Amino acid dipepetide frequency for Rhodosalinus sediminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	25.238AlaAla: 25.238 ± 0.296	1.133AlaCys: 1.133 ± 0.036	7.672AlaAsp: 7.672 ± 0.111	11.979AlaGlu: 11.979 ± 0.14	4.409AlaPhe: 4.409 ± 0.08	13.864AlaGly: 13.864 ± 0.163	2.824AlaHis: 2.824 ± 0.055	5.126AlaIle: 5.126 ± 0.079	2.673AlaLys: 2.673 ± 0.063	17.151AlaLeu: 17.151 ± 0.19	3.829AlaMet: 3.829 ± 0.074	2.134AlaAsn: 2.134 ± 0.051	8.797AlaPro: 8.797 ± 0.145	4.379AlaGln: 4.379 ± 0.071	13.871AlaArg: 13.871 ± 0.186	4.664AlaSer: 4.664 ± 0.072	6.53AlaThr: 6.53 ± 0.098	10.055AlaVal: 10.055 ± 0.125	1.756AlaTrp: 1.756 ± 0.051	2.554AlaTyr: 2.554 ± 0.054	0.001AlaXaa: 0.001 ± 0.001
Cys	1.126CysAla: 1.126 ± 0.039	0.077CysCys: 0.077 ± 0.008	0.511CysAsp: 0.511 ± 0.024	0.407CysGlu: 0.407 ± 0.021	0.274CysPhe: 0.274 ± 0.016	0.901CysGly: 0.901 ± 0.034	0.228CysHis: 0.228 ± 0.017	0.313CysIle: 0.313 ± 0.018	0.12CysLys: 0.12 ± 0.013	0.773CysLeu: 0.773 ± 0.028	0.109CysMet: 0.109 ± 0.012	0.166CysAsn: 0.166 ± 0.015	0.494CysPro: 0.494 ± 0.024	0.14CysGln: 0.14 ± 0.014	0.621CysArg: 0.621 ± 0.029	0.327CysSer: 0.327 ± 0.019	0.418CysThr: 0.418 ± 0.022	0.546CysVal: 0.546 ± 0.027	0.103CysTrp: 0.103 ± 0.011	0.163CysTyr: 0.163 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.775AspAla: 8.775 ± 0.114	0.463AspCys: 0.463 ± 0.023	3.241AspAsp: 3.241 ± 0.077	3.317AspGlu: 3.317 ± 0.066	2.097AspPhe: 2.097 ± 0.056	5.469AspGly: 5.469 ± 0.092	1.259AspHis: 1.259 ± 0.037	2.349AspIle: 2.349 ± 0.057	1.063AspLys: 1.063 ± 0.035	6.238AspLeu: 6.238 ± 0.094	1.405AspMet: 1.405 ± 0.039	0.863AspAsn: 0.863 ± 0.034	4.061AspPro: 4.061 ± 0.068	1.34AspGln: 1.34 ± 0.04	5.22AspArg: 5.22 ± 0.081	1.63AspSer: 1.63 ± 0.054	2.703AspThr: 2.703 ± 0.061	3.975AspVal: 3.975 ± 0.067	1.352AspTrp: 1.352 ± 0.039	1.486AspTyr: 1.486 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	11.569GluAla: 11.569 ± 0.157	0.293GluCys: 0.293 ± 0.018	3.539GluAsp: 3.539 ± 0.063	4.475GluGlu: 4.475 ± 0.087	1.506GluPhe: 1.506 ± 0.048	6.436GluGly: 6.436 ± 0.101	1.14GluHis: 1.14 ± 0.039	3.715GluIle: 3.715 ± 0.067	1.684GluLys: 1.684 ± 0.055	5.189GluLeu: 5.189 ± 0.072	2.02GluMet: 2.02 ± 0.048	1.324GluAsn: 1.324 ± 0.045	2.769GluPro: 2.769 ± 0.062	1.608GluGln: 1.608 ± 0.048	5.931GluArg: 5.931 ± 0.099	2.413GluSer: 2.413 ± 0.054	4.67GluThr: 4.67 ± 0.084	5.268GluVal: 5.268 ± 0.085	0.649GluTrp: 0.649 ± 0.023	0.889GluTyr: 