Amino acid dipepetide frequency for Streptomyces sp. SolWspMP-5a-2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.196AlaAla: 22.196 ± 0.135	1.07AlaCys: 1.07 ± 0.019	8.958AlaAsp: 8.958 ± 0.077	8.457AlaGlu: 8.457 ± 0.073	3.6AlaPhe: 3.6 ± 0.039	13.406AlaGly: 13.406 ± 0.086	3.167AlaHis: 3.167 ± 0.034	3.039AlaIle: 3.039 ± 0.037	2.436AlaLys: 2.436 ± 0.047	15.408AlaLeu: 15.408 ± 0.104	2.299AlaMet: 2.299 ± 0.03	1.772AlaAsn: 1.772 ± 0.028	7.785AlaPro: 7.785 ± 0.062	3.548AlaGln: 3.548 ± 0.042	11.584AlaArg: 11.584 ± 0.077	6.018AlaSer: 6.018 ± 0.057	7.286AlaThr: 7.286 ± 0.064	12.977AlaVal: 12.977 ± 0.089	1.912AlaTrp: 1.912 ± 0.029	2.595AlaTyr: 2.595 ± 0.029	0.0AlaXaa: 0.0 ± 0.0
Cys	1.192CysAla: 1.192 ± 0.021	0.091CysCys: 0.091 ± 0.007	0.46CysAsp: 0.46 ± 0.013	0.356CysGlu: 0.356 ± 0.013	0.213CysPhe: 0.213 ± 0.01	0.975CysGly: 0.975 ± 0.022	0.195CysHis: 0.195 ± 0.009	0.117CysIle: 0.117 ± 0.006	0.107CysLys: 0.107 ± 0.006	0.754CysLeu: 0.754 ± 0.017	0.1CysMet: 0.1 ± 0.007	0.115CysAsn: 0.115 ± 0.006	0.476CysPro: 0.476 ± 0.016	0.152CysGln: 0.152 ± 0.008	0.611CysArg: 0.611 ± 0.015	0.429CysSer: 0.429 ± 0.015	0.465CysThr: 0.465 ± 0.013	0.672CysVal: 0.672 ± 0.017	0.122CysTrp: 0.122 ± 0.007	0.141CysTyr: 0.141 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	8.247AspAla: 8.247 ± 0.069	0.406AspCys: 0.406 ± 0.014	3.901AspAsp: 3.901 ± 0.045	3.612AspGlu: 3.612 ± 0.041	1.594AspPhe: 1.594 ± 0.025	6.908AspGly: 6.908 ± 0.065	1.52AspHis: 1.52 ± 0.028	1.714AspIle: 1.714 ± 0.027	0.993AspLys: 0.993 ± 0.024	6.547AspLeu: 6.547 ± 0.056	0.723AspMet: 0.723 ± 0.018	0.845AspAsn: 0.845 ± 0.02	4.834AspPro: 4.834 ± 0.047	1.482AspGln: 1.482 ± 0.026	5.403AspArg: 5.403 ± 0.055	2.416AspSer: 2.416 ± 0.031	3.397AspThr: 3.397 ± 0.046	4.852AspVal: 4.852 ± 0.043	0.998AspTrp: 0.998 ± 0.021	0.996AspTyr: 0.996 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	6.854GluAla: 6.854 ± 0.074	0.361GluCys: 0.361 ± 0.013	2.606GluAsp: 2.606 ± 0.034	3.281GluGlu: 3.281 ± 0.041	1.386GluPhe: 1.386 ± 0.022	4.13GluGly: 4.13 ± 0.038	1.48GluHis: 1.48 ± 0.025	2.127GluIle: 2.127 ± 0.033	1.254GluLys: 1.254 ± 0.026	6.25GluLeu: 6.25 ± 0.057	0.788GluMet: 0.788 ± 0.022	0.966GluAsn: 0.966 ± 0.021	3.292GluPro: 3.292 ± 0.038	1.973GluGln: 1.973 ± 0.028	5.65GluArg: 5.65 ± 0.054	2.495GluSer: 2.495 ± 0.037	2.855GluThr: 2.855 ± 0.034	4.238GluVal: 4.238 ± 0.049	0.693GluTrp: 0.693 ± 0.016	0.985GluTyr: 