189TrpCys: 0.189 ± 0.011	0.773TrpAsp: 0.773 ± 0.024	0.882TrpGlu: 0.882 ± 0.024	0.565TrpPhe: 0.565 ± 0.019	1.041TrpGly: 1.041 ± 0.031	0.251TrpHis: 0.251 ± 0.014	0.909TrpIle: 0.909 ± 0.033	0.978TrpLys: 0.978 ± 0.027	1.245TrpLeu: 1.245 ± 0.028	0.486TrpMet: 0.486 ± 0.018	0.896TrpAsn: 0.896 ± 0.029	0.288TrpPro: 0.288 ± 0.015	0.568TrpGln: 0.568 ± 0.02	0.599TrpArg: 0.599 ± 0.016	0.813TrpSer: 0.813 ± 0.023	0.787TrpThr: 0.787 ± 0.024	0.816TrpVal: 0.816 ± 0.023	0.214TrpTrp: 0.214 ± 0.012	0.59TrpTyr: 0.59 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.256TyrAla: 3.256 ± 0.047	0.527TyrCys: 0.527 ± 0.019	2.587TyrAsp: 2.587 ± 0.044	2.439TyrGlu: 2.439 ± 0.044	2.146TyrPhe: 2.146 ± 0.035	3.045TyrGly: 3.045 ± 0.047	0.914TyrHis: 0.914 ± 0.026	2.885TyrIle: 2.885 ± 0.044	2.743TyrLys: 2.743 ± 0.041	4.083TyrLeu: 4.083 ± 0.055	1.12TyrMet: 1.12 ± 0.025	2.686TyrAsn: 2.686 ± 0.053	1.964TyrPro: 1.964 ± 0.038	1.776TyrGln: 1.776 ± 0.04	2.322TyrArg: 2.322 ± 0.041	3.04TyrSer: 3.04 ± 0.049	2.945TyrThr: 2.945 ± 0.047	2.54TyrVal: 2.54 ± 0.04	0.645TyrTrp: 0.645 ± 0.024	2.295TyrTyr: 2.295 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4841 proteins (1526201 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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