0.889 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.678PheAla: 4.678 ± 0.078	0.341PheCys: 0.341 ± 0.02	2.491PheAsp: 2.491 ± 0.055	2.222PheGlu: 2.222 ± 0.051	1.267PhePhe: 1.267 ± 0.046	3.369PheGly: 3.369 ± 0.065	0.708PheHis: 0.708 ± 0.028	1.128PheIle: 1.128 ± 0.038	0.58PheLys: 0.58 ± 0.024	3.13PheLeu: 3.13 ± 0.076	0.676PheMet: 0.676 ± 0.029	0.727PheAsn: 0.727 ± 0.027	1.502PhePro: 1.502 ± 0.037	0.789PheGln: 0.789 ± 0.033	2.339PheArg: 2.339 ± 0.051	1.559PheSer: 1.559 ± 0.043	1.856PheThr: 1.856 ± 0.042	2.592PheVal: 2.592 ± 0.058	0.497PheTrp: 0.497 ± 0.023	0.829PheTyr: 0.829 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	13.246GlyAla: 13.246 ± 0.166	0.854GlyCys: 0.854 ± 0.031	4.916GlyAsp: 4.916 ± 0.086	5.627GlyGlu: 5.627 ± 0.093	3.388GlyPhe: 3.388 ± 0.068	8.251GlyGly: 8.251 ± 0.118	2.003GlyHis: 2.003 ± 0.048	3.563GlyIle: 3.563 ± 0.06	2.196GlyLys: 2.196 ± 0.054	9.742GlyLeu: 9.742 ± 0.116	2.605GlyMet: 2.605 ± 0.055	1.452GlyAsn: 1.452 ± 0.047	4.529GlyPro: 4.529 ± 0.078	2.575GlyGln: 2.575 ± 0.061	7.693GlyArg: 7.693 ± 0.115	3.186GlySer: 3.186 ± 0.062	4.776GlyThr: 4.776 ± 0.073	6.954GlyVal: 6.954 ± 0.104	1.59GlyTrp: 1.59 ± 0.045	2.122GlyTyr: 2.122 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.679HisAla: 2.679 ± 0.059	0.2HisCys: 0.2 ± 0.015	1.246HisAsp: 1.246 ± 0.034	1.05HisGlu: 1.05 ± 0.036	0.759HisPhe: 0.759 ± 0.029	2.066HisGly: 2.066 ± 0.05	0.529HisHis: 0.529 ± 0.027	0.72HisIle: 0.72 ± 0.028	0.331HisLys: 0.331 ± 0.02	2.102HisLeu: 2.102 ± 0.051	0.481HisMet: 0.481 ± 0.025	0.35HisAsn: 0.35 ± 0.018	1.389HisPro: 1.389 ± 0.044	0.474HisGln: 0.474 ± 0.023	1.51HisArg: 1.51 ± 0.042	0.619HisSer: 0.619 ± 0.029	0.741HisThr: 0.741 ± 0.026	1.624HisVal: 1.624 ± 0.044	0.337HisTrp: 0.337 ± 0.019	0.54HisTyr: 0.54 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.543IleAla: 6.543 ± 0.086	0.438IleCys: 0.438 ± 0.024	2.913IleAsp: 2.913 ± 0.056	3.124IleGlu: 3.124 ± 0.056	1.329IlePhe: 1.329 ± 0.04	3.974IleGly: 3.974 ± 0.066	0.704IleHis: 0.704 ± 0.03	1.119IleIle: 1.119 ± 0.041	0.796IleLys: 0.796 ± 0.032	3.872IleLeu: 3.872 ± 0.083	0.761IleMet: 0.761 ± 0.031	0.875IleAsn: 0.875 ± 0.032	1.921IlePro: 1.921 ± 0.046	0.795IleGln: 0.795 ± 0.033	3.121IleArg: 3.121 ± 0.055	1.85IleSer: 1.85 ± 0.046	2.062IleThr: 2.062 ± 0.055	3.286IleVal: 3.286 ± 0.06	0.529IleTrp: 0.529 ± 0.023	0.911IleTyr: 0.911 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	