0.985 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.759PheAla: 3.759 ± 0.036	0.25PheCys: 0.25 ± 0.009	1.984PheAsp: 1.984 ± 0.029	1.355PheGlu: 1.355 ± 0.027	0.871PhePhe: 0.871 ± 0.022	2.955PheGly: 2.955 ± 0.035	0.603PheHis: 0.603 ± 0.015	0.582PheIle: 0.582 ± 0.014	0.46PheLys: 0.46 ± 0.016	2.605PheLeu: 2.605 ± 0.038	0.368PheMet: 0.368 ± 0.013	0.491PheAsn: 0.491 ± 0.015	1.401PhePro: 1.401 ± 0.023	0.672PheGln: 0.672 ± 0.016	1.859PheArg: 1.859 ± 0.03	1.386PheSer: 1.386 ± 0.026	2.008PheThr: 2.008 ± 0.027	2.222PheVal: 2.222 ± 0.032	0.408PheTrp: 0.408 ± 0.013	0.556PheTyr: 0.556 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	11.942GlyAla: 11.942 ± 0.087	0.822GlyCys: 0.822 ± 0.019	5.461GlyAsp: 5.461 ± 0.053	4.907GlyGlu: 4.907 ± 0.051	2.872GlyPhe: 2.872 ± 0.033	9.32GlyGly: 9.32 ± 0.082	2.478GlyHis: 2.478 ± 0.035	3.088GlyIle: 3.088 ± 0.041	2.074GlyLys: 2.074 ± 0.043	9.628GlyLeu: 9.628 ± 0.069	1.947GlyMet: 1.947 ± 0.028	1.661GlyAsn: 1.661 ± 0.033	5.515GlyPro: 5.515 ± 0.054	2.621GlyGln: 2.621 ± 0.036	8.304GlyArg: 8.304 ± 0.075	5.332GlySer: 5.332 ± 0.058	6.894GlyThr: 6.894 ± 0.063	7.995GlyVal: 7.995 ± 0.078	1.753GlyTrp: 1.753 ± 0.024	2.249GlyTyr: 2.249 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.833HisAla: 2.833 ± 0.042	0.193HisCys: 0.193 ± 0.009	1.402HisAsp: 1.402 ± 0.025	1.162HisGlu: 1.162 ± 0.02	0.647HisPhe: 0.647 ± 0.017	2.515HisGly: 2.515 ± 0.033	0.734HisHis: 0.734 ± 0.024	0.609HisIle: 0.609 ± 0.016	0.304HisLys: 0.304 ± 0.012	2.609HisLeu: 2.609 ± 0.036	0.304HisMet: 0.304 ± 0.011	0.333HisAsn: 0.333 ± 0.011	1.972HisPro: 1.972 ± 0.037	0.656HisGln: 0.656 ± 0.016	2.346HisArg: 2.346 ± 0.083	0.978HisSer: 0.978 ± 0.018	1.377HisThr: 1.377 ± 0.027	1.664HisVal: 1.664 ± 0.026	0.374HisTrp: 0.374 ± 0.012	0.469HisTyr: 0.469 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.383IleAla: 4.383 ± 0.05	0.25IleCys: 0.25 ± 0.01	2.027IleAsp: 2.027 ± 0.031	1.685IleGlu: 1.685 ± 0.027	0.581IlePhe: 0.581 ± 0.015	3.335IleGly: 3.335 ± 0.045	0.523IleHis: 0.523 ± 0.017	0.698IleIle: 0.698 ± 0.021	0.615IleLys: 0.615 ± 0.016	2.171IleLeu: 2.171 ± 0.032	0.385IleMet: 0.385 ± 0.012	0.603IleAsn: 0.603 ± 0.017	1.493IlePro: 1.493 ± 0.023	0.604IleGln: 0.604 ± 0.014	2.011IleArg: 2.011 ± 0.027	1.467IleSer: 1.467 ± 0.028	1.969IleThr: 1.969 ± 0.028	2.526IleVal: 2.526 ± 0.038	0.326IleTrp: 0.326 ± 0.011	0.452IleTyr: 0.452 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	