2.841LysAla: 2.841 ± 0.062	0.134LysCys: 0.134 ± 0.014	1.098LysAsp: 1.098 ± 0.041	1.115LysGlu: 1.115 ± 0.047	0.574LysPhe: 0.574 ± 0.027	1.912LysGly: 1.912 ± 0.053	0.419LysHis: 0.419 ± 0.021	0.984LysIle: 0.984 ± 0.041	0.804LysLys: 0.804 ± 0.045	2.167LysLeu: 2.167 ± 0.054	0.545LysMet: 0.545 ± 0.025	0.43LysAsn: 0.43 ± 0.026	1.268LysPro: 1.268 ± 0.039	0.577LysGln: 0.577 ± 0.027	1.809LysArg: 1.809 ± 0.047	1.188LysSer: 1.188 ± 0.039	1.345LysThr: 1.345 ± 0.036	1.628LysVal: 1.628 ± 0.049	0.258LysTrp: 0.258 ± 0.019	0.445LysTyr: 0.445 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	16.16LeuAla: 16.16 ± 0.21	0.858LeuCys: 0.858 ± 0.03	6.585LeuAsp: 6.585 ± 0.093	6.283LeuGlu: 6.283 ± 0.096	3.399LeuPhe: 3.399 ± 0.065	8.902LeuGly: 8.902 ± 0.112	1.803LeuHis: 1.803 ± 0.046	4.16LeuIle: 4.16 ± 0.071	2.246LeuLys: 2.246 ± 0.06	8.839LeuLeu: 8.839 ± 0.141	2.431LeuMet: 2.431 ± 0.056	1.873LeuAsn: 1.873 ± 0.044	5.661LeuPro: 5.661 ± 0.077	2.236LeuGln: 2.236 ± 0.048	8.273LeuArg: 8.273 ± 0.111	5.661LeuSer: 5.661 ± 0.079	5.661LeuThr: 5.661 ± 0.094	7.192LeuVal: 7.192 ± 0.104	1.43LeuTrp: 1.43 ± 0.045	1.919LeuTyr: 1.919 ± 0.049	0.001LeuXaa: 0.001 ± 0.001
Met	3.499MetAla: 3.499 ± 0.07	0.149MetCys: 0.149 ± 0.011	1.235MetAsp: 1.235 ± 0.036	1.429MetGlu: 1.429 ± 0.041	0.61MetPhe: 0.61 ± 0.028	2.145MetGly: 2.145 ± 0.045	0.453MetHis: 0.453 ± 0.022	1.157MetIle: 1.157 ± 0.032	0.715MetLys: 0.715 ± 0.031	2.275MetLeu: 2.275 ± 0.059	0.623MetMet: 0.623 ± 0.027	0.634MetAsn: 0.634 ± 0.026	1.461MetPro: 1.461 ± 0.042	0.865MetGln: 0.865 ± 0.033	2.044MetArg: 2.044 ± 0.044	1.426MetSer: 1.426 ± 0.041	1.957MetThr: 1.957 ± 0.047	1.599MetVal: 1.599 ± 0.042	0.22MetTrp: 0.22 ± 0.017	0.296MetTyr: 0.296 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.576AsnAla: 2.576 ± 0.055	0.155AsnCys: 0.155 ± 0.013	0.966AsnAsp: 0.966 ± 0.034	0.817AsnGlu: 0.817 ± 0.033	0.65AsnPhe: 0.65 ± 0.027	1.568AsnGly: 1.568 ± 0.044	0.384AsnHis: 0.384 ± 0.023	0.877AsnIle: 0.877 ± 0.035	0.396AsnLys: 0.396 ± 0.024	1.883AsnLeu: 1.883 ± 0.05	0.455AsnMet: 0.455 ± 0.023	0.424AsnAsn: 0.424 ± 0.027	1.423AsnPro: 1.423 ± 0.04	0.448AsnGln: 0.448 ± 0.026	1.373AsnArg: 1.373 ± 0.046	0.668AsnSer: 0.668 ± 0.027	0.958AsnThr: 0.958 ± 0.037	1.481AsnVal: 1.481 ± 0.039	0.281AsnTrp: 0.281 ± 0.018	0.453AsnTyr: 0.453 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	7.947ProAla: 7.947 ± 0.121	0.366ProCys: 0.366 ± 0.022	