2.548LysAla: 2.548 ± 0.046	0.096LysCys: 0.096 ± 0.007	1.206LysAsp: 1.206 ± 0.029	1.026LysGlu: 1.026 ± 0.025	0.391LysPhe: 0.391 ± 0.013	1.633LysGly: 1.633 ± 0.029	0.351LysHis: 0.351 ± 0.013	0.753LysIle: 0.753 ± 0.018	0.769LysLys: 0.769 ± 0.028	1.672LysLeu: 1.672 ± 0.031	0.33LysMet: 0.33 ± 0.012	0.466LysAsn: 0.466 ± 0.015	1.088LysPro: 1.088 ± 0.023	0.555LysGln: 0.555 ± 0.018	1.251LysArg: 1.251 ± 0.028	1.007LysSer: 1.007 ± 0.024	1.126LysThr: 1.126 ± 0.028	1.641LysVal: 1.641 ± 0.03	0.23LysTrp: 0.23 ± 0.009	0.387LysTyr: 0.387 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	15.699LeuAla: 15.699 ± 0.11	0.851LeuCys: 0.851 ± 0.022	7.044LeuAsp: 7.044 ± 0.064	4.384LeuGlu: 4.384 ± 0.048	2.595LeuPhe: 2.595 ± 0.036	9.416LeuGly: 9.416 ± 0.072	2.358LeuHis: 2.358 ± 0.038	2.973LeuIle: 2.973 ± 0.036	1.77LeuLys: 1.77 ± 0.029	11.789LeuLeu: 11.789 ± 0.095	1.572LeuMet: 1.572 ± 0.029	1.524LeuAsn: 1.524 ± 0.028	6.727LeuPro: 6.727 ± 0.067	2.045LeuGln: 2.045 ± 0.03	9.19LeuArg: 9.19 ± 0.071	5.236LeuSer: 5.236 ± 0.052	7.368LeuThr: 7.368 ± 0.065	9.029LeuVal: 9.029 ± 0.075	1.363LeuTrp: 1.363 ± 0.024	1.838LeuTyr: 1.838 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.058MetAla: 2.058 ± 0.03	0.13MetCys: 0.13 ± 0.007	0.839MetAsp: 0.839 ± 0.017	0.665MetGlu: 0.665 ± 0.018	0.424MetPhe: 0.424 ± 0.015	1.222MetGly: 1.222 ± 0.024	0.312MetHis: 0.312 ± 0.01	0.614MetIle: 0.614 ± 0.018	0.361MetLys: 0.361 ± 0.012	1.536MetLeu: 1.536 ± 0.025	0.271MetMet: 0.271 ± 0.011	0.414MetAsn: 0.414 ± 0.011	0.999MetPro: 0.999 ± 0.02	0.388MetGln: 0.388 ± 0.012	1.365MetArg: 1.365 ± 0.023	1.27MetSer: 1.27 ± 0.022	1.534MetThr: 1.534 ± 0.024	1.211MetVal: 1.211 ± 0.023	0.189MetTrp: 0.189 ± 0.008	0.312MetTyr: 0.312 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.016AsnAla: 2.016 ± 0.032	0.15AsnCys: 0.15 ± 0.008	0.861AsnAsp: 0.861 ± 0.018	0.713AsnGlu: 0.713 ± 0.018	0.45AsnPhe: 0.45 ± 0.013	1.756AsnGly: 1.756 ± 0.035	0.362AsnHis: 0.362 ± 0.013	0.588AsnIle: 0.588 ± 0.015	0.355AsnLys: 0.355 ± 0.013	1.533AsnLeu: 1.533 ± 0.028	0.262AsnMet: 0.262 ± 0.01	0.382AsnAsn: 0.382 ± 0.015	1.234AsnPro: 1.234 ± 0.025	0.478AsnGln: 0.478 ± 0.015	1.187AsnArg: 1.187 ± 0.021	0.891AsnSer: 0.891 ± 0.023	1.035AsnThr: 1.035 ± 0.021	1.253AsnVal: 1.253 ± 0.023	0.256AsnTrp: 0.256 ± 0.011	0.375AsnTyr: 0.375 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	9.412ProAla: 9.412 ± 0.087	0.342ProCys: 0.342 ± 0.012	4.717ProAsp: 4.717 ± 0.045	4.143ProGlu: 4.143 ± 0.042	1.536ProPhe: 1.536 ± 0.027	7.279ProGly: 7.279 ± 0.068	1.519ProHis: 1.519 ± 0.033	1.147ProIle: 1.147 ± 0.025	0.988ProLys: 0.988 ± 0.02	5.601ProLeu: 5.601 ± 0.05	0.929ProMet: 0.929 ± 0.02	0.78ProAsn: 0.78 ± 0.017	3.828ProPro: 3.828 ± 0.072	1.62ProGln: 1.62 ± 0.031	4.532ProArg: 4.532 ± 0.118	3.267ProSer: 3.267 ± 0.039	3.281ProThr: 3.281 ± 0.047	5.671ProVal: 5.671 ± 0.044	0.905ProTrp: 0.905 ± 0.02	1.33ProTyr: 1.33 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.379GlnAla: 3.379 ± 0.045	0.163GlnCys: 0.163 ± 0.008	1.421GlnAsp: 1.421 ± 0.025	1.395GlnGlu: 1.395 ± 0.026	0.655GlnPhe: 0.655 ± 0.017	2.198GlnGly: 2.198 ± 0.034	0.629GlnHis: 0.629 ± 0.017	1.003GlnIle: 1.003 ± 0.018	0.54GlnLys: 0.54 ± 0.019	2.68GlnLeu: 2.68 ± 0.032	0.423GlnMet: 0.423 ± 0.014	0.479GlnAsn: 0.479 ± 0.017	1.531GlnPro: 1.531 ± 0.026	1.157GlnGln: 1.157 ± 0.032	2.36GlnArg: 2.36 ± 0.038	1.182GlnSer: 1.182 ± 0.023	1.29GlnThr: 1.29 ± 0.023	2.228GlnVal: 2.228 ± 0.034	0.407GlnTrp: 0.407 ± 0.014	0.55GlnTyr: 0.55 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	11.174ArgAla: 11.174 ± 0.084	0.638ArgCys: 0.638 ± 0.017	4.704ArgAsp: 4.704 ± 0.051	4.762ArgGlu: 4.762 ± 0.05	2.38ArgPhe: 2.38 ± 0.028	6.425ArgGly: 6.425 ± 0.071	2.378ArgHis: 2.378 ± 0.073	2.964ArgIle: 2.964 ± 0.034	1.397ArgLys: 1.397 ± 0.027	9.412ArgLeu: 9.412 ± 0.081	1.68ArgMet: 1.68 ± 0.026	1.281ArgAsn: 1.281 ± 0.024	5.625ArgPro: 5.625 ± 0.144	2.239ArgGln: 2.239 ± 0.031	8.483ArgArg: 8.483 ± 0.245	4.119ArgSer: 4.119 ± 0.041	5.84ArgThr: 5.84 ± 0.051	6.407ArgVal: 6.407 ± 0.055	1.425ArgTrp: 1.425 ± 0.026	1.768ArgTyr: 1.768 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.871SerAla: 6.871 ± 0.059	0.404SerCys: 0.404 ± 0.014	2.655SerAsp: 2.655 ± 0.034	2.157SerGlu: 2.157 ± 0.032	1.495SerPhe: 1.495 ± 0.024	5.982SerGly: 5.982 ± 0.069	0.964SerHis: 0.964 ± 0.018	1.215SerIle: 1.215 ± 0.024	0.886SerLys: 0.886 ± 0.022	4.916SerLeu: 4.916 ± 0.049	0.975SerMet: 0.975 ± 0.022	0.794SerAsn: 0.794 ± 0.02	3.219SerPro: 3.219 ± 0.041	1.14SerGln: 1.14 ± 0.022	3.711SerArg: 3.711 ± 0.04	2.742SerSer: 2.742 ± 0.04	3.017SerThr: 3.017 ± 0.04	4.284SerVal: 4.284 ± 0.044	0.929SerTrp: 0.929 ± 0.02	1.17SerTyr: 1.17 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	9.588ThrAla: 9.588 ± 0.072	0.439ThrCys: 0.439 ± 0.013	3.748ThrAsp: 3.748 ± 0.043	