3.97ProAsp: 3.97 ± 0.063	5.741ProGlu: 5.741 ± 0.092	1.891ProPhe: 1.891 ± 0.039	5.661ProGly: 5.661 ± 0.097	1.058ProHis: 1.058 ± 0.036	1.693ProIle: 1.693 ± 0.048	1.145ProLys: 1.145 ± 0.035	4.913ProLeu: 4.913 ± 0.076	1.231ProMet: 1.231 ± 0.033	0.899ProAsn: 0.899 ± 0.027	3.163ProPro: 3.163 ± 0.088	1.409ProGln: 1.409 ± 0.041	3.965ProArg: 3.965 ± 0.079	2.038ProSer: 2.038 ± 0.044	2.072ProThr: 2.072 ± 0.052	4.711ProVal: 4.711 ± 0.077	0.794ProTrp: 0.794 ± 0.033	1.068ProTyr: 1.068 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.844GlnAla: 3.844 ± 0.065	0.15GlnCys: 0.15 ± 0.015	1.38GlnAsp: 1.38 ± 0.042	1.503GlnGlu: 1.503 ± 0.045	0.765GlnPhe: 0.765 ± 0.031	2.41GlnGly: 2.41 ± 0.052	0.413GlnHis: 0.413 ± 0.023	1.375GlnIle: 1.375 ± 0.042	0.661GlnLys: 0.661 ± 0.028	2.332GlnLeu: 2.332 ± 0.061	0.785GlnMet: 0.785 ± 0.029	0.551GlnAsn: 0.551 ± 0.025	1.423GlnPro: 1.423 ± 0.037	0.786GlnGln: 0.786 ± 0.036	2.015GlnArg: 2.015 ± 0.043	1.212GlnSer: 1.212 ± 0.039	1.379GlnThr: 1.379 ± 0.033	2.002GlnVal: 2.002 ± 0.038	0.311GlnTrp: 0.311 ± 0.019	0.432GlnTyr: 0.432 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	12.845ArgAla: 12.845 ± 0.169	0.516ArgCys: 0.516 ± 0.026	4.981ArgAsp: 4.981 ± 0.066	5.028ArgGlu: 5.028 ± 0.072	2.994ArgPhe: 2.994 ± 0.061	5.973ArgGly: 5.973 ± 0.094	1.818ArgHis: 1.818 ± 0.053	3.91ArgIle: 3.91 ± 0.075	1.788ArgLys: 1.788 ± 0.043	9.731ArgLeu: 9.731 ± 0.143	2.118ArgMet: 2.118 ± 0.044	1.415ArgAsn: 1.415 ± 0.04	4.594ArgPro: 4.594 ± 0.083	2.096ArgGln: 2.096 ± 0.058	7.748ArgArg: 7.748 ± 0.113	2.861ArgSer: 2.861 ± 0.053	3.433ArgThr: 3.433 ± 0.053	6.098ArgVal: 6.098 ± 0.089	1.173ArgTrp: 1.173 ± 0.035	1.564ArgTyr: 1.564 ± 0.05	0.001ArgXaa: 0.001 ± 0.001
Ser	5.121SerAla: 5.121 ± 0.069	0.338SerCys: 0.338 ± 0.021	2.541SerAsp: 2.541 ± 0.059	2.529SerGlu: 2.529 ± 0.056	1.729SerPhe: 1.729 ± 0.044	4.54SerGly: 4.54 ± 0.072	0.784SerHis: 0.784 ± 0.033	1.665SerIle: 1.665 ± 0.045	0.901SerLys: 0.901 ± 0.033	3.937SerLeu: 3.937 ± 0.079	1.007SerMet: 1.007 ± 0.04	0.837SerAsn: 0.837 ± 0.031	2.05SerPro: 2.05 ± 0.042	0.985SerGln: 0.985 ± 0.037	2.812SerArg: 2.812 ± 0.059	1.626SerSer: 1.626 ± 0.046	1.819SerThr: 1.819 ± 0.047	3.244SerVal: 3.244 ± 0.064	0.557SerTrp: 0.557 ± 0.028	0.988SerTyr: 0.988 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	6.561ThrAla: 6.561 ± 0.09	0.39ThrCys: 0.39 ± 0.022	2.907ThrAsp: 2.907 ± 0.07	3.311ThrGlu: 3.311 ± 0.062	1.702ThrPhe: 