3.201ThrGlu: 3.201 ± 0.031	1.6ThrPhe: 1.6 ± 0.026	7.417ThrGly: 7.417 ± 0.06	1.223ThrHis: 1.223 ± 0.021	1.448ThrIle: 1.448 ± 0.025	0.984ThrLys: 0.984 ± 0.023	5.988ThrLeu: 5.988 ± 0.052	0.889ThrMet: 0.889 ± 0.018	0.87ThrAsn: 0.87 ± 0.019	4.422ThrPro: 4.422 ± 0.056	1.238ThrGln: 1.238 ± 0.022	4.255ThrArg: 4.255 ± 0.046	3.176ThrSer: 3.176 ± 0.037	3.885ThrThr: 3.885 ± 0.053	6.373ThrVal: 6.373 ± 0.056	0.898ThrTrp: 0.898 ± 0.02	1.256ThrTyr: 1.256 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	11.003ValAla: 11.003 ± 0.084	0.767ValCys: 0.767 ± 0.015	5.114ValAsp: 5.114 ± 0.051	4.597ValGlu: 4.597 ± 0.045	2.413ValPhe: 2.413 ± 0.03	6.733ValGly: 6.733 ± 0.082	1.956ValHis: 1.956 ± 0.029	2.47ValIle: 2.47 ± 0.039	1.558ValLys: 1.558 ± 0.032	9.857ValLeu: 9.857 ± 0.075	1.363ValMet: 1.363 ± 0.021	1.577ValAsn: 1.577 ± 0.029	5.556ValPro: 5.556 ± 0.054	1.967ValGln: 1.967 ± 0.026	7.816ValArg: 7.816 ± 0.061	4.264ValSer: 4.264 ± 0.047	6.014ValThr: 6.014 ± 0.055	8.274ValVal: 8.274 ± 0.07	1.195ValTrp: 1.195 ± 0.022	1.558ValTyr: 1.558 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.679TrpAla: 1.679 ± 0.028	0.153TrpCys: 0.153 ± 0.008	0.875TrpAsp: 0.875 ± 0.02	0.711TrpGlu: 0.711 ± 0.018	0.494TrpPhe: 0.494 ± 0.015	1.053TrpGly: 1.053 ± 0.019	0.369TrpHis: 0.369 ± 0.012	0.524TrpIle: 0.524 ± 0.015	0.341TrpLys: 0.341 ± 0.012	1.767TrpLeu: 1.767 ± 0.03	0.281TrpMet: 0.281 ± 0.01	0.403TrpAsn: 0.403 ± 0.013	0.776TrpPro: 0.776 ± 0.019	0.579TrpGln: 0.579 ± 0.015	1.368TrpArg: 1.368 ± 0.024	0.987TrpSer: 0.987 ± 0.019	1.071TrpThr: 1.071 ± 0.021	0.96TrpVal: 0.96 ± 0.021	0.325TrpTrp: 0.325 ± 0.013	0.348TrpTyr: 0.348 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.68TyrAla: 2.68 ± 0.038	0.165TyrCys: 0.165 ± 0.008	1.405TyrAsp: 1.405 ± 0.032	1.095TyrGlu: 1.095 ± 0.025	0.598TyrPhe: 0.598 ± 0.014	2.206TyrGly: 2.206 ± 0.029	0.359TyrHis: 0.359 ± 0.011	0.429TyrIle: 0.429 ± 0.013	0.335TyrLys: 0.335 ± 0.013	2.048TyrLeu: 2.048 ± 0.028	0.224TyrMet: 0.224 ± 0.009	0.378TyrAsn: 0.378 ± 0.012	1.054TyrPro: 1.054 ± 0.024	0.559TyrGln: 0.559 ± 0.016	1.816TyrArg: 1.816 ± 0.028	0.862TyrSer: 0.862 ± 0.02	1.187TyrThr: 1.187 ± 0.022	1.576TyrVal: 1.576 ± 0.027	0.358TyrTrp: 0.358 ± 0.012	0.429TyrTyr: 0.429 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7895 proteins (2606032 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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