1.702 ± 0.046	5.515ThrGly: 5.515 ± 0.082	1.05ThrHis: 1.05 ± 0.032	2.099ThrIle: 2.099 ± 0.056	1.0ThrLys: 1.0 ± 0.04	6.181ThrLeu: 6.181 ± 0.104	0.996ThrMet: 0.996 ± 0.033	0.949ThrAsn: 0.949 ± 0.037	3.555ThrPro: 3.555 ± 0.067	1.253ThrGln: 1.253 ± 0.038	3.98ThrArg: 3.98 ± 0.065	2.012ThrSer: 2.012 ± 0.052	2.524ThrThr: 2.524 ± 0.062	4.23ThrVal: 4.23 ± 0.076	0.637ThrTrp: 0.637 ± 0.029	1.027ThrTyr: 1.027 ± 0.038	0.001ThrXaa: 0.001 ± 0.001
Val	11.008ValAla: 11.008 ± 0.131	0.626ValCys: 0.626 ± 0.025	3.957ValAsp: 3.957 ± 0.064	5.245ValGlu: 5.245 ± 0.077	2.666ValPhe: 2.666 ± 0.057	5.341ValGly: 5.341 ± 0.082	1.338ValHis: 1.338 ± 0.042	3.592ValIle: 3.592 ± 0.076	1.677ValLys: 1.677 ± 0.055	7.453ValLeu: 7.453 ± 0.102	1.952ValMet: 1.952 ± 0.047	1.623ValAsn: 1.623 ± 0.045	3.934ValPro: 3.934 ± 0.073	1.89ValGln: 1.89 ± 0.045	5.287ValArg: 5.287 ± 0.078	3.555ValSer: 3.555 ± 0.066	5.135ValThr: 5.135 ± 0.091	6.08ValVal: 6.08 ± 0.097	1.068ValTrp: 1.068 ± 0.032	1.408ValTyr: 1.408 ± 0.041	0.001ValXaa: 0.001 ± 0.001
Trp	1.657TrpAla: 1.657 ± 0.046	0.129TrpCys: 0.129 ± 0.011	0.701TrpAsp: 0.701 ± 0.03	0.727TrpGlu: 0.727 ± 0.027	0.562TrpPhe: 0.562 ± 0.025	1.045TrpGly: 1.045 ± 0.038	0.336TrpHis: 0.336 ± 0.019	0.66TrpIle: 0.66 ± 0.03	0.319TrpLys: 0.319 ± 0.019	1.694TrpLeu: 1.694 ± 0.048	0.359TrpMet: 0.359 ± 0.021	0.307TrpAsn: 0.307 ± 0.017	0.772TrpPro: 0.772 ± 0.027	0.568TrpGln: 0.568 ± 0.026	1.445TrpArg: 1.445 ± 0.044	0.688TrpSer: 0.688 ± 0.026	0.797TrpThr: 0.797 ± 0.03	0.839TrpVal: 0.839 ± 0.029	0.251TrpTrp: 0.251 ± 0.017	0.24TrpTyr: 0.24 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.725TyrAla: 2.725 ± 0.055	0.208TyrCys: 0.208 ± 0.014	1.454TyrAsp: 1.454 ± 0.046	1.161TyrGlu: 1.161 ± 0.044	0.71TyrPhe: 0.71 ± 0.029	1.926TyrGly: 1.926 ± 0.048	0.497TyrHis: 0.497 ± 0.023	0.714TyrIle: 0.714 ± 0.025	0.443TyrLys: 0.443 ± 0.021	1.97TyrLeu: 1.97 ± 0.047	0.403TyrMet: 0.403 ± 0.021	0.407TyrAsn: 0.407 ± 0.021	0.967TyrPro: 0.967 ± 0.032	0.516TyrGln: 0.516 ± 0.026	1.625TyrArg: 1.625 ± 0.045	0.828TyrSer: 0.828 ± 0.033	1.045TyrThr: 1.045 ± 0.039	1.437TyrVal: 1.437 ± 0.043	0.299TyrTrp: 0.299 ± 0.019	0.484TyrTyr: 0.484 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.001XaaTrp: 0.001 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2966 proteins (913301 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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